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Molecular and Cellular Biology Volume 26, 2006 - Issue 8
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Article

Structure and Function of the Saccharomyces cerevisiae Sir3 BAH Domain

Jessica J. Connelly1 Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York11794-5215
,
Peihua Yuan1 Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York11794-5215
,
Hao-Chi Hsu2 W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
,
Zhizhong Li2 W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724
,
Rui-Ming Xu2 W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York11724Correspondence[email protected] [email protected]
&
Rolf Sternglanz1 Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York11794-5215Correspondence[email protected] [email protected]
Pages 3256-3265 | Received 15 Jun 2005, Accepted 12 Jan 2006, Published online: 27 Mar 2023

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Na Yang & Rui-Ming Xu. (2013) Structure and function of the BAH domain in chromatin biology. Critical Reviews in Biochemistry and Molecular Biology 48:3, pages 211-221.
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Vinaya Sampath, Peihua Yuan, Isabel X. Wang, Evelyn Prugar, Fred van Leeuwen & Rolf Sternglanz. (2009) Mutational Analysis of the Sir3 BAH Domain Reveals Multiple Points of Interaction with Nucleosomes. Molecular and Cellular Biology 29:10, pages 2532-2545.
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Zhonggang Hou, John R. Danzer, Liza Mendoza, Melissa E. Bose, Ulrika Müller, Barry Williams & Catherine A. Fox. (2009) Phylogenetic Conservation and Homology Modeling Help Reveal a Novel Domain within the Budding Yeast Heterochromatin Protein Sir1. Molecular and Cellular Biology 29:3, pages 687-702.
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Johannes R. Buchberger, Megumi Onishi, Geng Li, Jan Seebacher, Adam D. Rudner, Steven P. Gygi & Danesh Moazed. (2008) Sir3-Nucleosome Interactions in Spreading of Silent Chromatin in Saccharomyces cerevisiae. Molecular and Cellular Biology 28:22, pages 6903-6918.
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Tibor van Welsem, Floor Frederiks, Kitty F. Verzijlbergen, Alex W. Faber, Zara W. Nelson, David A. Egan, Daniel E. Gottschling & Fred van Leeuwen. (2008) Synthetic Lethal Screens Identify Gene Silencing Processes in Yeast and Implicate the Acetylated Amino Terminus of Sir3 in Recognition of the Nucleosome Core. Molecular and Cellular Biology 28:11, pages 3861-3872.
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Steven J. McBryant, Christine Krause, Christopher L. Woodcock & Jeffrey C. Hansen. (2008) The Silent Information Regulator 3 Protein, SIR3p, Binds to Chromatin Fibers and Assembles a Hypercondensed Chromatin Architecture in the Presence of Salt. Molecular and Cellular Biology 28:11, pages 3563-3572.
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Shreyas Arvindekar, Matthew J. Jackman, Jason K. K. Low, Michael J. Landsberg, Joel P. Mackay & Shruthi Viswanath. (2022) Molecular architecture of nucleosome remodeling and deacetylase sub‐complexes by integrative structure determination. Protein Science 31:9.
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Haniam Maria & Laura N Rusche. (2022) The DNA replication protein Orc1 from the yeast Torulaspora delbrueckii is required for heterochromatin formation but not as a silencer-binding protein . Genetics 222:1.
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Ishan Deshpande, Jeremy J Keusch, Kiran Challa, Vytautas Iesmantavicius, Susan M Gasser & Heinz Gut. (2019) The Sir4 H‐ BRCT domain interacts with phospho‐proteins to sequester and repress yeast heterochromatin . The EMBO Journal 38:20.
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Sue-Hong Wang, Sue-Ping Lee, Shu-Yun Tung, Shu-Ping Tsai, Hsieh-Chin Tsai, Hsiao-Hsuian Shen, Jia-Yang Hong, Kuan-Chung Su, Feng-Jung Chen, Bang-Hung Liu, Yu-Yi Wu, Sheng-Pin Hsiao, Ming-Shiun Tsai & Gunn-Guang Liou. (2019) Stabilization of Sir3 interactions by an epigenetic metabolic small molecule, O-acetyl-ADP-ribose, on yeast SIR-nucleosome silent heterochromatin. Archives of Biochemistry and Biophysics 671, pages 167-174.
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Tung, Wang, Lee, Tsai, Su, Shen, Hong, Tsai & Liou. (2019) The Capability of O-Acetyl-ADP-Ribose, an Epigenetic Metabolic Small Molecule, on Promoting the Further Spreading of Sir3 along the Telomeric Chromatin. Genes 10:8, pages 577.
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Pablo De Ioannes, Victor A. Leon, Zheng Kuang, Miao Wang, Jef D. Boeke, Andreas Hochwagen & Karim-Jean Armache. (2019) Structure and function of the Orc1 BAH-nucleosome complex. Nature Communications 10:1.
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Dominika M Wloch-Salamon, Katarzyna Tomala, Dimitra Aggeli & Barbara Dunn. (2017) Adaptive Roles of SSY1 and SIR3 During Cycles of Growth and Starvation in Saccharomyces cerevisiae Populations Enriched for Quiescent or Nonquiescent Cells . G3 Genes|Genomes|Genetics 7:6, pages 1899-1911.
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Marc R Gartenberg & Jeffrey S Smith. (2016) The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae . Genetics 203:4, pages 1563-1599.
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Michelle L. Larin, Katherine Harding, Elizabeth C. Williams, Noel Lianga, Carole Doré, Sophie Pilon, Éric Langis, Corey Yanofsky & Adam D. Rudner. (2015) Competition between Heterochromatic Loci Allows the Abundance of the Silencing Protein, Sir4, to Regulate de novo Assembly of Heterochromatin. PLOS Genetics 11:11, pages e1005425.
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David S. Rogawski, Juliano Ndoj, Hyo Je Cho, Ivan Maillard, Jolanta Grembecka & Tomasz Cierpicki. (2015) Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. Biochemistry 54:35, pages 5401-5413.
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Robert K. McGinty & Song Tan. (2014) Nucleosome Structure and Function. Chemical Reviews 115:6, pages 2255-2273.
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Sarah G. Swygert, Benjamin J. Manning, Subhadip Senapati, Parminder Kaur, Stuart Lindsay, Borries Demeler & Craig L. Peterson. (2014) Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres. Nature Communications 5:1.
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Stephanie Kueng, Mariano Oppikofer & Susan M. Gasser. (2013) SIR Proteins and the Assembly of Silent Chromatin in Budding Yeast. Annual Review of Genetics 47:1, pages 275-306.
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Nadia Arnaudo, Israel S Fernández, Stephen H McLaughlin, Sew Y Peak-Chew, Daniela Rhodes & Fabrizio Martino. (2013) The N-terminal acetylation of Sir3 stabilizes its binding to the nucleosome core particle. Nature Structural & Molecular Biology 20:9, pages 1119-1121.
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Dongxue Yang, Qianglin Fang, Mingzhu Wang, Ren Ren, Hong Wang, Meng He, Youwei Sun, Na Yang & Rui-Ming Xu. (2013) Nα-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nature Structural & Molecular Biology 20:9, pages 1116-1118.
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Shalu M. Varunan, Jaishree Tripathi, Sunanda Bhattacharyya, Tanvi Suhane & Mrinal Kanti Bhattacharyya. (2013) Plasmodium falciparum origin recognition complex subunit 1 (PfOrc1) functionally complements Δsir3 mutant of Saccharomyces cerevisiae. Molecular and Biochemical Parasitology 191:1, pages 28-35.
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Mariano Oppikofer, Stephanie Kueng & Susan M. Gasser. (2013) SIR–nucleosome interactions: Structure–function relationships in yeast silent chromatin. Gene 527:1, pages 10-25.
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Anna A. Kalashnikova, Mary E. Porter-Goff, Uma M. Muthurajan, Karolin Luger & Jeffrey C. Hansen. (2013) The role of the nucleosome acidic patch in modulating higher order chromatin structure. Journal of The Royal Society Interface 10:82, pages 20121022.
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Shu-Yun Tung, Kuan-Wei Lee, Jia-Yang Hong, Sue-Ping Lee, Hsiao-Hsuian Shen & Gunn-Guang Liou. (2013) CHANGES IN THE GENOME-WIDE LOCALIZATION PATTERN OF SIR3 IN SACCHAROMYCES CEREVISIAE DURING DIFFERENT GROWTH STAGES. Computational and Structural Biotechnology Journal 7:8, pages e201304001.
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Mariano Oppikofer, Stephanie Kueng, Jeremy J Keusch, Markus Hassler, Andreas G Ladurner, Heinz Gut & Susan M Gasser. (2013) Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation. The EMBO Journal 32:3, pages 437-449.
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John J. Wyrick, McKenna N.M. Kyriss & William B. Davis. (2012) Ascending the nucleosome face: Recognition and function of structured domains in the histone H2A–H2B dimer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1819:8, pages 892-901.
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Karim-Jean ArmacheJoseph D. GarlickDaniele CanzioGeeta J. NarlikarRobert E. Kingston. (2011) Structural Basis of Silencing: Sir3 BAH Domain in Complex with a Nucleosome at 3.0 Å Resolution. Science 334:6058, pages 977-982.
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Meleah A. Hickman, Cara A. Froyd & Laura N. Rusche. (2011) Reinventing Heterochromatin in Budding Yeasts: Sir2 and the Origin Recognition Complex Take Center Stage. Eukaryotic Cell 10:9, pages 1183-1192.
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Stefan Ehrentraut, Markus Hassler, Mariano Oppikofer, Stephanie Kueng, Jan M. Weber, Jonathan W. Mueller, Susan M. Gasser, Andreas G. Ladurner & Ann E. Ehrenhofer-Murray. (2011) Structural basis for the role of the Sir3 AAA + domain in silencing: interaction with Sir4 and unmethylated histone H3K79 . Genes & Development 25:17, pages 1835-1846.
Crossref
Eugenia T Prescott, Alexias Safi & Laura N Rusche. (2011) A Region of the Nucleosome Required for Multiple Types of Transcriptional Silencing in Saccharomyces cerevisiae . Genetics 188:3, pages 535-548.
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Pegine B. Walrad, Saiyu Hang & J. Peter Gergen. (2011) Hairless is a cofactor for Runt-dependent transcriptional regulation. Molecular Biology of the Cell 22:8, pages 1364-1374.
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Myriam Ruault, Arnaud De Meyer, Isabelle Loïodice & Angela Taddei. (2011) Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeast. Journal of Cell Biology 192:3, pages 417-431.
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Meleah A. Hickman & Laura N. Rusche. (2010) Transcriptional silencing functions of the yeast protein Orc1/Sir3 subfunctionalized after gene duplication. Proceedings of the National Academy of Sciences 107:45, pages 19384-19389.
Crossref
Nicolas M. Berbenetz, Corey Nislow & Grant W. Brown. (2010) Diversity of Eukaryotic DNA Replication Origins Revealed by Genome-Wide Analysis of Chromatin Structure. PLoS Genetics 6:9, pages e1001092.
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Philipp Müller, Sookhee Park, Erika Shor, Dana J. Huebert, Christopher L. Warren, Aseem Z. Ansari, Michael Weinreich, Matthew L. Eaton, David M. MacAlpine & Catherine A. Fox. (2010) The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin. Genes & Development 24:13, pages 1418-1433.
Crossref
MAHMOOD HASSAN, KLAUS OLDACH, UTE BAUMANN, PETER LANGRIDGE & TIM SUTTON. (2010) Genes mapping to boron tolerance QTL in barley identified by suppression subtractive hybridization. Plant, Cell & Environment 33:2, pages 188-198.
Crossref
Anne Norris & Jef D. Boeke. (2010) Silent information regulator 3: the Goldilocks of the silencing complex. Genes & Development 24:2, pages 115-122.
Crossref
Bongyong LeeMark T. Muller. (2009) SUMOylation enhances DNA methyltransferase 1 activity. Biochemical Journal 421:3, pages 449-461.
Crossref
Jennifer E G Gallagher, Joshua E Babiarz, Leonid Teytelman, Kenneth H Wolfe & Jasper Rine. (2009) Elaboration, Diversification and Regulation of the Sir1 Family of Silencing Proteins in Saccharomyces. Genetics 181:4, pages 1477-1491.
Crossref
Fabrizio Martino, Stephanie Kueng, Philip Robinson, Monika Tsai-Pflugfelder, Fred van Leeuwen, Mathias Ziegler, Fabien Cubizolles, Moira M. Cockell, Daniela Rhodes & Susan M. Gasser. (2009) Reconstitution of Yeast Silent Chromatin: Multiple Contact Sites and O-AADPR Binding Load SIR Complexes onto Nucleosomes In Vitro. Molecular Cell 33:3, pages 323-334.
Crossref
Anne Norris, Mario A. Bianchet & Jef D. Boeke. (2008) Compensatory Interactions between Sir3p and the Nucleosomal LRS Surface Imply Their Direct Interaction. PLoS Genetics 4:12, pages e1000301.
Crossref
Lei Wang & Chih-Cheng Tsai. (2008) Atrophin Proteins: An Overview of a New Class of Nuclear Receptor Corepressors. Nuclear Receptor Signaling 6:1, pages nrs.06009.
Crossref
Megumi Onishi, Gunn-Guang Liou, Johannes R. Buchberger, Thomas Walz & Danesh Moazed. (2007) Role of the Conserved Sir3-BAH Domain in Nucleosome Binding and Silent Chromatin Assembly. Molecular Cell 28:6, pages 1015-1028.
Crossref
Kohji Noguchi, Alex Vassilev, Soma Ghosh, John L Yates & Melvin L DePamphilis. (2006) The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo. The EMBO Journal 25:22, pages 5372-5382.
Crossref
. (2006) Current awareness on yeast. Yeast 23:14-15, pages 1115-1122.
Crossref
Paul B. Talbert & Steven Henikoff. (2006) Spreading of silent chromatin: inaction at a distance. Nature Reviews Genetics 7:10, pages 793-803.
Crossref

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