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Molecular and Cellular Biology Volume 26, 2006 - Issue 9
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Article

Protein Kinase C δ Activates Topoisomerase IIα To Induce Apoptotic Cell Death in Response to DNA Damage

Kiyotsugu Yoshida1 Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo113-8510, JapanCorrespondence[email protected]
,
Tomoko Yamaguchi1 Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo113-8510, Japan
,
Hirokuni Shinagawa1 Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo113-8510, Japan
,
Naoe Taira1 Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo113-8510, Japan
,
Keiichi I. Nakayama2 Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka812-8582, Japan
&
Yoshio Miki1 Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo113-8510, Japan
Pages 3414-3431 | Received 17 Jan 2006, Accepted 03 Feb 2006, Published online: 27 Mar 2023

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Hanshao Liu, Zheng-Guang Lu, Yoshio Miki & Kiyotsugu Yoshida. (2007) Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic Response to DNA Damage. Molecular and Cellular Biology 27:24, pages 8480-8491.
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Sten M. Wie, Tariq S. Adwan, James DeGregori, Steven M. Anderson & Mary E. Reyland. (2014) Inhibiting Tyrosine Phosphorylation of Protein Kinase Cδ (PKCδ) Protects the Salivary Gland from Radiation Damage. Journal of Biological Chemistry 289:15, pages 10900-10908.
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Li Xia, Tong-Dan Wang, Shao-Ming Shen, Meng Zhao, Han Sun, Ying He, Lu Xie, Zhao-Xia Wu, San-Feng Han, Li-Shun Wang & Guo-Qiang Chen. (2013) Phosphoproteomics Study on the Activated PKCδ-Induced Cell Death. Journal of Proteome Research 12:10, pages 4280-4301.
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S. Hicks, N. Labinskyy, B. Piteo, D. Laurent, J. E. Mathew, S. A. Gupte & J. G. Edwards. (2013) Type II diabetes increases mitochondrial DNA mutations in the left ventricle of the Goto-Kakizaki diabetic rat. American Journal of Physiology-Heart and Circulatory Physiology 304:7, pages H903-H915.
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Daniel Arango, Arti Parihar, Frederick A. Villamena, Liwen Wang, Michael A. Freitas, Erich Grotewold & Andrea I. Doseff. (2012) Apigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair. Biochemical Pharmacology 84:12, pages 1571-1580.
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Riikka Mattila, Jaana Rautava & Stina Syrjänen. (2012) Human papillomavirus in oral atrophic lichen planus lesions. Oral Oncology 48:10, pages 980-984.
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Meng Zhao, Li Xia & Guo-Qiang Chen. (2012) Protein Kinase Cδ in Apoptosis: A Brief Overview. Archivum Immunologiae et Therapiae Experimentalis 60:5, pages 361-372.
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Eriko Taniai, Hitomi Hayashi, Atsunori Yafune, Maiko Watanabe, Hirotoshi Akane, Kazuhiko Suzuki, Kunitoshi Mitsumori & Makoto Shibutani. (2012) Cellular distribution of cell cycle-related molecules in the renal tubules of rats treated with renal carcinogens for 28 days: relationship between cell cycle aberration and carcinogenesis. Archives of Toxicology 86:9, pages 1453-1464.
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Naoe Taira, Rei Mimoto, Morito Kurata, Tomoko Yamaguchi, Masanobu Kitagawa, Yoshio Miki & Kiyotsugu Yoshida. (2012) DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. Journal of Clinical Investigation 122:3, pages 859-872.
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Hoi Chin Hew, Hanshao Liu, Zheng-Guang Lu, Junko Kimura, Yoshio Miki & Kiyotsugu Yoshida. (2011) Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1809:7, pages 285-294.
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Mei-Chuan Chen, Chun-Han Chen, Hsiao-Ching Chuang, Samuel K. Kulp, Che-Ming Teng & Ching-Shih Chen. (2011) Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells. Hepatology 53:1, pages 148-159.
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Younsoo Bae, Adam W. G. Alani, Nicole C. Rockich, T. S. Z. Chung Lai & Glen S. Kwon. (2010) Mixed pH-Sensitive Polymeric Micelles for Combination Drug Delivery. Pharmaceutical Research 27:11, pages 2421-2432.
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Tomoko Yamaguchi, Yoshio Miki & Kiyotsugu Yoshida. (2010) The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage. Apoptosis 15:8, pages 927-935.
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S McNamara, J N Nichol, H Wang & W H MillerJrJr. (2010) Targeting PKCδ-mediated topoisomerase IIβ overexpression subverts the differentiation block in a retinoic acid-resistant APL cell line. Leukemia 24:4, pages 729-739.
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K Nihira, Y Ando, T Yamaguchi, Y Kagami, Y Miki & K Yoshida. (2009) Pim-1 controls NF-κB signalling by stabilizing RelA/p65. Cell Death & Differentiation 17:4, pages 689-698.
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Naoe Taira, Hiroyuki Yamamoto, Tomoko Yamaguchi, Yoshio Miki & Kiyotsugu Yoshida. (2010) ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage. Journal of Biological Chemistry 285:7, pages 4909-4919.
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Edward L. LaGory, Leonid A. Sitailo & Mitchell F. Denning. (2010) The Protein Kinase Cδ Catalytic Fragment Is Critical for Maintenance of the G2/M DNA Damage Checkpoint. Journal of Biological Chemistry 285:3, pages 1879-1887.
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Kiyotsugu Yoshida. 2010. Protein Kinase C in Cancer Signaling and Therapy. Protein Kinase C in Cancer Signaling and Therapy 253 265 .
Kaori Kato, Dai Yamanouchi, Karla Esbona, Kentaro Kamiya, Fan Zhang, K. Craig Kent & Bo Liu. (2009) Caspase-mediated protein kinase C-δ cleavage is necessary for apoptosis of vascular smooth muscle cells. American Journal of Physiology-Heart and Circulatory Physiology 297:6, pages H2253-H2261.
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Hanshao Liu, Hoi Chin Hew, Zheng-Guang Lu, Tomoko Yamaguchi, Yoshio Miki & Kiyotsugu Yoshida. (2009) DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter. Biochemical Journal 422:3, pages 543-551.
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Zheng-Guang Lu, Hanshao Liu, Tomoko Yamaguchi, Yoshio Miki & Kiyotsugu Yoshida. (2009) Protein Kinase Cδ Activates RelA/p65 and Nuclear Factor-κB Signaling in Response to Tumor Necrosis Factor-α. Cancer Research 69:14, pages 5927-5935.
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K Nihira, N Taira, Y Miki & K Yoshida. (2008) TTK/Mps1 controls nuclear targeting of c-Abl by 14-3-3-coupled phosphorylation in response to oxidative stress. Oncogene 27:58, pages 7285-7295.
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Yang Wang, Yoshiaki Azuma, David Moore, Neil Osheroff & Kristi L. Neufeld. (2008) Interaction between Tumor Suppressor Adenomatous Polyposis Coli and Topoisomerase IIα: Implication for the G2/M Transition. Molecular Biology of the Cell 19:10, pages 4076-4085.
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Kiyotsugu Yoshida. (2008) Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. Trends in Molecular Medicine 14:7, pages 305-313.
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Hirokuni ShinagawaYoshio MikiKiyotsugu Yoshida. (2008) BRCA1-Mediated Ubiquitination Inhibits Topoisomerase II α Activity in Response to Oxidative Stress . Antioxidants & Redox Signaling 10:5, pages 939-950.
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Tomoko Yamaguchi, Junko Kimura, Yoshio Miki & Kiyotsugu Yoshida. (2007) The Deubiquitinating Enzyme USP11 Controls an IκB Kinase α (IKKα)-p53 Signaling Pathway in Response to Tumor Necrosis Factor α (TNFα). Journal of Biological Chemistry 282:47, pages 33943-33948.
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Tomoko Yamaguchi, Yoshio Miki & Kiyotsugu Yoshida. (2007) Protein kinase C δ activates IκB-kinase α to induce the p53 tumor suppressor in response to oxidative stress. Cellular Signalling 19:10, pages 2088-2097.
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Tracie A. DeVries-Seimon, Angela M. Ohm, Michael J. Humphries & Mary E. Reyland. (2007) Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase Cδ. Journal of Biological Chemistry 282:31, pages 22307-22314.
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Kiyotsugu Yoshida. (2007) PKCδ signaling: Mechanisms of DNA damage response and apoptosis. Cellular Signalling 19:5, pages 892-901.
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Erin M. Griner & Marcelo G. Kazanietz. (2007) Protein kinase C and other diacylglycerol effectors in cancer. Nature Reviews Cancer 7:4, pages 281-294.
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Naoe Taira, Keishi Nihira, Tomoko Yamaguchi, Yoshio Miki & Kiyotsugu Yoshida. (2007) DYRK2 Is Targeted to the Nucleus and Controls p53 via Ser46 Phosphorylation in the Apoptotic Response to DNA Damage. Molecular Cell 25:5, pages 725-738.
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Riikka Mattila, Kalle Alanen & Stina Syrjänen. (2006) Immunohistochemical study on topoisomerase IIα, Ki-67 and cytokeratin-19 in oral lichen planus lesions. Archives of Dermatological Research 298:8, pages 381-388.
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