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Cell Growth and Development

The Human T-Lymphotropic Virus Type I tax Gene Can Cooperate with the ras Oncogene To Induce Neoplastic Transformation of Cells

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Pages 413-417 | Received 28 Jul 1989, Accepted 03 Oct 1989, Published online: 01 Apr 2023

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Read on this site (12)

Baoying Liu, Min-Hui Liang, Yu-liang Kuo, Wei Liao, Imre Boros, Tami Kleinberger, Jan Blancato & Chou-Zen Giam. (2003) Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability. Molecular and Cellular Biology 23:15, pages 5269-5281.
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Romas Geleziunas, Sharon Ferrell, Xin Lin, Yajun Mu, Emmett T. Cunningham$suffix/text()$suffix/text(), Mark Grant, Margery A. Connelly, John E. Hambor, Kenneth B. Marcu & Warner C. Greene. (1998) Human T-Cell Leukemia Virus Type 1 Tax Induction of NF-κB Involves Activation of the IκB Kinase α (IKKα) and IKKβ Cellular Kinases. Molecular and Cellular Biology 18:9, pages 5157-5165.
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Christine Neuveut, Kenneth G. Low, Frank Maldarelli, Iris Schmitt, Franca Majone, Ralph Grassmann & Kuan-Teh Jeang. (1998) Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb. Molecular and Cellular Biology 18:6, pages 3620-3632.
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Françoise Bex, Min-Jean Yin, Arsène Burny & Richard B. Gaynor. (1998) Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300. Molecular and Cellular Biology 18:4, pages 2392-2405.
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Cynthia A. Pise-Masison, Jürgen Dittmer, Karen E. Clemens & John N. Brady. (1997) Physical and Functional Interaction between the Human T-Cell Lymphotropic Virus Type 1 Tax1 Protein and the CCAAT Binding Protein NF-Y. Molecular and Cellular Biology 17:3, pages 1236-1243.
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Timothy A. Mckinsey, Jeffrey A. Brockman, David C. Scherer, Samer W. Al-Murrani, Patrick L. Green & Dean W. Ballard. (1996) Inactivation of IκBβ by the Tax Protein of Human T-Cell Leukemia Virus Type 1: a Potential Mechanism for Constitutive Induction of NF-κB. Molecular and Cellular Biology 16:5, pages 2083-2090.
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Shao-Cong Sun, John Elwood, Christophe Béraud & Warner C. Greene. (1994) Human T-Cell Leukemia Virus Type I Tax Activation of NF-ΝB/Rel Involves Phosphorylation and Degradation of IΙBκ and RelA (p65)-Mediated Induction of the italic toc-rel Gene. Molecular and Cellular Biology 14:11, pages 7377-7384.
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Christophe Béraud, Shao-Cong Sun, Parham Ganchi, Dean W. Ballard & Warner C. Greene. (1994) Human T-Cell Leukemia Virus Type I Tax Associates with and Is Negatively Regulated by the NF-κB2 p100 Gene Product: Implications for Viral Latency. Molecular and Cellular Biology 14:2, pages 1374-1382.
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Maura-Ann H. Matthews, Rhea-Beth Markowitz & William S. Dynan. (1992) In Vitro Activation of Transcription by the Human T-Cell Leukemia Virus Type I Tax Protein. Molecular and Cellular Biology 12:5, pages 1986-1996.
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Susan J. Marriott, Paul F. Lindholm, Kenneth M. Brown, Scott D. Gitlin, Janet F. Duvall, Michael F. Radonovich & John N. Brady. (1990) A 36-Kilodalton Cellular Transcription Factor Mediates an Indirect Interaction of Human T-Cell Leukemia/Lymphoma Virus Type I TAX1 with a Responsive Element in the Viral Long Terminal Repeat. Molecular and Cellular Biology 10:8, pages 4192-4201.
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Articles from other publishers (32)

Yik-Khuan Ho, Huijun Zhi, Dominic DeBiaso, Subha Philip, Hsiu-Ming Shih & Chou-Zen Giam. (2012) HTLV-1 Tax-Induced Rapid Senescence Is Driven by the Transcriptional Activity of NF-κB and Depends on Chronically Activated IKKα and p65/RelA. Journal of Virology 86:17, pages 9474-9483.
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Man Lung Yeung, Jun-ichirou Yasunaga, Yamina Bennasser, Nelson Dusetti, David Harris, Nafees Ahmad, Masao Matsuoka & Kuan-Teh Jeang. (2008) Roles for MicroRNAs, miR-93 and miR-130b, and Tumor Protein 53–Induced Nuclear Protein 1 Tumor Suppressor in Cell Growth Dysregulation by Human T-Cell Lymphotrophic Virus 1. Cancer Research 68:21, pages 8976-8985.
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Kyung-Jin Jung, Arindam Dasgupta, Keven Huang, Soo-Jin Jeong, Cynthia Pise-Masison, Katerina V. Gurova & John N. Brady. (2008) Small-Molecule Inhibitor Which Reactivates p53 in Human T-Cell Leukemia Virus Type 1-Transformed Cells. Journal of Virology 82:17, pages 8537-8547.
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S A Chevalier, L Meertens, C Pise-Masison, S Calattini, H Park, A A Alhaj, M Zhou, A Gessain, F Kashanchi, J N Brady & R Mahieux. (2006) The tax protein from the primate T-cell lymphotropic virus type 3 is expressed in vivo and is functionally related to HTLV-1 Tax rather than HTLV-2 Tax. Oncogene 25:32, pages 4470-4482.
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Pavel Klener, Maud Szynal, Yvette Cleuter, Makram Merimi, Hugues Duvillier, Françoise Lallemand, Claude Bagnis, Philip Griebel, Christos Sotiriou, Arsène Burny, Philippe Martiat & Anne Van den Broeke. (2006) Insights into Gene Expression Changes Impacting B-Cell Transformation: Cross-Species Microarray Analysis of Bovine Leukemia Virus Tax-Responsive Genes in Ovine B Cells. Journal of Virology 80:4, pages 1922-1938.
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Mitsuaki Yoshida. (2005) Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene 24:39, pages 5931-5937.
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Shao-Cong Sun & Shoji Yamaoka. (2005) Activation of NF-κB by HTLV-I and implications for cell transformation. Oncogene 24:39, pages 5952-5964.
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Akiko Miyazato, Sergey Sheleg, Hidekatsu Iha, Yan Li & Kuan-Teh Jeang. (2005) Evidence for NF-κB- and CBP-Independent Repression of p53's Transcriptional Activity by Human T-Cell Leukemia Virus Type 1 Tax in Mouse Embryo and Primary Human Fibroblasts. Journal of Virology 79:14, pages 9346-9350.
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Jun Matsumoto, Takayuki Ohshima, Osamu Isono & Kunitada Shimotohno. (2004) HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene 24:6, pages 1001-1010.
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Jean-Marie PeloponeseJr.Jr., Hidekatsu Iha, Venkat R. K. Yedavalli, Akiko Miyazato, Yan Li, Kerstin Haller, Monsef Benkirane & Kuan-Teh Jeang. (2004) Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity. Journal of Virology 78:21, pages 11686-11695.
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Maud Szynal, Yvette Cleuter, Terry Beskorwayne, Claude Bagnis, Carine Van Lint, Pierre Kerkhofs, Aisene Burny, Philippe Martiat, Philip Griebel & Anne Van den Broeke. (2003) Disruption of B-cell homeostatic control mediated by the BLV-Tax oncoprotein: association with the upregulation of Bcl-2 and signaling through NF-κB. Oncogene 22:29, pages 4531-4542.
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Cyril J. Cohen, Offra Sarig, Yoshihisa Yamano, Utano Tomaru, Steven Jacobson & Yoram Reiter. (2003) Direct Phenotypic Analysis of Human MHC Class I Antigen Presentation: Visualization, Quantitation, and In Situ Detection of Human Viral Epitopes Using Peptide-Specific, MHC-Restricted Human Recombinant Antibodies. The Journal of Immunology 170:8, pages 4349-4361.
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Masahiko Okada & Kuan-Teh Jeang. (2002) Differential Requirements for Activation of Integrated and Transiently Transfected Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat. Journal of Virology 76:24, pages 12564-12573.
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Francene J Lemoine & Susan J Marriott. (2002) Genomic instability driven by the human T-cell leukemia virus type I (HTLV-I) oncoprotein, Tax. Oncogene 21:47, pages 7230-7234.
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Laurent Lefèbvre, Vincenzo Ciminale, Alain Vanderplasschen, Donna D'Agostino, Arsène Burny, Luc Willems & Richard Kettmann. (2002) Subcellular Localization of the Bovine Leukemia Virus R3 and G4 Accessory Proteins. Journal of Virology 76:15, pages 7843-7854.
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Min-Hui Liang, Thomas Geisbert, Yao Yao, Steven H. Hinrichs & Chou-Zen Giam. (2002) Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes S-Phase Entry but Blocks Mitosis. Journal of Virology 76:8, pages 4022-4033.
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Yan Liu, Yin Wang, Munekazu Yamakuchi, Satoko Masuda, Takeshi Tokioka, Shoji Yamaoka, Ikuro Maruyama & Isao Kitajima. (2001) Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax. Oncogene 20:20, pages 2514-2526.
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Karen V. Kibler & Kuan-Teh Jeang. (2001) CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein. Journal of Virology 75:5, pages 2161-2173.
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A. Van den Broeke, Y. Cleuter, T. Beskorwayne, P. KerkhofsM. Szynal, C. Bagnis, A. Burny & P. Griebel. (2001) CD154 Costimulated Ovine Primary B Cells, a Cell Culture System That Supports Productive Infection by Bovine Leukemia Virus. Journal of Virology 75:3, pages 1095-1103.
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Phillip L. Van, Kyong-Wook Yim, Dong-Yan Jin, George Dapolito, Akihiro Kurimasa & Kuan-Teh Jeang. (2001) Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53. Journal of Virology 75:1, pages 396-407.
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Robert A. Kirken, Rebecca A. Erwin, Lihua Wang, Yuling Wang, Hallgeir Rui & William L. Farrar. (2000) Functional Uncoupling of the Janus Kinase 3-Stat5 Pathway in Malignant Growth of Human T Cell Leukemia Virus Type 1-Transformed Human T Cells. The Journal of Immunology 165:9, pages 5097-5104.
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Jean-Claude Twizere, Pierre Kerkhofs, Arsène Burny, Daniel Portetelle, Richard Kettmann & Luc Willems. (2000) Discordance between Bovine Leukemia Virus Tax Immortalization In Vitro and Oncogenicity In Vivo. Journal of Virology 74:21, pages 9895-9902.
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Christophe Nicot, Renaud Mahieux, Rene Opavsky, Anna Cereseto, Linda Wolff, John N Brady & Genoveffa Franchini. (2000) HTLV-I Tax transrepresses the human c-Myb promoter independently of its interaction with CBP or p300. Oncogene 19:17, pages 2155-2164.
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Shao-Cong Sun & Dean W Ballard. (1999) Persistent activation of NF-κB by the Tax transforming protein of HTLV-1: hijacking cellular IκB kinases. Oncogene 18:49, pages 6948-6958.
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John A. Blaho & Stuart A. Aaronson. (1999) Convicting a human tumor virus: Guilt by association?. Proceedings of the National Academy of Sciences 96:14, pages 7619-7621.
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Shyan-Yuan Kao & Susan J. Marriott. (1999) Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein. Journal of Virology 73:5, pages 4299-4304.
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Naomi Nakamura, Masahiro Fujii, Tomonori Tsukahara, Masaaki Arai, Takashi Ohashi, Hiroshi Wakao, Mari Kannagi & Naoki Yamamoto. (1999) Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells. Oncogene 18:17, pages 2667-2675.
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Vassilis Doucas & Ronald M. Evans. (1999) Human T-cell leukemia retrovirus-Tax protein is a repressor of nuclear receptor signaling. Proceedings of the National Academy of Sciences 96:6, pages 2633-2638.
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Anne Van Den Broeke, Claude BagnisMalgorzata Ciesiolka, Yvette Cleuter, Hans Gelderblom, Pierre KerkhofsPhilip Griebel, Patrice MannoniArsene Burny. (1999) In Vivo Rescue of a Silent tax -Deficient Bovine Leukemia Virus from a Tumor-Derived Ovine B-Cell Line by Recombination with a Retrovirally Transduced Wild-Type tax Gene . Journal of Virology 73:2, pages 1054-1065.
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Françoise Bex, Kathy Murphy, Ruddy Wattiez, Arsène Burny & Richard B. Gaynor. (1999) Phosphorylation of the Human T-Cell Leukemia Virus Type 1 Transactivator Tax on Adjacent Serine Residues Is Critical for Tax Activation. Journal of Virology 73:1, pages 738-745.
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Pierre Kerkhofs, Hubertine Heremans, Arsène Burny, Richard Kettmann & Luc Willems. (1998) In Vitro and In Vivo Oncogenic Potential of Bovine Leukemia Virus G4 Protein. Journal of Virology 72:3, pages 2554-2559.
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Iris Schmitt, Oliver Rosin, Peter Rohwer, Manfred Gossen & Ralph Grassmann. (1998) Stimulation of Cyclin-Dependent Kinase Activity and G 1 - to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein . Journal of Virology 72:1, pages 633-640.
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