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Cell Growth and Development

Site-Directed Mutagenesis of the SH2- and SH3-Coding Domains of c-src Produces Varied Phenotypes, Including Oncogenic Activation of p60c-src

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Pages 1307-1318 | Received 31 Jul 1989, Accepted 12 Dec 1989, Published online: 31 Mar 2023

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Mehreen Gul, Ahmad Navid & Sajid Rashid. (2023) Structural basis of constitutive c-Src kinase activity due to R175L and W118A mutations. Journal of Biomolecular Structure and Dynamics 41:2, pages 634-645.
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Myeong Gu Yeo, Michael A. Partridge, Ellen J. Ezratty, Qiong Shen, Gregg G. Gundersen & Eugene E. Marcantonio. (2006) Src SH2 Arginine 175 Is Required for Cell Motility: Specific Focal Adhesion Kinase Targeting and Focal Adhesion Assembly Function. Molecular and Cellular Biology 26:12, pages 4399-4409.
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Hellinida Thomadaki & Andreas Scorilas. (2006) BCL2 Family of Apoptosis-Related Genes: Functions and Clinical Implications in Cancer. Critical Reviews in Clinical Laboratory Sciences 43:1, pages 1-67.
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Kristiina Vuori, Hisamaru Hirai, Shinichi Aizawa & Erkki Ruoslahti. (1996) Induction of p130 Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases. Molecular and Cellular Biology 16:6, pages 2606-2613.
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Govindaswamy Panchamoorthy, Toru Fukazawa, Lesley Stolz, Gillian Payne, Kris Reedquist, Steven Shoelson, Zhou Songyang, Lewis Cantley, Christopher Walsh & Hamid Band. (1994) Physical and Functional Interactions between SH2 and SH3 Domains of the Src Family Protein Tyrosine Kinase p59. Molecular and Cellular Biology 14:9, pages 6372-6385.
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Kirsten B. Bibbins, Helene Boeuf & Harold E. Varmus. (1993) Binding of the Src SH2 Domain to Phosphopeptides is Determined by Residues in both the SH2 Domain and the Phosphopeptides. Molecular and Cellular Biology 13:12, pages 7278-7287.
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Steven M. Murphy, Mathias Bergman & David O. Morgan. (1993) Suppression of c-Src Activity by C-Terminal Src Kinase Involves the c-Src SH2 and SH3 Domains: Analysis with Saccharomyces cerevisiae. Molecular and Cellular Biology 13:9, pages 5290-5300.
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Andrei Goga, Jami McLaughlin, Ann Marie Pendergast, Kalindi Parmar, Alexander Muller, Naomi Rosenberg & Owen N. Witte. (1993) Oncogenic Activation of c-ABL by Mutation within Its Last Exon. Molecular and Cellular Biology 13:8, pages 4967-4975.
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Margaret M. Chou, J. Eduardo Fajardo & Hidesaburo Hanafusa. (1992) The SH2- and SH3-Containing Nck Protein Transforms Mammalian Fibroblasts in the Absence of Elevated Phosphotyrosine Levels. Molecular and Cellular Biology 12:12, pages 5834-5842.
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Jean Dahl, Usha Thathamangalam, Robert Freund & Thomas L. Benjamin. (1992) Functional Asymmetry of the Regions Juxtaposed to the MembraneBinding Sequence of Polyomavirus Middle T Antigen. Molecular and Cellular Biology 12:11, pages 5050-5058.
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Kunxin Luo & Bartholomew M. Sefton. (1992) Activated lek Tyrosine Protein Kinase Stimulates AntigenIndependent Interleukin-2 Production in T Cells. Molecular and Cellular Biology 12:10, pages 4724-4732.
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Cynthia Seidel-Dugan, Barbara E. Meyer, Sheila Μ. Thomas & Joan S. Brugge. (1992) Effects of SH2 and SH3 Deletions on the Functional Activities of Wild-Type and Transforming Variants of c-Src. Molecular and Cellular Biology 12:4, pages 1835-1845.
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Bruce J. Mayer, Peter K. Jackson, Richard A. Van Etten & David Baltimore. (1992) Point Mutations in the abl SH2 Domain Coordinately Impair Phosphotyrosine Binding In Vitro and Transforming Activity In Vivo. Molecular and Cellular Biology 12:2, pages 609-618.
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Hong Wu, Albert B. Reynolds, Steven B. Kanner, Richard R. Vines & J. Thomas Parsons. (1991) Identification and Characterization of a Novel Cytoskeleton-Associated pp60 Substrate. Molecular and Cellular Biology 11:10, pages 5113-5124.
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Martin McMahon, Randall C. Schatzman & J. Michael Bishop. (1991) The Amino-Terminal 14 Amino Acids of v-src Can Functionally Replace the Extracellular and Transmembrane Domains of v-erbB. Molecular and Cellular Biology 11:9, pages 4760-4770.
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Yasuhisa Fukui & Hidesaburo Hanafusa. (1991) Requirement of Phosphatidylinositol-3 Kinase Modification for Its Association with p60. Molecular and Cellular Biology 11:4, pages 1972-1979.
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Alexander J. Muller, Judy C. Young, Ann-Marie Pendergast, Mark Pondel, Nathaniel R. Landau, Dan R. Littman & Owen N. Witte. (1991) BCR First Exon Sequences Specifically Activate the BCR/ABL Tyrosine Kinase Oncogene of Philadelphia ChromosomePositive Human Leukemias. Molecular and Cellular Biology 11:4, pages 1785-1792.
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Michiyuki Matsuda, Bruce J. Mayer & Hidesaburo Hanafusa. (1991) Identification of Domains of the v-crk Oncogene Product Sufficient for Association with Phosphotyrosine-Containing Proteins. Molecular and Cellular Biology 11:3, pages 1607-1613.
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Yasuhisa Fukui, Melanie C. O’Brien & Hidesaburo Hanafusa. (1991) Deletions in the SH2 Domain of p60v- Prevent Association with the Detergent-Insoluble Cellular Matrix. Molecular and Cellular Biology 11:3, pages 1207-1213.
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Amy H. Bouton, Steven B. Kanner, Richard R. Vines, Hwa-Chain R. Wang, Jackson B. Gibbs & J. Thomas Parsons. (1991) Transformation by pp60 or Stimulation of Cells with Epidermal Growth Factor Induces the Stable Association of Tyrosine-Phosphorylated Cellular Proteins with GTPase-Activating Protein. Molecular and Cellular Biology 11:2, pages 945-953.
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Articles from other publishers (5)

Natsumi Kobayashi, Ryohei Katayama, Kentaro Minamoto, Takashi Kawaguchi & Shuji Tani. (2023) C-terminus of serine–arginine protein kinase-like protein, SrpkF, is involved in conidiophore formation and hyphal growth under salt stress in Aspergillus aculeatus. International Microbiology.
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Helen Barnes, Elizabeth J Ackermann & Peter van der Geer. (2003) v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1. Oncogene 22:23, pages 3589-3597.
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Bradley B Brasher, Sergei Roumiantsev & Richard A Van Etten. (2001) Mutational analysis of the regulatory function of the c-Abl Src homology 3 domain. Oncogene 20:53, pages 7744-7752.
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Kimya F. Harris, Ikuo Shoji, Eric M. Cooper, Sushant Kumar, Hideaki Oda & Peter M. Howley. (1999) Ubiquitin-mediated degradation of active Src tyrosine kinase. Proceedings of the National Academy of Sciences 96:24, pages 13738-13743.
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Albert Weijland, John C. Williams, Gitte Neubauer, Sara A. Courtneidge, Rik K. Wierenga & Giulio Superti-Furga. (1997) Src regulated by C-terminal phosphorylation is monomeric. Proceedings of the National Academy of Sciences 94:8, pages 3590-3595.
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