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Molecular and Cellular Biology Volume 10, 1990 - Issue 4
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Gene Expression

Identification of a Pancreatic β-Cell Insulin Gene Transcription Factor That Binds to and Appears To Activate Cell-Type-Specific Expression: Its Possible Relationship to Other Cellular Factors That Bind to a Common Insulin Gene Sequence

James Whelan1 Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee37232-0615
,
Susan R. Cordle1 Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee37232-0615
,
Eva Henderson1 Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee37232-0615
,
P. Anthony Weil1 Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee37232-0615
&
Roland Stein1 Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee37232-0615
Pages 1564-1572 | Received 29 Sep 1989, Accepted 21 Dec 1989, Published online: 31 Mar 2023

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Taka-aki Matsuoka, Li Zhao, Isabella Artner, Harry W. Jarrett, David Friedman, Anna Means & Roland Stein. (2003) Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells. Molecular and Cellular Biology 23:17, pages 6049-6062.
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Yi Qiu, Min Guo, Suming Huang & Roland Stein. (2002) Insulin Gene Transcription Is Mediated by Interactions between the p300 Coactivator and PDX-1, BETA2, and E47. Molecular and Cellular Biology 22:2, pages 412-420.
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Mark Eben Massari & Cornelis Murre. (2000) Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms. Molecular and Cellular Biology 20:2, pages 429-440.
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Mark Eben Massari, Richard R. Rivera, Joseph R. Voland, Melanie W Quong, Timo M. Breit, Jacques J. M. van Dongen, Oncko de Smit & Cornelis Murre. (1998) Characterization of ABF-1, a Novel Basic Helix-Loop-Helix Transcription Factor Expressed in Activated B Lymphocytes. Molecular and Cellular Biology 18:6, pages 3130-3139.
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Kuo-Liang Wu, Maureen Gannon, Mina Peshavaria, Martin F. Offield, Eva Henderson, Michael Ray, Antonio Marks, Laura W. Gamer, Christopher V. E. Wright & Roland Stein. (1997) Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene. Molecular and Cellular Biology 17:10, pages 6002-6013.
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Gretchen Bain, Isaac Engel, Els C. Robanus Maandag, Hein P. J. te Riele, Joseph R. Voland, Leslie L. Sharp, Jerold Chun, Bing Huey, Dan Pinkel & Cornelis Murre. (1997) E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas. Molecular and Cellular Biology 17:8, pages 4782-4791.
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Mina Peshavaria, Eva Henderson, Arun Sharma, Christopher V. E. Wright & Roland Stein. (1997) Functional Characterization of the Transactivation Properties of the PDX-1 Homeodomain Protein. Molecular and Cellular Biology 17:7, pages 3987-3996.
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Gary L. W. G. Robinson, Eva Henderson, Mark E. Massari, Cornelis Murre & Roland Stein. (1995) c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products. Molecular and Cellular Biology 15:3, pages 1398-1404.
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Gary L. W. G. Robinson, Susan R. Cordle, Eva Henderson, P. Anthony Weil, Gladys Teitelman & Roland Stein. (1994) Isolation and Characterization of a Novel Transcription Factor That Binds to and Activates Insulin Control Element-Mediated Expression. Molecular and Cellular Biology 14:10, pages 6704-6714.
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Tom Genetta, Diane Ruezinsky & Tom Kadesch. (1994) Displacement of an E-Box-Binding Repressor by Basic HelixLoop-Helix Proteins: Implications for B-Cell Specificity of the Immunoglobulin Heavy-Chain Enhancer. Molecular and Cellular Biology 14:9, pages 6153-6163.
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Michael S. German & Juehu Wang. (1994) The Insulin Gene Contains Multiple Transcriptional Elements That Respond to Glucose. Molecular and Cellular Biology 14:6, pages 4067-4075.
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Arun Sharma & Roland Stein. (1994) Glucose-Induced Transcription of the Insulin Gene Is Mediated by Factors Required for β-Cell-Type-Specific Expression. Molecular and Cellular Biology 14:2, pages 871-879.
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Eva Henderson & Roland Stein. (1994) c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control. Molecular and Cellular Biology 14:1, pages 655-662.
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Gretchen Bain, Stefan Gruenwald & Cornelis Murre. (1993) E2A and E2-2 are Subunits of B-Cell-Specific E2-Box DNA-Binding Proteins. Molecular and Cellular Biology 13:6, pages 3522-3529.
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Kathy D. Shelton, Alan J. Franklin, Andras Khoor, Joseph Beechem & Mark A. Magnuson. (1992) Multiple Elements in the Upstream Glucokinase Promoter Contribute to Transcription in Insulinoma Cells. Molecular and Cellular Biology 12:10, pages 4578-4589.
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Michael S. German, Larry Gene Moss, Juehu Wang & William J. Rutter. (1992) The Insulin and Islet Amyloid Polypeptide Genes Contain Similar Cell-Specific Promoter Elements That Bind Identical β-Cell Nuclear Complexes. Molecular and Cellular Biology 12:4, pages 1777-1788.
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Susan R. Cordle, James Whelan, Eva Henderson, Howard Masuoka, P. Anthony Weil & Roland Stein. (1991) NOTES/Insulin Gene Expression in Nonexpressing Cells Appears To Be Regulated by Multiple Distinct Negative-Acting Control Elements. Molecular and Cellular Biology 11:5, pages 2881-2886.
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Susan R. Cordle, Eva Henderson, Howard Masuoka, P. Anthony Weil & Roland Stein. (1991) Pancreatic β-Cell-Type-Specific Transcription of the Insulin Gene Is Mediated by Basic Helix-Loop-Helix DNA-Binding Proteins. Molecular and Cellular Biology 11:3, pages 1734-1738.
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Dena Leshkowitz & Michael D. Walker. (1991) Extinction of Insulin Gene Expression in Hybrids between β Cells and Fibroblasts Is Accompanied by Loss of the Putative β-Cell- Specific Transcription Factor IEF1. Molecular and Cellular Biology 11:3, pages 1547-1552.
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Cornelis Murre, Anna Voronova & David Baltimore. (1991) B-Cell- and Myocyte-Specific E2-Box-Binding Factors Contain E12/E47-Like Subunits. Molecular and Cellular Biology 11:2, pages 1156-1160.
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Articles from other publishers (1)

Daniela Ulgiati & V. Michael Holers. (2001) CR2/CD21 Proximal Promoter Activity Is Critically Dependent on a Cell Type-Specific Repressor. The Journal of Immunology 167:12, pages 6912-6919.
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