Citations (28)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (24)
Christopher M. Browne, Parimal Samir, J. Scott Fites, Seth A. Villarreal & Andrew J. Link. (2013) The Yeast Eukaryotic Translation Initiation Factor 2B Translation Initiation Complex Interacts with the Fatty Acid Synthesis Enzyme YBR159W and Endoplasmic Reticulum Membranes. Molecular and Cellular Biology 33:5, pages 1041-1056.
Read now
Read now
Vera Cherkasova, Hongfang Qiu & Alan G. Hinnebusch. (2010) Snf1 Promotes Phosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2 by Activating Gcn2 and Inhibiting Phosphatases Glc7 and Sit4. Molecular and Cellular Biology 30:12, pages 2862-2873.
Read now
Read now
Andrés Gárriz, Hongfang Qiu, Madhusudan Dey, Eun-Joo Seo, Thomas E. Dever & Alan G. Hinnebusch. (2009) A Network of Hydrophobic Residues Impeding Helix αC Rotation Maintains Latency of Kinase Gcn2, Which Phosphorylates the α Subunit of Translation Initiation Factor 2. Molecular and Cellular Biology 29:6, pages 1592-1607.
Read now
Read now
Sarah S. Mohammad-Qureshi, Raphaël Haddad, Elizabeth J. Hemingway, Jonathan P. Richardson & Graham D. Pavitt. (2007) Critical Contacts between the Eukaryotic Initiation Factor 2B (eIF2B) Catalytic Domain and both eIF2β and -2γ Mediate Guanine Nucleotide Exchange. Molecular and Cellular Biology 27:14, pages 5225-5234.
Read now
Read now
Krishnamurthy Natarajan, Michael R. Meyer, Belinda M. Jackson, David Slade, Christopher Roberts, Alan G. Hinnebusch & Matthew J. Marton. (2001) Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast. Molecular and Cellular Biology 21:13, pages 4347-4368.
Read now
Read now
Ruojing Yang, Sheree A. Wek & Ronald C. Wek. (2000) Glucose Limitation Induces GCN4 Translation by Activation of Gcn2 Protein Kinase. Molecular and Cellular Biology 20:8, pages 2706-2717.
Read now
Read now
Hongfang Qiu, Cuihua Hu, James Anderson, Glenn R. Björk, Srimonti Sarkar, Anita K. Hopper & Alan G. Hinnebusch. (2000) Defects in tRNA Processing and Nuclear Export Induce GCN4 Translation Independently of Phosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2. Molecular and Cellular Biology 20:7, pages 2505-2516.
Read now
Read now
Olivier Donzé & Didier Picard. (1999) Hsp90 Binds and Regulates the Ligand-Inducible α Subunit of Eukaryotic Translation Initiation Factor Kinase Gcn2. Molecular and Cellular Biology 19:12, pages 8422-8432.
Read now
Read now
Yuguang Shi, Krishna M. Vattem, Ruchira Sood, Jie An, Jingdong Liang, Lawrence Stramm & Ronald C. Wek. (1998) Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control. Molecular and Cellular Biology 18:12, pages 7499-7509.
Read now
Read now
Hongfang Qiu, Minerva T. Garcia-Barrio & Alan G. Hinnebusch. (1998) Dimerization by Translation Initiation Factor 2 Kinase GCN2 Is Mediated by Interactions in the C-Terminal Ribosome-Binding Region and the Protein Kinase Domain. Molecular and Cellular Biology 18:5, pages 2697-2711.
Read now
Read now
Patrick R. Romano, Minerva T. Garcia-Barrio, Xiaolong Zhang, Qizhi Wang, Deborah R. Taylor, Fan Zhang, Christopher Herring, Michael B. Mathews, Jun Qin & Alan G. Hinnebusch. (1998) Autophosphorylation in the Activation Loop Is Required for Full Kinase Activity In Vivo of Human and Yeast Eukaryotic Initiation Factor 2α Kinases PKR and GCN2. Molecular and Cellular Biology 18:4, pages 2282-2297.
Read now
Read now
Graham D. Pavitt, Weimin Yang & Alan G. Hinnebusch. (1997) Homologous Segments in Three Subunits of the Guanine Nucleotide Exchange Factor eIF2B Mediate Translational Regulation by Phosphorylation of eIF2. Molecular and Cellular Biology 17:3, pages 1298-1313.
Read now
Read now
Sheree A. Wek, Shuhao Zhu & Ronald C. Wek. (1995) The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids. Molecular and Cellular Biology 15:8, pages 4497-4506.
Read now
Read now
Carlos R. Vazquez De Aldana, Ronald C. Wek, Pedro San Segundo, Alexander G. Truesdell & Alan G. Hinnebusch. (1994) Multicopy tRNA Genes Functionally Suppress Mutations in Yeast eIF-2α Kinase GCN2: Evidence for Separate Pathways Coupling GCN4 Expression to Uncharged tRNA. Molecular and Cellular Biology 14:12, pages 7920-7932.
Read now
Read now
Andrew R. Butler, John H. White, Yetunde Folawiyo, Angela Edlin, Donald Gardiner & Michael J. R. Stark. (1994) Two Saccharomyces cerevisiae Genes Which Control Sensitivity to G1 Arrest Induced by Kluyveromyces lactis Toxin. Molecular and Cellular Biology 14:9, pages 6306-6316.
Read now
Read now
Lan Feng, Heejeong Yoon & Thomas F. Donahue. (1994) Casein Kinase II Mediates Multiple Phosphorylation of Saccharomyces cerevisiae eIF-2α (Encoded by SUI2), Which Is Required for Optimal eIF-2 Function in S. cerevisiae. Molecular and Cellular Biology 14:8, pages 5139-5153.
Read now
Read now
Carlos R. Vazquez De Aldana & Alan G. Hinnebusch. (1994) Mutations in the GCD7 Subunit of Yeast Guanine Nucleotide Exchange Factor eIF-2B Overcome the Inhibitory Effects of Phosphorylated eIF-2 on Translation Initiation. Molecular and Cellular Biology 14:5, pages 3208-3222.
Read now
Read now
Ronda J. Rolfes & Alan G. Hinnebusch. (1993) Translation of the Yeast Transcriptional Activator GCN4 Is Stimulated by Purine Limitation: Implications for Activation of the Protein Kinase GCN2. Molecular and Cellular Biology 13:8, pages 5099-5111.
Read now
Read now
Matthew J. Marton, Deborah Crouch & Alan G. Hinnebusch. (1993) GCN1, a Translational Activator of GCN4 in Saccharomyces cerevisiae, is Required for Phosphorylation of Eukaryotic Translation Initiation Factor 2 by Protein Kinase GCN2. Molecular and Cellular Biology 13:6, pages 3541-3556.
Read now
Read now
Ernest M. Hannig, A. Mark Cigan, Barbara A. Freeman & Terri Goss Kinzy. (1993) GCD11, a Negative Regulator of GCN4 Expression, Encodes the γ Subunit of eIF-2 in Saccharomyces cerevisiae. Molecular and Cellular Biology 13:1, pages 506-520.
Read now
Read now
Manuel Ramirez, Ronald C. Wek, Carlos R. Vazquez De Aldana, Belinda M. Jackson, Barbara Freeman & Alan G. Hinnebusch. (1992) Mutations Activating the Yeast eIF-2a Kinase GCN2: Isolation of Alleles Altering the Domain Related to Histidyl-tRNA Synthetases. Molecular and Cellular Biology 12:12, pages 5801-5815.
Read now
Read now
Ronald C. Wek, John F. Cannon, Thomas E. Dever & Alan G. Hinnebusch. (1992) Truncated Protein Phosphatase GLC7 Restores Translational Activation of GCN4 Expression in Yeast Mutants Defective for the eIF-2α Kinase GCN2. Molecular and Cellular Biology 12:12, pages 5700-5710.
Read now
Read now
Manuel Ramirez, Ronald C. Wek & Alan G. Hinnebusch. (1991) Ribosome Association of GCN2 Protein Kinase, a Translational Activator of the GCN4 Gene of Saccharomyces cerevisiae. Molecular and Cellular Biology 11:6, pages 3027-3036.
Read now
Read now
Charles M. Moehle & Alan G. Hinnebusch. (1991) Association of RAP1 Binding Sites with Stringent Control of Ribosomal Protein Gene Transcription in Saccharomyces cerevisiae. Molecular and Cellular Biology 11:5, pages 2723-2735.
Read now
Read now
Articles from other publishers (4)
Hongyan Yu, Fucheng Liu, Kaining Chen, Yufen Xu, Yishuai Wang, Lanyan Fu, Huazhong Zhou, Lei Pi, Di Che, Hehong Li & Xiaoqiong Gu. (2022) The EIF2AK4/rs4594236 AG/GG Genotype Is a Hazard Factor of Immunoglobulin Therapy Resistance in Southern Chinese Kawasaki Disease Patients. Frontiers in Genetics 13.
Crossref
Crossref
Maaike Van Trimpont, Evelien Peeters, Yanti De Visser, Amanda M. Schalk, Veerle Mondelaers, Barbara De Moerloose, Arnon Lavie, Tim Lammens, Steven Goossens & Pieter Van Vlierberghe. (2022) Novel Insights on the Use of L-Asparaginase as an Efficient and Safe Anti-Cancer Therapy. Cancers 14:4, pages 902.
Crossref
Crossref
Akito NakamuraTadahiro NambuShunsuke EbaraYuka HasegawaKosei ToyoshimaYasuko TsuchiyaDaisuke TomitaJun FujimotoOsamu KurasawaChisato TakaharaAyumi AndoRyuichi NishigakiYoshinori SatomiAkito Hata & Takahito Hara. (2018) Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response. Proceedings of the National Academy of Sciences 115:33.
Crossref
Crossref
Margarito RojasAnne-Claude Gingras & Thomas E. Dever. (2014) Protein phosphatase PP1/GLC7 interaction domain in yeast eIF2γ bypasses targeting subunit requirement for eIF2α dephosphorylation. Proceedings of the National Academy of Sciences 111:14.
Crossref
Crossref