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Molecular and Cellular Biology Volume 10, 1990 - Issue 7
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Gene Expression

Conversion of the lac Repressor into an Allosterically Regulated Transcriptional Activator for Mammalian Cells

Mark A. Labow1 Department of Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey08544
,
Steven B. Baim1 Department of Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey08544;2 Howard Hughes Medical Institute, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey08544
,
Thomas Shenk1 Department of Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey08544;2 Howard Hughes Medical Institute, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey08544
&
Arnold J. Levine1 Department of Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey08544
Pages 3343-3356 | Published online: 31 Mar 2023

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Read on this site (4)

Binh N. Trinh, Tiffany I. Long, Andrea E. Nickel, Darryl Shibata & Peter W. Laird. (2002) DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair. Molecular and Cellular Biology 22:9, pages 2906-2917.
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Graham G. Miao & Tom Curran. (1994) Cell Transformation by c-fos Requires an Extended Period of Expression and Is Independent of the Cell Cycle. Molecular and Cellular Biology 14:6, pages 4295-4310.
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Daniel E. Syroid, Richard I. Tapping & John P. Capone. (1992) Regulated Expression of a Mammalian Nonsense Suppressor tRNA Gene In Vivo and In Vitro Using the lac Operator/Repressor System. Molecular and Cellular Biology 12:10, pages 4271-4278.
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Mickey C.-T. Hu & Norman Davidson. (1990) A Combination of Derepression of the lac Operator-Repressor System with Positive Induction by Glucocorticoid and Metal Ions Provides a High-Level-Inducible Gene Expression System Based on the Human Metallothionein-IIA Promoter. Molecular and Cellular Biology 10:12, pages 6141-6151.
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Articles from other publishers (3)

Jared M Ordway, Katy Williams & Tom Curran. (2004) Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene 23:21, pages 3737-3748.
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Joachim Messing. (1998) Plant science in lac : A continuation of using tools from Escherichia coli in studying gene function in heterologous systems . Proceedings of the National Academy of Sciences 95:1, pages 93-94.
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Ian Moore, Leo Gälweiler, Debora Grosskopf, Jeff Schell & Klaus Palme. (1998) A transcription activation system for regulated gene expression in transgenic plants. Proceedings of the National Academy of Sciences 95:1, pages 376-381.
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