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Molecular and Cellular Biology Volume 11, 1991 - Issue 10
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Cell Growth and Development

axl, a Transforming Gene Isolated from Primary Human Myeloid Leukemia Cells, Encodes a Novel Receptor Tyrosine Kinase

John P. O'bryan1 Curriculum in Genetics, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Roy A. Frye2 Department of Medicine, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Patricia C. Cogswell2 Department of Medicine, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Andreas Neubauer2 Department of Medicine, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Barry Kitch2 Department of Medicine, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
Carol Prokop2 Department of Medicine, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
,
III Rafael Espinosa3 Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois60637
,
Michelle M. Le Beau3 Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, Illinois60637
,
H. Shelton Earp2 Department of Medicine, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
&
Edison T. Liu1 Curriculum in Genetics, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599;2 Department of Medicine, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina27599
 show all
Pages 5016-5031 | Received 23 May 1991, Accepted 05 Jul 1991, Published online: 31 Mar 2023

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Aubhishek Zaman & Trever G Bivona. (2021) Targeting AXL in NSCLC. Lung Cancer: Targets and Therapy 12, pages 67-79.
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Lavanya Nagamalla & J. V. Shanmukha Kumar. (2021) In silico screening of FDA approved drugs on AXL kinase and validation for breast cancer cell line. Journal of Biomolecular Structure and Dynamics 39:6, pages 2056-2070.
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Wenting Du & Rolf A. Brekken. (2018) Does Axl have potential as a therapeutic target in pancreatic cancer?. Expert Opinion on Therapeutic Targets 22:11, pages 955-966.
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Sheng Zhang, Xiang Shang Xu, Jie Xi Yang, Jian Hui Guo, Teng Fei Chao & YiXin Tong. (2018) The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review. OncoTargets and Therapy 11, pages 509-519.
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Shibo Zhu, Guochang Liu, Wen Fu, Jinhua Hu, Kai Fu & Wei Jia. (2017) Axl promotes the proliferation, invasion and migration of Wilms’ tumor and can be used as a prognostic factor. OncoTargets and Therapy 10, pages 955-963.
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Ross A Okimoto & Trever G Bivona. (2015) AXL receptor tyrosine kinase as a therapeutic target in NSCLC. Lung Cancer: Targets and Therapy 6, pages 27-34.
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Melanie Janning, Isabel Ben-Batalla & Sonja Loges. (2015) Axl inhibition: a potential road to a novel acute myeloid leukemia therapy?. Expert Review of Hematology 8:2, pages 135-138.
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Afnan Abu-Thuraia, Rosemarie Gauthier, Rony Chidiac, Yoshinori Fukui, Robert A. Screaton, Jean-Philippe Gratton & Jean-François Côté. (2015) Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion. Molecular and Cellular Biology 35:1, pages 76-87.
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Yongfu Zhao, Xiance Sun, Lili Jiang, Fengjuan Yang, Zhaohai Zhang & Li Jia. (2012) Differential Expression of Axl and Correlation with Invasion and Multidrug Resistance in Cancer Cells. Cancer Investigation 30:4, pages 287-294.
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Carrie V. Breton, Muhammad T. Salam & Frank D. Gilliland. (2011) Heritability and role for the environment in DNA methylation in AXL receptor tyrosine kinase. Epigenetics 6:7, pages 895-898.
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Alvarez Hector, Elizabeth A. Montgomery, Collins Karikari, Marcia I. Canto, Kerry B. Dunbar, Jean S. Wang, Georg Feldmann, Seung-Mo Hong, Michael C. Haffner, Alan K. Meeker, Sacha J. Holland, Jiaxin Yu, Thilo J. Heckrodt, Jing Zhang, Pingyu Ding, Dane Goff, Rajinder Singh, Juan Carlos Roa, Arivusudar Marimuthu, Gregory J. Riggins, James R. Eshleman, Barry D. Nelkin, Akhilesh Pandey & Anirban Maitra. (2010) The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma . Cancer Biology & Therapy 10:10, pages 1009-1018.
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Rachel MA Linger, Amy K Keating, H Shelton Earp & Douglas K Graham. (2010) Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors. Expert Opinion on Therapeutic Targets 14:10, pages 1073-1090.
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Niclas Lindqvist, Ulrika Lönngren, Marta Agudo, Ulla Näpänkangas, Manuel Vidal-Sanz & Finn Hallböök. (2010) Multiple receptor tyrosine kinases are expressed in adult rat retinal ganglion cells as revealed by single-cell degenerate primer polymerase chain reaction. Upsala Journal of Medical Sciences 115:1, pages 65-80.
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Melissa P. Allen, Daniel A. Linseman, Hiroshi Udo, Mei Xu, Jerome B. Schaack, Brian Varnum, Eric R. Kandel, Kim A. Heidenreich & Margaret E. Wierman. (2002) Novel Mechanism for Gonadotropin-Releasing Hormone Neuronal Migration Involving Gas6/Ark Signaling to p38 Mitogen-Activated Protein Kinase. Molecular and Cellular Biology 22:2, pages 599-613.
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Sandro Goruppi, Cristina Chiaruttini, Maria Elisabetta Ruaro, Brian Varnum & Claudio Schneider. (2001) Gas6 Induces Growth, β-Catenin Stabilization, and T-Cell Factor Transcriptional Activation in Contact-Inhibited C57 Mammary Cells. Molecular and Cellular Biology 21:3, pages 902-915.
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Wei-Ping Lee, Yong Liao, Dan Robinson, Hsing-Jien Kung, Edison T. Liu & Mien-Chie Hung. (1999) Axl-Gas6 Interaction Counteracts E1A-Mediated Cell Growth Suppression and Proapoptotic Activity. Molecular and Cellular Biology 19:12, pages 8075-8082.
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Daniel Besser, Jacqueline F. Bromberg, James E. Darnell$suffix/text()$suffix/text() & Hidesaburo Hanafusa. (1999) A Single Amino Acid Substitution in the v-Eyk Intracellular Domain Results in Activation of Stat3 and Enhances Cellular Transformation. Molecular and Cellular Biology 19:2, pages 1401-1409.
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Maria-Magdalena Georgescu, Kathrin H. Kirsch, Tomoyuki Shishido, Chen Zong & Hidesaburo Hanafusa. (1999) Biological Effects of c-Mer Receptor Tyrosine Kinase in Hematopoietic Cells Depend on the Grb2 Binding Site in the Receptor and Activation of NF-κB. Molecular and Cellular Biology 19:2, pages 1171-1181.
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Colin W. Ward. (1999) Members of the Insulin Receptor Family Contain Three Fibronectin Type III Domains. Growth Factors 16:4, pages 315-322.
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Sandro Goruppi, Elisabetta Ruaro, Brian Varnum & Claudio Schneider. (1997) Requirement of Phosphatidylinositol 3-Kinase-Dependent Pathway and Src for Gas6-Axl Mitogenic and Survival Activities in NIH 3T3 Fibroblasts. Molecular and Cellular Biology 17:8, pages 4442-4453.
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Andreas Neubauer, Andreas Burchert, Carolyn Maiwald, Hans-JÜRgen Gruss, Stefan Serke, Dieter Huhn, Burghardt Wittig & Edison Liu. (1997) Recent Progress On the Role of Axl, A Receptor Tyrosine Kinase, in Malignant Transformation of Myeloid Leukemias. Leukemia & Lymphoma 25:1-2, pages 91-96.
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Kathryn E. Crosier & Philip S. Crosier. (1997) New insights into the control of cell growth; The role of the Axl family. Pathology 29:2, pages 131-135.
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Lei Ling & Hsing-Jien Kung. (1995) Mitogenic Signals and Transforming Potential of Nyk, a Newly Identified Neural Cell Adhesion Molecule-Related Receptor Tyrosine Kinase. Molecular and Cellular Biology 15:12, pages 6582-6592.
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Ian Whitehead, Heather Kirk & Robert Kay. (1995) Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries. Molecular and Cellular Biology 15:2, pages 704-710.
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Paola Bellosta, Mario Costa, Debby A. Lin & Claudio Basilico. (1995) The Receptor Tyrosine Kinase ARK Mediates Cell Aggregation by Homophilic Binding. Molecular and Cellular Biology 15:2, pages 614-625.
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Philip S. Crosier, Louanne R. Hall, Maria R. Vitas, Paula M. Lewis & Kathryn E. Crosier. (1995) Identification of a Novel Receptor Tyrosine Kinase Expressed in Acute Myeloid Leukemic Blasts. Leukemia & Lymphoma 18:5-6, pages 443-449.
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Andreas Neubauer, Kecia Richiero & Dieter Huhn. (1995) Alterations of the Retinoblastoma a Susceptibility Gene in Chronic Lymphocytic Leukemia. Leukemia & Lymphoma 18:5-6, pages 399-404.
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Kathryn E. Crosier, Louanne R. Hall, Paula M. Lewis, Christine M. Morris, Clive R. Woods, John C. Morris & Philip S. Crosier. (1994) Isolation and Characterization of the Human DTK Receptor Tyrosine Kinase. Growth Factors 11:2, pages 137-144.
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Philip S. Crosier, Paula M. Lewis, Louanne R. Hall, Maria R. Vitas, Christine M. Morris, David R. Beier, Clive R. Wood & Kathryn E. Crosier. (1994) Isolation of a Receptor Tyrosine Kinase (DTK) from Embryonic Stem Cells: Structure, Genetic Mapping and Analysis of Expression. Growth Factors 11:2, pages 125-136.
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Y.-P. Jiang, H. Wang, P. D'Eustachio, J. M. Musacchio, J. Schlessinger & J. Sap. (1993) Cloning and Characterization of R-PTP-κ, a New Member of the Receptor Protein Tyrosine Phosphatase Family with a Proteolytically Cleaved Cellular Adhesion Molecule-Like Extracellular Region. Molecular and Cellular Biology 13:5, pages 2942-2951.
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Jay D. Potts, George J. Harocopos & David C. Beebe. (1993) Identification of receptor tyrosine kinases in the embryonic chicken lens. Current Eye Research 12:8, pages 759-763.
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Juha Partanen, Elina Armstrong, Tomi P. Mäkelä, Jaana Korhonen, Minna Sandberg, Risto Renkonen, Sakari Knuutila, Kay Huebner & Kari Alitalo. (1992) A Novel Endothelial Cell Surface Receptor Tyrosine Kinase with Extracellular Epidermal Growth Factor Homology Domains. Molecular and Cellular Biology 12:4, pages 1698-1707.
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