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Molecular and Cellular Biology Volume 11, 1991 - Issue 11
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Cell Growth and Development

Functional Expression and RNA Binding Analysis of the Interferon-Induced, Double-Stranded RNA-Activated, 68,000-Mr Protein Kinase in a Cell-Free System

Michael G. Katze1 Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington98195
,
Marlene Wambach1 Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington98195
,
Min-Liang Wong1 Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington98195
,
Michele Garfinkel1 Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington98195
,
Eliane Meurs2 Unite de Virologie and Immunologie Cellulaire, Institut Pasteur, Paris, France
,
Karen Chong3 The Hospital for Sick Children and Department of Medical Genetics, University of Toronto, Toronto, Canada
,
Bryan R. G. Williams3 The Hospital for Sick Children and Department of Medical Genetics, University of Toronto, Toronto, Canada
,
Ara G. Hovanessian2 Unite de Virologie and Immunologie Cellulaire, Institut Pasteur, Paris, France
&
Glen N. Barber1 Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington98195
 show all
Pages 5497-5505 | Received 31 May 1991, Accepted 15 Aug 1991, Published online: 31 Mar 2023

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Ezharul Hoque Chowdhury. (2011) Strategies for tumor-directed delivery of siRNA. Expert Opinion on Drug Delivery 8:3, pages 389-401.
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Shane M. Colley & Peter J. Leedman. (2009) SRA and its binding partners: an expanding role for RNA-binding coregulators in nuclear receptor-mediated gene regulation. Critical Reviews in Biochemistry and Molecular Biology 44:1, pages 25-33.
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Marion C. Bonnet, Robert Weil, Elisabeth Dam, Ara G. Hovanessian & Eliane F. Meurs. (2000) PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex. Molecular and Cellular Biology 20:13, pages 4532-4542.
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Rekha C. Patel & Ganes C. Sen. (1998) Requirement of PKR Dimerization Mediated by Specific Hydrophobic Residues for Its Activation by Double-Stranded RNA and Its Antigrowth Effects in Yeast. Molecular and Cellular Biology 18:12, pages 7009-7019.
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Michael Gale$suffix/text()$suffix/text(), Collin M. Blakely, Bart Kwieciszewski, Seng-Lai Tan, Michelle Dossett, Norina M. Tang, Marcus J. Korth, Stephen J. Polyak, David R. Gretch & Michael G. Katze. (1998) Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation. Molecular and Cellular Biology 18:9, pages 5208-5218.
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Seng-Lai Tan, Michael J. Gale$suffix/text()$suffix/text() & Michael G. Katze. (1998) Double-Stranded RNA-Independent Dimerization of Interferon-Induced Protein Kinase PKR and Inhibition of Dimerization by the Cellular P58IPK Inhibitor. Molecular and Cellular Biology 18:5, pages 2431-2443.
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Michael Gale$suffix/text()$suffix/text(), Collin M. Blakely, Deborah A. Hopkins, Mark W. Melville, Marlene Wambach, Patrick R. Romano & Michael G. Katze. (1998) Regulation of Interferon-Induced Protein Kinase PKR: Modulation of P58IPK Inhibitory Function by a Novel Protein, P52rIPK. Molecular and Cellular Biology 18:2, pages 859-871.
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Wen-Ming Chu, Ruth Ballard, Bruce W. Carpick, Bryan R. G. Williams & Carl W. Schmid. (1998) Potential Alu Function: Regulation of the Activity of Double-Stranded RNA-Activated Kinase PKR. Molecular and Cellular Biology 18:1, pages 58-68.
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Deborah R. Taylor, Sean Bong Lee, Patrick R. Romano, Daniel R. Marshak, Alan G. Hinnebusch, Mariano Esteban & Michael B. Mathews. (1996) Autophosphorylation Sites Participate in the Activation of the Double-Stranded-RNA-Activated Protein Kinase PKR. Molecular and Cellular Biology 16:11, pages 6295-6302.
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Michael Gale$suffix/text()$suffix/text(), Seng-Lai Tan, Marlene Wambach & Michael G. Katze. (1996) Interaction of the Interferon-Induced PKR Protein Kinase with Inhibitory Proteins P58IPK and Vaccinia Virus K3L Is Mediated by Unique Domains: Implications for Kinase Regulation. Molecular and Cellular Biology 16:8, pages 4172-4181.
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Dhananjaya V. Kalvakolanu & Ernest C. Borden. (1996) An Overview of the Interferon System: Signal Transduction and Mechanisms of Action. Cancer Investigation 14:1, pages 25-53.
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Glen N. Barber, Marlene Wambach, Samantha Thompson, Rosemary Jagus & Michael G. Katze. (1995) Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation. Molecular and Cellular Biology 15:6, pages 3138-3146.
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Maria L. Jaramillo, Ninan Abraham & John C. Bell. (1995) Molecular Biology: The Interferon System: A Review with Emphasis on the Role of PKR in Growth Control. Cancer Investigation 13:3, pages 327-338.
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Patrick R. Romano, Simon R. Green, Glen N. Barber, Michael B. Mathews & Alan G. Hinnebusch. (1995) Structural Requirements for Double-Stranded RNA Binding, Dimerization, and Activation of the Human eIF-2α Kinase DAI in Saccharomyces cerevisiae. Molecular and Cellular Biology 15:1, pages 365-378.
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Simon R. Green, Lisa Manche & Michael B. Mathews. (1995) Two Functionally Distinct RNA-Binding Motifs in the Regulatory Domain of the Protein Kinase DAI. Molecular and Cellular Biology 15:1, pages 358-364.
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Tae Gyu Lee, Norina Tang, Samantha Thompson, James Miller & Michael G. Katze. (1994) The 58,000-Dalton Cellular Inhibitor of the Interferon-Induced Double-Stranded RNA-Activated Protein Kinase (PKR) Is a member of the Tetratricopeptide Repeat Family of Proteins. Molecular and Cellular Biology 14:4, pages 2331-2342.
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Lisa Manche, Simon R. Green, Christian Schmedt & Michael B. Mathews. (1992) Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI. Molecular and Cellular Biology 12:11, pages 5238-5248.
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Rong Zhu, Yi-Bing Zhang, Qi-Ya Zhang & Jian-Fang Gui. (2008) Functional Domains and the Antiviral Effect of the Double-Stranded RNA-Dependent Protein Kinase PKR from Paralichthys olivaceus . Journal of Virology 82:14, pages 6889-6901.
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Stefan Rothenburg, Nikolaus Deigendesch, Katharina Dittmar, Friedrich Koch-Nolte, Friedrich Haag, Ky Lowenhaupt & Alexander Rich. (2005) A PKR-like eukaryotic initiation factor 2α kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains. Proceedings of the National Academy of Sciences 102:5, pages 1602-1607.
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Charles E. Samuel. (2001) Antiviral Actions of Interferons. Clinical Microbiology Reviews 14:4, pages 778-809.
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Deborah R. TaylorBin Tian, Patrick R. Romano, Alan G. Hinnebusch, Michael M. C. LaiMichael B. Mathews. (2001) Hepatitis C Virus Envelope Protein E2 Does Not Inhibit PKR by Simple Competition with Autophosphorylation Sites in the RNA-Binding Domain. Journal of Virology 75:3, pages 1265-1273.
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Michael GaleJr.Jr., Seng-Lai Tan & Michael G. Katze. (2000) Translational Control of Viral Gene Expression in Eukaryotes. Microbiology and Molecular Biology Reviews 64:2, pages 239-280.
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Madhur Kumar & Gordon G. Carmichael. (1998) Antisense RNA: Function and Fate of Duplex RNA in Cells of Higher Eukaryotes. Microbiology and Molecular Biology Reviews 62:4, pages 1415-1434.
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