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Molecular and Cellular Biology Volume 11, 1991 - Issue 2
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Cell Growth and Development

The Transforming Potential of the c-erbB-2 Protein Is Regulated by Its Autophosphorylation at the Carboxyl-Terminal Domain

Tetsu Akiyama1 Department of Oncogene Research, Research Institute of Microbial Diseases, Osaka University, 3-1, Yamada-oka, Suita, Osaka565, Japan;2 Department of Oncology, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo108, Japan
,
Satoru Matsuda2 Department of Oncology, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo108, Japan
,
Yujirou Namba3 Department of Pathology, Institute for Virus Research, Kyoto University, Kawahara-machi, Shogoin, Sakyo-ku, Kyoto606, Japan
,
Toshiyuki Saito2 Department of Oncology, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo108, Japan
,
Kumao Toyoshima1 Department of Oncogene Research, Research Institute of Microbial Diseases, Osaka University, 3-1, Yamada-oka, Suita, Osaka565, Japan;2 Department of Oncology, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo108, Japan
&
Tadashi Yamamoto2 Department of Oncology, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo108, Japan
Pages 833-842 | Received 19 Jun 1990, Accepted 31 Oct 1990, Published online: 31 Mar 2023

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Milos Dokmanovic, Yun Wu, Yi Shen, Jieqing Chen, Dianne S Hirsch & Wen Jin Wu. (2014) Trastuzumab-induced recruitment of Csk-homologous kinase (CHK) to ErbB2 receptor is associated with ErbB2-Y1248 phosphorylation and ErbB2 degradation to mediate cell growth inhibition. Cancer Biology & Therapy 15:8, pages 1029-1041.
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Wendy Béguelin, María Celeste Díaz Flaqué, Cecilia J. Proietti, Florencia Cayrol, Martín A. Rivas, Mercedes Tkach, Cinthia Rosemblit, Johanna M. Tocci, Eduardo H. Charreau, Roxana Schillaci & Patricia V. Elizalde. (2010) Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3. Molecular and Cellular Biology 30:23, pages 5456-5472.
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Gregory J. Tsongalis & Andrew Ricci Jr.. (2001) HER2: The Neu Prognostic Marker for Breast Cancer. Critical Reviews in Clinical Laboratory Sciences 38:2, pages 167-182.
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David L. Dankort, Zhixiang Wang, Valerie Blackmore, Michael F. Moran & William J. Muller. (1997) Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation. Molecular and Cellular Biology 17:9, pages 5410-5425.
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Hideshi Ishii, Teruhiko Yoshida, Hakumei Oh, Sho Yoshida & Masaaki Terada. (1995) A Truncated K-sam Product Lacking the Distal Carboxyl-Terminal Portion Provides a Reduced Level of Autophosphorylation and Greater Resistance against Induction of Differentiation. Molecular and Cellular Biology 15:7, pages 3664-3671.
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Peter M. Siegel, David L. Dankort, William R. Hardy & William J. Muller. (1994) Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors. Molecular and Cellular Biology 14:11, pages 7068-7077.
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Paula J. Whittington, Marie P. Piechocki, Henry H. Heng, Jennifer B. Jacob, Richard F. Jones, Jessica B. Back & Wei-Zen Wei. (2008) DNA Vaccination Controls Her-2+ Tumors that Are Refractory to Targeted Therapies. Cancer Research 68:18, pages 7502-7511.
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Torsten Trowe, Sotiria Boukouvala, Keith Calkins, Richard E. CutlerJr.Jr., Ryan Fong, Roel Funke, Steven B. Gendreau, Yong D. Kim, Nicole Miller, John R. Woolfrey, Valentina Vysotskaia, Jing Ping Yang, Mary E. Gerritsen, David J. Matthews, Peter Lamb & Timothy S. Heuer. (2008) EXEL-7647 Inhibits Mutant Forms of ErbB2 Associated with Lapatinib Resistance and Neoplastic Transformation. Clinical Cancer Research 14:8, pages 2465-2475.
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Ming Tan, Ping Li, Kristine S. Klos, Jing Lu, Keng-Hsueh Lan, Yoichi Nagata, Dexing Fang, Tong Jing & Dihua Yu. (2005) ErbB2 Promotes Src Synthesis and Stability: Novel Mechanisms of Src Activation That Confer Breast Cancer Metastasis. Cancer Research 65:5, pages 1858-1867.
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Satoru Yamasaki, Keigo Nishida, Yuichi Yoshida, Motoyuki Itoh, Masahiko Hibi & Toshio Hirano. (2003) Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2. Oncogene 22:10, pages 1546-1556.
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