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Transcriptional Regulation

Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation

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Pages 4412-4421 | Received 04 Jun 1992, Accepted 14 Jul 1992, Published online: 01 Apr 2023

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David E. Nowak, Bing Tian, Mohammad Jamaluddin, Istvan Boldogh, Leoncio A. Vergara, Sanjeev Choudhary & Allan R. Brasier. (2008) RelA Ser276 Phosphorylation Is Required for Activation of a Subset of NF-κB-Dependent Genes by Recruiting Cyclin-Dependent Kinase 9/Cyclin T1 Complexes. Molecular and Cellular Biology 28:11, pages 3623-3638.
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Hao-Yuan Jiang, Sheree A. Wek, Barbara C. McGrath, Donalyn Scheuner, Randal J. Kaufman, Douglas R. Cavener & Ronald C. Wek. (2003) Phosphorylation of the α Subunit of Eukaryotic Initiation Factor 2 Is Required for Activation of NF-κB in Response to Diverse Cellular Stresses. Molecular and Cellular Biology 23:16, pages 5651-5663.
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Christine L Curran, Timothy S Blackwell & John W Christman. (2001) NF-κB: a therapeutic target in inflammatory diseases. Emerging Therapeutic Targets 5:2, pages 197-204.
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Irina A. Udalova, Anna Richardson, Agnes Denys, Clive Smith, Hans Ackerman, Brian Foxwell & Dominic Kwiatkowski. (2000) Functional Consequences of a Polymorphism Affecting NF-κB p50-p50 Binding to the TNF Promoter Region. Molecular and Cellular Biology 20:24, pages 9113-9119.
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Henry Chan, David P. Bartos & Laurie B. Owen-Schaub. (1999) Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment. Molecular and Cellular Biology 19:3, pages 2098-2108.
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Mark Baer, Allan Dillner, Richard C. Schwartz, Constance Sedon, Sergei Nedospasov & Peter F. Johnson. (1998) Tumor Necrosis Factor Alpha Transcription in Macrophages Is Attenuated by an Autocrine Factor That Preferentially Induces NF-κB p50. Molecular and Cellular Biology 18:10, pages 5678-5689.
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Hermann Baeuml, Uta Behrends, Ralph U. Peter, Stefan Mueller, Claudia Wmerbauer, S. Wright Caughmai & Klaus Degitz. (1997) Ionizing Radiation Induces, via Generation of Reactive Oxygen Intermediates, Intercellular Adhesion Molecule-1 (ICAM-1) Gene Transcription and NFκB-like Binding Activity in the ICAM-1 Transcriptional Regulatory Region. Free Radical Research 27:2, pages 127-142.
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Edward T. Morgan. (1997) Regulation of Cytochromes P450 During Inflammation and Infection. Drug Metabolism Reviews 29:4, pages 1129-1188.
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Rongtuan Lin, Pierre Beauparlant, Constantin Makris, Sylvain Meloche & John Hiscott. (1996) Phosphorylation of IκBα in the C-Terminal PEST Domain by Casein Kinase II Affects Intrinsic Protein Stability. Molecular and Cellular Biology 16:4, pages 1401-1409.
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Jenn-Haung Lai, GyöRgyi Horvath, Jeff Subleski, Joseph Bruder, Paritosh Ghosh & Tse-Hua Tan. (1995) RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter. Molecular and Cellular Biology 15:8, pages 4260-4271.
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Paloma Perez, Sergio A. Lira & Rodrigo Bravo. (1995) Overexpression of RelA in Transgenic Mouse Thymocytes: Specific Increase in Levels of the Inhibitor Protein IκBα. Molecular and Cellular Biology 15:7, pages 3523-3530.
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Jae B. Kim, Gerald D. Spotts, Yuan-Di Halvorsen, Hsiu-Ming Shih, Tom Ellenberger, Howard C. Towle & Bruce M. Spiegelman. (1995) Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain. Molecular and Cellular Biology 15:5, pages 2582-2588.
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Andrew S. Neish, Margaret A. Read, Dimitris Thanos, Richard Pine, Tom Maniatis & Tucker Collins. (1995) Endothelial Interferon Regulatory Factor 1 Cooperates with NF-κB as a Transcriptional Activator of Vascular Cell Adhesion Molecule 1. Molecular and Cellular Biology 15:5, pages 2558-2569.
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Dimitris Thanos & Tom Maniatis. (1995) Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene. Molecular and Cellular Biology 15:1, pages 152-164.
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Árpád Molnár & Katia Georgopoulos. (1994) The Ikaros Gene Encodes a Family of Functionally Diverse Zinc Finger DNA-Binding Proteins. Molecular and Cellular Biology 14:12, pages 8292-8303.
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Junichi Tsukada, Kazuyoshi Saito, Wayne R. Waterman, Andrew C. Webb & Philip E. Auron. (1994) Transcription Factors NF-IL6 and CREB Recognize a Common Essential Site in the Human Prointerleukin 1β Gene. Molecular and Cellular Biology 14:11, pages 7285-7297.
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Tomohiko Kanno, Keith Brown, Guido Franzoso & Ulrich Siebenlist. (1994) Kinetic Analysis of Human T-cell Leukemia Virus Type I Tax-Mediated Activation of NF-κB. Molecular and Cellular Biology 14:10, pages 6443-6451.
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Ulrike Schindler & Vijay R. Baichwal. (1994) Three NF-κΒ Binding Sites in the Human E-Selectin Gene Required for Maximal Tumor Necrosis Factor Alpha-Induced Expression. Molecular and Cellular Biology 14:9, pages 5820-5831.
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Hannah Lewis, Wiweka Kaszubska, John F. Delamarter & James Whelan. (1994) Cooperativity between Two NF-κΒ Complexes, Mediated by High-Mobility-Group Protein I(Y), Is Essential for Cytokine-Induced Expression of the E-Selectin Promoter. Molecular and Cellular Biology 14:9, pages 5701-5709.
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Jose R. Perez, Kimberly A. Higgins-Sochaski, Jean-Yves Maltese & Ramaswamy Narayanan. (1994) Regulation of Adhesion and Growth of Fibrosarcoma Cells by NF-κB RelA Involves Transforming Growth Factor β. Molecular and Cellular Biology 14:8, pages 5326-5332.
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Igor C. Oliveira, Naofumi Mukaida, Kouji Matsushima & Jan Vilcek. (1994) Transcriptional Inhibition of the Interleukin-8 Gene by Interferon Is Mediated by the NF-κB Site. Molecular and Cellular Biology 14:8, pages 5300-5308.
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Paul A. Oeth, Graham C. N. Parry, Charles Kunsch, Pascale Nantermet, Craig A. Rosen & Nigel Mackman. (1994) Lipopolysaccharide Induction of Tissue Factor Gene Expression in Monocytic Cells Is Mediated by Binding of c-Rel/p65 Heterodimers to a κB-Like Site. Molecular and Cellular Biology 14:6, pages 3772-3781.
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Francis A. La Rosa, Jacqueline W. Pierce & Gail E. Sonenshein. (1994) Differential Regulation of the c- Oncogene Promoter by the NF-κB Rel Family of Transcription Factors. Molecular and Cellular Biology 14:2, pages 1039-1044.
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Rebecca L. Shattuck, Lauren D. Wood, Glenn J. Jaffe & Ann Richmond. (1994) MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells. Molecular and Cellular Biology 14:1, pages 791-802.
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Parham A. Ganchi, Shao-Cong Sun, Warner C. Greene & Dean W. Ballard. (1993) A Novel NF-κB Complex Containing p65 Homodimers: Implications for Transcriptional Control at the Level of Subunit Dimerization. Molecular and Cellular Biology 13:12, pages 7826-7835.
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Bernd Stein & Albert S. Baldwin$suffix/text()$suffix/text(). (1993) Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB. Molecular and Cellular Biology 13:11, pages 7191-7198.
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John Hiscott, James Marois, Jenny Garoufalis, Mario D'Addario, Anne Roulston, Ivy Kwan, Normand Pepin, Judith Lacoste, Hannah Nguyen, Giuliano Bensi & Matthew Fenton. (1993) Characterization of a Functional NF-κB Site in the Human Interleukin 1β Promoter: Evidence for a Positive Autoregulatory Loop. Molecular and Cellular Biology 13:10, pages 6231-6240.
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Charles Kunsch & Craig A. Rosen. (1993) NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter. Molecular and Cellular Biology 13:10, pages 6137-6146.
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Robert I. Scheinman, Amer A. Beg & Albert S. Baldwin$suffix/text()$suffix/text(). (1993) NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule. Molecular and Cellular Biology 13:10, pages 6089-6101.
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Menie Merika & Stuart H. Orkin. (1993) DNA-Binding Specificity of GATA Family Transcription Factors. Molecular and Cellular Biology 13:7, pages 3999-4010.
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Timothy A. Coleman, Charles Kunsch, Maureen Maher, Steven M. Ruben & Craig A. Rosen. (1993) Acquisition of NFKB1-Selective DNA Binding by Substitution of Four Amino Acid Residues from NFKB1 into RelA. Molecular and Cellular Biology 13:7, pages 3850-3859.
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Ramaswamy Narayanan, Kimberly A. Higgins, Jose R. Perez, Timothy A. Coleman & Craig A. Rosen. (1993) Evidence for Differential Functions of the p50 and p65 Subunits of NF-κB with a Cell Adhesion Model. Molecular and Cellular Biology 13:6, pages 3802-3810.
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Amer A. Beg, Timothy S. Finco, Pascale V. Nantermet & Albert S. Baldwin$suffix/text()$suffix/text(). (1993) Tumor Necrosis Factor and Interleukin-1 Lead to Phosphorylation and Loss of IκBα: a Mechanism for NF-κB Activation. Molecular and Cellular Biology 13:6, pages 3301-3310.
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