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Cell Growth and Development

RelB, a New Rel Family Transcription Activator That Can Interact with p50-NF-κB

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Pages 674-684 | Received 23 Sep 1991, Accepted 11 Nov 1991, Published online: 01 Apr 2023

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Pedro J. Cejas, Louise M. Carlson, Despina Kolonias, Jian Zhang, Inna Lindner, Daniel D. Billadeau, Lawrence H. Boise & Kelvin P. Lee. (2005) Regulation of RelB Expression during the Initiation of Dendritic Cell Differentiation. Molecular and Cellular Biology 25:17, pages 7900-7916.
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Yves St-Pierre, Julie Couillard & Céline Van Themsche. (2004) Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opinion on Therapeutic Targets 8:5, pages 473-489.
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Yiyang Xia, Shizhong Chen, Yibin Wang, Nigel Mackman, George Ku, David Lo & Lili Feng. (1999) RelB Modulation of IκBα Stability as a Mechanism of Transcription Suppression of Interleukin-1α (IL-1α), IL-1β, and Tumor Necrosis Factor Alpha in Fibroblasts. Molecular and Cellular Biology 19:11, pages 7688-7696.
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Roderick J. Phillips & Sankar Ghosh. (1997) Regulation of IκBβ in WEHI 231 Mature B Cells. Molecular and Cellular Biology 17:8, pages 4390-4396.
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Gilles Courtois, Simon T. Whiteside, Carol H. Sibley & Alain Israel. (1997) Characterization of a Mutant Cell Line That Does Not Activate NF-κB in Response to Multiple Stimuli. Molecular and Cellular Biology 17:3, pages 1441-1449.
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Roderick J. Phillips, Sarah Gustafson & Sankar Ghosh. (1996) Identification of a Novel NF-κB p50-Related Protein in B Lymphocytes. Molecular and Cellular Biology 16:12, pages 7089-7097.
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Stefan Bell, James R. Matthews, Ellis Jaffray & Ronald T. Hay. (1996) IκBγ Inhibits DNA Binding of NF-κB p50 Homodimers by Interacting with Residues That Contact DNA. Molecular and Cellular Biology 16:11, pages 6477-6485.
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Shih-Chang Lin & Janet Stavnezer. (1996) Activation of NF-κB/Rel by CD40 Engagement Induces the Mouse Germ Line Immunoglobulin Cγ1 Promoter. Molecular and Cellular Biology 16:9, pages 4591-4603.
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Rongtuan Lin, Pierre Beauparlant, Constantin Makris, Sylvain Meloche & John Hiscott. (1996) Phosphorylation of IκBα in the C-Terminal PEST Domain by Casein Kinase II Affects Intrinsic Protein Stability. Molecular and Cellular Biology 16:4, pages 1401-1409.
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Shubha Govind, Eric Drier, Leslie H. Huang & Ruth Steward. (1996) Regulated Nuclear Import of the Drosophila Rel Protein Dorsal: Structure-Function Analysis. Molecular and Cellular Biology 16:3, pages 1103-1114.
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Paloma Perez, Sergio A. Lira & Rodrigo Bravo. (1995) Overexpression of RelA in Transgenic Mouse Thymocytes: Specific Increase in Levels of the Inhibitor Protein IκBα. Molecular and Cellular Biology 15:7, pages 3523-3530.
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Rolf-Peter Ryseck, Jiri Novotny & Rodrigo Bravo. (1995) Characterization of Elements Determining the Dimerization Properties of RelB and p50. Molecular and Cellular Biology 15:6, pages 3100-3109.
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Andrew S. Neish, Margaret A. Read, Dimitris Thanos, Richard Pine, Tom Maniatis & Tucker Collins. (1995) Endothelial Interferon Regulatory Factor 1 Cooperates with NF-κB as a Transcriptional Activator of Vascular Cell Adhesion Molecule 1. Molecular and Cellular Biology 15:5, pages 2558-2569.
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Ellis Jaffray, Katrina M. Wood & Ronald T. Hay. (1995) Domain Organization of IκBα and Sites of Interaction with NF-κB p65. Molecular and Cellular Biology 15:4, pages 2166-2172.
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Joseph A. DiDonato, Frank Mercurio & Michael Karin. (1995) Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB. Molecular and Cellular Biology 15:3, pages 1302-1311.
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Robert I. Scheinman, Antonio Gualberto, Christine M. Jewell, John A. Cidlowski & Albert S. Baldwin$suffix/text()$suffix/text(). (1995) Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors. Molecular and Cellular Biology 15:2, pages 943-953.
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Dimitris Thanos & Tom Maniatis. (1995) Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene. Molecular and Cellular Biology 15:1, pages 152-164.
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Susanne Liptay, Roland M. Schmid, Elizabeth G. Nabel & Gary J. Nabel. (1994) Transcriptional Regulation of NF-κB2: Evidence for κB-Mediated Positive and Negative Autoregulation. Molecular and Cellular Biology 14:12, pages 7695-7703.
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J. Alan Diehl & Mark Hannink. (1994) Identification of a C/EBP-Rel Complex in Avian Lymphoid Cells. Molecular and Cellular Biology 14:10, pages 6635-6646.
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Neil D. Perkins, Adam B. Agranoff, Erica Pascal & Gary J. Nabel. (1994) An Interaction between the DNA-Binding Domains of RelA(p65) and Sp1 Mediates Human Immunodeficiency Virus Gene Activation. Molecular and Cellular Biology 14:10, pages 6570-6583.
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Tomohiko Kanno, Keith Brown, Guido Franzoso & Ulrich Siebenlist. (1994) Kinetic Analysis of Human T-cell Leukemia Virus Type I Tax-Mediated Activation of NF-κB. Molecular and Cellular Biology 14:10, pages 6443-6451.
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Hannah Lewis, Wiweka Kaszubska, John F. Delamarter & James Whelan. (1994) Cooperativity between Two NF-κΒ Complexes, Mediated by High-Mobility-Group Protein I(Y), Is Essential for Cytokine-Induced Expression of the E-Selectin Promoter. Molecular and Cellular Biology 14:9, pages 5701-5709.
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Hsiou-Chi Liou, William C. Sha, Martin L. Scott & David Baltimore. (1994) Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation. Molecular and Cellular Biology 14:8, pages 5349-5359.
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Shigeki Miyamoto, Paul J. Chiao & Inder M. Verma. (1994) Enhanced ΙκΒα Degradation Is Responsible for Constitutive NF-κΒ Activity in Mature Murine B-Cell Lines. Molecular and Cellular Biology 14:5, pages 3276-3282.
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David E. Gutsch, Elizabeth A. Holley-Guthrie, Qin Zhang, Bernd Stein, Michael A. Blanar, Albert S. Baldwin & Shannon C. Kenney. (1994) The bZIP Transactivator of Epstein-Barr Virus, BZLF1, Functionally and Physically Interacts with the p65 Subunit of NF-kB. Molecular and Cellular Biology 14:3, pages 1939-1948.
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Christophe Béraud, Shao-Cong Sun, Parham Ganchi, Dean W. Ballard & Warner C. Greene. (1994) Human T-Cell Leukemia Virus Type I Tax Associates with and Is Negatively Regulated by the NF-κB2 p100 Gene Product: Implications for Viral Latency. Molecular and Cellular Biology 14:2, pages 1374-1382.
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Parham A. Ganchi, Shao-Cong Sun, Warner C. Greene & Dean W. Ballard. (1993) A Novel NF-κB Complex Containing p65 Homodimers: Implications for Transcriptional Control at the Level of Subunit Dimerization. Molecular and Cellular Biology 13:12, pages 7826-7835.
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John Hiscott, James Marois, Jenny Garoufalis, Mario D'Addario, Anne Roulston, Ivy Kwan, Normand Pepin, Judith Lacoste, Hannah Nguyen, Giuliano Bensi & Matthew Fenton. (1993) Characterization of a Functional NF-κB Site in the Human Interleukin 1β Promoter: Evidence for a Positive Autoregulatory Loop. Molecular and Cellular Biology 13:10, pages 6231-6240.
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James H. Segars, Toshi Nagata, Vincent Bours, Jeffrey A. Medin, Guido Franzoso, Jorge C. G. Blanco, Paul D. Drew, Kevin G. Becker, Jiabin An, Terry Tang, David A. Stephany, Benjamin Neel, Ulrich Siebenlist & Keiko Ozato. (1993) Retinoic Acid Induction of Major Histocompatibility Complex Class I Genes in NTera-2 Embryonal Carcinoma Cells Involves Induction of NF-κB (p50-p65) and Retinoic Acid Receptor β-Retinoid X Receptor β Heterodimers. Molecular and Cellular Biology 13:10, pages 6157-6169.
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Rosemary B. Evans, Paul D. Gottlieb & Henry R. Bose$suffix/text()$suffix/text(). (1993) Identification of a Rel-Related Protein in the Nucleus During the S Phase of the Cell Cycle. Molecular and Cellular Biology 13:10, pages 6147-6156.
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Charles Kunsch & Craig A. Rosen. (1993) NF-κB Subunit-Specific Regulation of the Interleukin-8 Promoter. Molecular and Cellular Biology 13:10, pages 6137-6146.
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Robert I. Scheinman, Amer A. Beg & Albert S. Baldwin$suffix/text()$suffix/text(). (1993) NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule. Molecular and Cellular Biology 13:10, pages 6089-6101.
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Tetsuro Noguchi, Richard Metz, Lihong Chen, Marie-Geneviève Mattéi, Daniel Carrasco & Rodrigo Bravo. (1993) Structure, Mapping, and Expression of erp, a Growth Factor-Inducible Gene Encoding a Nontransmembrane Protein Tyrosine Phosphatase, and Effect of ERP on Cell Growth. Molecular and Cellular Biology 13:9, pages 5195-5205.
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Timothy A. Coleman, Charles Kunsch, Maureen Maher, Steven M. Ruben & Craig A. Rosen. (1993) Acquisition of NFKB1-Selective DNA Binding by Substitution of Four Amino Acid Residues from NFKB1 into RelA. Molecular and Cellular Biology 13:7, pages 3850-3859.
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J. Alan Diehl, Timothy A. McKinsey & Mark Hannink. (1993) Differential pp40IκB-β Inhibition of DNA Binding by rel Proteins. Molecular and Cellular Biology 13:3, pages 1769-1778.
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Pawel Dobrzanski, Rolf-Peter Ryseck & Rodrigo Bravo. (1993) Both N- and C-Terminal Domains of RelB Are Required for Full Transactivation: Role of the N-Terminal Leucine Zipper-Like Motif. Molecular and Cellular Biology 13:3, pages 1572-1582.
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Michel B. Toledano, David Ghosh, Frank Trinh & Warren J. Leonard. (1993) N-Terminal DNA-Binding Domains Contribute to Differential DNA-Binding Specificities of NF-κB p50 and p65. Molecular and Cellular Biology 13:2, pages 852-860.
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Charles Kunsch, Steven M. Ruben & Craig A. Rosen. (1992) Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation. Molecular and Cellular Biology 12:10, pages 4412-4421.
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Tse-Hua Tan, Grace P. Huang, Antonio Sica, Paritosh Ghosh, Howard A. Young, Dan L. Longo & Nancy R. Rice. (1992) κB Site-Dependent Activation of the Interleukin-2 Receptor α-Chain Gene Promoter by Human c-Rel. Molecular and Cellular Biology 12:9, pages 4067-4075.
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Sushant Kumar, Arnold B. Rabson & Celine Gélinas. (1992) The RxxRxRxxC Motif Conserved in All Rel/κΒ Proteins Is Essential for the DNA-Binding Activity and Redox Regulation of the v-Rel Oncoprotein. Molecular and Cellular Biology 12:7, pages 3094-3106.
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Manorama Tewari, Pawel Dobrzanski, Kenneth L. Mohn, Drew E. Cressman, Jui-Chou Hsu, Rodrigo Bravo & Rebecca Taub. (1992) Rapid Induction in Regenerating Liver of RL/IF-1 (an ΙκΒ That Inhibits NF-κΒ, RelB-p50, and c-Rel-p50) and PHF, a Novel κΒ Site-Binding Complex. Molecular and Cellular Biology 12:6, pages 2898-2908.
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Vincent Bours, Parris R. Burd, Keith Brown, Juanita Villalobos, Sun Park, Rolf-Peter Ryseck, Rodrigo Bravo, Kathy Kelly & Ulrich Siebenlist. (1992) A Novel Mitogen-Inducible Gene Product Related to p50/pl05- NF-κB Participates in Transactivation through a κB Site. Molecular and Cellular Biology 12:2, pages 685-695.
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Carlos G. BriseñoMarco GargaroVivek DuraiJesse T. DavidsonDerek J. TheisenDavid A. AndersonIIIIIIDeborah V. NovackTheresa L. MurphyKenneth M. Murphy. (2017) Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proceedings of the National Academy of Sciences 114:15, pages 3957-3962.
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Jian Wang, Juan Tan, Hongyan Guo, Qicheng Zhang, Rui Jia, Xuan Xu, Yunqi Geng & Wentao Qiao. (2010) Bovine Foamy Virus Transactivator BTas Interacts with Cellular RelB To Enhance Viral Transcription. Journal of Virology 84:22, pages 11888-11897.
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Sergio VairaTrevor JohnsonAngela C. HirbeMuhammad AlhawagriImani AnwisyeBenedicte SammutJulie O'NealWei ZouKatherine N. Weilbaecher, Roberta Faccio & Deborah Veis Novack. (2008) RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation. Proceedings of the National Academy of Sciences 105:10, pages 3897-3902.
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S Josson, Y Xu, F Fang, S K Dhar, D K St Clair & W H St Clair. (2005) RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Oncogene 25:10, pages 1554-1559.
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H. Y. Jiang, Constantinos Petrovas & Gail E. Sonenshein. (2002) RelB-p50 NF-κB Complexes Are Selectively Induced by Cytomegalovirus Immediate-Early Protein 1: Differential Regulation of Bcl-x L Promoter Activity by NF-κB Family Members . Journal of Virology 76:11, pages 5737-5747.
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Ralf Marienfeld, Friederike Berberich-Siebelt, Ingolf Berberich, Andrea Denk, Edgar Serfling & Manfred Neumann. (2001) Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-κB control. Oncogene 20:56, pages 8142-8147.
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Gary D Bren, Nancie J Solan, Hiroko Miyoshi, Kevin N Pennington, Lori J Pobst & Carlos V Paya. (2001) Transcription of the RelB gene is regulated by NF-κB. Oncogene 20:53, pages 7722-7733.
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Brendan J. O'Sullivan, Kelli P. A. MacDonald, Allison R. Pettit & Ranjeny Thomas. (2000) RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function. Proceedings of the National Academy of Sciences 97:21, pages 11421-11426.
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Modem Suhasini & Renate B Pilz. (1999) Transcriptional elongation of c-myb is regulated by NF-κB (p50/RelB). Oncogene 18:51, pages 7360-7369.
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Takahiro S. Doi, Michael W. Marino, Toshitada Takahashi, Toshimichi Yoshida, Teruyo Sakakura, Lloyd J. Old & Yuichi Obata. (1999) Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proceedings of the National Academy of Sciences 96:6, pages 2994-2999.
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Christophe Béraud, William J. Henzel & Patrick A. Baeuerle. (1999) Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation. Proceedings of the National Academy of Sciences 96:2, pages 429-434.
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