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Cell Growth and Development

GTPase-Activating Protein and Phosphatidylinositol 3-Kinase Bind to Distinct Regions of the Platelet-Derived Growth Factor Receptor β Subunit

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Pages 2534-2544 | Received 19 Aug 1991, Accepted 26 Feb 1992, Published online: 31 Mar 2023

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Hetian Lei, Cynthia X. Qian, Jinghu Lei, Luis J. Haddock, Shizuo Mukai & Andrius Kazlauskas. (2015) RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology. Molecular and Cellular Biology 35:10, pages 1673-1685.
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T. Guy Hamilton, Richard A. Klinghoffer, Philip D. Corrin & Philippe Soriano. (2003) Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms. Molecular and Cellular Biology 23:11, pages 4013-4025.
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Si Qing Zhang, William G. Tsiaras, Toshiyuki Araki, Gengyun Wen, Liliana Minichiello, Ruediger Klein & Benjamin G. Neel. (2002) Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2. Molecular and Cellular Biology 22:12, pages 4062-4072.
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Jian Wang, Heping Dai, Nasim Yousaf, Mustapha Moussaif, Youping Deng, Amale Boufelliga, O. Rama Swamy, Michelle E. Leone & Heimo Riedel. (1999) Grb10, a Positive, Stimulatory Signaling Adapter in Platelet-Derived Growth Factor BB-, Insulin-Like Growth Factor I-, and Insulin-Mediated Mitogenesis. Molecular and Cellular Biology 19:9, pages 6217-6228.
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Lisa A. Cass, Scott A. Summers, Gregory V. Prendergast, Jonathan M. Backer, Morris J. Birnbaum & Judy L. Meinkoth. (1999) Protein Kinase A-Dependent and -Independent Signaling Pathways Contribute to Cyclic AMP-Stimulated Proliferation. Molecular and Cellular Biology 19:9, pages 5882-5891.
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Stephan Rosenkranz & Andrius Kazlauskas. (1999) Evidence for Distinct Signaling Properties and Biological Responses Induced by the PDGF Receptor α and β Subtypes. Growth Factors 16:3, pages 201-216.
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Serge Roche, J. Downward, Patrick Raynal & Sara A. Courtneidge. (1998) A Function for Phosphatidylinositol 3-Kinase β (p85α-p110β) in Fibroblasts during Mitogenesis: Requirement for Insulin- and Lysophosphatidic Acid-Mediated Signal Transduction. Molecular and Cellular Biology 18:12, pages 7119-7129.
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Kris A. DeMali & Andrius Kazlauskas. (1998) Activation of Src Family Members Is Not Required for the Platelet-Derived Growth Factor β Receptor To Initiate Mitogenesis. Molecular and Cellular Biology 18:4, pages 2014-2022.
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Peter van der Geer, Mark Henkemeyer, Yler Jacks & Tony Pawson. (1997) Aberrant Ras Regulation and Reduced p190 Tyrosine Phosphorylation in Cells Lacking p120-Gap. Molecular and Cellular Biology 17:4, pages 1840-1847.
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Chantal E. Bazenet, Julie A. Gelderloos & Andrius Kazlauskas. (1996) Phosphorylation of Tyrosine 720 in the Platelet-Derived Growth Factor α Receptor Is Required for Binding of Grb2 and SHP-2 but Not for Activation of Ras or Cell Proliferation. Molecular and Cellular Biology 16:12, pages 6926-6936.
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Richard A. Klinghoffer, Brian Duckworth, Mindaugas Valius, Lewis Cantley & Andrius Kazlauskas. (1996) Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras Activity. Molecular and Cellular Biology 16:10, pages 5905-5914.
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Mindaugas Valius, John Paul Secrist & Andrius Kazlauskas. (1995) The GTPase-Activating Protein of Ras Suppresses Platelet-Derived Growth Factor β Receptor Signaling by Silencing Phospholipase C-γ1. Molecular and Cellular Biology 15:6, pages 3058-3071.
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Daniela Drummond-Barbosa, Richard R. Vaillancourt, Andrius Kazlauskas & Daniel DiMaio. (1995) Ligand-Independent Activation of the Platelet-Derived Growth Factor β Receptor: Requirements for Bovine Papillomavirus E5-Induced Mitogenic Signaling. Molecular and Cellular Biology 15:5, pages 2570-2581.
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Serge Roche, Manfred Koegl, M. Vittoria Barone, Martine F. Roussel & Sara A. Courtneidge. (1995) DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases. Molecular and Cellular Biology 15:2, pages 1102-1109.
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A. G. Batzer, D. Rotin, J. M. Urena, E. Y. Skolnik & J. Schlessinger. (1994) Hierarchy of Binding Sites for Grb2 and Shc on the Epidermal Growth Factor Receptor. Molecular and Cellular Biology 14:8, pages 5192-5201.
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Marijane Russell, Sim Winitz & Gary L. Johnson. (1994) Acetylcholine Muscarinic m1 Receptor Regulation of Cyclic AMP Synthesis Controls Growth Factor Stimulation of Raf Activity. Molecular and Cellular Biology 14:4, pages 2343-2351.
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K. V. S. Prasad, Rosana Kapeller, Ottmar Janssen, Heinrich Repke, Jonathan S. Duke-Cohan, Lewis C. Cantley & Christopher E. Rudd. (1993) Phosphatidylinositol (PI) 3-Kinase and PI 4-Kinase Binding to the CD4-p56 Complex: the p56 SH3 Domain Binds to PI 3-Kinase but Not PI 4-Kinase. Molecular and Cellular Biology 13:12, pages 7708-7717.
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P. Hu, A. Mondino, E. Y. Skolnik & J. Schlessinger. (1993) Cloning of a Novel, Ubiquitously Expressed Human Phosphatidylinositol 3-Kinase and Identification of Its Binding Site on p85. Molecular and Cellular Biology 13:12, pages 7677-7688.
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J. Eduardo Fajardo, Raymond B. Birge & Hidesaburo Hanafusa. (1993) A 31-Amino-Acid N-Terminal Extension Regulates c-Crk Binding to Tyrosine-Phosphorylated Proteins. Molecular and Cellular Biology 13:12, pages 7295-7302.
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R. Nishimura, W. Li, A. Kashishian, A. Mondino, M. Zhou, J. Cooper & J. Schlessinger. (1993) Two Signaling Molecules Share a Phosphotyrosine-Containing Binding Site in the Platelet-Derived Growth Factor Receptor. Molecular and Cellular Biology 13:11, pages 6889-6896.
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Christopher M. Pleiman, Marcus R. Clark, Lisa K. Timson Gauen, Sim Winitz, K. Mark Coggeshall, Gary L. Johnson, Andrey S. Shaw & John C. Cambier. (1993) Mapping of Sites on the Src Family Protein Tyrosine Kinases p55, p59, and p56 Which Interact with the Effector Molecules Phospholipase C-γ2, Microtubule-Associated Protein Kinase, GTPase-Activating Protein, and Phosphatidylinositol 3-Kinase. Molecular and Cellular Biology 13:9, pages 5877-5887.
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Xingquan Liu, Luc E. M. Marengere, C. Anne Koch & Tony Pawson. (1993) The v-Src SH3 Domain Binds Phosphatidylinositol 3'-Kinase. Molecular and Cellular Biology 13:9, pages 5225-5232.
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Takaya Satoh, Wendy J. Fantl, Jaime A. Escobedo, Lewis T. Williams & Yoshito Kaziro. (1993) Platelet-Derived Growth Factor Receptor Mediates Activation of Ras through Different Signaling Pathways in Different Cell Types. Molecular and Cellular Biology 13:6, pages 3706-3713.
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Jonathan A. Cooper & Adam Kashishian. (1993) In Vivo Binding Properties of SH2 Domains from GTPase-Activating Protein and Phosphatidylinositol 3-Kinase. Molecular and Cellular Biology 13:3, pages 1737-1745.
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W. Li, P. Hu, E. Y. Skolnik, A. Ullrich & J. Schlessinger. (1992) The SH2 and SH3 Domain-Containing Nek Protein Is Oncogenic and a Common Target for Phosphorylation by Different Surface Receptors. Molecular and Cellular Biology 12:12, pages 5824-5833.
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Articles from other publishers (4)

Caroline Saucier, Vasilios Papavasiliou, Alexander Palazzo, Monica A Naujokas, Richard Kremer & Morag Park. (2002) Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis. Oncogene 21:12, pages 1800-1811.
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Lisa A Cass & Judy L Meinkoth. (2000) Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation. Oncogene 19:7, pages 924-932.
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Heimo Riedel, Nasim Yousaf, Yuyuan Zhao, Dai Heping, Youping Deng & Jian Wang. (2000) PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis. Oncogene 19:1, pages 39-50.
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Simon Ekman, Eva Rupp Thuresson, Carl-Henrik Heldin & Lars Rönnstrand. (1999) Increased mitogenicity of an αβ heterodimeric PDGF receptor complex correlates with lack of RasGAP binding. Oncogene 18:15, pages 2481-2488.
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