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Transcriptional Regulation

The RxxRxRxxC Motif Conserved in All Rel/κΒ Proteins Is Essential for the DNA-Binding Activity and Redox Regulation of the v-Rel Oncoprotein

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Pages 3094-3106 | Received 06 Feb 1992, Accepted 23 Apr 1992, Published online: 01 Apr 2023

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Read on this site (14)

Cailin Chen, François Agnès & Céline Gélinas. (1999) Mapping of a Serine-Rich Domain Essential for the Transcriptional, Antiapoptotic, and Transforming Activities of the v-Rel Oncoprotein. Molecular and Cellular Biology 19:1, pages 307-316.
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Jarmila Kralova, Andrew S. Liss, William Bargmann & Henry R. Bose$suffix/text()$suffix/text(). (1998) AP-1 Factors Play an Important Role in Transformation Induced by the v-rel Oncogene. Molecular and Cellular Biology 18:5, pages 2997-3009.
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A. M. Moormann, R. J. Koenig & S. R. Meshnick. (1996) Effects of hydrogen peroxide, nitric oxide and antioxidants on NF-κB. Redox Report 2:4, pages 249-256.
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Rolf-Peter Ryseck, Jiri Novotny & Rodrigo Bravo. (1995) Characterization of Elements Determining the Dimerization Properties of RelB and p50. Molecular and Cellular Biology 15:6, pages 3100-3109.
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Mary K. Ernst, Linda L. Dunn & Nancy R. Rice. (1995) The Pest-Like Sequence of IκBα Is Responsible for Inhibition of DNA Binding but Not for Cytoplasmic Retention of c-Rel or RelA Homodimers. Molecular and Cellular Biology 15:2, pages 872-882.
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Neil D. Perkins, Adam B. Agranoff, Erica Pascal & Gary J. Nabel. (1994) An Interaction between the DNA-Binding Domains of RelA(p65) and Sp1 Mediates Human Immunodeficiency Virus Gene Activation. Molecular and Cellular Biology 14:10, pages 6570-6583.
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Parham A. Ganchi, Shao-Cong Sun, Warner C. Greene & Dean W. Ballard. (1993) A Novel NF-κB Complex Containing p65 Homodimers: Implications for Transcriptional Control at the Level of Subunit Dimerization. Molecular and Cellular Biology 13:12, pages 7826-7835.
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Xiang Xu, Christine Prorock, Hideaki Ishikawa, Edio Maldonado, Yoshiaki Ito & Céline Gélinas. (1993) Functional Interaction of the v-Rel and c-Rel Oncoproteins with the TATA-Binding Protein and Association with Transcription Factor IIB. Molecular and Cellular Biology 13:11, pages 6733-6741.
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Lisa J. Walker, Craig N. Robson, Elizabeth Black, David Gillespie & Ian D. Hickson. (1993) Identification of Residues in the Human DNA Repair Enzyme HAP1 (Ref-1) That are Essential for Redox Regulation of Jun DNA Binding. Molecular and Cellular Biology 13:9, pages 5370-5376.
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Christina K. Galang & Craig A. Hauser. (1993) Cooperative DNA Binding of the Human HoxB5 (Hox-2.1) Protein Is Under Redox Regulation In Vitro. Molecular and Cellular Biology 13:8, pages 4609-4617.
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Alexandra C. Miller, Jeffery Gafner, Edward P. Clark & Dvorit Samid. (1993) Posttranscriptional Down-Regulation of ras Oncogene Expression by Inhibitors of Cellular Glutathione. Molecular and Cellular Biology 13:7, pages 4416-4422.
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Timothy A. Coleman, Charles Kunsch, Maureen Maher, Steven M. Ruben & Craig A. Rosen. (1993) Acquisition of NFKB1-Selective DNA Binding by Substitution of Four Amino Acid Residues from NFKB1 into RelA. Molecular and Cellular Biology 13:7, pages 3850-3859.
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Michel B. Toledano, David Ghosh, Frank Trinh & Warren J. Leonard. (1993) N-Terminal DNA-Binding Domains Contribute to Differential DNA-Binding Specificities of NF-κB p50 and p65. Molecular and Cellular Biology 13:2, pages 852-860.
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Articles from other publishers (6)

Anja ReintjesJulian E. FuchsLeopold KremserHerbert H. LindnerKlaus R. LiedlLukas A. Huber & Taras Valovka. (2016) Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response. Proceedings of the National Academy of Sciences 113:16, pages 4326-4331.
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Jui Dutta, Gaofeng Fan & Céline Gélinas. (2008) CAPERα Is a Novel Rel-TAD-Interacting Factor That Inhibits Lymphocyte Transformation by the Potent Rel/NF-κB Oncoprotein v-Rel. Journal of Virology 82:21, pages 10792-10802.
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Takayuki Ikezoe, Yang Yang, Kentaro Bandobashi, Tsuyako Saito, Shigeki Takemoto, Hisanori Machida, Kazuto Togitani, H. Phillip Koeffler & Hirokuni Taguchi. (2005) Oridonin, a diterpenoid purified from Rabdosia rubescens , inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways . Molecular Cancer Therapeutics 4:4, pages 578-586.
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Christopher B Phelps & Gourisankar Ghosh. (2004) Discreet mutations from c-Rel to v-Rel alter κB DNA recognition, IκBα binding, and dimerization: implications for v-Rel oncogenicity. Oncogene 23:6, pages 1229-1238.
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Andrew S. Liss & Henry R. Bose,Jr.Jr.. (2002) Mutational Analysis of the v-Rel Dimerization Interface Reveals a Critical Role for v-Rel Homodimers in Transformation. Journal of Virology 76:10, pages 4928-4939.
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Masaki Hiramoto, Noriaki Shimizu, Kotaro Sugimoto, Jianwei Tang, Yutaka Kawakami, Masaharu Ito, Shin Aizawa, Hirotoshi Tanaka, Isao Makino & Hiroshi Handa. (1998) Nuclear Targeted Suppression of NF-κB Activity by the Novel Quinone Derivative E3330. The Journal of Immunology 160:2, pages 810-819.
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