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Molecular and Cellular Biology Volume 13, 1993 - Issue 10
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Cell Growth and Development

Dominant Missense Mutations in a Novel Yeast Protein related to Mammalian Phosphatidylinositol 3-Kinase and VPS34 Abrogate Rapamycin Cytotoxicity

Robert Cafferkey1 Department of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Peter R. Young2 Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Megan M. McLaughlin1 Department of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Derk J. Bergsma2 Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Yigal Koltin3 Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Ganesh M. Sathe2 Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Leo Faucette3 Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Wai-Kwong Eng3 Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
,
Randall K. Johnson3 Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
&
George P. Livi1 Department of Gene Expression Sciences, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania19406.
 show all
Pages 6012-6023 | Received 10 May 1993, Accepted 06 Jul 1993, Published online: 31 Mar 2023

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Tito T. Jesus, Pedro F. Oliveira, Mário Sousa, C. Yan Cheng & Marco G. Alves. (2017) Mammalian target of rapamycin (mTOR): a central regulator of male fertility?. Critical Reviews in Biochemistry and Molecular Biology 52:3, pages 235-253.
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Nathan Wlodarchak & Yongna Xing. (2016) PP2A as a master regulator of the cell cycle. Critical Reviews in Biochemistry and Molecular Biology 51:3, pages 162-184.
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Hong Mei, Ye Wang, Zhenyu Lin & Qiangsong Tong. (2013) The mTOR Signaling Pathway in Pediatric Neuroblastoma. Pediatric Hematology and Oncology 30:7, pages 605-615.
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Nicolas Pallet & Christophe Legendre. (2013) Adverse events associated with mTOR inhibitors. Expert Opinion on Drug Safety 12:2, pages 177-186.
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Lucia F. Zacchi, Jonatan Gomez-Raja & Dana A. Davis. (2010) Mds3 Regulates Morphogenesis in Candida albicans through the TOR Pathway. Molecular and Cellular Biology 30:14, pages 3695-3710.
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Kamalesh Sankhala & Francis J Giles. (2009) Potential of mTOR inhibitors as therapeutic agents in hematological malignancies. Expert Review of Hematology 2:4, pages 399-414.
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Axel B. Berger, Laurence Decourty, Gwenaël Badis, Ulf Nehrbass, Alain Jacquier & Olivier Gadal. (2007) Hmo1 Is Required for TOR-Dependent Regulation of Ribosomal Protein Gene Transcription. Molecular and Cellular Biology 27:22, pages 8015-8026.
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Stefan Florian, Stefan Hümmer, Mario Catarinella & Thomas U. Mayer. (2007) Chemical genetics: Reshaping biology through chemistry. HFSP Journal 1:2, pages 104-114.
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Huamin Wang & Yu Jiang. (2003) The Tap42-Protein Phosphatase Type 2A Catalytic Subunit Complex Is Required for Cell Cycle-Dependent Distribution of Actin in Yeast. Molecular and Cellular Biology 23:9, pages 3116-3125.
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Lloyd P. McMahon, Kin M. Choi, Tai-An Lin, Robert T. Abraham & John C. Lawrence$suffix/text()$suffix/text(). (2002) The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin. Molecular and Cellular Biology 22:21, pages 7428-7438.
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M. Cristina Cruz, Lora M. Cavallo, Jenifer M. Görlach, Gary Cox, John R. Perfect, Maria E. Cardenas & Joseph Heitman. (1999) Rapamycin Antifungal Action Is Mediated via Conserved Complexes with FKBP12 and TOR Kinase Homologs in Cryptococcus neoformans. Molecular and Cellular Biology 19:6, pages 4101-4112.
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Anke Klippel, Maria-Amelia Escobedo, Matthew S. Wachowicz, Gerald Apell, Timothy W. Brown, Martin A. Giedlin, W. Michael Kavanaugh & Lewis T. Williams. (1998) Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation. Molecular and Cellular Biology 18:10, pages 5699-5711.
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Yan Luo, Steven O. Marx, Hiroaki Kiyokawa, Andrew Koff, Joan Massagué & Andrew R. Marks. (1996) Rapamycin Resistance Tied to Defective Regulation of p27. Molecular and Cellular Biology 16:12, pages 6744-6751.
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Kemin Zhou, Kaoru Takegawa, Scott D. Emr & Richard A. Firtel. (1995) A Phosphatidylinositol (PI) Kinase Gene Family in Dictyostelium discoideum: Biological Roles of Putative Mammalian p110 and Yeast Vps34p PI 3-Kinase Homologs during Growth and Development. Molecular and Cellular Biology 15:10, pages 5645-5656.
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Gerhard Cullmann, Karen Fien, Ryuji Kobayashi & Bruce Stillman. (1995) Characterization of the Five Replication Factor C Genes of Saccharomyces cerevisiae. Molecular and Cellular Biology 15:9, pages 4661-4671.
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Mercè Monfar, Katherine P. Lemon, Timothy C. Grammer, Lynn Cheatham, Jongkyeong Chung, Chris J. Vlahos & John Blenis. (1995) Activation of pp70/85 S6 Kinases in Interleukin-2-Responsive Lymphoid Cells Is Mediated by Phosphatidylinositol 3-Kinase and Inhibited by Cyclic AMP. Molecular and Cellular Biology 15:1, pages 326-337.
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Anke Klippel, Jaime A. Escobedo, Michiko Hirano & Lewis T. Williams. (1994) The Interaction of Small Domains Between the Subunits of Phosphatidylinositol 3-Kinase Determines Enzyme Activity. Molecular and Cellular Biology 14:4, pages 2675-2685.
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Articles from other publishers (15)

Chee Ho H’ng, Ashwini Khaladkar & Alberto Rosello-Diez. (2023) Look who’s TORking: mTOR-mediated integration of cell status and external signals during limb development and endochondral bone growth. Frontiers in Cell and Developmental Biology 11.
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Marie Girodengo, Sila K. Ultanir & Joseph M. Bateman. (2022) Mechanistic target of rapamycin signaling in human nervous system development and disease. Frontiers in Molecular Neuroscience 15.
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Lijun Li, Xiaojing Xia, Yunfeng Luo, Yuanting Zhu, Xuhong Luo, Baolin Yang & Lei Shang. (2022) Prospects and hot spots for mammalian target of rapamycin in the field of neuroscience from 2002 to 2021. Frontiers in Integrative Neuroscience 16.
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Dong Liu, Liqun Xu, Xiaoyan Zhang, Changhong Shi, Shubin Qiao, Zhiqiang Ma & Jiansong Yuan. (2019) Snapshot: Implications for mTOR in Aging-related Ischemia/Reperfusion Injury. Aging and disease 10:1, pages 116.
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David M. Sabatini. (2017) Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Proceedings of the National Academy of Sciences 114:45, pages 11818-11825.
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Robert J. Bastidas, Cecelia A. Shertz, Soo Chan Lee, Joseph Heitman & Maria E. Cardenas. (2012) Rapamycin Exerts Antifungal Activity In Vitro and In Vivo against Mucor circinelloides via FKBP12-Dependent Inhibition of Tor . Eukaryotic Cell 11:3, pages 270-281.
Crossref
Loredana Stoica, Ping Jun Zhu, Wei Huang, Hongyi Zhou, Sara C. Kozma & Mauro Costa-Mattioli. (2011) Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. Proceedings of the National Academy of Sciences 108:9, pages 3791-3796.
Crossref
Marianna Orlova, Ellen Kanter, David Krakovich & Sergei Kuchin. (2006) Nitrogen Availability and TOR Regulate the Snf1 Protein Kinase in Saccharomyces cerevisiae . Eukaryotic Cell 5:11, pages 1831-1837.
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David E. Levin. (2005) Cell Wall Integrity Signaling in Saccharomyces cerevisiae . Microbiology and Molecular Biology Reviews 69:2, pages 262-291.
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José L. Crespo & Michael N. Hall. (2002) Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae . Microbiology and Molecular Biology Reviews 66:4, pages 579-591.
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M. Cristina Cruz, Alan L. Goldstein, Jill Blankenship, Maurizio Del Poeta, John R. PerfectJohn H. McCusker, Youssef L. Bennani, Maria E. Cardenas & Joseph Heitman. (2001) Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR . Antimicrobial Agents and Chemotherapy 45:11, pages 3162-3170.
Crossref
Brian Raught, Anne-Claude Gingras & Nahum Sonenberg. (2001) The target of rapamycin (TOR) proteins. Proceedings of the National Academy of Sciences 98:13, pages 7037-7044.
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James S. Hardwick, Finny G. Kuruvilla, Jeffrey K. Tong, Alykhan F. Shamji & Stuart L. Schreiber. (1999) Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proceedings of the National Academy of Sciences 96:26, pages 14866-14870.
Crossref
Maria E. Cardenas, M. Cristina Cruz, Maurizio Del Poeta, Namjin Chung, John R. Perfect & Joseph Heitman. (1999) Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action . Clinical Microbiology Reviews 12:4, pages 583-611.
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Michael D. Mendenhall & Amy E. Hodge. (1998) Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae . Microbiology and Molecular Biology Reviews 62:4, pages 1191-1243.
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