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Cell Growth and Development

Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

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Pages 7170-7179 | Received 29 Jul 1993, Accepted 19 Aug 1993, Published online: 31 Mar 2023

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Jens Rauch & Walter Kolch. (2019) Spatial regulation of ARAF controls the MST2-Hippo pathway. Small GTPases 10:4, pages 243-248.
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Yvonne Light, Hugh Paterson & Richard Marais. (2002) 14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity. Molecular and Cellular Biology 22:14, pages 4984-4996.
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Amardeep S. Dhillon, Claire Pollock, Helge Steen, Peter E. Shaw, Harald Mischak & Walter Kolch. (2002) Cyclic AMP-Dependent Kinase Regulates Raf-1 Kinase Mainly by Phosphorylation of Serine 259. Molecular and Cellular Biology 22:10, pages 3237-3246.
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Paul Shapiro. (2002) Ras-MAP Kinase Signaling Pathways and Control of Cell Proliferation: Relevance to Cancer Therapy. Critical Reviews in Clinical Laboratory Sciences 39:4-5, pages 285-330.
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Antonio Chiloeches, Clive S. Mason & Richard Marais. (2001) S338 Phosphorylation of Raf-1 Is Independent of Phosphatidylinositol 3-Kinase and Pak3. Molecular and Cellular Biology 21:7, pages 2423-2434.
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Sheng Wang, Niharika Nath, Gina Fusaro & Srikumar Chellappan. (1999) Rb and Prohibitin Target Distinct Regions of E2F1 for Repression and Respond to Different Upstream Signals. Molecular and Cellular Biology 19:11, pages 7447-7460.
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Peter Erhardt, Erin J. Schremser & Geoffrey M. Cooper. (1999) B-Raf Inhibits Programmed Cell Death Downstream of Cytochrome c Release from Mitochondria by Activating the MEK/Erk Pathway. Molecular and Cellular Biology 19:8, pages 5308-5315.
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Kai Xia, Robert S. Lee, Radha P. Narsimhan, Nishit K. Mukhopadhyay, Benjamin G. Neel & Thomas M. Roberts. (1999) Tyrosine Phosphorylation of the Proto-Oncoprotein Raf-1 Is Regulated by Raf-1 Itself and the Phosphatase Cdc25A. Molecular and Cellular Biology 19:7, pages 4819-4824.
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Pieter H. Anborgh, Xiaolan Qian, Alex G. Papageorge, William C. Vass, Jeffrey E. DeClue & Douglas R. Lowy. (1999) Ras-Specific Exchange Factor GRF: Oligomerization through Its Dbl Homology Domain and Calcium-Dependent Activation of Raf. Molecular and Cellular Biology 19:7, pages 4611-4622.
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Nicholas Grammatikakis, Jun-Hsiang Lin, Aliki Grammatikakis, Philip N. Tsichlis & Brent H. Cochran. (1999) p50 Acting in Concert with Hsp90 Is Required for Raf-1 Function. Molecular and Cellular Biology 19:3, pages 1661-1672.
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Natasha Aziz, Holly Cherwinski & Martin McMahon. (1999) Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src. Molecular and Cellular Biology 19:2, pages 1101-1115.
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Sheng Wang, Richik N. Ghosh & Srikumar P. Chellappan. (1998) Raf-1 Physically Interacts with Rb and Regulates Its Function: a Link between Mitogenic Signaling and Cell Cycle Regulation. Molecular and Cellular Biology 18:12, pages 7487-7498.
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Sandrine Roy, Robert A. McPherson, Ann Apolloni, Jun Yan, Annette Lane, Jodi Clyde-Smith & John F. Hancock. (1998) 14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo. Molecular and Cellular Biology 18:7, pages 3947-3955.
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Irene E. Zohn, Marc Symons, Magdalena Chrzanowska-Wodnicka, John K. Westwick & Channing J. Der. (1998) Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac. Molecular and Cellular Biology 18:3, pages 1225-1235.
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Douglas Woods, David Parry, Holly Cherwinski, Elizabeth Bosch, Emma Lees & Martin McMahon. (1997) Raf-Induced Proliferation or Cell Cycle Arrest Is Determined by the Level of Raf Activity with Arrest Mediated by p21Cip1. Molecular and Cellular Biology 17:9, pages 5598-5611.
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Marie-Christine Rouyez, Christine Boucheron, Sylvie Gisselbrecht, Isabelle Dusanter-Fourt & Françoise Porteu. (1997) Control of Thrombopoietin-Induced Megakaryocytic Differentiation by the Mitogen-Activated Protein Kinase Pathway. Molecular and Cellular Biology 17:9, pages 4991-5000.
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Bruce Diaz, Darlene Barnard, Adele Filson, Susan MacDonald, Alastair King & Mark Marshall. (1997) Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling. Molecular and Cellular Biology 17:8, pages 4509-4516.
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Louis F. Stancato, Minoru Sakatsume, Michael David, Paul Dent, Fan Dong, Emanuel F. Petricoin, John J. Krolewski, Olli Silvennoinen, Pipsa Saharinen, Jacalyn Pierce, Christopher J. Marshall, Thomas Sturgill, David S. Finbloom & Andrew C. Larner. (1997) Beta Interferon and Oncostatin M Activate Raf-1 and Mitogen-Activated Protein Kinase through a JAK1-Dependent Pathway. Molecular and Cellular Biology 17:7, pages 3833-3840.
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Mark S. Spector, Kelly L. Auer, W. David Jarvis, Edward J. N. Ishac, Bin Gao, George Kunos & Paul Dent. (1997) Differential Regulation of the Mitogen-Activated Protein and Stress-Activated Protein Kinase Cascades by Adrenergic Agonists in Quiescent and Regenerating Adult Rat Hepatocytes. Molecular and Cellular Biology 17:7, pages 3556-3565.
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Eva M. Weissinger, Günther Eissner, Christine Grammer, Susanne Fackler, Burkhard Haefner, Luke S. Yoon, Kimberly S. Lu, Alex Bazarov, John M. Sedivy, Harald Mischak & Walter Kolch. (1997) Inhibition of the Raf-1 Kinase by Cyclic AMP Agonists Causes Apoptosis of v-abl-Transformed Cells. Molecular and Cellular Biology 17:6, pages 3229-3241.
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Stacey Stang, Drell Bottorff & James C. Stone. (1997) Interaction of Activated Ras with Raf-1 Alone May Be Sufficient for Transformation of rat2 Cells. Molecular and Cellular Biology 17:6, pages 3047-3055.
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Wendy M. Yee & Paul F. Worley. (1997) Rheb Interacts with Raf-1 Kinase and May Function To Integrate Growth Factor- and Protein Kinase A-Dependent Signals. Molecular and Cellular Biology 17:2, pages 921-933.
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Hong Cai, Ute Smola, Viktor Wixler, Iris Eisenmann-Tappe, Maria T. Diaz-Meco, Jorge Moscat, Ulf Rapp & Geoffrey M. Cooper. (1997) Role of Diacylglycerol-Regulated Protein Kinase C Isotypes in Growth Factor Activation of the Raf-1 Protein Kinase. Molecular and Cellular Biology 17:2, pages 732-741.
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Theodor W. Schulte, Mikhail V. Blagosklonny, Larissa Romanova, J. Frederic Mushinski, Brett P. Monia, Joseph F. Johnston, Phuongmai Nguyen, Jane Trepel & Leonard M. Neckers. (1996) Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway. Molecular and Cellular Biology 16:10, pages 5839-5845.
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Harald Mischak, Thomas Seitz, Petra Janosch, Manfred Eulitz, Helge Steen, Miriam Schellerer, Alex Philipp & Walter Kolch. (1996) Negative Regulation of Raf-1 by Phosphorylation of Serine 621. Molecular and Cellular Biology 16:10, pages 5409-5418.
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Roya Khosravi-Far, Michael A. White, John K. Westwick, Patricia A. Solski, Magdalena Chrzanowska-Wodnicka, Linda Van Aelst, Michael H. Wigler & Channing J. Der. (1996) Oncogenic Ras Activation of Raf/Mitogen-Activated Protein Kinase-Independent Pathways Is Sufficient To Cause Tumorigenic Transformation. Molecular and Cellular Biology 16:7, pages 3923-3933.
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Tomas Jelinek, Paul Dent, Thomas W. Sturgill & Michael J. Weber. (1996) Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation. Molecular and Cellular Biology 16:3, pages 1027-1034.
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Roya Khosravi-Far, Patricia A. Solski, Geoffrey J. Clark, Michael S. Kinch & Channing J. Der. (1995) Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation. Molecular and Cellular Biology 15:11, pages 6443-6453.
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Catrin A. Pritchard, Michael L. Samuels, Elizabeth Bosch & Martin McMahon. (1995) Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells. Molecular and Cellular Biology 15:11, pages 6430-6442.
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Paul Dent, Dean B. Reardon, Deborah K. Morrison & Thomas W. Sturgill. (1995) Regulation of Raf-1 and Raf-1 Mutants by Ras-Dependent and Ras-Independent Mechanisms In Vitro. Molecular and Cellular Biology 15:8, pages 4125-4135.
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Neil R. Michaud, John R. Fabian, Karen D. Mathes & Deborah K. Morrison. (1995) 14-3-3 Is Not Essential for Raf-1 Function: Identification of Raf-1 Proteins That Are Biologically Activated in a 14-3-3- and Ras-Independent Manner. Molecular and Cellular Biology 15:6, pages 3390-3397.
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Dirk Büscher, Robert A. Hipskind, Stefan Krautwald, Thomas Reimann & Manuela Baccarini. (1995) Ras-Dependent and -Independent Pathways Target the Mitogen-Activated Protein Kinase Network in Macrophages. Molecular and Cellular Biology 15:1, pages 466-475.
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Kevin Pumiglia, Yu-Hua Chow, John Fabian, Deborah Morrison, Stuart Decker & Richard Jove. (1995) Raf-1 N-Terminal Sequences Necessary for Ras-Raf Interaction and Signal Transduction. Molecular and Cellular Biology 15:1, pages 398-406.
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Susanne Häfner, Henric S. Adler, Harald Mischak, Petra Janosch, Gisela Heidecker, Alan Wolfman, Susanne Pippig, Martin Lohse, Marius Ueffing & Walter Kolch. (1994) Mechanism of Inhibition of Raf-1 by Protein Kinase A. Molecular and Cellular Biology 14:10, pages 6696-6703.
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