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Transcriptional Regulation

Distinct Mechanisms for Regulation of the Interleukin-8 Gene Involve Synergism and Cooperativity between C/EBP and NF-κB

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Pages 7191-7198 | Received 25 Jun 1993, Accepted 13 Aug 1993, Published online: 31 Mar 2023

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James A Cotton, Jaye M Platnich, Daniel A Muruve, Humberto B Jijon, Andre G Buret & Paul L Beck. (2016) Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences. International Journal of Interferon, Cytokine and Mediator Research 8, pages 13-34.
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Jun Liu, Steve O. Simmons & Ruoting Pei. (2014) Regulation of IL-8 Promoter Activity by Verrucarin A in Human Monocytic THP-1 Cells. Journal of Toxicology and Environmental Health, Part A 77:19, pages 1125-1140.
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William A Li, Shannon Moore-Langston, Tia Chakraborty, Jose A Rafols, Alana C Conti & Yuchuan Ding. (2013) Hyperglycemia in stroke and possible treatments. Neurological Research 35:5, pages 479-491.
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Dezheng Zhao & Charalabos Pothoulakis. (2003) Rho GTPases as therapeutic targets for the treatment of inflammatory diseases. Expert Opinion on Therapeutic Targets 7:5, pages 583-592.
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Michelle N. Bradley, Liang Zhou & Stephen T. Smale. (2003) C/EBPβ Regulation in Lipopolysaccharide-Stimulated Macrophages. Molecular and Cellular Biology 23:14, pages 4841-4858.
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Leonard C. Edelstein, Lynn Lagos, Matthew Simmons, Hemamalini Tirumalai & Céline Gélinas. (2003) NF-κB-Dependent Assembly of an Enhanceosome-Like Complex on the Promoter Region of Apoptosis Inhibitor Bfl-1/A1. Molecular and Cellular Biology 23:8, pages 2749-2761.
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Nywana Sizemore, Stewart Leung & George R. Stark. (1999) Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit. Molecular and Cellular Biology 19:7, pages 4798-4805.
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Li-Fen Lee, J. Stephen Haskill, Naofumi Mukaida, Kouji Matsushima & Jenny P.-Y. Ting. (1997) Identification of Tumor-Specific Paclitaxel (Taxol)-Responsive Regulatory Elements in the Interleukin-8 Promoter. Molecular and Cellular Biology 17:9, pages 5097-5105.
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Scott E. Plevy, James H. M. Gemberling, Sang Hsu, Andrew J. Dorner & Stephen T. Smale. (1997) Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins. Molecular and Cellular Biology 17:8, pages 4572-4588.
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Chitra Kannabiran, Xiaoya Zeng & Lynne D. Vales. (1997) The Mammalian Transcriptional Repressor RBP (CBF1) Regulates Interleukin-6 Gene Expression. Molecular and Cellular Biology 17:1, pages 1-9.
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L. K. Mcglynn, C. R. Mueller, M. Begbie, C. R. Notley & D. Lillicrap. (1996) Role of the Liver-Enriched Transcription Factor Hepatocyte Nuclear Factor 1 in Transcriptional Regulation of the Factor VIII Gene. Molecular and Cellular Biology 16:5, pages 1936-1945.
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Bernd Stein & Maria X. Yang. (1995) Repression of the Interleukin-6 Promoter by Estrogen Receptor Is Mediated by NF-κB and C/EBPβ. Molecular and Cellular Biology 15:9, pages 4971-4979.
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Rolf-Peter Ryseck, Jiri Novotny & Rodrigo Bravo. (1995) Characterization of Elements Determining the Dimerization Properties of RelB and p50. Molecular and Cellular Biology 15:6, pages 3100-3109.
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Dimitris Thanos & Tom Maniatis. (1995) Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene. Molecular and Cellular Biology 15:1, pages 152-164.
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Junichi Tsukada, Kazuyoshi Saito, Wayne R. Waterman, Andrew C. Webb & Philip E. Auron. (1994) Transcription Factors NF-IL6 and CREB Recognize a Common Essential Site in the Human Prointerleukin 1β Gene. Molecular and Cellular Biology 14:11, pages 7285-7297.
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J. Alan Diehl & Mark Hannink. (1994) Identification of a C/EBP-Rel Complex in Avian Lymphoid Cells. Molecular and Cellular Biology 14:10, pages 6635-6646.
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Szu-Yao Lu, Maria Rodriguez & Warren S.-L. Liao. (1994) YY1 Represses Rat Serum Amyloid A1 Gene Transcription and Is Antagonized by NF-κΒ during Acute-Phase Response. Molecular and Cellular Biology 14:9, pages 6253-6263.
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Hannah Lewis, Wiweka Kaszubska, John F. Delamarter & James Whelan. (1994) Cooperativity between Two NF-κΒ Complexes, Mediated by High-Mobility-Group Protein I(Y), Is Essential for Cytokine-Induced Expression of the E-Selectin Promoter. Molecular and Cellular Biology 14:9, pages 5701-5709.
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Jose R. Perez, Kimberly A. Higgins-Sochaski, Jean-Yves Maltese & Ramaswamy Narayanan. (1994) Regulation of Adhesion and Growth of Fibrosarcoma Cells by NF-κB RelA Involves Transforming Growth Factor β. Molecular and Cellular Biology 14:8, pages 5326-5332.
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Igor C. Oliveira, Naofumi Mukaida, Kouji Matsushima & Jan Vilcek. (1994) Transcriptional Inhibition of the Interleukin-8 Gene by Interferon Is Mediated by the NF-κB Site. Molecular and Cellular Biology 14:8, pages 5300-5308.
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Ulrich Dendorfer, Peter Oettgen & Towia A. Libermann. (1994) Multiple Regulatory Elements in the Interleukin-6 Gene Mediate Induction by Prostaglandins, Cyclic AMP, and Lipopolysaccharide. Molecular and Cellular Biology 14:7, pages 4443-4454.
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Elaine Y. Fukuda, Sonya P. Lad, David P. Mikolon, Milena Iacobelli-Martinez & Erguang Li. (2005) Activation of Lipid Metabolism Contributes to Interleukin-8 Production during Chlamydia trachomatis Infection of Cervical Epithelial Cells . Infection and Immunity 73:7, pages 4017-4024.
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Shih-Min Huang & D. J. McCance. (2002) Down Regulation of the Interleukin-8 Promoter by Human Papillomavirus Type 16 E6 and E7 through Effects on CREB Binding Protein/p300 and P/CAF. Journal of Virology 76:17, pages 8710-8721.
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Alok Agrawal, Hyunjoo Cha-Molstad, David Samols & Irving Kushner. (2001) Transactivation of C-Reactive Protein by IL-6 Requires Synergistic Interaction of CCAAT/Enhancer Binding Protein β (C/EBPβ) and Rel p50. The Journal of Immunology 166:4, pages 2378-2384.
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Heather L. Ross, Michael R. Nonnemacher, Tricia H. Hogan, Shane J. Quiterio, Andrew Henderson, John J. McAllister, Fred C. Krebs & Brian Wigdahl. (2001) Interaction between CCAAT/Enhancer Binding Protein and Cyclic AMP Response Element Binding Protein 1 Regulates Human Immunodeficiency Virus Type 1 Transcription in Cells of the Monocyte/Macrophage Lineage. Journal of Virology 75:4, pages 1842-1856.
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R. Mahieux, P. F. Lambert, E. Agbottah, M. A. Halanski, L. Deng, F. Kashanchi & J. N. Brady. (2001) Cell Cycle Regulation of Human Interleukin-8 Gene Expression by the Human Immunodeficiency Virus Type 1 Tat Protein. Journal of Virology 75:4, pages 1736-1743.
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Lynette H. Thomas, Melissa I. Y. Wickremasinghe, Mike Sharland & Jon S. Friedland. (2000) Synergistic Upregulation of Interleukin-8 Secretion from Pulmonary Epithelial Cells by Direct and Monocyte-Dependent Effects of Respiratory Syncytial Virus Infection. Journal of Virology 74:18, pages 8425-8433.
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Dana J. Philpott, Shoji Yamaoka, Alain Israël & Philippe J. Sansonetti. (2000) Invasive Shigella flexneri Activates NF-κB Through a Lipopolysaccharide-Dependent Innate Intracellular Response and Leads to IL-8 Expression in Epithelial Cells . The Journal of Immunology 165:2, pages 903-914.
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Philippe Roux, Caroline Alfieri, Mohammed Hrimech, Eric A. Cohen & Jerome E. Tanner. (2000) Activation of Transcription Factors NF-κB and NF-IL-6 by Human Immunodeficiency Virus Type 1 Protein R (Vpr) Induces Interleukin-8 Expression. Journal of Virology 74:10, pages 4658-4665.
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Mau T. Tran, Mary H. Ritchie, Robert N. Lausch & John E. Oakes. (2000) Calcitonin Gene-Related Peptide Induces IL-8 Synthesis in Human Corneal Epithelial Cells. The Journal of Immunology 164:8, pages 4307-4312.
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Satoshi Matsukura, Cristiana Stellato, James R. Plitt, Carol Bickel, Katsushi Miura, Steve N. Georas, Vincenzo Casolaro & Robert P. Schleimer. (1999) Activation of Eotaxin Gene Transcription by NF-κB and STAT6 in Human Airway Epithelial Cells. The Journal of Immunology 163:12, pages 6876-6883.
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Chao-Kuen Lai & Ling-Pai Ting. (1999) Transcriptional Repression of Human Hepatitis B Virus Genes by a bZIP Family Member, E4BP4. Journal of Virology 73:4, pages 3197-3209.
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Alex B. Lentsch, Boris J. Czermak, Jacqueline A. Jordan & Peter A. Ward. (1999) Regulation of Acute Lung Inflammatory Injury by Endogenous IL-13. The Journal of Immunology 162:2, pages 1071-1076.
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Dragan V. Jovanovic, John A. Di Battista, Johanne Martel-Pelletier, François C. Jolicoeur, Yulan He, Mengkun Zhang, François Mineau & Jean-Pierre Pelletier. (1998) IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-β and TNF-α, by Human Macrophages. The Journal of Immunology 160:7, pages 3513-3521.
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Hsien-Ming Hu, Mark Baer, Simon C. Williams, Peter F. Johnson & Richard C. Schwartz. (1998) Redundancy of C/EBPα, -β, and -δ in Supporting the Lipopolysaccharide-Induced Transcription of IL-6 and Monocyte Chemoattractant Protein-1. The Journal of Immunology 160:5, pages 2334-2342.
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Tobias Bauknecht & Yang Shi. (1998) Overexpression of C/EBPβ Represses Human Papillomavirus Type 18 Upstream Regulatory Region Activity in HeLa Cells by Interfering with the Binding of TATA-Binding Protein. Journal of Virology 72:3, pages 2113-2124.
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