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DNA Dynamics and Chromosome Structure

V(D)J Recombination in Mammalian Cell Mutants Defective in DNA Double-Strand Break Repair

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Pages 3464-3471 | Received 22 Dec 1992, Accepted 12 Mar 1993, Published online: 01 Apr 2023

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Read on this site (19)

Christine J. Williams, Ildiko Grandal, Danny J. Vesprini, Urszula Wojtyra, Jayne S. Danska & Cynthia J. Guidos. (2001) Irradiation Promotes V(D)J Joining and RAG-Dependent Neoplastic Transformation in SCID T-Cell Precursors. Molecular and Cellular Biology 21:2, pages 400-413.
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B. K. Singleton, M. I. Torres-Arzayus, S. T. Rottinghaus, G. E. Taccioli & P. A. Jeggo. (1999) The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit. Molecular and Cellular Biology 19:5, pages 3267-3277.
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Vaughn Smider, W. Kimryn Rathmell, Greg Brown, Susanna Lewis & Gilbert Chu. (1998) Failure of Hairpin-Ended and Nicked DNA To Activate DNA-Dependent Protein Kinase: Implications for V(D)J Recombination. Molecular and Cellular Biology 18:11, pages 6853-6858.
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Robert B. West, Mariana Yaneva & Michael R. Lieber. (1998) Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini. Molecular and Cellular Biology 18:10, pages 5908-5920.
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Wenhui Li, Patrick Swanson & Stephen Desiderio. (1997) RAG-1 and RAG-2-Dependent Assembly of Functional Complexes with V(D)J Recombination Substrates in Solution. Molecular and Cellular Biology 17:12, pages 6932-6939.
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Frances Weis-Garcia, Eva Besmer, Dennis J. Sawchuk, Wong Yu, Yun Hu, Sylvanie Cassard, Michel C. Nussenzweig & Patricia Cortes. (1997) V(D)J Recombination: In Vitro Coding Joint Formation. Molecular and Cellular Biology 17:11, pages 6379-6385.
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Jung-Ok Han, Sharri B. Steen & David B. Roth. (1997) Ku86 Is Not Required for Protection of Signal Ends or for Formation of Nonstandard V(D)J Recombination Products. Molecular and Cellular Biology 17:4, pages 2226-2234.
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B. K. Singleton, A. Priestley, H. Steingrimsdottir, D. Gell, T. Blunt, S. P. Jackson, A. R. Lehmann & P. A. Jeggo. (1997) Molecular and Biochemical Characterization of xrs Mutants Defective in Ku80. Molecular and Cellular Biology 17:3, pages 1264-1273.
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Jayne S. Danska, Dianne P. Holland, Sanjeev Mariathasan, Kelly M. Williams & Cynthia J. Guidos. (1996) Biochemical and Genetic Defects in the DNA-Dependent Protein Kinase in Murine scid Lymphocytes. Molecular and Cellular Biology 16:10, pages 5507-5517.
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Xiantuo Wu & Michael R. Lieber. (1996) Protein-Protein and Protein-DNA Interaction Regions within the DNA End-Binding Protein Ku70-Ku86. Molecular and Cellular Biology 16:9, pages 5186-5193.
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Abdellatif Errami, Vaughn Smider, W. Kimryn Rathmell, Dong Ming He, Eric A. Hendrickson, Małgorzata Z. Zdzienicka & Gilbert Chu. (1996) Ku86 Defines the Genetic Defect and Restores X-Ray Resistance and V(D)J Recombination to Complementation Group 5 Hamster Cell Mutants. Molecular and Cellular Biology 16:4, pages 1519-1526.
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Eugenia Spanopoulou. (1996) Cellular and Molecular Analysis of Lymphoid Development Using RAG-Deficient Mice. International Reviews of Immunology 13:4, pages 257-288.
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Nikolai V. Boubnov & David T. Weaver. (1995) scid Cells Are Deficient in Ku and Replication Protein A Phosphorylation by the DNA-Dependent Protein Kinase. Molecular and Cellular Biology 15:10, pages 5700-5706.
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Fen Xia, Sally A. Amundson, Jac A. Nickoloff & Howard L. Liber. (1994) Different Capacities for Recombination in Closely Related Human Lymphoblastoid Cell Lines with Different Mutational Responses to X-Irradiation. Molecular and Cellular Biology 14:9, pages 5850-5857.
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John W. Phillips & William F. Morgan. (1994) Illegitimate Recombination Induced by DNA Double-Strand Breaks in a Mammalian Chromosome. Molecular and Cellular Biology 14:9, pages 5794-5803.
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W. Kimryn Rathmell & Gilbert Chu. (1994) A DNA End-Binding Factor Involved in Double-Strand Break Repair and V(D)J Recombination. Molecular and Cellular Biology 14:7, pages 4741-4748.
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I.R. Kirsch. (1994) V(D)J Recombination and Ataxia-telangiectasia: A Review. International Journal of Radiation Biology 66:sup6, pages S97-S108.
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Nikolai V. Boubnov, Zachary P. Wills & David T. Weaver. (1993) V(D)J Recombination Coding Junction Formation without DNA Homology: Processing of Coding Termini. Molecular and Cellular Biology 13:11, pages 6957-6968.
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Articles from other publishers (6)

Keisuke Ito, Keiyo Takubo, Fumio Arai, Hitoshi Satoh, Sahoko Matsuoka, Masako Ohmura, Kazuhito Naka, Masaki Azuma, Kana Miyamoto, Kentaro Hosokawa, Yasuo Ikeda, Tak W. Mak, Toshio Suda & Atsushi Hirao. (2007) Regulation of Reactive Oxygen Species by Atm Is Essential for Proper Response to DNA Double-Strand Breaks in Lymphocytes . The Journal of Immunology 178:1, pages 103-110.
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Bosun Min, Brian T. Weinert & Donald C. Rio. (2004) Interplay between Drosophila Bloom's syndrome helicase and Ku autoantigen during nonhomologous end joining repair of P element-induced DNA breaks . Proceedings of the National Academy of Sciences 101:24, pages 8906-8911.
Crossref
Euy Kyun Shin, Tonnie Rijkers, Albert Pastink & Katheryn Meek. (2000) Analyses of TCRB Rearrangements Substantiate a Profound Deficit in Recombination Signal Sequence Joining in SCID Foals: Implications for the Role of DNA-Dependent Protein Kinase in V(D)J Recombination. The Journal of Immunology 164:3, pages 1416-1424.
Crossref
Molly A. Bogue, Chamelli Jhappan & David B. Roth. (1998) Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Proceedings of the National Academy of Sciences 95:26, pages 15559-15564.
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Yansong Gu, Shengfang Jin, Yijie Gao, David T. Weaver & Frederick W. Alt. (1997) Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proceedings of the National Academy of Sciences 94:15, pages 8076-8081.
Crossref
Georjana Barnes & Donald Rio. (1997) DNA double-strand-break sensitivity, DNA replication, and cell cycle arrest phenotypes of Ku-deficient Saccharomyces cerevisiae . Proceedings of the National Academy of Sciences 94:3, pages 867-872.
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