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Molecular and Cellular Biology Volume 13, 1993 - Issue 6
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Gene Expression

GCN1, a Translational Activator of GCN4 in Saccharomyces cerevisiae, is Required for Phosphorylation of Eukaryotic Translation Initiation Factor 2 by Protein Kinase GCN2

Matthew J. MartonSection on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland20892.
,
Deborah CrouchSection on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland20892.
&
Alan G. HinnebuschSection on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland20892.
Pages 3541-3556 | Received 09 Feb 1993, Accepted 23 Mar 1993, Published online: 01 Apr 2023

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Jinsheng Dong, Ruby Lai, Jennifer L. Jennings, Andrew J. Link & Alan G. Hinnebusch. (2005) The Novel ATP-Binding Cassette Protein ARB1 Is a Shuttling Factor That Stimulates 40S and 60S Ribosome Biogenesis. Molecular and Cellular Biology 25:22, pages 9859-9873.
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Frank W. King & Emma Shtivelman. (2004) Inhibition of Nuclear Import by the Proapoptotic Protein CC3. Molecular and Cellular Biology 24:16, pages 7091-7101.
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Krishnamurthy Natarajan, Michael R. Meyer, Belinda M. Jackson, David Slade, Christopher Roberts, Alan G. Hinnebusch & Matthew J. Marton. (2001) Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast. Molecular and Cellular Biology 21:13, pages 4347-4368.
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Ruojing Yang, Sheree A. Wek & Ronald C. Wek. (2000) Glucose Limitation Induces GCN4 Translation by Activation of Gcn2 Protein Kinase. Molecular and Cellular Biology 20:8, pages 2706-2717.
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Hongfang Qiu, Cuihua Hu, James Anderson, Glenn R. Björk, Srimonti Sarkar, Anita K. Hopper & Alan G. Hinnebusch. (2000) Defects in tRNA Processing and Nuclear Export Induce GCN4 Translation Independently of Phosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2. Molecular and Cellular Biology 20:7, pages 2505-2516.
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Matthew J. Marton, Carlos R. Vazquez de Aldana, Hongfang Qiu, Kalpana Chakraburtty & Alan G. Hinnebusch. (1997) Evidence that GCN1 and GCN20, Translational Regulators of GCN4, Function on Elongating Ribosomes in Activation of eIF2α Kinase GCN2. Molecular and Cellular Biology 17:8, pages 4474-4489.
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Carlos R. Vazquez De Aldana & Alan G. Hinnebusch. (1994) Mutations in the GCD7 Subunit of Yeast Guanine Nucleotide Exchange Factor eIF-2B Overcome the Inhibitory Effects of Phosphorylated eIF-2 on Translation Initiation. Molecular and Cellular Biology 14:5, pages 3208-3222.
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Ronda J. Rolfes & Alan G. Hinnebusch. (1993) Translation of the Yeast Transcriptional Activator GCN4 Is Stimulated by Purine Limitation: Implications for Activation of the Protein Kinase GCN2. Molecular and Cellular Biology 13:8, pages 5099-5111.
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Articles from other publishers (4)

Corey M. Knowles, David Goich, Amanda L. M. Bloom, Murat C. Kalem & John C. Panepinto. (2023) Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction . mBio 14:2.
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Hongjia Liu, Xue Gong, Hui Deng, Jinjuan Tan, Yanqing Sun, Fang Wang, Wenjuan Wu, Zhongjing Zhou, Rumeng Xu, Haiyan He & Clive Lo. (2022) The Rice Aspartyl-tRNA Synthetase YLC3 Regulates Amino Acid Homeostasis and Chloroplast Development Under Low Temperature. Frontiers in Plant Science 13.
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Agnieszka A. PochopienBertrand Beckert, Sergo Kasvandik, Otto Berninghausen, Roland Beckmann, Tanel Tenson & Daniel N. Wilson. (2021) Structure of Gcn1 bound to stalled and colliding 80S ribosomes. Proceedings of the National Academy of Sciences 118:14.
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P. K. Wout, E. Sattlegger, S. M. Sullivan & J. R. Maddock. (2009) Saccharomyces cerevisiae Rbg1 Protein and Its Binding Partner Gir2 Interact on Polyribosomes with Gcn1 . Eukaryotic Cell 8:7, pages 1061-1071.
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