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Gene Expression

An Enhancer/Locus Control Region Is Not Sufficient To Open Chromatin

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Pages 3990-3998 | Received 04 Feb 1993, Accepted 09 Apr 1993, Published online: 31 Mar 2023

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Zhijun Duan, George Stamatoyannopoulos & Qiliang Li. (2001) Role of NF-Y in In Vivo Regulation of the γ-Globin Gene. Molecular and Cellular Biology 21:9, pages 3083-3095.
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Luis A. Fernández, Michael Winkler & Rudolf Grosschedl. (2001) Matrix Attachment Region-Dependent Function of the Immunoglobulin μ Enhancer Involves Histone Acetylation at a Distance without Changes in Enhancer Occupancy. Molecular and Cellular Biology 21:1, pages 196-208.
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Andreas Reik, Agnes Telling, Galynn Zitnik, Daniel Cimbora, Elliot Epner & Mark Groudine. (1998) The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells. Molecular and Cellular Biology 18:10, pages 5992-6000.
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Andrew Weng, Peter Engler & Ursula Storb. (1995) The Bulk Chromatin Structure of a Murine Transgene Does Not Vary with Its Transcriptional or DNA Methylation Status. Molecular and Cellular Biology 15:1, pages 572-579.
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Mark M. Mason, Eric Lee, Heiner Westphal & Marc Reitman. (1995) Expression of the Chicken β-Globin Gene Cluster in Mice: Correct Developmental Expression and Distributed Control. Molecular and Cellular Biology 15:1, pages 407-414.
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Peter J. Sabo, Michael Hawrylycz, James C. Wallace, Richard Humbert, Man Yu, Anthony Shafer, Janelle Kawamoto, Robert Hall, Joshua Mack, Michael O. Dorschner, Michael McArthur & John A. Stamatoyannopoulos. (2004) Discovery of functional noncoding elements by digital analysis of chromatin structure. Proceedings of the National Academy of Sciences 101:48, pages 16837-16842.
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Peter J. Sabo, Richard Humbert, Michael Hawrylycz, James C. Wallace, Michael O. Dorschner, Michael McArthur & John A. Stamatoyannopoulos. (2004) Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries. Proceedings of the National Academy of Sciences 101:13, pages 4537-4542.
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Dawn M. Tanamachi, Deborah C. Moniot, Dragana Cado, Scot D. Liu, Jennifer K. Hsia & David H. Raulet. (2004) Genomic Ly49A Transgenes: Basis of Variegated Ly49A Gene Expression and Identification of a Critical Regulatory Element . The Journal of Immunology 172:2, pages 1074-1082.
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Dirk Schübeler, Mark Groudine & M. A. Bender. (2001) The murine β-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes. Proceedings of the National Academy of Sciences 98:20, pages 11432-11437.
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Catherine M. Farrell, Alexander Grinberg, Sing Ping Huang, Dan Chen, José G. Pichel, Heiner Westphal & Gary Felsenfeld. (2000) A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse β-globin locus. Proceedings of the National Academy of Sciences 97:26, pages 14554-14559.
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Maria Vernucci, Flavia Cerrato, Nathalie Besnard, Stefano Casola, Paolo V Pedone, Carmelo B Bruni & Andrea Riccio. (2000) The H19 endodermal enhancer is required for Igf2 activation and tumor formation in experimental liver carcinogenesis. Oncogene 19:54, pages 6376-6385.
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Jong-Soo Lee, Chang-Hun Lee & Jay H. Chung. (1999) The β-globin promoter is important for recruitment of erythroid Krüppel-like factor to the locus control region in erythroid cells. Proceedings of the National Academy of Sciences 96:18, pages 10051-10055.
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Shuhua Yu, Dawen Yu, Eric Lee, Michael Eckhaus, Randy Lee, Zakia Corria, Domenico Accili, Heiner Westphal & Lee S. Weinstein. (1998) Variable and tissue-specific hormone resistance in heterotrimeric G s protein α-subunit (G s α) knockout mice is due to tissue-specific imprinting of the G s α gene . Proceedings of the National Academy of Sciences 95:15, pages 8715-8720.
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Michelle Craig Barton, Navid Madani & Beverly M. Emerson. (1997) Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro . Proceedings of the National Academy of Sciences 94:14, pages 7257-7262.
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