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Molecular and Cellular Biology Volume 13, 1993 - Issue 8
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Cell Growth and Development

A Novel Recognition Motif for Phosphatidylinositol 3-Kinase Binding Mediates Its Association with the Hepatocyte Growth Factor/Scatter Factor Receptor

Carola Ponzetto1 Department of Biomedical Sciences and Oncology, University of Turin, Corso Massimo d'Azeglio 52, 10126Turin, Italy
,
Alberto Bardelli1 Department of Biomedical Sciences and Oncology, University of Turin, Corso Massimo d'Azeglio 52, 10126Turin, Italy
,
Flavio Maina1 Department of Biomedical Sciences and Oncology, University of Turin, Corso Massimo d'Azeglio 52, 10126Turin, Italy
,
Paola Longati1 Department of Biomedical Sciences and Oncology, University of Turin, Corso Massimo d'Azeglio 52, 10126Turin, Italy
,
George Panayotou2 Ludwig Institute for Cancer Research, LondonW1P 8BT, United Kingdom
,
Ritu Dhand2 Ludwig Institute for Cancer Research, LondonW1P 8BT, United Kingdom
,
Michael D. Waterfield2 Ludwig Institute for Cancer Research, LondonW1P 8BT, United Kingdom;3 Molecular Biology, University College London, LondonWC1E 6BT, United Kingdom
&
Paolo M. Comoglio1 Department of Biomedical Sciences and Oncology, University of Turin, Corso Massimo d'Azeglio 52, 10126Turin, Italy
 show all
Pages 4600-4608 | Received 11 Mar 1993, Accepted 26 Apr 1993, Published online: 31 Mar 2023

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Marco Petrillo, Giovanni Scambia & Gabriella Ferrandina. (2012) Novel targets for VEGF-independent anti-angiogenic drugs. Expert Opinion on Investigational Drugs 21:4, pages 451-472.
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Darren M. Kamikura, Hanane Khoury, Christiane Maroun, Monica A. Naujokas & Morag Park. (2000) Enhanced Transformation by a Plasma Membrane-Associated Met Oncoprotein: Activation of a Phosphoinositide 3′-Kinase-Dependent Autocrine Loop Involving Hyaluronic Acid and CD44. Molecular and Cellular Biology 20:10, pages 3482-3496.
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Toshiyuki Otsuka, John Jakubczak, Wilfred Vieira, Donald P. Bottaro, Diane Breckenridge, William J. Larochelle & Glenn Merlino. (2000) Disassociation of Met-Mediated Biological Responses In Vivo: the Natural Hepatocyte Growth Factor/Scatter Factor Splice Variant NK2 Antagonizes Growth but Facilitates Metastasis. Molecular and Cellular Biology 20:6, pages 2055-2065.
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Christopher D. Kontos, Thomas P. Stauffer, Wen-Pin Yang, John D. York, Liwen Huang, Michael A. Blanar, Tobias Meyer & Kevin G. Peters. (1998) Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt. Molecular and Cellular Biology 18:7, pages 4131-4140.
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Maria Grazia Borrello, Luisella Alberti, Elena Arighi, Italia Bongarzone, Carlo Battistini, Alberto Bardelli, Barbara Pasini, Claudia Piutti, Maria Grazia Rizzetti, Piera Mondellini, Maria Teresa Radice & Marco A. Pierotti. (1996) The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ. Molecular and Cellular Biology 16:5, pages 2151-2163.
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Yuanyan WeiYizhou JiangFei ZouYingchao LiuShanshan WangNuo XuWenlong Xu, Chunhong CuiYang XingYing LiuBenjin CaoChanjuan LiuGuoqiang WuHong Ao, Xiaobiao Zhang & Jianhai Jiang. (2013) Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells. Proceedings of the National Academy of Sciences 110:17, pages 6829-6834.
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Kerstin Schag, Susanne M. Schmidt, Martin R. Müller, Toni Weinschenk, Silke Appel, Markus M. Weck, Frank Grünebach, Stefan Stevanovic, Hans-Georg Rammensee & Peter Brossart. (2004) Identification of C-Met Oncogene as a Broadly Expressed Tumor-Associated Antigen Recognized by Cytotoxic T-Lymphocytes. Clinical Cancer Research 10:11, pages 3658-3666.
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Tonya D. Russell, Qingyun Yan, Guangshun Fan, Anthony P. Khalifah, D. Keith Bishop, Steven L. Brody & Michael J. Walter. (2003) IL-12 p40 Homodimer-Dependent Macrophage Chemotaxis and Respiratory Viral Inflammation Are Mediated through IL-12 Receptor β1. The Journal of Immunology 171:12, pages 6866-6874.
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Yehenew Agazie, Irene Ischenko & Michael Hayman. (2002) Concomitant activation of the PI3K-Akt and the Ras-ERK signaling pathways is essential for transformation by the V-SEA tyrosine kinase oncogene. Oncogene 21:5, pages 697-707.
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Alberto Bardelli, Maria Lisa Basile, Enrica Audero, Silvia Giordano, Stefan Wennström, Sylvie Ménard, Paolo M Comoglio & Carola Ponzetto. (1999) Concomitant activation of pathways downstream of Grb2 and PI 3-kinase is required for MET-mediated metastasis. Oncogene 18:5, pages 1139-1146.
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