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Cell Growth and Development

A Region of the 85-Kilodalton (kDa) Subunit of Phosphatidylinositol 3-Kinase Binds the 110-kDa Catalytic Subunit In Vivo

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Pages 5560-5566 | Received 08 Apr 1993, Accepted 21 Jun 1993, Published online: 31 Mar 2023

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Sauveur-Michel Maira, Charles Voliva & Carlos Garcia-Echeverria. (2008) Class IA phosphatidylinositol 3-kinase: from their biologic implication in human cancers to drug discovery. Expert Opinion on Therapeutic Targets 12:2, pages 223-238.
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Shu-yue Ren, Elisabeth Bolton, M. Golam Mohi, Andrea Morrione, Benjamin G. Neel & Tomasz Skorski. (2005) Phosphatidylinositol 3-Kinase p85α Subunit-Dependent Interaction with BCR/ABL-Related Fusion Tyrosine Kinases: Molecular Mechanisms and Biological Consequences. Molecular and Cellular Biology 25:18, pages 8001-8008.
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Kun Jiang, Domenico Coppola, Nichole C. Crespo, Santo V. Nicosia, Andrew D. Hamilton, Said M. Sebti & Jin Q. Cheng. (2000) The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis. Molecular and Cellular Biology 20:1, pages 139-148.
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Anke Klippel, Maria-Amelia Escobedo, Matthew S. Wachowicz, Gerald Apell, Timothy W. Brown, Martin A. Giedlin, W. Michael Kavanaugh & Lewis T. Williams. (1998) Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation. Molecular and Cellular Biology 18:10, pages 5699-5711.
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Jinghua Yu, Yitao Zhang, James McIlroy, Tamara Rordorf-Nikolic, George A. Orr & Jonathan M. Backer. (1998) Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit. Molecular and Cellular Biology 18:3, pages 1379-1387.
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Susan K. Logan, Marco Falasca, Patrick Hu & Joseph Schlessinger. (1997) Phosphatidylinositol 3-Kinase Mediates Epidermal Growth Factor-Induced Activation of the c-Jun N-Terminal Kinase Signaling Pathway. Molecular and Cellular Biology 17:10, pages 5784-5790.
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Warren G. King, Mark D. Mattaliano, Tung O. Chan, Philip N. Tsichlis & Joan S. Brugge. (1997) Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation. Molecular and Cellular Biology 17:8, pages 4406-4418.
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Anke Klippel, Jaime A. Escobedo, Michiko Hirano & Lewis T. Williams. (1994) The Interaction of Small Domains Between the Subunits of Phosphatidylinositol 3-Kinase Determines Enzyme Activity. Molecular and Cellular Biology 14:4, pages 2675-2685.
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Patrick Hu & Joseph Schlessinger. (1994) Direct Association of p110β Phosphatidylinositol 3-kinase with p85 Is Mediated by an N-Terminal Fragment of p110β. Molecular and Cellular Biology 14:4, pages 2577-2583.
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Kathleen H. Holt, Ann Louise Olson, W. Scott Moye-Rowley & Jeffrey E. Pessin. (1994) Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits. Molecular and Cellular Biology 14:1, pages 42-49.
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Articles from other publishers (3)

Tatsuyuki Yoshii, Choji Oki, Rei Watahiki, Akinobu Nakamura, Kai Tahara, Keiko Kuwata, Toshiaki Furuta & Shinya Tsukiji. (2021) Chemo-optogenetic Protein Translocation System Using a Photoactivatable Self-Localizing Ligand. ACS Chemical Biology 16:8, pages 1557-1565.
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Zheng Fu, Eliah Aronoff-Spencer, Jonathan M. Backer & Gary J. Gerfen. (2003) The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling. Proceedings of the National Academy of Sciences 100:6, pages 3275-3280.
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Zeng Qiang Yuan, Mei Sun, Richard I Feldman, Gen Wang, Xiao-ling Ma, Chen Jiang, Domenico Coppola, Santo V Nicosia & Jin Q Cheng. (2000) Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene 19:19, pages 2324-2330.
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