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Molecular and Cellular Biology Volume 14, 1994 - Issue 11
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Cell Growth and Development

Novel Activating Mutations in the neu Proto-oncogene Involved in Induction of Mammary Tumors

Peter M. Siegel1 Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1;2 Department of Biology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1
,
David L. Dankort1 Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1;2 Department of Biology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1
,
William R. Hardy1 Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1;2 Department of Biology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1
&
William J. Muller1 Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1;3 Department of Pathology, McMaster University, Hamilton, Ontario, CanadaL8S 4K1Correspondence[email protected]
Pages 7068-7077 | Received 13 Jun 1994, Accepted 09 Aug 1994, Published online: 30 Mar 2023

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Chenguang Wang, Yanhong Tai, Michael P. Lisanti & D. Joshua Liao. (2011) c-Myc induction of programmed cell death may contribute to carcinogenesis. Cancer Biology & Therapy 11:7, pages 615-626.
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Jason J. Northey, Juliann Chmielecki, Elaine Ngan, Caterina Russo, Matthew G. Annis, William J. Muller & Peter M. Siegel. (2008) Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion. Molecular and Cellular Biology 28:10, pages 3162-3176.
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Albert K. Man, Lawrence J. T. Young, John A. Tynan, Jacqueline Lesperance, Mikala Egeblad, Zena Werb, Craig A. Hauser, William J. Muller, Robert D. Cardiff & Robert G. Oshima. (2003) Ets2-Dependent Stromal Regulation of Mouse Mammary Tumors. Molecular and Cellular Biology 23:23, pages 8614-8625.
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Eran R. Andrechek, William R. Hardy, Adele A. Girgis-Gabardo, Robert L. S. Perry, Richard Butler, Frank L. Graham, Ronald C. Kahn, Michael A. Rudnicki & William J. Muller. (2002) ErbB2 Is Required for Muscle Spindle and Myoblast Cell Survival. Molecular and Cellular Biology 22:13, pages 4714-4722.
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Rebecca S. Muraoka, Anne E. G. Lenferink, Brian Law, Elizabeth Hamilton, Dana M. Brantley, L. Renee Roebuck & Carlos L. Arteaga. (2002) ErbB2/Neu-Induced, Cyclin D1-Dependent Transformation Is Accelerated in p27-Haploinsufficient Mammary Epithelial Cells but Impaired in p27-Null Cells. Molecular and Cellular Biology 22:7, pages 2204-2219.
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Richard Chan, William R. Hardy, Michael A. Laing, Sarah E. Hardy & William J. Muller. (2002) The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development. Molecular and Cellular Biology 22:4, pages 1073-1078.
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David Dankort, Bart Maslikowski, Neil Warner, Nubufumi Kanno, Harold Kim, Zhixiang Wang, Michael F. Moran, Robert G. Oshima, Robert D. Cardiff & William J. Muller. (2001) Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer. Molecular and Cellular Biology 21:5, pages 1540-1551.
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Richard J. Lee, Chris Albanese, Maofu Fu, Mark D'Amico, Bing Lin, Genichi Watanabe, George K. Haines$suffix/text()$suffix/text(), Peter M. Siegel, Mien-Chie Hung, Yosef Yarden, Jonathan M. Horowitz, William J. Muller & Richard G. Pestell. (2000) Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway. Molecular and Cellular Biology 20:2, pages 672-683.
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Senthil K. Muthuswamy, Michael Gilman & Joan S. Brugge. (1999) Controlled Dimerization of ErbB Receptors Provides Evidence for Differential Signaling by Homo- and Heterodimers. Molecular and Cellular Biology 19:10, pages 6845-6857.
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Christine L. Burke & David F. Stern. (1998) Activation of Neu (ErbB-2) Mediated by Disulfide Bond-Induced Dimerization Reveals a Receptor Tyrosine Kinase Dimer Interface. Molecular and Cellular Biology 18:9, pages 5371-5379.
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David L. Dankort, Zhixiang Wang, Valerie Blackmore, Michael F. Moran & William J. Muller. (1997) Distinct Tyrosine Autophosphorylation Sites Negatively and Positively Modulate Neu-Mediated Transformation. Molecular and Cellular Biology 17:9, pages 5410-5425.
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Baolin Li, Jeffrey M. Rosen, Jonathan McMenamin-Balano, William J. Muller & Archibald S. Perkins. (1997) neu/ERBB2 Cooperates with p53-172H during Mammary Tumorigenesis in Transgenic Mice. Molecular and Cellular Biology 17:6, pages 3155-3163.
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William J. Muller, Carlos L. Arteaga, Senthil K. Muthuswamy, Peter M. Siegel, Marc A. Webster, Robert D. Cardiff, Katherine S. Meise, Feng Li, Susan A. Halter & Robert J. Coffey. (1996) Synergistic Interaction of the Neu Proto-Oncogene Product and Transforming Growth Factor α in the Mammary Epithelium of Transgenic Mice. Molecular and Cellular Biology 16:10, pages 5726-5736.
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Chiara Collesi, Massimo M. Santoro, Giovanni Gaudino & Paolo M. Comoglio. (1996) A Splicing Variant of the RON Transcript Induces Constitutive Tyrosine Kinase Activity and an Invasive Phenotype. Molecular and Cellular Biology 16:10, pages 5518-5526.
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Wendy S. Katz, Giovanni M. Lesa, Drakoulis Yannoukakos, Thomas R. Clandinin, Joseph Schlessinger & Paul W. Sternberg. (1996) A Point Mutation in the Extracellular Domain Activates LET-23, the Caenorhabditis elegans Epidermal Growth Factor Receptor Homolog. Molecular and Cellular Biology 16:2, pages 529-537.
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Eran R. Andrechek, Robert D. Cardiff, Jeffrey T. Chang, Michael L. Gatza, Chaitanya R. Acharya, Anil Potti & Joseph R. Nevins. (2009) Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential. Proceedings of the National Academy of Sciences 106:38, pages 16387-16392.
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M D Landis, D D Seachrist, F W Abdul-Karim & R A Keri. (2006) Sustained trophism of the mammary gland is sufficient to accelerate and synchronize development of ErbB2/Neu-induced tumors. Oncogene 25:23, pages 3325-3334.
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Melissa D Landis, Darcie D Seachrist, Marjorie E Montañez-Wiscovich, David Danielpour & Ruth A Keri. (2005) Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice. Oncogene 24:33, pages 5173-5190.
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Eran R. Andrechek, William R. Hardy, Michael A. Laing & William J. Muller. (2004) Germ-line expression of an oncogenic erbB2 allele confers resistance to erbB2 -induced mammary tumorigenesis . Proceedings of the National Academy of Sciences 101:14, pages 4984-4989.
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David Finkle, Zhi Ricky Quan, Vida Asghari, Jessica Kloss, Nazli Ghaboosi, Elaine Mai, Wai Lee Wong, Philip Hollingshead, Ralph Schwall, Hartmut Koeppen & Sharon Erickson. (2004) HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice. Clinical Cancer Research 10:7, pages 2499-2511.
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Shiquan Liu, Wenjing Liu, John L. Jakubczak, Gregory L. Erexson, Kenneth R. Tindall, Richard Chan, William J. Muller, Sankar Adhya, Susan Garges & Glenn Merlino. (2002) Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis. Proceedings of the National Academy of Sciences 99:6, pages 3770-3775.
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Eran R. Andrechek, William R. Hardy, Peter M. Siegel, Michael A. Rudnicki, Robert D. Cardiff & William J. Muller. (2000) Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis . Proceedings of the National Academy of Sciences 97:7, pages 3444-3449.
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David L Dankort & William J Muller. (2000) Signal transduction in mammary tumorigenesis: a transgenic perspective. Oncogene 19:8, pages 1038-1044.
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