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Molecular and Cellular Biology Volume 14, 1994 - Issue 5
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Cell Growth and Development

The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase

Peter H. Stein1 Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California94143;2 Department of Medicine, University of California, San Francisco, San Francisco, California94143
,
James D. Fraser3 Tularik, Inc., South San Francisco, California94066
&
Arthur Weiss1 Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California94143;2 Department of Medicine, University of California, San Francisco, San Francisco, California94143;4 Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California94143
Pages 3392-3402 | Received 21 Dec 1993, Accepted 21 Feb 1994, Published online: 30 Mar 2023

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Lindzy F. Dodson, Jonathan S. Boomer, Christine M. Deppong, Dulari D. Shah, Julia Sim, Traci L. Bricker, John H. Russell & Jonathan M. Green. (2009) Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation. Molecular and Cellular Biology 29:13, pages 3710-3721.
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Patrick Legembre, Sophie Daburon, Patrick Moreau, François Ichas, Francesca de Giorgi, Jean-François Moreau & Jean-Luc Taupin. (2005) Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment. Molecular and Cellular Biology 25:15, pages 6811-6820.
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Jynho Kim & Ricardo A. Feldman. (2002) Activated Fes Protein Tyrosine Kinase Induces Terminal Macrophage Differentiation of Myeloid Progenitors (U937 Cells) and Activation of the Transcription Factor PU.1. Molecular and Cellular Biology 22:6, pages 1903-1918.
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M. E. Casey Crooks, Dan R. Littman, Robert H. Carter, Douglas T. Fearon, Arthur Weiss & Peter H. Stein. (1995) CD28-Mediated Costimulation in the Absence of Phosphatidylinositol 3-Kinase Association and Activation. Molecular and Cellular Biology 15:12, pages 6820-6828.
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Jenn-Haung Lai, GyöRgyi Horvath, Jeff Subleski, Joseph Bruder, Paritosh Ghosh & Tse-Hua Tan. (1995) RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter. Molecular and Cellular Biology 15:8, pages 4260-4271.
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Articles from other publishers (8)

Guido H. Wabnitz, Gabriele Nebl, Martin Klemke, Andreas J. Schröder & Yvonne Samstag. (2006) Phosphatidylinositol 3-Kinase Functions as a Ras Effector in the Signaling Cascade That Regulates Dephosphorylation of the Actin-Remodeling Protein Cofilin after Costimulation of Untransformed Human T Lymphocytes. The Journal of Immunology 176:3, pages 1668-1674.
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Leonard J. Appleman, Andre A. F. L. van Puijenbroek, Kirstin M. Shu, Lee M. Nadler & Vassiliki A. Boussiotis. (2002) CD28 Costimulation Mediates Down-Regulation of p27 kip1 and Cell Cycle Progression by Activation of the PI3K/PKB Signaling Pathway in Primary Human T Cells . The Journal of Immunology 168:6, pages 2729-2736.
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John S. Burr, Nigel D. L. Savage, Grace E. Messah, Stephanie L. Kimzey, Andrey S. Shaw, Robert H. Arch & Jonathan M. Green. (2001) Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL. The Journal of Immunology 166:9, pages 5331-5335.
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Yohsuke Harada, Miyoko Tokushima, Yasuyo Matsumoto, Shuhei Ogawa, Masataka Otsuka, Katsuhiko Hayashi, Bonnie D. Weiss, Carl H. June & Ryo Abe. (2001) Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo. The Journal of Immunology 166:6, pages 3797-3803.
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Bernadine L. Leung, Loralee Haughn, André Veillette, Robert G. Hawley, Robert Rottapel & Michael Julius. (1999) TCRαβ-Independent CD28 Signaling and Costimulation Require Non-CD4-Associated Lck. The Journal of Immunology 163:3, pages 1334-1341.
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Yiling Lu, Bruce Cuevas, Spencer Gibson, Humera Khan, Ruth LaPushin, John Imboden & Gordon B. Mills. (1998) Phosphatidylinositol 3-Kinase Is Required for CD28 But Not CD3 Regulation of the TEC Family Tyrosine Kinase EMT/ITK/TSK: Functional and Physical Interaction of EMT with Phosphatidylinositol 3-Kinase. The Journal of Immunology 161:10, pages 5404-5412.
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Corinna Barz, Thomas Nagel, Kenneth E. Truitt & John B. Imboden. (1998) Mutational Analysis of CD28-Mediated Costimulation of Jun-N-Terminal Kinase and IL-2 Production. The Journal of Immunology 161:10, pages 5366-5372.
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Helene M. Finney, Alastair D. G. Lawson, Christopher R. Bebbington & A. Neil C. Weir. (1998) Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product. The Journal of Immunology 161:6, pages 2791-2797.
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