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Cell Growth and Development

Role of IRS-l-GRB-2 Complexes in Insulin Signaling

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Pages 3577-3587 | Received 13 Oct 1993, Accepted 28 Feb 1994, Published online: 30 Mar 2023

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Ryoko Ishida-Takahashi, Felicia Rosario, Yusong Gong, Keely Kopp, Zlatina Stancheva, Xiaohong Chen, Edward P. Feener & Martin G. Myers$suffix/text()$suffix/text(). (2006) Phosphorylation of Jak2 on Ser523 InhibitsJak2-Dependent Leptin ReceptorSignaling. Molecular and Cellular Biology 26:11, pages 4063-4073.
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Yu Li, Shoshana Eitan, Jiong Wu, Christopher J. Evans, Brigitte Kieffer, Xiaojian Sun & Roberto D. Polakiewicz. (2003) Morphine Induces Desensitization of Insulin Receptor Signaling. Molecular and Cellular Biology 23:17, pages 6255-6266.
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Angela M. Valverde, Cecilia Mur, Sebastián Pons, Alberto M. Alvarez, Morris F. White, C. Ronald Kahn & Manuel Benito. (2001) Association of Insulin Receptor Substrate 1 (IRS-1) Y895 with Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis. Molecular and Cellular Biology 21:7, pages 2269-2280.
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Kristina M. Kriauciunas, Martin G. Myers$suffix/text()$suffix/text() & C. Ronald Kahn. (2000) Cellular Compartmentalization in Insulin Action: Altered Signaling by a Lipid-Modified IRS-1. Molecular and Cellular Biology 20:18, pages 6849-6859.
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Pietro Formisano, Francesco Oriente, Francesca Fiory, Matilde Caruso, Claudia Miele, Maria Alessandra Maitan, Francesco Andreozzi, Giovanni Vigliotta, Gerolama Condorelli & Francesco Beguinot. (2000) Insulin-Activated Protein Kinase Cβ Bypasses Ras and Stimulates Mitogen-Activated Protein Kinase Activity and Cell Proliferation in Muscle Cells. Molecular and Cellular Biology 20:17, pages 6323-6333.
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Tohru Uchida, Martin G. Myers$suffix/text()$suffix/text() & Morris F. White. (2000) IRS-4 Mediates Protein Kinase B Signaling during Insulin Stimulation without Promoting Antiapoptosis. Molecular and Cellular Biology 20:1, pages 126-138.
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Lynne Yenush, Christine Zanella, Tohru Uchida, Dolores Bernal & Morris F. White. (1998) The Pleckstrin Homology and Phosphotyrosine Binding Domains of Insulin Receptor Substrate 1 Mediate Inhibition of Apoptosis by Insulin. Molecular and Cellular Biology 18:11, pages 6784-6794.
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Raul Mendez, Gwen Kollmorgen, Morris F. White & Robert E. Rhoads. (1997) Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin. Molecular and Cellular Biology 17:9, pages 5184-5192.
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Jens C. Brüning, Jonathon Winnay, Bentley Cheatham & C. Ronald Kahn. (1997) Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells. Molecular and Cellular Biology 17:3, pages 1513-1521.
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Martin G. Myers$suffix/text()$suffix/text(), Yitao Zhang, Gladys A. I. Aldaz, Timothy Grammer, Erin M. Glasheen, Lynne Yenush, Ling Mei Wang, Xiao Jian Sun, John Blenis, Jacalyn H. Pierce & Morris F. White. (1996) YMXM Motifs and Signaling by an Insulin Receptor Substrate 1 Molecule without Tyrosine Phosphorylation Sites. Molecular and Cellular Biology 16:8, pages 4147-4155.
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Toshimasa Yamauchi, Kazuyuki Tobe, Hiroyuki Tamemoto, Kohjiro Ueki, Yasushi Kaburagi, Ritsuko Yamamoto-Honda, Yoshihiko Takahashi, Fumiaki Yoshizawa, Shinichi Aizawa, Yasuo Akanuma, Nahum Sonenberg, Yoshio Yazaki & Takashi Kadowaki. (1996) Insulin Signalling and Insulin Actions in the Muscles and Livers of Insulin-Resistant, Insulin Receptor Substrate 1-Deficient Mice. Molecular and Cellular Biology 16:6, pages 3074-3084.
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Raul Mendez, Martin G. Myers$suffix/text()$suffix/text(), Morris F. White & Robert E. Rhoads. (1996) Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase. Molecular and Cellular Biology 16:6, pages 2857-2864.
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Lynne Yenush, Rafael Fernandez, Martin G. Myers$suffix/text()$suffix/text(), Timothy C. Grammer, Xiao Jian Sun, John Blenis, Jacalyn H. Pierce, Joseph Schlessinger & Morris F. White. (1996) The Drosophila Insulin Receptor Activates Multiple Signaling Pathways but Requires Insulin Receptor Substrate Proteins for DNA Synthesis. Molecular and Cellular Biology 16:5, pages 2509-2517.
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Michael J. Quon, Hui Chen, Brian L. Ing, Mian-Lai Liu, Mary Jane Zarnowski, Kazuyoshi Yonezawa, Masato Kasuga, Samuel W. Cushman & Simeon I. Taylor. (1995) Roles of 1-Phosphatidylinositol 3-Kinase and ras in Regulating Translocation of GLUT4 in Transfected Rat Adipose Cells. Molecular and Cellular Biology 15:10, pages 5403-5411.
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Daxin Chen, Debra J. Van Horn, Morris F. White & Jonathan M. Backer. (1995) Insulin Receptor Substrate 1 Rescues Insulin Action in CHO Cells Expressing Mutant Insulin Receptors That Lack a Juxtamembrane NPXY Motif. Molecular and Cellular Biology 15:9, pages 4711-4717.
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Thomas A. Gustafson, Weimin He, Ann Craparo, Charles D. Schaub & Thomas J. O'Neill. (1995) Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain. Molecular and Cellular Biology 15:5, pages 2500-2508.
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Motoyoshi Sakaue, David Bowtell & Masato Kasuga. (1995) A Dominant-Negative Mutant of mSOS1 Inhibits Insulin-Induced Ras Activation and Reveals Ras-Dependent and -Independent Insulin Signaling Pathways. Molecular and Cellular Biology 15:1, pages 379-388.
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Articles from other publishers (4)

Brooks P. LeitnerStephan SiebelNgozi D. AkingbesoteXinyi ZhangRachel J. Perry. (2022) Insulin and cancer: a tangled web. Biochemical Journal 479:5, pages 583-607.
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Sonia V del Rincón, Caroline Rousseau, Ratna Samanta & Wilson H MillerJrJr. (2003) Retinoic acid-induced growth arrest of MCF-7 cells involves the selective regulation of the IRS-1/PI 3-kinase/AKT pathway. Oncogene 22:22, pages 3353-3360.
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Vanesa Gottifredi, Giuliana Pelicci, Eliana Munarriz, Rossella Maione, Pier Giuseppe Pelicci & Paolo Amati. (1999) Polyomavirus Large T Antigen Induces Alterations in Cytoplasmic Signalling Pathways Involving Shc Activation. Journal of Virology 73:2, pages 1427-1437.
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Cristina M. Rondinone, Ling-Mei Wang, Peter Lonnroth, Christian Wesslau, Jacalyn H. Pierce & Ulf Smith. (1997) Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proceedings of the National Academy of Sciences 94:8, pages 4171-4175.
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