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Molecular and Cellular Biology Volume 14, 1994 - Issue 6
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Cell Growth and Development

A Novel Inhibitor of Cyclin-Cdk Activity Detected in Transforming Growth Factor β-Arrested Epithelial Cells

Joyce M. Slingerland1 Department of Molecular Biology, The Scripps Research Institute, La Jolla, California92037
,
Ludger Hengst1 Department of Molecular Biology, The Scripps Research Institute, La Jolla, California92037
,
Chin-Huei Pan2 Lawrence Berkeley Laboratory, Life Sciences Division, University of California, Berkeley, California94720
,
David Alexander2 Lawrence Berkeley Laboratory, Life Sciences Division, University of California, Berkeley, California94720
,
Martha R. Stampfer2 Lawrence Berkeley Laboratory, Life Sciences Division, University of California, Berkeley, California94720
&
Steven I. Reed1 Department of Molecular Biology, The Scripps Research Institute, La Jolla, California92037
Pages 3683-3694 | Received 16 Sep 1993, Accepted 25 Feb 1994, Published online: 30 Mar 2023

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Savitha S. Sharma & W. Jackson Pledger. (2016) The non-canonical functions of p27Kip1 in normal and tumor biology. Cell Cycle 15:9, pages 1189-1201.
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Savitha S Sharma, Le Ma & W Jackson Pledger. (2015) p27Kip1 inhibits the cell cycle through non-canonical G1/S phase-specific gatekeeper mechanism. Cell Cycle 14:24, pages 3954-3964.
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Sophie Bustany, Julie Cahu, Alexandra Moros, Xavier Troussard, Roué Gaël & Brigitte Sola. (2014) Expression and subcellular localization of cyclin-dependent kinase inhibitor p27 does not correlate with proliferation pattern of mantle lymphoma cells. Leukemia & Lymphoma 55:9, pages 2204-2206.
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Myra L. Wang, Ryan Walsh, Kristin L. Robinson, Julja Burchard, Steven R. Bartz, Michele Cleary, Denise A. Galloway & Carla Grandori. (2011) Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ. Cell Cycle 10:15, pages 2540-2548.
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Adriana Borriello, Debora Bencivenga, Maria Criscuolo, Ilaria Caldarelli, Valeria Cucciolla, Annunziata Tramontano, Alessia Borgia, Annamaria Spina, Adriana Oliva, Silvio Naviglio & Fulvio Della Ragione. (2011) Targeting p27Kip1 protein: its relevance in the therapy of human cancer. Expert Opinion on Therapeutic Targets 15:6, pages 677-693.
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Michelle D. Larrea, Jiyong Liang, Thiago Da Silva, Feng Hong, Shan H. Shao, Kathy Han, D. Dumont & Joyce M. Slingerland. (2008) Phosphorylation of p27Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4. Molecular and Cellular Biology 28:20, pages 6462-6472.
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Melissa K. James, Arpita Ray, Dina Leznova & Stacy W. Blain. (2008) Differential Modification of p27Kip1 Controls Its Cyclin D-cdk4 Inhibitory Activity. Molecular and Cellular Biology 28:1, pages 498-510.
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Sandra Ciarallo, Venkateswaran Subramaniam, Wesley Hung, Jin-Hwa Lee, Rouslan Kotchetkov, Charanjit Sandhu, Andrea Milic & Joyce M. Slingerland. (2002) Altered p27Kip1 Phosphorylation, Localization, and Function in Human Epithelial Cells Resistant to Transforming Growth Factor β-Mediated G1 Arrest. Molecular and Cellular Biology 22:9, pages 2993-3002.
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Heidi A. Lane, Iwan Beuvink, Andrea B. Motoyama, John M. Daly, Richard M. Neve & Nancy E. Hynes. (2000) ErbB2 Potentiates Breast Tumor Proliferation through Modulation of p27Kip1-Cdk2 Complex Formation: Receptor Overexpression Does Not Determine Growth Dependency. Molecular and Cellular Biology 20:9, pages 3210-3223.
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Xiaotang Hu & Kenneth S. Zuckerman. (2000) Cell Cycle and Transcriptional Control of Human Myeloid Leukemic Cells by Transforming Growth Factor Beta. Leukemia & Lymphoma 38:3-4, pages 235-246.
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Michael B. Møller. (2000) p27 in Cell Cycle Control and Cancer. Leukemia & Lymphoma 39:1-2, pages 19-27.
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Lena Kanter-Lewensohn, Anica Dricu, Leonard Girnita, Johan Wejde & Olle Larsson. (2000) Expression of Insulin-Like Growth Factor-1 Receptor (IGF-1R) and p27Kip1 in Melanocyte Tumors: A Potential Regulatory Role of IGF-1 Pathway in Distribution of p27Kip1 between Different Cyclins. Growth Factors 17:3, pages 193-202.
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Minna Tsubari, Jussi Taipale, Erja Tiihonen, Jorma Keski-Oja & Marikki Laiho. (1999) Hepatocyte Growth Factor Releases Mink Epithelial Cells from Transforming Growth Factor β1-Induced Growth Arrest by Restoring Cdk6 Expression and Cyclin E-Associated Cdk2 Activity. Molecular and Cellular Biology 19:5, pages 3654-3663.
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Jean M. Gudas, Marc Payton, Sushil Thukral, Eddy Chen, Michael Bass, Murray O. Robinson & Steve Coats. (1999) Cyclin E2, a Novel G1 Cyclin That Binds Cdk2 and Is Aberrantly Expressed in Human Cancers. Molecular and Cellular Biology 19:1, pages 612-622.
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Alexander B. Niculescu$suffix/text()$suffix/text(), Xinbin Chen, Monique Smeets, Ludger Hengst, Carol Prives & Steven I. Reed. (1998) Effects of p21Cip1/Waf1 at Both the G1/S and the G2/M Cell Cycle Transitions: pRb Is a Critical Determinant in Blocking DNA Replication and in Preventing Endoreduplication. Molecular and Cellular Biology 18:1, pages 629-643.
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Vjekoslav Dulić, Gretchen H. Stein, Dariush Farahi Far & Steven I. Reed. (1998) Nuclear Accumulation of p21Cip1 at the Onset of Mitosis: a Role at the G2/M-Phase Transition. Molecular and Cellular Biology 18:1, pages 546-557.
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Huseyin Aktas, Hong Cai & Geoffrey M. Cooper. (1997) Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27. Molecular and Cellular Biology 17:7, pages 3850-3857.
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C. Sandhu, J. Garbe, N. Bhattacharya, J. Daksis, C.-H. Pan, P. Yaswen, J. Koh, J. M. Slingerland & M. R. Stampfer. (1997) Transforming Growth Factor β Stabilizes p15 Protein, Increases p15-cdk4 Complexes, and Inhibits Cyclin D1-cdk4 Association in Human Mammary Epithelial Cells. Molecular and Cellular Biology 17:5, pages 2458-2467.
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Yan Luo, Steven O. Marx, Hiroaki Kiyokawa, Andrew Koff, Joan Massagué & Andrew R. Marks. (1996) Rapamycin Resistance Tied to Defective Regulation of p27. Molecular and Cellular Biology 16:12, pages 6744-6751.
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Kun Guo, Jian Wang, Vicente Andrés, Roy C. Smith & Kenneth Walsh. (1995) MyoD-Induced Expression of p21 Inhibits Cyclin-Dependent Kinase Activity upon Myocyte Terminal Differentiation. Molecular and Cellular Biology 15:7, pages 3823-3829.
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Motoaki Ohtsubo, Anne M. Theodoras, Jill Schumacher, James M. Roberts & Michele Pagano. (1995) Human Cyclin E, a Nuclear Protein Essential for the G1-to-S Phase Transition. Molecular and Cellular Biology 15:5, pages 2612-2624.
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Articles from other publishers (2)

Per Höllsberg. (1999) Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I. Microbiology and Molecular Biology Reviews 63:2, pages 308-333.
Crossref
Holger Bastians, Fiona M. Townsley & Joan V. Ruderman. (1998) The cyclin-dependent kinase inhibitor p27 Kip1 induces N-terminal proteolytic cleavage of cyclin A . Proceedings of the National Academy of Sciences 95:26, pages 15374-15381.
Crossref

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