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Transcriptional Regulation

Constitutive NF-kB Activity in Neurons

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Pages 3981-3992 | Received 01 Dec 1993, Accepted 11 Mar 1994, Published online: 30 Mar 2023

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Mythily Srinivasan & Debomoy K Lahiri. (2015) Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis. Expert Opinion on Therapeutic Targets 19:4, pages 471-487.
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Hugo Peluffo, Pau Gonzalez, Laia Acarin, Anna Arís, Rudy Beyaert, Antonio Villaverde & Berta Gonzalez. (2013) Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain. Neurological Research 35:3, pages 308-319.
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Meige Zheng, Jing Liu, Zhigang Ruan, Sumin Tian, Yuxin Ma, Jiayong Zhu & Guoying Li. (2013) Intrahippocampal injection of Aβ1-42 inhibits neurogenesis and down-regulates IFN-γ and NF-κB expression in hippocampus of adult mouse brain. Amyloid 20:1, pages 13-20.
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Jehan Mohamed Alsharnoubi, Hans Henrik Odland & Ola Didrik Saugstad. (2012) Nicotine does not influence NF-κB activity in neonatal mice reoxygenated with room-air or 100% oxygen. The Journal of Maternal-Fetal & Neonatal Medicine 25:10, pages 2102-2105.
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Erika Cecon, Pedro A. Fernandes, Luciana Pinato, Zulma S. Ferreira & Regina P. Markus. (2010) DAILY VARIATION OF CONSTITUTIVELY ACTIVATED NUCLEAR FACTOR KAPPA B (NFKB) IN RAT PINEAL GLAND. Chronobiology International 27:1, pages 52-67.
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Simonetta Camandola & Mark P Mattson. (2007) NF-κB as a therapeutic target in neurodegenerative diseases. Expert Opinion on Therapeutic Targets 11:2, pages 123-132.
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Barbara Kaltschmidt, Delphine Ndiaye, Martin Korte, Stéphanie Pothion, Laurence Arbibe, Maria Prüllage, Julia Pfeiffer, Antje Lindecke, Volker Staiger, Alain Israël, Christian Kaltschmidt & Sylvie Mémet. (2006) NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling. Molecular and Cellular Biology 26:8, pages 2936-2946.
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Yanmei Tao, Dong Yan, Qiaoyun Yang, Rui Zeng & Yizheng Wang. (2006) Low K+ Promotes NF-κB/DNA Binding in Neuronal Apoptosis Induced by K+ Loss. Molecular and Cellular Biology 26:3, pages 1038-1050.
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Charlene Cho & Richard J Miller. (2002) Chemokine Receptors and Neural Function. Journal of Neurovirology 8:6, pages 573-584.
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Kevin Rostasy, Laura Monti, Constantin Yiannoutsos, Joyce Wu, Jeanne Bell, John Hedreen & Bradford A Navia. (2000) NFKB activation, TNF-α expression, and apoptosis in the AIDS-Dementia-Complex. Journal of Neurovirology 6:6, pages 537-543.
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Articles from other publishers (12)

Grazyna Lietzau, Waldemar Sienkiewicz, Zbigniew Karwacki, Jerzy Dziewiątkowski, Jerzy Kaleczyc & Przemysław Kowiański. (2023) The Effect of Simvastatin on the Dynamics of NF-κB-Regulated Neurodegenerative and Neuroprotective Processes in the Acute Phase of Ischemic Stroke. Molecular Neurobiology 60:9, pages 4935-4951.
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Tarek Niemann, Johannes F.W. Greiner, Christian Kaltschmidt & Barbara Kaltschmidt. (2023) EPO regulates neuronal differentiation of adult human neural-crest derived stem cells in a sex-specific manner. BMC Neuroscience 24:1.
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Barbara Kaltschmidt, Laureen P. Helweg, Johannes F. W. Greiner & Christian Kaltschmidt. (2022) NF-κB in neurodegenerative diseases: Recent evidence from human genetics. Frontiers in Molecular Neuroscience 15.
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Hwi Wen Meng, Ah Young Lee, Hyun Young Kim, Eun Ju Cho & Ji Hyun Kim. (2022) Neuroprotective effects of paeoniflorin against neuronal oxidative stress and neuroinflammation induced by lipopolysaccharide in mice. Journal of Applied Biological Chemistry 65:1, pages 23-31.
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Taisia Rolova, Hiramani Dhungana, Paula Korhonen, Piia Valonen, Natalia Kolosowska, Henna Konttinen, Katja Kanninen, Heikki Tanila, Tarja Malm & Jari Koistinaho. (2016) Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage. Aging and disease 7:4, pages 450.
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Joerg SchreiberRichard G. JennerHeather L. MurrayGeorg K. Gerber, David K. Gifford & Richard A. Young. (2006) Coordinated binding of NF-κB family members in the response of human cells to lipopolysaccharide. Proceedings of the National Academy of Sciences 103:15, pages 5899-5904.
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Soizic Bourteele, Katja Oesterle, Stephan Pleschka, Gunhild Unterstab, Christina Ehrhardt, Thorsten Wolff, Stephan Ludwig & Oliver Planz. (2005) Constitutive Activation of the Transcription Factor NF-κB Results in Impaired Borna Disease Virus Replication. Journal of Virology 79:10, pages 6043-6051.
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Christian Schwartz, Philippe Catez, Olivier Rohr, Dominique Lecestre, Dominique Aunis & Evelyne Schaeffer. (2000) Functional Interactions between C/EBP, Sp1, and COUP-TF Regulate Human Immunodeficiency Virus Type 1 Gene Transcription in Human Brain Cells. Journal of Virology 74:1, pages 65-73.
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Barbara Kaltschmidt, Martin Uherek, Henning Wellmann, Benedikt Volk & Christian Kaltschmidt. (1999) Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis. Proceedings of the National Academy of Sciences 96:16, pages 9409-9414.
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Daniel Krappmann, Florian Emmerich, Uwe Kordes, Erika Scharschmidt, Bernd Dörken & Claus Scheidereit. (1999) Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene 18:4, pages 943-953.
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Hiroyuki Miyoshi, Ulrike Blömer, Masayo Takahashi, Fred H. Gage & Inder M. Verma. (1998) Development of a Self-Inactivating Lentivirus Vector. Journal of Virology 72:10, pages 8150-8157.
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Barbara Kaltschmidt, Martin Uherek, Benedikt Volk, Patrick A. Baeuerle & Christian Kaltschmidt. (1997) Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proceedings of the National Academy of Sciences 94:6, pages 2642-2647.
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