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Molecular and Cellular Biology Volume 14, 1994 - Issue 7
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Cell Growth and Development

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Bentley Cheatham1 Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts02215
,
Chris J. Vlahos2 Cardiovascular Research, Lilly Research Laboratories, Indianapolis, Indiana46285
,
Lynn Cheatham3 Department of Cell and Molecular Physiology and Program in Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts02115
,
Lois Wang1 Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts02215
,
John Blenis3 Department of Cell and Molecular Physiology and Program in Cell and Developmental Biology, Harvard Medical School, Boston, Massachusetts02115
&
C. Ronald Kahn1 Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts02215
Pages 4902-4911 | Received 15 Mar 1994, Accepted 25 Apr 1994, Published online: 30 Mar 2023

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Alexander J Knights, Alister PW Funnell, Richard CM Pearson, Merlin Crossley & Kim S Bell-Anderson. (2014) Adipokines and insulin action. Adipocyte 3:2, pages 88-96.
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Bettina  Dummler, Oliver Tschopp, Debby Hynx, Zhong-Zhou Yang, Stephan Dirnhofer & Brian A. Hemmings. (2006) Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies. Molecular and Cellular Biology 26:21, pages 8042-8051.
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Weizhou Zhang, Cong S. Zong, Ulrich Hermanto, Pablo Lopez-Bergami, Ze'ev Ronai & Lu-Hai Wang. (2006) RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth. Molecular and Cellular Biology 26:2, pages 413-424.
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Saskia M. Brachmann, Kohjiro Ueki, Jeffrey A. Engelman, Ronald C. Kahn & Lewis C. Cantley. (2005) Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice. Molecular and Cellular Biology 25:5, pages 1596-1607.
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Jinghua Yu, Yitao Zhang, James McIlroy, Tamara Rordorf-Nikolic, George A. Orr & Jonathan M. Backer. (1998) Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit. Molecular and Cellular Biology 18:3, pages 1379-1387.
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R.M. Knott, E. Muckersie, M. Robertson & J.V. Forrester. (1998) Glucose-dependent regulation of DNA synthesis in bovine retinal endothelial cells. Current Eye Research 17:1, pages 1-8.
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Prem M. Sharma, Katsuya Egawa, Thomas A. Gustafson, Jody L. Martin & Jerrold M. Olefsky. (1997) Adenovirus-Mediated Overexpression of IRS-1 Interacting Domains Abolishes Insulin-Stimulated Mitogenesis without Affecting Glucose Transport in 3T3-L1 Adipocytes. Molecular and Cellular Biology 17:12, pages 7386-7397.
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Jens C. Brüning, Jonathon Winnay, Bentley Cheatham & C. Ronald Kahn. (1997) Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells. Molecular and Cellular Biology 17:3, pages 1513-1521.
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James McIlroy, Daxin Chen, Christina Wjasow, Tamar Michaeli & Jonathan M. Backer. (1997) Specific Activation of p85-p110 Phosphatidylinositol 3′-Kinase Stimulates DNA Synthesis by ras- and p70 S6 Kinase-Dependent Pathways. Molecular and Cellular Biology 17:1, pages 248-255.
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Ernst U. Frevert & Barbara B. Kahn. (1997) Differential Effects of Constitutively Active Phosphatidylinositol 3-Kinase on Glucose Transport, Glycogen Synthase Activity, and DNA Synthesis in 3T3-L1 Adipocytes. Molecular and Cellular Biology 17:1, pages 190-198.
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Raul Mendez, Martin G. Myers$suffix/text()$suffix/text(), Morris F. White & Robert E. Rhoads. (1996) Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase. Molecular and Cellular Biology 16:6, pages 2857-2864.
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Jean Dahl, Robert Freund, John Blenis & Thomas L. Benjamin. (1996) Studies of Partially Transforming Polyomavirus Mutants Establish a Role for Phosphatidylinositol 3-Kinase in Activation of pp70 S6 Kinase. Molecular and Cellular Biology 16:6, pages 2728-2735.
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X. Johné Liu, Alexander Sorisky, Li Zhu & Tony Pawson. (1995) Molecular Cloning of an Amphibian Insulin Receptor Substrate 1-Like cDNA and Involvement of Phosphatidylinositol 3-Kinase in Insulin-Induced Xenopus Oocyte Maturation. Molecular and Cellular Biology 15:7, pages 3563-3570.
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W. Pruett, Y. Yuan, E. Rose, A. G. Batzer, N. Harada & E. Y. Skolnik. (1995) Association between GRB2/Sos and Insulin Receptor Substrate 1 Is Not Sufficient for Activation of Extracellular Signal-Regulated Kinases by Interleukin-4: Implications for Ras Activation by Insulin. Molecular and Cellular Biology 15:3, pages 1778-1785.
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