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Molecular and Cellular Biology Volume 14, 1994 - Issue 8
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Cell Growth and Development

Hierarchical Phosphorylation at N-Terminal Transformation-Sensitive Sites in c-Myc Protein Is Regulated by Mitogens and in Mitosis

Bart LutterbachDepartment of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee37232-2175
&
Stephen R. HannDepartment of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee37232-2175
Pages 5510-5522 | Received 09 Aug 1993, Accepted 12 May 1994, Published online: 30 Mar 2023

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Daniel Massó-Vallés, Marie-Eve Beaulieu & Laura Soucek. (2020) MYC, MYCL, and MYCN as therapeutic targets in lung cancer. Expert Opinion on Therapeutic Targets 24:2, pages 101-114.
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Johannes Brägelmann, Stefanie Böhm, Matthew R. Guthrie, Gurkan Mollaoglu, Trudy G. Oliver & Martin L. Sos. (2017) Family matters: How MYC family oncogenes impact small cell lung cancer. Cell Cycle 16:16, pages 1489-1498.
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Xiao-Xin Sun, Rosalie C Sears & Mu-Shui Dai. (2015) Deubiquitinating c-Myc: USP36 steps up in the nucleolus. Cell Cycle 14:24, pages 3786-3793.
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Román González-Prieto, Sabine AG Cuijpers, Ramesh Kumar, Ivo A Hendriks & Alfred CO Vertegaal. (2015) c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4. Cell Cycle 14:12, pages 1859-1872.
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Amy S. Farrell, Carl Pelz, Xiaoyan Wang, Colin J. Daniel, Zhiping Wang, Yulong Su, Mahnaz Janghorban, Xiaoli Zhang, Charlie Morgan, Soren Impey & Rosalie C. Sears. (2013) Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis. Molecular and Cellular Biology 33:15, pages 2930-2949.
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Archana Anantharaman, I-Ju Lin, Joeva Barrow, Shermi Y. Liang, Jude Masannat, John Strouboulis, Suming Huang & Jörg Bungert. (2011) Role of Helix-Loop-Helix Proteins during Differentiation of Erythroid Cells. Molecular and Cellular Biology 31:7, pages 1332-1343.
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Jaroslav Pejchal, Jan Österreicher, Zdeňka Vilasová, Aleš Tichý & Jir˘ina Vávrová. (2008) Expression of activated ATF-2, CREB and c-Myc in rat colon transversum after whole-body γ-irradiation and its contribution to pathogenesis and biodosimetry. International Journal of Radiation Biology 84:4, pages 315-324.
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Victoria H. Cowling, Sanjay Chandriani, Michael L. Whitfield & Michael D. Cole. (2006) A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest. Molecular and Cellular Biology 26:11, pages 4226-4239.
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Hugh K. Arnold & Rosalie C. Sears. (2006) Protein Phosphatase 2A Regulatory Subunit B56α Associates with c-Myc and Negatively Regulates c-Myc Accumulation. Molecular and Cellular Biology 26:7, pages 2832-2844.
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Zhongdong Huang, Jolinda A. Traugh & J. Michael Bishop. (2004) Negative Control of the Myc Protein by the Stress-Responsive Kinase Pak2. Molecular and Cellular Biology 24:4, pages 1582-1594.
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Jacek Niklinski, Gisela Claassen, Cheryl Meyers, Mark A. Gregory, Carmen J. Allegra, Frederic J. Kaye, Stephen R. Hann & Maria Zajac-Kaye. (2000) Disruption of Myc-Tubulin Interaction by Hyperphosphorylation of c-Myc during Mitosis or by Constitutive Hyperphosphorylation of Mutant c-Myc in Burkitt's Lymphoma. Molecular and Cellular Biology 20:14, pages 5276-5284.
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David W. Chang, Gisela F. Claassen, Stephen R. Hann & Michael D. Cole. (2000) The c-Myc Transactivation Domain Is a Direct Modulator of Apoptotic versus Proliferative Signals. Molecular and Cellular Biology 20:12, pages 4309-4319.
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Mark A. Gregory & Stephen R. Hann. (2000) c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells. Molecular and Cellular Biology 20:7, pages 2423-2435.
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Chi V. Dang. (1999) c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism. Molecular and Cellular Biology 19:1, pages 1-11.
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Gerald D. Spotts, Sadhna V. Patel, Qiurong Xiao & Stephen R. Hann. (1997) Identification of Downstream-Initiated c-Myc Proteins Which Are Dominant-Negative Inhibitors of Transactivation by Full-Length c-Myc Proteins. Molecular and Cellular Biology 17:3, pages 1459-1468.
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Arthur T. Hoang, Bart Lutterbach, Brian C. Lewis, Takahiro Yano, Teh-Ying Chou, John F. Barrett, Mark Raffeld, Stephen R. Hann & Chi V. Dang. (1995) A Link between Increased Transforming Activity of Lymphoma-Derived MYC Mutant Alleles, Their Defective Regulation by p107, and Altered Phosphorylation of the c-Myc Transactivation Domain. Molecular and Cellular Biology 15:8, pages 4031-4042.
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Articles from other publishers (14)

Xiao-Xin SunXia He, Li Yin, Masayuki Komada, Rosalie C. SearsMu-Shui Dai. (2015) The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc. Proceedings of the National Academy of Sciences 112:12, pages 3734-3739.
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M Huang, U Kamasani & G C Prendergast. (2005) RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3. Oncogene 25:9, pages 1281-1289.
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Xiaolu L Ang & J Wade Harper. (2005) SCF-mediated protein degradation and cell cycle control. Oncogene 24:17, pages 2860-2870.
Crossref
Aaron M Domina, Julie A Vrana, Mark A Gregory, Stephen R Hann & Ruth W Craig. (2004) MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. Oncogene 23:31, pages 5301-5315.
Crossref
Markus Welcker, Amir Orian, Jianping Jin, Jonathan A. Grim, J. Wade Harper, Robert N. Eisenman & Bruce E. Clurman. (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proceedings of the National Academy of Sciences 101:24, pages 9085-9090.
Crossref
Dania Alarcon-Vargas, William P Tansey & Ze'ev Ronai. (2002) Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127–189 of c-myc. Oncogene 21:28, pages 4384-4391.
Crossref
Linda M Boxer & Chi V Dang. (2001) Translocations involving c-myc and c-myc function. Oncogene 20:40, pages 5595-5610.
Crossref
Mark A Gregory, Qiurong Xiao, Gail A Cornwall, Bart Lutterbach & Stephen R Hann. (2000) B-Myc is preferentially expressed in hormonally-controlled tissues and inhibits cellular proliferation. Oncogene 19:42, pages 4886-4895.
Crossref
Chadd E Nesbit, Jean M Tersak, Linette E Grove, Amy Drzal, Hyunjung Choi & Edward V Prochownik. (2000) Genetic dissection of c-myc apoptotic pathways. Oncogene 19:28, pages 3200-3212.
Crossref
Paul R Gavine, James C Neil & Dorothy H Crouch. (1999) Protein stabilization: a common consequence of mutations in independently derived v-Myc alleles. Oncogene 18:52, pages 7552-7558.
Crossref
Michael D Cole & Steven B McMahon. (1999) The Myc oncoprotein: a critical evaluation of transactivation and target gene regulation. Oncogene 18:19, pages 2916-2924.
Crossref
Gisela F Claassen & Stephen R Hann. (1999) Myc-mediated transformation: the repression connection. Oncogene 18:19, pages 2925-2933.
Crossref
Chadd E Nesbit, Jean M Tersak & Edward V Prochownik. (1999) MYC oncogenes and human neoplastic disease. Oncogene 18:19, pages 3004-3016.
Crossref
Daitoku Sakamuro & George C Prendergast. (1999) New Myc-interacting proteins: a second Myc network emerges. Oncogene 18:19, pages 2942-2954.
Crossref

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