Advanced search
Publication Cover
Molecular and Cellular Biology Volume 5, 1985 - Issue 7
Submit an article Journal homepage
0
Views
16
CrossRef citations to date
0
Altmetric
Research Article

A Mutation at the ATP-Binding Site of pp60v-src Abolishes Kinase Activity, Transformation, and Tumorigenicity

Mark A. Snyder1 G. W. Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, California94143
,
J. Michael Bishop1 G. W. Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, California94143
,
John P. McGrath2 Genentech, Inc., South San Francisco, California94080
&
Arthur D. Levinson2 Genentech, Inc., South San Francisco, California94080
Pages 1772-1779 | Received 22 Jan 1985, Accepted 03 Apr 1985, Published online: 31 Mar 2023

Citations (16)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (14)

Kai Ping Sem, Baharak Zahedi, Ivan Tan, Maria Deak, Louis Lim & Nicholas Harden. (2002) ACK Family Tyrosine Kinase Activity Is a Component of Dcdc42 Signaling during Dorsal Closure in Drosophila melanogaster. Molecular and Cellular Biology 22:11, pages 3685-3697.
Read now
Michael G. Katze, Marlene Wambach, Min-Liang Wong, Michele Garfinkel, Eliane Meurs, Karen Chong, Bryan R. G. Williams, Ara G. Hovanessian & Glen N. Barber. (1991) Functional Expression and RNA Binding Analysis of the Interferon-Induced, Double-Stranded RNA-Activated, 68,000-Mr Protein Kinase in a Cell-Free System. Molecular and Cellular Biology 11:11, pages 5497-5505.
Read now
Barbara K. Brott, Stuart Decker, Melanie C. O'brien & Richard Jove. (1991) Molecular Features of the Viral and Cellular Src Kinases Involved in Interactions with the GTPase-Activating Protein. Molecular and Cellular Biology 11:10, pages 5059-5067.
Read now
Xingquan Liu & Tony Pawson. (1991) The Epidermal Growth Factor Receptor Phosphorylates GTPase-Activating Protein (GAP) at Tyr-460, Adjacent to the GAP SH2 Domains. Molecular and Cellular Biology 11:5, pages 2511-2516.
Read now
Yasuhisa Fukui, Melanie C. O’Brien & Hidesaburo Hanafusa. (1991) Deletions in the SH2 Domain of p60v- Prevent Association with the Detergent-Insoluble Cellular Matrix. Molecular and Cellular Biology 11:3, pages 1207-1213.
Read now
Thambi Dorai & Lu-Hai Wang. (1990) An Alternative Non-Tyrosine Protein Kinase Product of the c-src Gene in Chicken Skeletal Muscle. Molecular and Cellular Biology 10:8, pages 4068-4079.
Read now
Hisamaru Hirai & Harold E. Varmus. (1990) Site-Directed Mutagenesis of the SH2- and SH3-Coding Domains of c-src Produces Varied Phenotypes, Including Oncogenic Activation of p60c-. Molecular and Cellular Biology 10:4, pages 1307-1318.
Read now
Susan A. Nadin-Davis & Anwar Nasim. (1990) Schizosaccharomyces pombe ras1 and byr1 Are Functionally Related Genes of the ste Family That Affect Starvation-Induced Transcription of Mating-Type Genes. Molecular and Cellular Biology 10:2, pages 549-560.
Read now
Noboru Kuzumaki, Yoshifumi Ogiso, Atsushi Oda, Hisakazu Fujita, Hiroaki Suzuki, Chiharu Sato & Leonhard Müllauer. (1989) Resistance to Oncogenic Transformation in Revertant R1 of Human ras-Transformed NIH 3T3 cells. Molecular and Cellular Biology 9:5, pages 2258-2263.
Read now
Yasuhisa Fukui & Hidesaburo Hanafusa. (1989) Phosphatidylinositol Kinase Activity Associates with Viral p60 Protein. Molecular and Cellular Biology 9:4, pages 1651-1658.
Read now
Yehiel Zick. (1989) The Insulin Receptor: Structure and Functio. Critical Reviews in Biochemistry and Molecular Biology 24:3, pages 217-269.
Read now
A. M. Honegger, D. Szapary, A. Schmidt, R. Lyall, E. Van Obberghen, T. J. Dull, A. Ullrich & J. Schlessinger. (1987) A Mutant Epidermal Growth Factor Receptor with Defective Protein Tyrosine Kinase Is Unable To Stimulate Proto-Oncogene Expression and DNA Synthesis. Molecular and Cellular Biology 7:12, pages 4568-4571.
Read now
Robert Booher & David Beach. (1986) Site-Specific Mutagenesis of cdc2+, a Cell Cycle Control Gene of the Fission Yeast Schizosaccharomyces pombe. Molecular and Cellular Biology 6:10, pages 3523-3530.
Read now
Mark P. Kamps & Bartholomew M. Sefton. (1986) Neither Arginine nor Histidine Can Carry Out the Function of Lysine-295 in the ATP-Binding Site of p60src. Molecular and Cellular Biology 6:3, pages 751-757.
Read now

Articles from other publishers (2)

Edgar E. BoczekLasse G. ReefschlägerMarco Dehling, Tobias J. StrullerElisabeth HäuslerAndreas Seidl, Ville R. I. KailaJohannes Buchner. (2015) Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90. Proceedings of the National Academy of Sciences 112:25.
Crossref
Kimya F. Harris, Ikuo Shoji, Eric M. Cooper, Sushant Kumar, Hideaki Oda & Peter M. Howley. (1999) Ubiquitin-mediated degradation of active Src tyrosine kinase. Proceedings of the National Academy of Sciences 96:24, pages 13738-13743.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.