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Molecular and Cellular Biology Volume 7, 1987 - Issue 4
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Research Article

Inactivation of a Transfected Gene in Human Fibroblasts Can Occur by Deletion, Amplification, Phenotypic Switching, or Methylation

Maha M. GebaraMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
,
Cecile DrevonMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
,
Susan A. HarcourtMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
,
Herdis SteingrimsdottirMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
,
Michael R. JamesMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
,
Julian F. BurkeMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
,
Colin F. ArlettMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
&
Alan R. LehmannMedical Research Council Cell Mutation Unit, Sussex University, Falmer, BrightonBN1 9RR, United Kingdom
 show all
Pages 1459-1464 | Received 17 Oct 1986, Accepted 07 Jan 1987, Published online: 31 Mar 2023

Citations (6)

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Read on this site (5)

Ana C. D'Alessio, Ian C. G. Weaver & Moshe Szyf. (2007) Acetylation-Induced Transcription Is Required for Active DNA Demethylation in Methylation-Silenced Genes. Molecular and Cellular Biology 27:21, pages 7462-7474.
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Limor Broday, Yong-Woo Lee & Max Costa. (1999) 5-Azacytidine Induces Transgene Silencing by DNA Methylation in Chinese Hamster Cells. Molecular and Cellular Biology 19:4, pages 3198-3204.
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Y.-W. Lee, C. B. Klein, B. Kargacin, K. Salnikow, J. Kitahara, K. Dowjat, A. Zhitkovich, N. T. Christie & M. Costa. (1995) Carcinogenic Nickel Silences Gene Expression by Chromatin Condensation and DNA Methylation: a New Model for Epigenetic Carcinogens. Molecular and Cellular Biology 15:5, pages 2547-2557.
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T.E. Godfrey, M. Ikebuchi, R.J. Reynolds & C.K. Hill. (1995) Characterization of a Mammalian Cell Line that Exhibits Spontaneous and Ultraviolet Light-induced Hypermutability While Retaining Resistance to Cell Killing by Ultraviolet Light. International Journal of Radiation Biology 67:6, pages 661-670.
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A. Nozibusiso Magewu & Peter A. Jones. (1994) Ubiquitous and Tenacious Methylation of the CpG Site in Codon 248 of the p53 Gene May Explain Its Frequent Appearance as a Mutational Hot Spot in Human Cancer. Molecular and Cellular Biology 14:6, pages 4225-4232.
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Articles from other publishers (1)

Catherine B Klein & Max Costa. (1997) DNA methylation, heterochromatin and epigenetic carcinogens. Mutation Research/Reviews in Mutation Research 386:2, pages 163-180.
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