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Research Article

Molecular Analysis of GCN3, a Translational Activator of GCN4: Evidence for Posttranslational Control of GCN3 Regulatory Function

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Pages 4808-4820 | Received 20 May 1988, Accepted 16 Aug 1988, Published online: 31 Mar 2023

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Read on this site (17)

Christopher M. Browne, Parimal Samir, J. Scott Fites, Seth A. Villarreal & Andrew J. Link. (2013) The Yeast Eukaryotic Translation Initiation Factor 2B Translation Initiation Complex Interacts with the Fatty Acid Synthesis Enzyme YBR159W and Endoplasmic Reticulum Membranes. Molecular and Cellular Biology 33:5, pages 1041-1056.
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Chingakham Ranjit Singh, Cynthia Curtis, Yasufumi Yamamoto, Nathan S. Hall, Dustin S. Kruse, Hui He, Ernest M. Hannig & Katsura Asano. (2005) Eukaryotic Translation Initiation Factor 5 Is Critical for Integrity of the Scanning Preinitiation Complex and Accurate Control of GCN4 Translation. Molecular and Cellular Biology 25:13, pages 5480-5491.
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Jonathan P. Richardson, Sarah S. Mohammad & Graham D. Pavitt. (2004) Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity. Molecular and Cellular Biology 24:6, pages 2352-2363.
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Thanuja Krishnamoorthy, Graham D. Pavitt, Fan Zhang, Thomas E. Dever & Alan G. Hinnebusch. (2001) Tight Binding of the Phosphorylated α Subunit of Initiation Factor 2 (eIF2α) to the Regulatory Subunits of Guanine Nucleotide Exchange Factor eIF2B Is Required for Inhibition of Translation Initiation. Molecular and Cellular Biology 21:15, pages 5018-5030.
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Ruojing Yang, Sheree A. Wek & Ronald C. Wek. (2000) Glucose Limitation Induces GCN4 Translation by Activation of Gcn2 Protein Kinase. Molecular and Cellular Biology 20:8, pages 2706-2717.
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Graham D. Pavitt, Weimin Yang & Alan G. Hinnebusch. (1997) Homologous Segments in Three Subunits of the Guanine Nucleotide Exchange Factor eIF2B Mediate Translational Regulation by Phosphorylation of eIF2. Molecular and Cellular Biology 17:3, pages 1298-1313.
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Thomas E. Dever, Weimin Yang, Stefan Åström, Anders S. Byström & Alan G. Hinnebusch. (1995) Modulation of tRNA(iMet), eIF-2, and eIF-2B Expression Shows that GCN4 Translation Is Inversely Coupled to the Level of eIF-2·GTP·Met-tRNA(iMet) Ternary Complexes. Molecular and Cellular Biology 15:11, pages 6351-6363.
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Jack R. Perry, Munira A. Basrai, Henry-York Steiner, Fred Naider & Jeffrey M. Becker. (1994) Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene. Molecular and Cellular Biology 14:1, pages 104-115.
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Janet L. Bushman, Marco Foiani, A. Mark Cigan, Christopher J. Paddon & Alan G. Hinnebusch. (1993) Guanine Nucleotide Exchange Factor for Eukaryotic Translation Initiation Factor 2 in Saccharomyces cerevisiae: Interactions between the Essential Subunits GCD2, GCD6, and GCD7 and the Regulatory Subunit GCN3. Molecular and Cellular Biology 13:8, pages 4618-4631.
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Janet L. Bushman, Agatha I. Asuru, Robert L. Matts & Alan G. Hinnebusch. (1993) Evidence that GCD6 and GCD7, Translational Regulators of GCN4, Are Subunits of the Guanine Nucleotide Exchange Factor for eIF-2 in Saccharomyces cerevisiae. Molecular and Cellular Biology 13:3, pages 1920-1932.
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Ernest M. Hannig, A. Mark Cigan, Barbara A. Freeman & Terri Goss Kinzy. (1993) GCD11, a Negative Regulator of GCN4 Expression, Encodes the γ Subunit of eIF-2 in Saccharomyces cerevisiae. Molecular and Cellular Biology 13:1, pages 506-520.
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Manuel Ramirez, Ronald C. Wek, Carlos R. Vazquez De Aldana, Belinda M. Jackson, Barbara Freeman & Alan G. Hinnebusch. (1992) Mutations Activating the Yeast eIF-2a Kinase GCN2: Isolation of Alleles Altering the Domain Related to Histidyl-tRNA Synthetases. Molecular and Cellular Biology 12:12, pages 5801-5815.
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A. Mark Cigan, Marco Foiani, Ernest M. Hannig & Alan G. Hinnebusch. (1991) Complex Formation by Positive and Negative Translational Regulators of GCN4. Molecular and Cellular Biology 11:6, pages 3217-3228.
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Marco Foiani, A. Mark Cigan, Christopher J. Paddon, Satoshi Harashima & Alan G. Hinnebusch. (1991) GCD2, a Translational Repressor of the GCN4 Gene, Has a General Function in the Initiation of Protein Synthesis in Saccharomyces cerevisiae. Molecular and Cellular Biology 11:6, pages 3203-3216.
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Ronald C. Wek, Manuel Ramirez, Belinda M. Jackson & Alan G. Hinnebusch. (1990) Identification of Positive-Acting Domains in GCN2 Protein Kinase Required for Translational Activation of GCN4 Expression. Molecular and Cellular Biology 10:6, pages 2820-2831.
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Articles from other publishers (2)

Xuemin Wang & Christopher G. Proud. (2022) The role of eIF2 phosphorylation in cell and organismal physiology: new roles for well-known actors. Biochemical Journal 479:10, pages 1059-1082.
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Rachel Elsby, Joshua F. Heiber, Peter Reid, Scot R. Kimball, Graham D. Pavitt & Glen N. Barber. (2011) The Alpha Subunit of Eukaryotic Initiation Factor 2B (eIF2B) Is Required for eIF2-Mediated Translational Suppression of Vesicular Stomatitis Virus. Journal of Virology 85:19, pages 9716-9725.
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