Advanced search
Publication Cover
Molecular and Cellular Biology Volume 8, 1988 - Issue 6
Submit an article Journal homepage
10
Views
20
CrossRef citations to date
0
Altmetric
Research Article

B-raf, a New Member of the raf Family, is Activated by DNA Rearrangement

Shuntaro Ikawa1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan
,
Mikiharu Fukui1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan
,
Yoshito Ueyama2 Department of Pathology, School of Medicine, Tokai University, 259-11 Bouseidai, Isehara-shi, Kanagawa, Japan
,
Norikazu Tamaoki2 Department of Pathology, School of Medicine, Tokai University, 259-11 Bouseidai, Isehara-shi, Kanagawa, Japan
,
Tadashi Yamamoto1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan
&
Kumao Toyoshima1 Department of Oncology, Institiate of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-kia, Tokyo, Japan
Pages 2651-2654 | Received 19 Nov 1987, Accepted 14 Mar 1988, Published online: 31 Mar 2023

Citations (20)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (15)

Paula Soares, Ana Preto & Manuel Sobrinho-Simões. (2009) BRAFV600E mutation in papillary thyroid carcinoma: a potential target for therapy?. Expert Review of Endocrinology & Metabolism 4:5, pages 467-480.
Read now
Isabelle Hmitou, Sabine Druillennec, Agathe Valluet, Carole Peyssonnaux & Alain Eychène. (2007) Differential Regulation of B-Raf Isoforms by Phosphorylation and AutoinhibitoryMechanisms. Molecular and Cellular Biology 27:1, pages 31-43.
Read now
Andreas Sewing, Bryony Wiseman, Alison C. Lloyd & Hartmut Land. (1997) High-Intensity Raf Signal Causes Cell Cycle Arrest Mediated by p21Cip1. Molecular and Cellular Biology 17:9, pages 5588-5597.
Read now
Eugen Kerkhoff & Ulf R. Rapp. (1997) Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1. Molecular and Cellular Biology 17:5, pages 2576-2586.
Read now
Catrin A. Pritchard, Michael L. Samuels, Elizabeth Bosch & Martin McMahon. (1995) Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells. Molecular and Cellular Biology 15:11, pages 6430-6442.
Read now
Kevin Pumiglia, Yu-Hua Chow, John Fabian, Deborah Morrison, Stuart Decker & Richard Jove. (1995) Raf-1 N-Terminal Sequences Necessary for Ras-Raf Interaction and Signal Transduction. Molecular and Cellular Biology 15:1, pages 398-406.
Read now
Michael L. Samuels & Martin McMahon. (1994) Inhibition of Platelet-Derived Growth Factor- and Epidermal Growth Factor-Mediated Mitogenesis and Signaling in 3T3 Cells Expressing ARaf-1:ER, an Estradiol-Regulated Form of Raf-1†. Molecular and Cellular Biology 14:12, pages 7855-7866.
Read now
John R. Fabian, Ira O. Darr & Deborah K. Morrison. (1993) Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase. Molecular and Cellular Biology 13:11, pages 7170-7179.
Read now
Michael L. Samuels, Michael J. Weber, J. Michael Bishop & Martin McMahon. (1993) Conditional Transformation of Cells and Rapid Activation of the Mitogen-Activated Protein Kinase Cascade by An Estradiol-Dependent Human Raf-1 Protein Kinase. Molecular and Cellular Biology 13:10, pages 6241-6252.
Read now
Robert M. Stephens, Gunamani Sithanandam, Terry D. Copeland, David R. Kaplan, Ulf R. Rapp & Deborah K. Morrison. (1992) 95-Kilodalton B-Raf Serine/Threonine Kinase: Identification of the Protein and Its Major Autophosphorylation Site. Molecular and Cellular Biology 12:9, pages 3733-3742.
Read now
Harald App, Rachel Hazan, Asher Zilberstein, Axel Ullrich, Joseph Schlessinger & Ulf Rapp. (1991) Epidermal Growth Factor (EGF) Stimulates Association and Kinase Activity of Raf-1 with the EGF Receptor. Molecular and Cellular Biology 11:2, pages 913-919.
Read now
Mark R. Smith, Gisela Heidecker, Ulf R. Rapp & Hsiang-Fu Kung. (1990) Induction of Transformation and DNA Synthesis after Microinjection of raf Proteins. Molecular and Cellular Biology 10:7, pages 3828-3833.
Read now
T. W. Beck, U. Brennscheidt, G. Sithanandam, J. Cleveland & U. R. Rapp. (1990) Molecular Organization of the Human Raf-1 Promoter Region. Molecular and Cellular Biology 10:7, pages 3325-3333.
Read now
G. Heidecker, M. Huleihel, J. L. Cleveland, W. Kolch, T. W. Beck, P. Lloyd, T. Pawson & U. R. Rapp. (1990) Mutational Activation of c-raf-1 and Definition of the Minimal Transforming Sequence. Molecular and Cellular Biology 10:6, pages 2503-2512.
Read now
Vincent P. Stanton$suffix/text()$suffix/text(), David W. Nichols, Andrew P. Laudano & Geoffrey M. Cooper. (1989) Definition of the Human raf Amino-Terminal Regulatory Region by Deletion Mutagenesis. Molecular and Cellular Biology 9:2, pages 639-647.
Read now

Articles from other publishers (5)

Zixi Wang, Yurou Xing, Bingjie Li, Xiaoyu Li, Bin Liu & Yongsheng Wang. (2022) Molecular pathways, resistance mechanisms and targeted interventions in non-small-cell lung cancer. Molecular Biomedicine 3:1.
Crossref
Jingtong Zhao & Zhijun Luo. (2022) Discovery of Raf Family Is a Milestone in Deciphering the Ras-Mediated Intracellular Signaling Pathway. International Journal of Molecular Sciences 23:9, pages 5158.
Crossref
Joshua Abd Alla & Ursula Quitterer. (2022) The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart. Cells 11:4, pages 654.
Crossref
Letícia Martins Guimarães, Bruna Pizziolo Coura, Ricardo Santiago Gomez & Carolina Cavalieri Gomes. (2021) The Molecular Pathology of Odontogenic Tumors: Expanding the Spectrum of MAPK Pathway Driven Tumors. Frontiers in Oral Health 2.
Crossref
Richard E. CutlerJr.Jr., Robert M. Stephens, Misty R. Saracino & Deborah K. Morrison. (1998) Autoregulation of the Raf-1 serine/threonine kinase. Proceedings of the National Academy of Sciences 95:16, pages 9214-9219.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.