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Research Article

Identification of Upstream and Intragenic Regulatory Elements That Confer Cell-Type-Restricted and Differentiation-Specific Expression on the Muscle Creatine Kinase Gene

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Pages 2896-2909 | Received 31 Dec 1987, Accepted 28 Mar 1988, Published online: 31 Mar 2023

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Charis L. Himeda, Jeffrey A. Ranish & Stephen D. Hauschka. (2008) Quantitative Proteomic Identification of MAZ as a Transcriptional Regulator of Muscle-Specific Genes in Skeletal and Cardiac Myocytes . Molecular and Cellular Biology 28:20, pages 6521-6535.
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Ji Luo, Julie R. McMullen, Cassandra L. Sobkiw, Li Zhang, Adam L. Dorfman, Megan C. Sherwood, M. Nicole Logsdon, James W. Horner, Ronald A. DePinho, Seigo Izumo & Lewis C. Cantley. (2005) Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy. Molecular and Cellular Biology 25:21, pages 9491-9502.
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Charis L. Himeda, Jeffrey A. Ranish, John C. Angello, Pascal Maire, Ruedi Aebersold & Stephen D. Hauschka. (2004) Quantitative Proteomic Identification of Six4 as the Trex-Binding Factor in the Muscle Creatine Kinase Enhancer. Molecular and Cellular Biology 24:5, pages 2132-2143.
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W. Robb MacLellan, G. Xiao, M. Abdellatif & Michael D. Schneider. (2000) A Novel Rb- and p300-Binding Protein Inhibits Transactivation by MyoD. Molecular and Cellular Biology 20:23, pages 8903-8915.
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Madhu Gupta, Radovan Zak, Towia A. Libermann & Mahesh P. Gupta. (1998) Tissue-Restricted Expression of the Cardiac α-Myosin Heavy Chain Gene Is Controlled by a Downstream Repressor Element Containing a Palindrome of Two Ets-Binding Sites. Molecular and Cellular Biology 18:12, pages 7243-7258.
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Heather H. Shih, Sergei G. Tevosian & Amy S. Yee. (1998) Regulation of Differentiation by HBP1, a Target of the Retinoblastoma Protein. Molecular and Cellular Biology 18:8, pages 4732-4743.
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J.M. Reecy, C.A. Bidwell, O.M. Andrisani, D.E. Gerrard & A.L. Grant. (1998) Multiple regions of the porcine α‐skeletal actin gene modulate muscle‐specific expression in cell culture and directly injected skeletal muscle. Animal Biotechnology 9:2, pages 101-120.
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Stephen J. Miller, Erik Ulleras, Colin L. Moncrieff, Colum Walsh, Gail I.R. Adam & Gary C. Franklin. (1998) A Novel Type of Regulatory Element is Required for Promoter-specific Activity of the PDGF-B Intronic Enhancer Region. Growth Factors 16:2, pages 137-151.
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Mahesh P. Gupta, Chirag S. Amin, Madhu Gupta, Nissim Hay & Radovan Zak. (1997) Transcription Enhancer Factor 1 Interacts with a Basic Helix-Loop-Helix Zipper Protein, Max, for Positive Regulation of Cardiac α-Myosin Heavy-Chain Gene Expression. Molecular and Cellular Biology 17:7, pages 3924-3936.
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Youngsook Lee, Bernardo Nadal-Ginard, Vijak Mahdavi & Seigo Izumo. (1997) Myocyte-Specific Enhancer Factor 2 and Thyroid Hormone Receptor Associate and Synergistically Activate the α-Cardiac Myosin Heavy-Chain Gene. Molecular and Cellular Biology 17:5, pages 2745-2755.
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Margaret A. Shield, Harald S. Haugen, Christopher H. Clegg & Stephen D. Hauschka. (1996) E-Box Sites and a Proximal Regulatory Region of the Muscle Creatine Kinase Gene Differentially Regulate Expression in Diverse Skeletal Muscles and Cardiac Muscle of Transgenic Mice. Molecular and Cellular Biology 16:9, pages 5058-5068.
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Jeffery D. Molkentin, Anthony B. Firulli, Brian L. Black, James F. Martin, Carolyn M. Hustad, Neal Copeland, Nancy Jenkins, Gary Lyons & Eric N. Olson. (1996) MEF2B Is a Potent Transactivator Expressed in Early Myogenic Lineages. Molecular and Cellular Biology 16:7, pages 3814-3824.
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Dorit B. Donoviel, Margaret A. Shield, Jean N. Buskin, Harald S. Haugen, Christopher H. Clegg & Stephen D. Hauschka. (1996) Analysis of Muscle Creatine Kinase Gene Regulatory Elements in Skeletal and Cardiac Muscles of Transgenic Mice. Molecular and Cellular Biology 16:4, pages 1649-1658.
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Michael Peyton, Christine M. M. Stellrecht, Francisco J. Naya, Hsiang-Po Huang, Patrick J. Samora & Ming-Jer Tsai. (1996) BETA3, a Novel Helix-Loop-Helix Protein, Can Act as a Negative Regulator of BETA2 and MyoD-Responsive Genes. Molecular and Cellular Biology 16:2, pages 626-633.
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Elinor K. Shin, Alice Shin, Charles Paulding, Brian Schaffhausen & Amy S. Yee. (1995) Multiple Changes in E2F Function and Regulation Occur upon Muscle Differentiation. Molecular and Cellular Biology 15:4, pages 2252-2262.
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Sutip Navankasattusas, Michele Sawadogo, Marc Van Bilsen, Chi V. Dang & Kenneth R. Chien. (1994) The Basic Helix-Loop-Helix Protein Upstream Stimulating Factor Regulates the Cardiac Ventricular Myosin Light-Chain 2 Gene via Independent cis Regulatory Elements. Molecular and Cellular Biology 14:11, pages 7331-7339.
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Jumin Zhou & Eric N. Olson. (1994) Dimerization through the Helix-Loop-Helix Motif Enhances Phosphorylation of the Transcription Activation Domains of Myogenin. Molecular and Cellular Biology 14:9, pages 6232-6243.
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Jeffery D. Molkentin, Dhananjaya V. Kalvakolanu & Bruce E. Markham. (1994) Transcription Factor GATA-4 Regulates Cardiac Muscle-Specific Expression of the α-Myosin Heavy-Chain Gene. Molecular and Cellular Biology 14:7, pages 4947-4957.
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Michael S. Parmacek, Hon S. Ip, Frank Jung, Tingliang Shen, James F. Martin, Anuradha J. Vora, Eric N. Olson & Jeffrey M. Leiden. (1994) A Novel Myogenic Regulatory Circuit Controls Slow/Cardiac Troponin C Gene Transcription in Skeletal Muscle. Molecular and Cellular Biology 14:3, pages 1870-1885.
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R. F. Santerre, K. R. Bales, M. J. Janney, K. Hannon, L. F. Fisher, C. S. Bailey, J. Morris, R. Ivarie & C. K. Smith$suffix/text()$suffix/text(). (1993) Expression of Bovine myf5 Induces Ectopic Skeletal Muscle Formation in Transgenic Mice. Molecular and Cellular Biology 13:10, pages 6044-6051.
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Doris A. Taylor, Virginia B. Kraus, John J. Schwarz, Eric N. Olson & William E. Kraus. (1993) E1A-Mediated Inhibition of Myogenesis Correlates with a Direct Physical Interaction of E1A12S and Basic Helix-Loop-Helix Proteins. Molecular and Cellular Biology 13:8, pages 4714-4727.
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Sharon L. Amacher, Jean N. Buskin & Stephen D. Hauschka. (1993) Multiple Regulatory Elements Contribute Differentially to Muscle Creatine Kinase Enhancer Activity in Skeletal and Cardiac Muscle. Molecular and Cellular Biology 13:5, pages 2753-2764.
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Christopher K. Vincent, Antonio Gualberto, Chandrashekhar V. Patel & Kenneth Walsh. (1993) Different Regulatory Sequences Control Creatine Kinase-M Gene Expression in Directly Injected Skeletal and Cardiac Muscle. Molecular and Cellular Biology 13:2, pages 1264-1272.
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Laura A. Johnston, Stephen J. Tapscott & Harvey Eisen. (1992) Sodium Butyrate Inhibits Myogenesis by Interfering with the Transcriptional Activation Function of MyoD and Myogenin. Molecular and Cellular Biology 12:11, pages 5123-5130.
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Diane G. Edmondson, Tse-Chang Cheng, Peter Cserjesi, Tushar Chakraborty & Eric N. Olson. (1992) Analysis of the Myogenin Promoter Reveals an Indirect Pathway for Positive Autoregulation Mediated by the Muscle-Specific Enhancer Factor MEF-2. Molecular and Cellular Biology 12:9, pages 3665-3677.
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Jing-Shan Hu, Eric N. Olson & Robert E. Kingston. (1992) HEB, a Helix-Loop-Helix Protein Related to E2A and ITF2 That Can Modulate the DNA-Binding Ability of Myogenic Regulatory Factors. Molecular and Cellular Biology 12:3, pages 1031-1042.
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John J. Schwarz, Tushar Chakraborty, James Martin, Jumin Zhou & Eric N. Olson. (1992) The Basic Region of Myogenin Cooperates with Two Transcription Activation Domains To Induce Muscle-Specific Transcription. Molecular and Cellular Biology 12:1, pages 266-275.
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Tushar Chakraborty & Eric N. Olson. (1991) Domains Outside of the DNA-Binding Domain Impart Target Gene Specificity to Myogenin and MRF4. Molecular and Cellular Biology 11:12, pages 6103-6108.
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Peter Cserjesi & Eric N. Olson. (1991) Myogenin Induces the Myocyte-Specific Enhancer Binding Factor MEF-2 Independently of Other Muscle-Specific Gene Products. Molecular and Cellular Biology 11:10, pages 4854-4862.
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Tushar Chakraborty, Thomas J. Brennan, Li Li, Diane Edmondson & Eric N. Olson. (1991) Inefficient Homooligomerization Contributes to the Dependence of Myogenin on E2A Products for Efficient DNA Binding. Molecular and Cellular Biology 11:7, pages 3633-3641.
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Germana Falcone, Stefano Alemà & Franco Tatò. (1991) Transcription of Muscle-Specific Genes Is Repressed by Reactivation of pp60v- in Postmitotic Quail Myotubes. Molecular and Cellular Biology 11:6, pages 3331-3338.
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Brent A. French, King-Lau Chow, Eric N. Olson & Robert J. Schwartz. (1991) Heterodimers of Myogenic Helix-Loop-Helix Regulatory Factors and E12 Bind a Complex Element Governing Myogenic Induction of the Avian Cardiac α-Actin Promoter. Molecular and Cellular Biology 11:5, pages 2439-2450.
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Hong Zhu, Arnold V. Garcia, Robert S. Ross, Sylvia M. Evans & Kenneth R. Chien. (1991) A Conserved 28-Base-Pair Element (HF-1) in the Rat Cardiac Myosin Light-Chain-2 Gene Confers Cardiac-Specific and α-Adrenergic-Inducible Expression in Cultured Neonatal Rat Myocardial Cells. Molecular and Cellular Biology 11:4, pages 2273-2281.
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Joshua R. Schultz, Terese Tansey, Linda Gremke & Robert V. Storti. (1991) A Muscle-Specific Intron Enhancer Required for Rescue of Indirect Flight Muscle and Jump Muscle Function Regulates Drosophila Tropomyosin I Gene Expression. Molecular and Cellular Biology 11:4, pages 1901-1911.
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  Ruoqian-Shen, Shyamal K. Goswami, Eduardo Mascareno, Ashok Kumar & M. A. Q. Siddiqui. (1991) Tissue-Specific Transcription of the Cardiac Myosin Light-Chain 2 Gene Is Regulated by an Upstream Repressor Element. Molecular and Cellular Biology 11:3, pages 1676-1685.
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Robert A. Horlick, Grace M. Hobson, James H. Patterson, Mark T. Mitchell & Pamela A. Benfield. (1990) Brain and Muscle Creatine Kinase Genes Contain Common TA-Rich Recognition Protein-Binding Regulatory Elements. Molecular and Cellular Biology 10:9, pages 4826-4836.
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Janet H. Mar & Charles P. Ordahl. (1990) M-CAT Binding Factor, a Novel trans-Acting Factor Governing Muscle-Specific Transcription. Molecular and Cellular Biology 10:8, pages 4271-4283.
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Katherine E. Yutzey, Simon J. Rhodes & Stephen F. Konieczny. (1990) Differential trans Activation Associated with the Muscle Regulatory Factors MyoD1, Myogenin, and MRF4. Molecular and Cellular Biology 10:8, pages 3934-3944.
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William Nikovits$suffix/text()$suffix/text(), Janet H. Mar & Charles P. Ordahl. (1990) Muscle-Specific Activity of the Skeletal Troponin I Promoter Requires Interaction between Upstream Regulatory Sequences and Elements Contained within the First Transcribed Exon. Molecular and Cellular Biology 10:7, pages 3468-3482.
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Henry J. Klamut, Suman B. Gangopadhyay, Ronald G. Worton & Peter N. Ray. (1990) Molecular and Functional Analysis of the Muscle-Specific Promoter Region of the Duchenne Muscular Dystrophy Gene. Molecular and Cellular Biology 10:1, pages 193-205.
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Robert L. Glaser & John T. Lis. (1990) Multiple, Compensatory Regulatory Elements Specify Spermatocyte- Specific Expression of the Drosophila melanogaster hsp26 Gene. Molecular and Cellular Biology 10:1, pages 131-137.
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Lani A. Gossett, David J. Kelvin, Edward A. Sternberg & Eric N. Olson. (1989) A New Myocyte-Specific Enhancer-Binding Factor That Recognizes a Conserved Element Associated with Multiple Muscle-Specific Genes. Molecular and Cellular Biology 9:11, pages 5022-5033.
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Jane E. Johnson, Barbara J. Wold & Stephen D. Hauschka. (1989) Muscle Creatine Kinase Sequence Elements Regulating Skeletal and Cardiac Muscle Expression in Transgenic Mice. Molecular and Cellular Biology 9:8, pages 3393-3399.
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Jean N. Buskin & Stephen D. Hauschka. (1989) Identification of a Myocyte Nuclear Factor That Binds to the Muscle-Specific Enhancer of the Mouse Muscle Creatine Kinase Gene. Molecular and Cellular Biology 9:6, pages 2627-2640.
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Robert A. Horlick & Pamela A. Benfield. (1989) The Upstream Muscle-Specific Enhancer of the Rat Muscle Creatine Kinase Gene Is Composed of Multiple Elements. Molecular and Cellular Biology 9:6, pages 2396-2413.
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Kenneth Walsh. (1989) Cross-Binding of Factors to Functionally Different Promoter Elements in c-fos and Skeletal Actin Genes. Molecular and Cellular Biology 9:5, pages 2191-2201.
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Katherine E. Yutzey, Robyn L. Kline & Stephen F. Konieczny. (1989) An Internal Regulatory Element Controls Troponin I Gene Expression. Molecular and Cellular Biology 9:4, pages 1397-1405.
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Edward A. Sternberg, Gwendolyn Spizz, Mary Ellen Perry & Eric N. Olson. (1989) A ras-Dependent Pathway Abolishes Activity of a Muscle-Specific Enhancer Upstream from the Muscle Creatine Kinase Gene. Molecular and Cellular Biology 9:2, pages 594-601.
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