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Molecular and Cellular Biology Volume 9, 1989 - Issue 5
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Cell Growth and Development

Alternative Forms of the BCR-ABL Oncogene Have Quantitatively Different Potencies for Stimulation of Immature Lymphoid Cells

Jami Mclaughlin1 Department of Microbiology and Molecular Biology Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California90024-1570
,
Erin Chianese1 Department of Microbiology and Molecular Biology Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California90024-1570;2 Howard Hughes Medical Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California90024-1570
&
Owen N. Witte1 Department of Microbiology and Molecular Biology Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California90024-1570;2 Howard Hughes Medical Institute, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California90024-1570
Pages 1866-1874 | Received 09 Nov 1988, Accepted 27 Jan 1989, Published online: 31 Mar 2023

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Ryan P. Million, Nari Harakawa, Sergei Roumiantsev, Lyuba Varticovski & Richard A. Van Etten. (2004) A Direct Binding Site for Grb2 Contributes to Transformation and Leukemogenesis by the Tel-Abl (ETV6-Abl) Tyrosine Kinase. Molecular and Cellular Biology 24:11, pages 4685-4695.
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Kevin S. Smith, Joon Whan Rhee & Michael L. Cleary. (2002) Transformation of Bone Marrow B-Cell Progenitors by E2A-HLF Requires Coexpression of BCL-2. Molecular and Cellular Biology 22:21, pages 7678-7687.
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Giuseppe Saglio, Fabrizio Pane, Giovanni Martinelli & Angelo Guerrasio. (1997) BCR/ABL Transcripts and Leukemia Phenotype: An Unsolved Puzzle. Leukemia & Lymphoma 26:3-4, pages 281-286.
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Marie-Chantal Léglise, Elisabeth Pluchon-riviére, GeneviÈVe Le Calvez, Jean-FranÇOis Abgrall, Christian Berthou, Claudie Autrand, Luc Sensebé, Denise Balcon & Anne-Marie Le Roux. (1996) Molecular Diagnosis and Follow Up in Myeloproliferative Syndromes and Acute Leukemias: Correlation Between Expression of Fusion Transcripts and Disease Progression in Chronic Myeloid Leukemia. Leukemia & Lymphoma 21:3-4, pages 187-199.
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Mark W. Renshaw, John R. McWhirter & Jean Y. J. Wang. (1995) The Human Leukemia Oncogene bcr-abl Abrogates the Anchorage Requirement but Not the Growth Factor Requirement for Proliferation. Molecular and Cellular Biology 15:3, pages 1286-1293.
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Yoshiro Maru, Kristi L. Peters, Daniel E. H. Afar, Masabumi Shibuya, Owen N. Witte & Thomas E. Smithgall. (1995) Tyrosine Phosphorylation of BCR by FPS/FES Protein-Tyrosine Kinases Induces Association of BCR with GRB-2/SOS. Molecular and Cellular Biology 15:2, pages 835-842.
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John R. McWhirter, Debora L. Galasso & Jean Y. J. Wang. (1993) A Coiled-Coil Oligomerization Domain of Bcr Is Essential for the Transforming Function of Bcr-Abl Oncoproteins. Molecular and Cellular Biology 13:12, pages 7587-7595.
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Kazuma Ohyashiki, Junko H. Ohyashiki & Keisuke Toyama. (1993) Therapy for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Possible Use of Interferon on the Basis of Some Novel Concepts. Leukemia & Lymphoma 9:1-2, pages 43-48.
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C. L. Sawyers. (1993) Molecular Consequences of the BCR-ABL Translocation in Chronic Myelogenous Leukemia. Leukemia & Lymphoma 11:sup2, pages 101-103.
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Ellen Freed & Tony Hunter. (1992) A 41-Kilodalton Protein Is a Potential Substrate for the p210 Protein-Tyrosine Kinase in Chronic Myelogenous Leukemia Cells. Molecular and Cellular Biology 12:3, pages 1312-1323.
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Michelle Kelliher, Amy Knott, Jami Mclaughlin, Owen N. Witte & Naomi Rosenberg. (1991) Differences in Oncogenic Potency but Not Target Cell Specificity Distinguish the Two Forms of the BCR/ABL Oncogene. Molecular and Cellular Biology 11:9, pages 4710-4716.
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Alexander J. Muller, Judy C. Young, Ann-Marie Pendergast, Mark Pondel, Nathaniel R. Landau, Dan R. Littman & Owen N. Witte. (1991) BCR First Exon Sequences Specifically Activate the BCR/ABL Tyrosine Kinase Oncogene of Philadelphia ChromosomePositive Human Leukemias. Molecular and Cellular Biology 11:4, pages 1785-1792.
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John R. Mcwhirter & Jean Y. J. Wang. (1991) Activation of Tyrosine Kinase and Microfilament-Binding Functions of c-abl by bcr Sequences in bcr/abl Fusion Proteins. Molecular and Cellular Biology 11:3, pages 1553-1565.
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Judy C. Young, Mikhail L. Gishizky & Owen N. Witte. (1991) Hyperexpression of Interleukin-7 Is Not Necessary or Sufficient for Transformation of a Pre-B Lymphoid Cell Line. Molecular and Cellular Biology 11:2, pages 854-863.
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Marieke von Lindern, Annemarie Poustka, Hans Lerach & Gerard Grosveld. (1990) The (6;9) Chromosome Translocation, Associated with a Specific Subtype of Acute Nonlymphocytic Leukemia, Leads to Aberrant Transcription of a Target Gene on 9q34. Molecular and Cellular Biology 10:8, pages 4016-4026.
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Elisabeth Paietta. (1990) Ambiguous Phenotypes In Acute Leukemia. Leukemia & Lymphoma 2:1-2, pages 17-33.
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Articles from other publishers (9)

Shawn P. Fessler, Naomi Rosenberg & Linda B. Baughn. (2011) SH2-Containing Inositol 5′-Phosphatase Inhibits Transformation of Abelson Murine Leukemia Virus. Journal of Virology 85:17, pages 9239-9242.
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Jami McLaughlin, Donghui ChengOded Singer, Rita U. Lukacs, Caius G. Radu, Inder M. Verma & Owen N. Witte. (2007) Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics. Proceedings of the National Academy of Sciences 104:51, pages 20501-20506.
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Brian J. SkaggsMercedes E. GorreAnn RyvkinMichael R. BurgessYongming XieYun HanEvangelia KomisopoulouLauren M. BrownJoseph A. LooElliot M. Landaw, Charles L. Sawyers & Thomas G. Graeber. (2006) Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants. Proceedings of the National Academy of Sciences 103:51, pages 19466-19471.
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Daniela M Dinulescu, Lisa J Wood, Lei Shen, Marc Loriaux, Christopher L Corless, Alec W Gross, Ruibao Ren, Michael W N Deininger & Brian J Druker. (2003) c-CBL is not required for leukemia induction by Bcr-Abl in mice. Oncogene 22:55, pages 8852-8860.
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Celine A. Mainville, Kalindi Parmar, Indira Unnikrishnan, Li Gong, Glen D. Raffel & Naomi Rosenberg. (2001) Temperature-Sensitive Transformation by an Abelson Virus Mutant Encoding an Altered SH2 Domain. Journal of Virology 75:4, pages 1816-1823.
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Young-Mi Lim, Stephane Wong, Gary Lau, Owen N. Witte & John Colicelli. (2000) BCR/ABL inhibition by an escort/phosphatase fusion protein. Proceedings of the National Academy of Sciences 97:22, pages 12233-12238.
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Jan Voss, Guido Posern, Jürgen R Hannemann, Leanne M Wiedemann, Ali G Turhan, Hélène Poirel, Olivier A Bernard, Knut Adermann, Christian Kardinal & Stephan M Feller. (2000) The leukaemic oncoproteins Bcr-Abl and Tel-Abl (ETV6/Abl) have altered substrate preferences and activate similar intracellular signalling pathways. Oncogene 19:13, pages 1684-1690.
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Paris A Skourides, Samanthi A Perera & Ruibao Ren. (1999) Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins. Oncogene 18:5, pages 1165-1176.
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Anne B. Satterthwaite, Hilde Cheroutre, Wasif N. Khan, Pascalis Sideras & Owen N. Witte. (1997) Btk dosage determines sensitivity to B cell antigen receptor cross-linking. Proceedings of the National Academy of Sciences 94:24, pages 13152-13157.
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