Advanced search
Publication Cover
Journal of Biomaterials Science, Polymer Edition Volume 21, 2010 - Issue 1
Submit an article Journal homepage
171
Views
53
CrossRef citations to date
0
Altmetric
Articles

Local Delivery of Tobramycin from Injectable Biodegradable Polyurethane Scaffolds

Andrea E. Hafeman Department of Chemical Engineering, 2301 Vanderbilt Place, VU Station B #351604, Vanderbilt University, Nashville, TN 37235, USA
,
Katarzyna J. Zienkiewicz Department of Chemical Engineering, 2301 Vanderbilt Place, VU Station B #351604, Vanderbilt University, Nashville, TN 37235, USA
,
Erin Carney Department of Pathology, Vanderbilt University, Nashville, TN 37232, USA
,
Brandon Litzner Department of Pathology, Vanderbilt University, Nashville, TN 37232, USA
,
Charles Stratton Department of Pathology, Vanderbilt University, Nashville, TN 37232, USA
,
Joseph C. Wenke US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
&
Scott A. Guelcher Department of Chemical Engineering, 2301 Vanderbilt Place, VU Station B #351604, Vanderbilt University, Nashville, TN 37235, USA
 show all
Pages 95-112 | Published online: 02 Apr 2012

Citations (53)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Caleb A. Ford & James E. Cassat. (2017) Advances in the local and targeted delivery of anti-infective agents for management of osteomyelitis. Expert Review of Anti-infective Therapy 15:9, pages 851-860.
Read now
Viviana Mouriño, Juan P Cattalini, Judith A Roether, Prachi Dubey, Ipsita Roy & Aldo R Boccaccini. (2013) Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering. Expert Opinion on Drug Delivery 10:10, pages 1353-1365.
Read now
Na Yan, Xuehui Zhang, Qing Cai, Xiaoping Yang, Xuegang Zhou, Bo Wang & Xuliang Deng. (2012) The Effects of Lactidyl/Glycolidyl Ratio and Molecular Weight of Poly(D,L -Lactide-co-Glycolide) on the Tetracycline Entrapment and Release Kinetics of Drug-Loaded Nanofibers. Journal of Biomaterials Science, Polymer Edition 23:8, pages 1005-1019.
Read now

Articles from other publishers (50)

David Wienen, Thomas Gries, Stuart L. Cooper & Daniel E. Heath. (2023) An overview of polyurethane biomaterials and their use in drug delivery. Journal of Controlled Release 363, pages 376-388.
Crossref
Chih-Yu Kuo, Tung-Yi Lin & Yi-Cheun Yeh. (2023) Hydrogel-Based Strategies for the Management of Osteomyelitis. ACS Biomaterials Science & Engineering 9:4, pages 1843-1861.
Crossref
Belén Olivares, Fabián A. Martínez, Marcelo Ezquer, Bernardo J. Morales, Ignacia Fuentes, Margarita Calvo & Paola R. Campodónico. (2022) Betaine-urea deep eutectic solvent improves imipenem antibiotic activity. Journal of Molecular Liquids 350, pages 118551.
Crossref
Viviana Mouriño. 2022. Tissue Engineering Using Ceramics and Polymers. Tissue Engineering Using Ceramics and Polymers 817 840 .
R. Rajakumari, Sabu Thomas & Nandakumar Kalarikkal. 2022. Encyclopedia of Materials: Plastics and Polymers. Encyclopedia of Materials: Plastics and Polymers 10 31 .
Sijing Jiang, Mohan Wang & Jiacai He. (2020) A review of biomimetic scaffolds for bone regeneration: Toward a cell‐free strategy. Bioengineering & Translational Medicine 6:2.
Crossref
Haolan Zhang, Hao Xiong, Wajiha Ahmed, Yuejun Yao, Shuqin Wang, Cunyi Fan & Changyou Gao. (2021) Reactive oxygen species-responsive and scavenging polyurethane nanoparticles for treatment of osteoarthritis in vivo. Chemical Engineering Journal 409, pages 128147.
Crossref
Stefanie M. Shiels, Nicole M. Sgromolo & Joseph C. Wenke. (2021) Negative pressure wound therapy does not diminish efficacy of topical antibiotic powder in a preclinical contaminated wound model. Bone & Joint Research 10:2, pages 149-155.
Crossref
Raquib Hasan, Abbey Wohlers, Jacob Shreffler, Pranothi Mulinti, Hunter Ostlie, Codi Schaper, Benjamin Brooks & Amanda Brooks. (2020) An Antibiotic-Releasing Bone Void Filling (ABVF) Putty for the Treatment of Osteomyelitis. Materials 13:22, pages 5080.
Crossref
Thomas J. Spoonmore, Caleb A. Ford, Jacob M. Curry, Scott A. Guelcher & James E. Cassat. (2020) Concurrent Local Delivery of Diflunisal Limits Bone Destruction but Fails To Improve Systemic Vancomycin Efficacy during Staphylococcus aureus Osteomyelitis. Antimicrobial Agents and Chemotherapy 64:7.
Crossref
Boris Bizet, Étienne Grau, Henri Cramail & José M. Asua. (2020) Water-based non-isocyanate polyurethane-ureas (NIPUUs). Polymer Chemistry 11:23, pages 3786-3799.
Crossref
Harry Kyriacou, Achi Kamaraj & Wasim S. Khan. (2020) Developments in Antibiotic-Eluting Scaffolds for the Treatment of Osteomyelitis. Applied Sciences 10:7, pages 2244.
Crossref
Leslie R. Pace, Zoe L. Harrison, Madison N. Brown, Warren O. Haggard & J. Amber Jennings. (2019) Characterization and Antibiofilm Activity of Mannitol–Chitosan-Blended Paste for Local Antibiotic Delivery System. Marine Drugs 17:9, pages 517.
Crossref
Marcus Hill, Richard N. Cunningham, Rania M. Hathout, Christopher Johnston, John G. Hardy & Marie E. Migaud. (2019) Formulation of Antimicrobial Tobramycin Loaded PLGA Nanoparticles via Complexation with AOT. Journal of Functional Biomaterials 10:2, pages 26.
Crossref
Ana Carmona-Ribeiro. (2018) Self-Assembled Antimicrobial Nanomaterials. International Journal of Environmental Research and Public Health 15:7, pages 1408.
Crossref
Michael Lowinger, Stephanie Barrett, Feng Zhang & Robert WilliamsIIIIII. (2018) Sustained Release Drug Delivery Applications of Polyurethanes. Pharmaceutics 10:2, pages 55.
Crossref
Qingxia Zhu, Xiaofei Li, Zhaobo Fan, Yanyi Xu, Hong Niu, Chao Li, Yu Dang, Zheng Huang, Yun Wang & Jianjun Guan. (2018) Biomimetic polyurethane/TiO2 nanocomposite scaffolds capable of promoting biomineralization and mesenchymal stem cell proliferation. Materials Science and Engineering: C 85, pages 79-87.
Crossref
M. Marzec, J. Kucińska-Lipka, I. Kalaszczyńska & H. Janik. (2017) Development of polyurethanes for bone repair. Materials Science and Engineering: C 80, pages 736-747.
Crossref
V. Chiono, S. Sartori, S. Calzone, M. Boffito, C. Tonda-Turo, C. Mattu, P. Gentile & G. Ciardelli. 2017. Science and Principles of Biodegradable and Bioresorbable Medical Polymers. Science and Principles of Biodegradable and Bioresorbable Medical Polymers 189 216 .
Zachary Jones, Amanda E. Brooks, Zachary Ferrell, David W. Grainger & Kristofer D. Sinclair. (2016) A resorbable antibiotic eluting bone void filler for periprosthetic joint infection prevention. Journal of Biomedical Materials Research Part B: Applied Biomaterials 104:8, pages 1632-1642.
Crossref
John R. Martin, Christopher E. Nelson, Mukesh K. Gupta, Fang Yu, Samantha M. Sarett, Kyle M. Hocking, Alonda C. Pollins, Lillian B. Nanney, Jeffrey M. Davidson, Scott A. Guelcher & Craig L. Duvall. (2016) Local Delivery of PHD2 siRNA from ROS‐Degradable Scaffolds to Promote Diabetic Wound Healing. Advanced Healthcare Materials 5:21, pages 2751-2757.
Crossref
David J. Tennent, Stefanie M. Shiels, Carlos J. Sanchez, Krista L. Niece, Kevin S. Akers, Daniel J. Stinner & Joseph C. Wenke. (2016) Time-Dependent Effectiveness of Locally Applied Vancomycin Powder in a Contaminated Traumatic Orthopaedic Wound Model. Journal of Orthopaedic Trauma 30:10, pages 531-537.
Crossref
Lucas Polo Fonseca, Rafael Bergamo Trinca & Maria Isabel Felisberti. (2016) Thermo-responsive polyurethane hydrogels based on poly(ethylene glycol) and poly(caprolactone): Physico-chemical and mechanical properties. Journal of Applied Polymer Science 133:25.
Crossref
David K. Dempsey, Hugh A. Benhardt & Elizabeth M. Cosgriff-Hernandez. 2015. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 6687 6711 .
S. Fernando, M. McEnery & S.A. Guelcher. 2016. Advances in Polyurethane Biomaterials. Advances in Polyurethane Biomaterials 481 501 .
M. Boffito, S. Sartori, C. Mattu & G. Ciardelli. 2016. Advances in Polyurethane Biomaterials. Advances in Polyurethane Biomaterials 387 416 .
L.-C. Xu & C.A. Siedlecki. 2016. Advances in Polyurethane Biomaterials. Advances in Polyurethane Biomaterials 247 284 .
Marián Parisi, Verónica E. Manzano, Sabrina Flor, María H. Lissarrague, Laura Ribba, Silvia Lucangioli, Norma B. D’Accorso & Silvia Goyanes. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 369 412 .
Jowan G. Penn-Barwell, Brett Baker & Joseph C. Wenke. (2015) Local Bismuth Thiols Potentiate Antibiotics and Reduce Infection in a Contaminated Open Fracture Model. Journal of Orthopaedic Trauma 29:2, pages e73-e78.
Crossref
Kate V Brown, J G Penn-Barwell, B C Rand & J C Wenke. (2014) Translational research to improve the treatment of severe extremity injuries. Journal of the Royal Army Medical Corps 160:2, pages 167-170.
Crossref
V. Mouriño, J.P. Cattalini, W. Li, A.R. Boccaccini & S. Lucangioli. 2014. Tissue Engineering Using Ceramics and Polymers. Tissue Engineering Using Ceramics and Polymers 648 675 .
Robert S. Moglia, Jennifer L. Robinson, Andrea D. Muschenborn, Tyler J. Touchet, Duncan J. Maitland & Elizabeth Cosgriff-Hernandez. (2014) Injectable polyMIPE scaffolds for soft tissue regeneration. Polymer 55:1, pages 426-434.
Crossref
Jonathan M. Page, Andrew J. Harmata & Scott A. Guelcher. (2013) Design and development of reactive injectable and settable polymeric biomaterials. Journal of Biomedical Materials Research Part A 101:12, pages 3630-3645.
Crossref
Carlos J. SanchezJr.Jr., Edna M. Prieto, Chad A. Krueger, Katarzyna J. Zienkiewicz, Desiree R. Romano, Catherine L. Ward, Kevin S. Akers, Scott A. Guelcher & Joseph C. Wenke. (2013) Effects of local delivery of d-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects. Biomaterials 34:30, pages 7533-7543.
Crossref
Qingqing Yao, Patcharakamon Nooeaid, Judith A. Roether, Yanming Dong, Qiqing Zhang & Aldo R. Boccaccini. (2013) Bioglass®-based scaffolds incorporating polycaprolactone and chitosan coatings for controlled vancomycin delivery. Ceramics International 39:7, pages 7517-7522.
Crossref
Jong Yuh Cherng, Ting Yi Hou, Mei Fen Shih, Herre Talsma & Wim E. Hennink. (2013) Polyurethane-based drug delivery systems. International Journal of Pharmaceutics 450:1-2, pages 145-162.
Crossref
Kevin J. Schreader, Ilker S. Bayer, Derek J. Milner, Eric Loth & Iwona Jasiuk. (2012) A polyurethane‐based nanocomposite biocompatible bone adhesive. Journal of Applied Polymer Science 127:6, pages 4974-4982.
Crossref
Pablo Christian Caracciolo, Cristina Sanz Pita, Gustavo Abel Abraham, José Alberto Méndez & Jordi Gironès Molera. (2012) Synthesis, characterization and applications of amphiphilic elastomeric polyurethane networks in drug delivery. Polymer Journal 45:3, pages 331-338.
Crossref
Qizhi Chen, Shuling Liang & George A. Thouas. (2013) Elastomeric biomaterials for tissue engineering. Progress in Polymer Science 38:3-4, pages 584-671.
Crossref
Ahmad Yari Khosroushahi, Hossein Naderi-Manesh, Hamid Yeganeh, Jaleh Barar & Yadollah Omidi. (2012) Novel water-soluble polyurethane nanomicelles for cancer chemotherapy: physicochemical characterization and cellular activities. Journal of Nanobiotechnology 10:1.
Crossref
Elizabeth J. Adolph, Andrea E. Hafeman, Jeffrey M. Davidson, Lillian B. Nanney & Scott A. Guelcher. (2011) Injectable polyurethane composite scaffolds delay wound contraction and support cellular infiltration and remodeling in rat excisional wounds. Journal of Biomedical Materials Research Part A 100A:2, pages 450-461.
Crossref
Wenshou Wang & Chun Wang. 2012. The Design and Manufacture of Medical Devices. The Design and Manufacture of Medical Devices 115 151 .
Ping Gao, Xin Nie, Meijuan Zou, Yijie Shi & Gang Cheng. (2011) Recent advances in materials for extended-release antibiotic delivery system. The Journal of Antibiotics 64:9, pages 625-634.
Crossref
Kate V. BrownBing LiTeja GudaDaniel S. PerrienScott A. GuelcherJoseph C. Wenke. (2011) Improving Bone Formation in a Rat Femur Segmental Defect by Controlling Bone Morphogenetic Protein-2 Release. Tissue Engineering Part A 17:13-14, pages 1735-1746.
Crossref
Christopher R. Rathbone, Jessica D. Cross, Kate V. Brown, Clinton K. Murray & Joseph C. Wenke. (2011) Effect of various concentrations of antibiotics on osteogenic cell viability and activity. Journal of Orthopaedic Research 29:7, pages 1070-1074.
Crossref
Devin M. Nelson, Priya R. Baraniak, Zuwei Ma, Jianjun Guan, N. Scott Mason & William R. Wagner. (2011) Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold. Pharmaceutical Research 28:6, pages 1282-1293.
Crossref
Maluta S. Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. Du Toit, Girish Modi, Dinesh Naidoo & Valence M. K. Ndesendo. (2011) A Review on Composite Liposomal Technologies for Specialized Drug Delivery. Journal of Drug Delivery 2011, pages 1-19.
Crossref
Davide Campoccia, Lucio Montanaro, Pietro Speziale & Carla Renata Arciola. (2010) Antibiotic-loaded biomaterials and the risks for the spread of antibiotic resistance following their prophylactic and therapeutic clinical use. Biomaterials 31:25, pages 6363-6377.
Crossref
Bing Li, Kate V. Brown, Joseph C. Wenke & Scott A. Guelcher. (2010) Sustained release of vancomycin from polyurethane scaffolds inhibits infection of bone wounds in a rat femoral segmental defect model. Journal of Controlled Release 145:3, pages 221-230.
Crossref
Toshitaka YoshiiAndrea E. HafemanJeffry S. NymanJavier M. EsparzaKenichi ShinomiyaDan M. SpenglerGregory R. MundyGloria E. GutierrezScott A. Guelcher. (2010) A Sustained Release of Lovastatin from Biodegradable, Elastomeric Polyurethane Scaffolds for Enhanced Bone Regeneration. Tissue Engineering Part A 16:7, pages 2369-2379.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.