Advanced search
Publication Cover
Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 27, 2005 - Issue 4
Submit an article Journal homepage
158
Views
55
CrossRef citations to date
0
Altmetric
Articles

Are gadolinium contrast agents suitable for gadolinium neutron capture therapy?

Gelsomina De StasioUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
Deepika RajeshUniversity of Wisconsin, Department of Human Oncology, Madison WI 53792, USA
,
Patrizia CasalboreIstituto di Biologia Cellulare, CNR, Viale Marx 15, I-00137 Roma, Italy
,
Matthew J. DanielsUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
Robert J. ErhardtUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
Bradley H. FrazerUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
Lisa M. WieseUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
Katherine L. RichterBob Jones UniversityGreenville, SC 29614, USA
,
Brandon R. SondereggerUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
Benjamin GilbertUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
Sebastien SchaubBiomedical Engineering LaboratoryPSE-A, Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland
,
Rachel J. CannaraUniversity of Wisconsin-Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton WI 53589, USA
,
John F. CrawfordHengelweg 37, CH-5303 Würenlingen, Switzerland
,
Mary K. GillesLawrence Berkeley National Laboratory1 Cyclotron Rd. MS 6-2100, Berkeley, CA 94720, USA
,
Tolek TyliszczakLawrence Berkeley National Laboratory1 Cyclotron Rd. MS 6-2100, Berkeley, CA 94720, USA
,
John F. FowlerUniversity of Wisconsin, Department of Human Oncology, Madison WI 53792, USA
,
Luigi M. LaroccaIstituto di Anatomia Patologica, Universita' Cattolica del Sacro Cuore, Largo A. Gemelli 8, I-00168 Roma, Italy
,
Steven P. HowardUniversity of Wisconsin, Department of Human Oncology, Madison WI 53792, USA
,
Delio MercantiIstituto di Neurobiologia e Medicina Molecolare, CNR, Viale Marx 15, 00137 Roma, Italy
,
Minesh P. MehtaUniversity of Wisconsin, Department of Human Oncology, Madison WI 53792, USA
&
Roberto PalliniIstituto di Neurochirurgia, Universita' Cattolica del Sacro Cuore, Largo A. Gemelli 8, I-00168 Roma, Italy
 show all
Pages 387-398 | Published online: 19 Jul 2013

Citations (55)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Linda S. Yasui, Christine Andorf, Linda Schneider, Thomas Kroc, Arlene Lennox & K. R. Saroja. (2008) Gadolinium neutron capture in glioblastoma multiforme cells. International Journal of Radiation Biology 84:12, pages 1130-1139.
Read now
Sayana R Thomas & Deepak Khuntia. (2007) Motexafin gadolinium injection for the treatment of brain metastases in patients with non-small cell lung cancer. International Journal of Nanomedicine 2:1, pages 79-87.
Read now

Articles from other publishers (53)

Reza Shamsabadi & Hamid Reza Baghani. (2023) Impact of gadolinium concentration and cell oxygen levels on radiobiological characteristics of gadolinium neutron capture therapy technique in brain tumor treatment. Radiological Physics and Technology.
Crossref
Andrew J. Hall, Amy G. Robertson, Robert W. Baker, Leila R. Hill & Louis M. Rendina. (2023) Significant cell uptake of Gd( iii )-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector . Chemical Communications 59:83, pages 12511-12514.
Crossref
Vladimir Kanygin, Alexander Zaboronok, Aleksandr Kichigin, Elena Petrova, Tatyana Guselnikova, Andrey Kozlov, Dmitriy Lukichev, Bryan J. Mathis & Sergey Taskaev. (2023) Gadolinium Neutron Capture Therapy for Cats and Dogs with Spontaneous Tumors Using Gd-DTPA. Veterinary Sciences 10:4, pages 274.
Crossref
Yen-Ho Lai, Chia-Yu Su, Hung-Wei Cheng, Chao-Yi Chu, Long-Bin Jeng, Chih-Sheng Chiang, Woei-Cherng Shyu & San-Yuan Chen. (2023) Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy. Nature Communications 14:1.
Crossref
Farshid Tabbakh, Narayan S. Hosmane, Suffian M. Tajudin, Amir-Hossein Ghorashi & Nader Morshedian. (2022) Using 157Gd doped carbon and 157GdF4 nanoparticles in proton-targeted therapy for effectiveness enhancement and thermal neutron reduction: a simulation study. Scientific Reports 12:1.
Crossref
Masud Golshani, Ali Asghar Mowlavi & Behnam Azadegan. (2022) Gadolinium neutron capture therapy: Calculation of 157Gd kerma factor and a dosimetry study using MCNP Monte Carlo code. Radiation Physics and Chemistry 197, pages 110155.
Crossref
Alberto Lanfranco, Diego Alberti, Stefano Parisotto, Polyssena Renzi, Valentin Lecomte, Simonetta Geninatti Crich & Annamaria Deagostino. (2022) Biotinylation of a MRI/Gd BNCT theranostic agent to access a novel tumour-targeted delivery system. Organic & Biomolecular Chemistry 20:26, pages 5342-5354.
Crossref
Zhiyong Zhang & Xiangyun Wang. (2021) Gadolinium delivery agents for neutron capture therapy. Chinese Science Bulletin 67:14, pages 1508-1516.
Crossref
Son Long Ho, Huan Yue, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Shuwen Liu, Sung-Wook Nam, Yongmin Chang & Gang Ho Lee. (2022) Gadolinium Neutron Capture Therapy (GdNCT) Agents from Molecular to Nano: Current Status and Perspectives. ACS Omega 7:3, pages 2533-2553.
Crossref
G. A. Kulabdullaev, A. A. Kim, G. A. Abdullaeva, G. T. Djuraeva, I. I. Sadikov, B. Kh. Yarmatov, M. I. Salimov, R. T. Kadirbekov, N. R. Kadirbekov & I. R. Mavlyanov. (2022) Studying the Accumulation of Gadolinium in Human Brain Glioma for Gadolinium-Neutron Capture Therapy. Bulletin of the Russian Academy of Sciences: Physics 85:12, pages 1445-1450.
Crossref
Masud Golshani, Behnam Azadegan & Ali Asghar Mowlavi. (2021) Microdosimetry calculations and estimation of the relative biological effectiveness of the low-energy electrons released during Gd neutron capture reaction. Radiation Physics and Chemistry 188, pages 109585.
Crossref
Amy G. Robertson & Louis M. Rendina. (2021) Gadolinium theranostics for the diagnosis and treatment of cancer. Chemical Society Reviews 50:7, pages 4231-4244.
Crossref
Andrew J. Hall, Amy G. Robertson, Leila R. Hill & Louis M. Rendina. (2021) Synthesis and tumour cell uptake studies of gadolinium(III)–phosphonium complexes. Scientific Reports 11:1.
Crossref
Okan Icten. 2021. Synthetic Inorganic Chemistry. Synthetic Inorganic Chemistry 279 340 .
Changyuan Qin, Xuan Hou, Thahomina Khan, Nobuhiro Nitta, Masashi Yanagawa, Yuriko Sakurai, Minoru Suzuki, Shin‐Ichiro Masunaga, Hiroki Tanaka, Yoshinori Sakurai, Hiroyuki Takahashi, Ichio Aoki, Hironobu Yanagie & Horacio Cabral. (2020) Enhanced MRI‐Guided Gadolinium (III) Neutron Capture Therapy by Polymeric Nanocarriers Promoting Tumor Accumulation and Intracellular Delivery. ChemNanoMat 6:3, pages 412-419.
Crossref
Son Long Ho, Garam Choi, Huan Yue, Hee-Kyung Kim, Ki-Hye Jung, Ji Ae Park, Mi Hyun Kim, Yong Jin Lee, Jung Young Kim, Xu Miao, Mohammad Yaseen Ahmad, Shanti Marasini, Adibehalsadat Ghazanfari, Shuwen Liu, Kwon-Seok Chae, Yongmin Chang & Gang Ho Lee. (2020) In vivo neutron capture therapy of cancer using ultrasmall gadolinium oxide nanoparticles with cancer-targeting ability . RSC Advances 10:2, pages 865-874.
Crossref
Masud Golshani, Ali Asghar Mowlavi & Behnam Azadegan. (2019) Computational assessment of the cellular dosimetry and microdosimetry of the gadolinium electrons released during neutron capture therapy. Biomedical Physics & Engineering Express 5:2, pages 025031.
Crossref
Mitra Safavi-Naeini, Andrew Chacon, Susanna Guatelli, Daniel R. Franklin, Keith Bambery, Marie-Claude Gregoire & Anatoly Rosenfeld. (2018) Opportunistic dose amplification for proton and carbon ion therapy via capture of internally generated thermal neutrons. Scientific Reports 8:1.
Crossref
Mohammad Yaseen Ahmad, Mohammad Wasi Ahmad, Hyunsil Cha, In‐Taek Oh, Tirusew Tegafaw, Xu Miao, Son Long Ho, Shanti Marasini, Adibehalsadat Ghazanfari, Huan Yue, Hun‐Kyu Ryeom, Jongmin Lee, Kwon Seok Chae, Yongmin Chang & Gang Ho Lee. (2018) Cyclic RGD‐Coated Ultrasmall Gd 2 O 3 Nanoparticles as Tumor‐Targeting Positive Magnetic Resonance Imaging Contrast Agents . European Journal of Inorganic Chemistry 2018:26, pages 3070-3079.
Crossref
Son Long Ho, Hyunsil Cha, In Taek Oh, Ki-Hye Jung, Mi Hyun Kim, Yong Jin Lee, Xu Miao, Tirusew Tegafaw, Mohammad Yaseen Ahmad, Kwon Seok Chae, Yongmin Chang & Gang Ho Lee. (2018) Magnetic resonance imaging, gadolinium neutron capture therapy, and tumor cell detection using ultrasmall Gd 2 O 3 nanoparticles coated with polyacrylic acid-rhodamine B as a multifunctional tumor theragnostic agent . RSC Advances 8:23, pages 12653-12665.
Crossref
Madleen Busse, Madeline S.A. Windsor, Alexander J. Tefay, Mingyue Kardashinsky, Jacob M. Fenton, Daniel E. Morrison, Hugh H. Harris & Louis M. Rendina. (2017) Tumor cell uptake and selectivity of gadolinium(III)-phosphonium complexes: The role of delocalisation at the phosphonium centre. Journal of Inorganic Biochemistry 177, pages 313-321.
Crossref
Rachel Delorme, Florence Taupin, Mélanie Flaender, Jean-Luc Ravanat, Christophe Champion, Mathieu Agelou & Hélène Elleaume. (2017) Comparison of gadolinium nanoparticles and molecular contrast agents for radiation therapy-enhancement. Medical Physics 44:11, pages 5949-5960.
Crossref
Peng Mi, Fang Wang, Nobuhiro Nishiyama & Horacio Cabral. (2017) Molecular Cancer Imaging with Polymeric Nanoassemblies: From Tumor Detection to Theranostics. Macromolecular Bioscience 17:1, pages 1600305.
Crossref
Yongmin Chang, Kwon Seok Chae & Gang Ho Lee. (2016) Gadolinium agents for theragnosis of malignant tumors. Bioinspired, Biomimetic and Nanobiomaterials 5:4, pages 167-170.
Crossref
Wenlong Xu, Xu Miao, In‐Taek Oh, Kwon Seok Chae, Hyunsil Cha, Yongmin Chang & Gang Ho Lee. (2016) Dextran‐Coated Ultrasmall Gd 2 O 3 Nanoparticles as Potential T 1 MRI Contrast Agent . ChemistrySelect 1:19, pages 6086-6091.
Crossref
Novriana Dewi, Peng Mi, Hironobu Yanagie, Yuriko Sakurai, Yasuyuki Morishita, Masashi Yanagawa, Takayuki Nakagawa, Atsuko Shinohara, Takehisa Matsukawa, Kazuhito Yokoyama, Horacio Cabral, Minoru Suzuki, Yoshinori Sakurai, Hiroki Tanaka, Koji Ono, Nobuhiro Nishiyama, Kazunori Kataoka & Hiroyuki Takahashi. (2015) In vivo evaluation of neutron capture therapy effectivity using calcium phosphate-based nanoparticles as Gd-DTPA delivery agent. Journal of Cancer Research and Clinical Oncology 142:4, pages 767-775.
Crossref
Peng Mi, Novriana Dewi, Hironobu Yanagie, Daisuke Kokuryo, Minoru Suzuki, Yoshinori Sakurai, Yanmin Li, Ichio Aoki, Koji Ono, Hiroyuki Takahashi, Horacio Cabral, Nobuhiro Nishiyama & Kazunori Kataoka. (2015) Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy. ACS Nano 9:6, pages 5913-5921.
Crossref
Md. Wasi Ahmad, Wenlong Xu, Sung June Kim, Jong Su Baeck, Yongmin Chang, Ji Eun Bae, Kwon Seok Chae, Ji Ae Park, Tae Jeong Kim & Gang Ho Lee. (2015) Potential dual imaging nanoparticle: Gd2O3 nanoparticle. Scientific Reports 5:1.
Crossref
Paolo Boggio, Antonio Toppino, Simonetta Geninatti Crich, Diego Alberti, Domenica Marabello, Claudio Medana, Cristina Prandi, Paolo Venturello, Silvio Aime & Annamaria Deagostino. (2015) The hydroboration reaction as a key for a straightforward synthesis of new MRI-NCT agents. Organic & Biomolecular Chemistry 13:11, pages 3288-3297.
Crossref
Daniel E. Morrison, Jade B. Aitken, Martin D. de Jonge, Fatiah Issa, Hugh H. Harris & Louis M. Rendina. (2014) Synthesis and Biological Evaluation of a Class of Mitochondrially‐Targeted Gadolinium(III) Agents. Chemistry – A European Journal 20:50, pages 16602-16612.
Crossref
Markus Ziegner, Tobias Schmitz, Rustam Khan, Matthias Blaickner, Hugo Palmans, Peter Sharpe, Gabriele Hampel & Helmuth Böck. (2014) Confirmation of a realistic reactor model for BNCT dosimetry at the TRIGA Mainz. Medical Physics 41:11, pages 111706.
Crossref
Md. Wasi Ahmad, Cho Rong Kim, Jong Su Baeck, Yongmin Chang, Tae Jeong Kim, Ji Eun Bae, Kwon Seok Chae & Gang Ho Lee. (2014) Bovine serum albumin (BSA) and cleaved-BSA conjugated ultrasmall Gd2O3 nanoparticles: Synthesis, characterization, and application to MRI contrast agents. Colloids and Surfaces A: Physicochemical and Engineering Aspects 450, pages 67-75.
Crossref
Gang Ho Lee, Yongmin Chang & Tae-Jeong Kim. 2014. Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy. Ultrasmall Lanthanide Oxide Nanoparticles for Biomedical Imaging and Therapy 97 102 .
Shirin A. Enger, Valerio Giusti, Marc-André Fortin, Hans Lundqvist & Per Munck af Rosenschöld. (2013) Dosimetry for gadolinium neutron capture therapy (GdNCT). Radiation Measurements 59, pages 233-240.
Crossref
Novriana Dewi, Hironobu Yanagie, Haito Zhu, Kazuyuki Demachi, Atsuko Shinohara, Kazuhito Yokoyama, Masaki Sekino, Yuriko Sakurai, Yasuyuki Morishita, Naoko Iyomoto, Takeshi Nagasaki, Yukichi Horiguchi, Yukio Nagasaki, Jun Nakajima, Minoru Ono, Kazuhiro Kakimi & Hiroyuki Takahashi. (2013) Tumor growth suppression by gadolinium-neutron capture therapy using gadolinium-entrapped liposome as gadolinium delivery agent. Biomedicine & Pharmacotherapy 67:6, pages 451-457.
Crossref
Rémy Guillet-Nicolas, Myriam Laprise-Pelletier, Mahesh M. Nair, Pascale Chevallier, Jean Lagueux, Yves Gossuin, Sophie Laurent, Freddy Kleitz & Marc-André Fortin. (2013) Manganese-impregnated mesoporous silica nanoparticles for signal enhancement in MRI cell labelling studies. Nanoscale 5:23, pages 11499.
Crossref
F. Issa, J.A. Ioppolo & L.M. Rendina. 2013. Comprehensive Inorganic Chemistry II. Comprehensive Inorganic Chemistry II 877 900 .
Luc Faucher, Mélanie Tremblay, Jean Lagueux, Yves Gossuin & Marc-André Fortin. (2012) Rapid Synthesis of PEGylated Ultrasmall Gadolinium Oxide Nanoparticles for Cell Labeling and Tracking with MRI. ACS Applied Materials & Interfaces 4:9, pages 4506-4515.
Crossref
Loredana Marcu, Eva Bezak & Barry AllenLoredana Marcu, Eva Bezak & Barry Allen. 2012. Biomedical Physics in Radiotherapy for Cancer. Biomedical Physics in Radiotherapy for Cancer 345 368 .
Ellen L. Crossley, H. Y. Vincent Ching, Joseph A. Ioppolo & Louis M. Rendina. 2011. Bioinorganic Medicinal Chemistry. Bioinorganic Medicinal Chemistry 283 305 .
Heui Kyoung Cho, Hyun-Jong Cho, Saifullah Lone, Dae-Duk Kim, Jeong Hyun Yeum & In Woo Cheong. (2011) Preparation and characterization of MRI-active gadolinium nanocomposite particles for neutron capture therapy. Journal of Materials Chemistry 21:39, pages 15486.
Crossref
Luis Solorio, Ravi B Patel, Hanping Wu, Tianyi Krupka & Agata A Exner. (2010) Advances in image-guided intratumoral drug delivery techniques. Therapeutic Delivery 1:2, pages 307-322.
Crossref
Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris & Louis M. Rendina. (2010) Selective Aggregation of a Platinum–Gadolinium Complex Within a Tumor‐Cell Nucleus. Angewandte Chemie International Edition 49:7, pages 1231-1233.
Crossref
Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris & Louis M. Rendina. (2010) Selective Aggregation of a Platinum–Gadolinium Complex Within a Tumor‐Cell Nucleus. Angewandte Chemie 122:7, pages 1253-1255.
Crossref
Zhang Xiang-Zhi, Xu Zi-Jian, Zhen Xiang-Jun, Wang Yong, Guo Zhi, Yan Rui, Chang Rui, Zhou Ran-Ran & Tai Ren-Zhong. (2010) Soft X-ray spectromicroscopy dual-energy contrast image for element spatial distribution analysis. Acta Physica Sinica 59:7, pages 4535.
Crossref
Sanaz A. Jansen, Tatjana Paunesku, Xiaobing Fan, Gayle E. Woloschak, Stefan Vogt, Suzanne D. Conzen, Thomas Krausz, Gillian M. Newstead & Gregory S. Karczmar. (2009) Ductal Carcinoma in Situ: X-ray Fluorescence Microscopy and Dynamic Contrast-enhanced MR Imaging Reveals Gadolinium Uptake within Neoplastic Mammary Ducts in a Murine Model. Radiology 253:2, pages 399-406.
Crossref
Igor N. Pronin, Kathleen A. McManus, Andrei I. Holodny, Kyung K. Peck & Valeri N. Kornienko. (2009) Quantification of dispersion of Gd-DTPA from the initial area of enhancement into the peritumoral zone of edema in brain tumors. Journal of Neuro-Oncology 94:3, pages 399-408.
Crossref
Basetti Madhu, Simon P. Robinson, Franklyn A. Howe & John R. Griffiths. (2008) Effect of Gd‐DTPA‐BMA on choline signals of HT29 tumors detected by in vivo 1 H MRS . Journal of Magnetic Resonance Imaging 28:5, pages 1201-1208.
Crossref
M. L. Shmatov. (2008) The possibility of using antiproton annihilation on uranium and thorium nuclei for killing cancer cells. Technical Physics Letters 34:4, pages 335-337.
Crossref
Parvesh Sharma, Scott C. Brown, Glenn Walter, Swadeshmukul Santra, Edward Scott, Hideki Ichikawa, Yoshinobu Fukumori & Brij M. Moudgil. (2007) Gd nanoparticulates: from magnetic resonance imaging to neutron capture therapy. Advanced Powder Technology 18:6, pages 663-698.
Crossref
Gelsomina De Stasio, Deepika Rajesh, Judith M. Ford, Matthew J. Daniels, Robert J. Erhardt, Bradley H. Frazer, Tolek Tyliszczak, Mary K. Gilles, Robert L. Conhaim, Steven P. Howard, John F. Fowler, François Estève & Minesh P. Mehta. (2006) Motexafin-Gadolinium Taken Up In vitro by at Least 90% of Glioblastoma Cell Nuclei . Clinical Cancer Research 12:1, pages 206-213.
Crossref
Minesh P. Mehta. 2006. Multimodal Concepts for Integration of Cytotoxic Drugs. Multimodal Concepts for Integration of Cytotoxic Drugs 139 149 .
Hideki Ichikawa, Hiroyuki Tokumitsu, Masahito Miyamoto & Yoshinobu Fukumori. 2007. Nanotechnologies for the Life Sciences. Nanotechnologies for the Life Sciences.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.