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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 28, 2006 - Issue 3: Multiple Sclerosis
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Articles

The role of CD8+ T-cells in lesion formation and axonal dysfunction in multiple sclerosis

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Pages 256-261 | Published online: 19 Jul 2013

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Mark D. Mannie & Alan D. Curtis, II. (2013) Tolerogenic vaccines for Multiple Sclerosis. Human Vaccines & Immunotherapeutics 9:5, pages 1032-1038.
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Alireza Minagar. (2006) Multiple sclerosis: current knowledge and future directions. Neurological Research 28:3, pages 227-229.
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Cole D. Libner, Hannah E. Salapa & Michael C. Levin. (2020) The Potential Contribution of Dysfunctional RNA-Binding Proteins to the Pathogenesis of Neurodegeneration in Multiple Sclerosis and Relevant Models. International Journal of Molecular Sciences 21:13, pages 4571.
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Courtney S. Malo, Roman H. Khadka, Katayoun Ayasoufi, Fang Jin, Jackson E. AbouChehade, Michael J. Hansen, Raymond Iezzi, Kevin D. Pavelko & Aaron J. Johnson. (2018) Immunomodulation Mediated by Anti-angiogenic Therapy Improves CD8 T Cell Immunity Against Experimental Glioma. Frontiers in Oncology 8.
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April M. Huseby Kelcher, Pascal A. Atanga, Jeffrey D. Gamez, Luz M. Cumba Garcia, Stephanie J. Teclaw, Kevin D. Pavelko, Slobodan I. Macura & Aaron J. Johnson. (2017) Brain atrophy in picornavirus‐infected FVB mice is dependent on the H‐2D b class I molecule . The FASEB Journal 31:6, pages 2267-2275.
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Peter A. Morawski, Chen-Feng Qi & Silvia Bolland. (2017) Non-pathogenic tissue-resident CD8+ T cells uniquely accumulate in the brains of lupus-prone mice. Scientific Reports 7:1.
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Maureen H. Richards, Srinivas D. Narasipura, Stephanie Kim, Melanie S. Seaton, Victoria Lutgen & Lena Al-Harthi. (2015) Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS. Glia 63:3, pages 441-451.
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Holly L. Johnson, Robin C. Willenbring, Fang Jin, Whitney A. Manhart, Stephanie J. LaFrance, Istvan Pirko & Aaron J. Johnson. (2014) Perforin Competent CD8 T Cells Are Sufficient to Cause Immune-Mediated Blood-Brain Barrier Disruption. PLoS ONE 9:10, pages e111401.
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Marta Tejera-Alhambra, Armanda Casrouge, Clara de Andr?s, Roc?o Ramos-Medina, B?rbara Alonso, Janet Vega, Matthew L. Albert & Silvia S?nchez-Ram?n. (2014) Low DPP4 expression and activity in multiple sclerosis. Clinical Immunology 150:2, pages 170-183.
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Jinjong Myoung, Hyun Seok Kang, Wanqiu Hou, Liping Meng, Mauro C. Dal Canto & Byung S. Kim. (2012) Epitope-Specific CD8 + T Cells Play a Differential Pathogenic Role in the Development of a Viral Disease Model for Multiple Sclerosis . Journal of Virology 86:24, pages 13717-13728.
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Holly L. Johnson, Yi Chen, Fang Jin, Lisa M. Hanson, Jeffrey D. Gamez, Istvan Pirko & Aaron J. Johnson. (2012) CD8 T Cell-Initiated Blood–Brain Barrier Disruption Is Independent of Neutrophil Support. The Journal of Immunology 189:4, pages 1937-1945.
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Jorg J. A. Calis, Rob J. de Boer & Can Ke?mir. (2012) Degenerate T-cell Recognition of Peptides on MHC Molecules Creates Large Holes in the T-cell Repertoire. PLoS Computational Biology 8:3, pages e1002412.
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Istvan Pirko, Yi Chen, Anne K. Lohrey, Jeremiah McDole, Jeffrey D. Gamez, Kathleen S. Allen, Kevin D. Pavelko, Diana M. Lindquist, R. Scott Dunn, Slobodan I. Macura & Aaron J. Johnson. (2012) Contrasting Roles for CD4 vs. CD8 T-Cells in a Murine Model of Virally Induced ?T1 Black Hole? Formation. PLoS ONE 7:2, pages e31459.
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Shehzad Ali, Noman Paracha, Stuart Cook, Gavin Giovannoni, Giancarlo Comi, Kottil Rammohan, Peter Rieckmann, Per Soelberg Sørensen, Patrick Vermersch, Steven Greenberg, David A. Scott & Alexandre Joyeux. (2012) Reduction in Healthcare and Societal Resource Utilization Associated with Cladribine Tablets in Patients with Relapsing-Remitting Multiple Sclerosis. Clinical Drug Investigation 32:1, pages 15-27.
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Bharath Wootla, Makoto Eriguchi & Moses Rodriguez. (2012) Is Multiple Sclerosis an Autoimmune Disease?. Autoimmune Diseases 2012, pages 1-12.
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Ana L. Cardoso, Joana R. Guedes, Luís Pereira de Almeida & Maria C. Pedroso de Lima. (2011) miR‐155 modulates microglia‐mediated immune response by down‐regulating SOCS‐1 and promoting cytokine and nitric oxide production. Immunology 135:1, pages 73-88.
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Thomas P. Leist & Robert Weissert. (2011) Cladribine. Clinical Neuropharmacology 34:1, pages 28-35.
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Jeremiah R. McDole, Steve C. Danzer, Raymund Y.K. Pun, Yi Chen, Holly L. Johnson, Istvan Pirko & Aaron J. Johnson. (2010) Rapid Formation of Extended Processes and Engagement of Theiler's Virus-Infected Neurons by CNS-Infiltrating CD8 T Cells. The American Journal of Pathology 177:4, pages 1823-1833.
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Hans-Peter HartungBernd C. Kieseier. (2010) Atacicept: targeting B cells in multiple sclerosis. Therapeutic Advances in Neurological Disorders 3:4, pages 205-216.
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Sandra Amor, Fabiola Puentes, David Baker & Paul Van Der Valk. (2010) Inflammation in neurodegenerative diseases. Immunology 129:2, pages 154-169.
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Carol Aristimuño, Clara de Andrés, Manuel Bartolomé, Virginia de las Heras, Ma. Luisa Martínez-Ginés, Rafael Arroyo, Eduardo Fernández-Cruz & Silvia Sánchez-Ramón. (2010) IFNβ-1a therapy for multiple sclerosis expands regulatory CD8+ T cells and decreases memory CD8+ subset: A longitudinal 1-year study. Clinical Immunology 134:2, pages 148-157.
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Georgette L. Suidan, Jonathan W. Dickerson, Yi Chen, Jeremiah R. McDole, Pulak Tripathi, Istvan Pirko, Kim B. Seroogy & Aaron J. Johnson. (2010) CD8 T Cell-Initiated Vascular Endothelial Growth Factor Expression Promotes Central Nervous System Vascular Permeability under Neuroinflammatory Conditions. The Journal of Immunology 184:2, pages 1031-1040.
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H.-P. Hartung. (2009) Atacicept bei Multipler SkleroseAtacicept: a new B lymphocyte-targeted therapy for multiple sclerosis. Der Nervenarzt 80:12, pages 1462-1472.
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Nalini Kumar Vudattu, Sharon Kuhlmann-Berenzon, Mohsen Khademi, Vicki Seyfert, Thomas Olsson & Markus J. Maeurer. (2009) Increased Numbers of IL-7 Receptor Molecules on CD4+CD25−CD107a+ T-Cells in Patients with Autoimmune Diseases Affecting the Central Nervous System. PLoS ONE 4:8, pages e6534.
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Anita Schildknecht, Hans Christian Probst, Kathy D. McCoy, Iris Miescher, Corinne Brenner, Dino P. Leone, Ueli Suter, Pamela S. Ohashi & Maries van den Broek. (2009) Antigens expressed by myelinating glia cells induce peripheral cross‐tolerance of endogenous CD8 + T cells . European Journal of Immunology 39:6, pages 1505-1515.
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W.A. Roscoe, M.E. Welsh, D.E. Carter & S.J. Karlik. (2009) VEGF and angiogenesis in acute and chronic MOG(35–55) peptide induced EAE. Journal of Neuroimmunology 209:1-2, pages 6-15.
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Georgette L. Suidan, Jeremiah R. Mcdole, Yi Chen, Istvan Pirko & Aaron J. Johnson. (2008) Induction of Blood Brain Barrier Tight Junction Protein Alterations by CD8 T Cells. PLoS ONE 3:8, pages e3037.
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Laureline Berthelot, David‐Axel Laplaud, Ségolène Pettré, Caroline Ballet, Laure Michel, Sophie Hillion, Cécile Braudeau, Francine Connan, Fabienne Lefrère, Sandrine Wiertlewski, Jean‐Gérard Guillet, Sophie Brouard, Jeannine Choppin & Jean‐Paul Soulillou. (2008) Blood CD8 + T cell responses against myelin determinants in multiple sclerosis and healthy individuals . European Journal of Immunology 38:7, pages 1889-1899.
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Pamela A. Carpentier, Meghann Teague Getts & Stephen D. Miller. (2008) Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease. Virology 375:1, pages 24-36.
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RuiRong Yuan, Yasuhiro Maeda, Weiping Li, Wei Lu, Stuart Cook & Peter Dowling. (2008) Erythropoietin: A Potent Inducer of Peripheral Immuno/Inflammatory Modulation in Autoimmune EAE. PLoS ONE 3:4, pages e1924.
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Istvan Pirko, Tifany K. Nolan, Scott K. Holland & Aaron J. Johnson. (2008) Multiple Sclerosis: Pathogenesis and MR Imaging Features of T1 Hypointensities in Murine Model. Radiology 246:3, pages 790-795.
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Mohanpal Singh Dulai, Christopher Y. Park, William D. Howell, Lawrence T. Smyth, Mayuri Desai, Diane M. Carter & Hannes Vogel. (2008) CNS T-cell lymphoma: an under-recognized entity?. Acta Neuropathologica 115:3, pages 345-356.
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Amanda L. Martin, Matthew D. Schwartz, Stephen C. Jameson & Yoji Shimizu. (2008) Selective Regulation of CD8 Effector T Cell Migration by the p110γ Isoform of Phosphatidylinositol 3-Kinase. The Journal of Immunology 180:4, pages 2081-2088.
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Irene Cortese & Henry F. McFarland. 2008. Clinical Immunology. Clinical Immunology 963 975 .
Maria Nikodemova, Jyoti J. Watters, Samuel J. Jackson, Shaun K. Yang & Ian D. Duncan. (2007) Minocycline Down-regulates MHC II Expression in Microglia and Macrophages through Inhibition of IRF-1 and Protein Kinase C (PKC)α/βII. Journal of Biological Chemistry 282:20, pages 15208-15216.
Crossref
Prisca Schuler, Emmanuel Contassot & Bertrand Huard. (2007) T cell tolerance to the skin: a central role for central tolerance. Seminars in Immunopathology 29:1, pages 59-64.
Crossref
Georges M. G. M. VerjansRogier Q. Hintzen, Jessica M. van Dun, Angelique PootJohannes C. Milikan, Jon D. LamanAnton W. LangerakPaul R. Kinchington & Albert D. M. E. Osterhaus. (2007) Selective retention of herpes simplex virus-specific T cells in latently infected human trigeminal ganglia. Proceedings of the National Academy of Sciences 104:9, pages 3496-3501.
Crossref
Fabrizio G. Mastronardi, D. Denise Wood, Jiang Mei, Reinout Raijmakers, Vivian Tseveleki, Hans-Michael Dosch, Lesley Probert, Patrizia Casaccia-Bonnefil & Mario A. Moscarello. (2006) Increased Citrullination of Histone H3 in Multiple Sclerosis Brain and Animal Models of Demyelination: A Role for Tumor Necrosis Factor-Induced Peptidylarginine Deiminase 4 Translocation. The Journal of Neuroscience 26:44, pages 11387-11396.
Crossref
Ingunn M Stromnes & Joan M Goverman. (2006) Active induction of experimental allergic encephalomyelitis. Nature Protocols 1:4, pages 1810-1819.
Crossref
Ingunn M Stromnes & Joan M Goverman. (2006) Passive induction of experimental allergic encephalomyelitis. Nature Protocols 1:4, pages 1952-1960.
Crossref

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