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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 32, 2010 - Issue 1: Neuromyology II
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Articles

Carnosine inhibits ATP production in cells from malignant glioma

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Pages 101-105 | Published online: 19 Jul 2013

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Hawraa Alsayed, Hussein Fakih, Alain Miranville & Ali Wehbe. (2023) On an optimal control problem describing lactate production inhibition. Applicable Analysis 102:6, pages 1711-1731.
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Guilherme Giannini Artioli, Craig Sale & Rebecca Louise Jones. (2019) Carnosine in health and disease. European Journal of Sport Science 19:1, pages 30-39.
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Ansgar Asperger, Christof Renner, Mandy Menzel, Rolf Gebhardt, Jürgen Meixensberger & Frank Gaunitz. (2011) Identification of Factors Involved in the Anti-Tumor Activity of Carnosine on Glioblastomas Using a Proteomics Approach. Cancer Investigation 29:4, pages 272-281.
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Articles from other publishers (56)

I. F. Bielenichev, N. A. Gorchakova, E. Yu. Doroshenko, I. B. Samura, V. P. Ryzhenko & N. V. Bukhtiiarova. (2023) Use of metabolites, metabolithotropic agents and nutritional supplements in sports and sports medicine: a modern view on the problem. Modern medical technology:4, pages 76-88.
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K. Habra, J. R. D. Pearson, P. Le Vu, C. Puig‐Saenz, M. J. Cripps, M. A. Khan, M. D. Turner, C. Sale & S. E. B. McArdle. (2023) Anticancer actions of carnosine in cellular models of prostate cancer. Journal of Cellular and Molecular Medicine.
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Jennifer Ose, Biljana Gigic, Stefanie Brezina, Tengda Lin, Anita R. Peoples, Pauline P. Schobert, Andreas Baierl, Eline van Roekel, Nivonirina Robinot, Audrey Gicquiau, David Achaintre, Augustin Scalbert, Fränzel J. B. van Duijnhoven, Andreana N. Holowatyj, Tanja Gumpenberger, Petra Schrotz-King, Alexis B. Ulrich, Arve Ulvik, Per-Magne Ueland, Matty P. Weijenberg, Nina Habermann, Pekka Keski-Rahkonen, Andrea Gsur, Dieuwertje E. Kok & Cornelia M. Ulrich. (2023) Higher Plasma Creatinine Is Associated with an Increased Risk of Death in Patients with Non-Metastatic Rectal but Not Colon Cancer: Results from an International Cohort Consortium. Cancers 15:13, pages 3391.
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Dhrubajyoti Majumdar, Amit Dubey, Aisha Tufail, Dipankar Sutradhar & Sourav Roy. (2023) Synthesis, spectroscopic investigation, molecular docking, ADME/T toxicity predictions, and DFT study of two trendy ortho vanillin-based scaffolds. Heliyon 9:6, pages e16057.
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Sudeep Kumar, Jonghwa Jin, Hyeon Young Park, Mi-Jin Kim, Jungwook Chin, Sungwoo Lee, Jina Kim, Jung-Guk Kim, Yeon-Kyung Choi & Keun-Gyu Park. (2022) DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation. Endocrinology and Metabolism 37:5, pages 800-809.
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Thomas N. Seyfried, Gabriel Arismendi-Morillo, Giulio Zuccoli, Derek C. Lee, Tomas Duraj, Ahmed M. Elsakka, Joseph C. Maroon, Purna Mukherjee, Linh Ta, Laura Shelton, Dominic D'Agostino, Michael Kiebish & Christos Chinopoulos. (2022) Metabolic management of microenvironment acidity in glioblastoma. Frontiers in Oncology 12.
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Xingfen Liu, Jixiang Song, Ruining Yang, Shao Su, Lei Zhang, Yanqin Huang & Quli Fan. (2022) Recent Advances of Biosensors Based on Split Aptamers in Biological Analysis: A Review. IEEE Sensors Journal 22:13, pages 12460-12472.
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Fabiola Cardoso Diniz, Alan Roger Hipkiss & Gustavo Costa Ferreira. (2022) The Potential Use of Carnosine in Diabetes and Other Afflictions Reported in Long COVID Patients. Frontiers in Neuroscience 16.
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M.S. Meenukutty, Arsha P. Mohan, V.G. Vidya & V.G. Viju Kumar. (2022) Synthesis, characterization, DFT analysis and docking studies of a novel Schiff base using 5-bromo salicylaldehyde and β-alanine. Heliyon 8:6, pages e09600.
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Henry Oppermann, Stefanie Elsel, Claudia Birkemeyer, Jürgen Meixensberger & Frank Gaunitz. (2021) Erythrocytes Prevent Degradation of Carnosine by Human Serum Carnosinase. International Journal of Molecular Sciences 22:23, pages 12802.
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Mark D. Turner, Craig Sale, A. Christopher Garner & Alan R. Hipkiss. (2021) Anti-cancer actions of carnosine and the restoration of normal cellular homeostasis. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:11, pages 119117.
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Thomas N. Seyfried & Christos Chinopoulos. (2021) Can the Mitochondrial Metabolic Theory Explain Better the Origin and Management of Cancer than Can the Somatic Mutation Theory?. Metabolites 11:9, pages 572.
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Ivana Jukić, Nikolina Kolobarić, Ana Stupin, Anita Matić, Nataša Kozina, Zrinka Mihaljević, Martina Mihalj, Petar Šušnjara, Marko Stupin, Željka Breškić Ćurić, Kristina Selthofer-Relatić, Aleksandar Kibel, Anamarija Lukinac, Luka Kolar, Gordana Kralik, Zlata Kralik, Aleksandar Széchenyi, Marija Jozanović, Olivera Galović, Martina Medvidović-Kosanović & Ines Drenjančević. (2021) Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation. Antioxidants 10:7, pages 1037.
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Yu-jia Fang, Ming Wu, Hai-ni Chen, Tian-tian Wen, Jian-xin Lyu & Yao Shen. (2020) Carnosine suppresses human glioma cells under normoxic and hypoxic conditions partly via inhibiting glutamine metabolism. Acta Pharmacologica Sinica 42:5, pages 767-779.
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Olga V. Kosmachevskaya, Natalia N. Novikova & Alexey F. Topunov. (2021) Carbonyl Stress in Red Blood Cells and Hemoglobin. Antioxidants 10:2, pages 253.
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Thomas N. Seyfried, Gabriel Arismendi-Morillo, Purna Mukherjee & Christos Chinopoulos. (2020) On the Origin of ATP Synthesis in Cancer. iScience 23:11, pages 101761.
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Marie-France Palin, Jérôme Lapointe, Claude Gariépy, Danièle Beaudry & Claudia Kalbe. (2020) Characterisation of intracellular molecular mechanisms modulated by carnosine in porcine myoblasts under basal and oxidative stress conditions. PLOS ONE 15:9, pages e0239496.
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Klaudia Chmielewska, Krystyna Dzierzbicka, Iwona Inkielewicz-Stępniak & Maja Przybyłowska. (2020) Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases. Chemical Research in Toxicology 33:7, pages 1561-1578.
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Henry Oppermann, Claudia Birkemeyer, Jürgen Meixensberger & Frank Gaunitz. (2019) Non‐enzymatic reaction of carnosine and glyceraldehyde‐3‐phosphate accompanies metabolic changes of the pentose phosphate pathway. Cell Proliferation 53:2.
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Geoffrey Burnstock. 2020. Glioma Signaling. Glioma Signaling 1 12 .
Jiao-yan Cheng, Jian-bo Yang, Yuan Liu, Min Xu, Yu-yan Huang, Jing-jing Zhang, Pei Cao, Jian-xin Lyu & Yao Shen. (2018) Profiling and targeting of cellular mitochondrial bioenergetics: inhibition of human gastric cancer cell growth by carnosine. Acta Pharmacologica Sinica 40:7, pages 938-948.
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Vitale Miceli, Mariangela Pampalone, Giovanna Frazziano, Giuseppe Grasso, Enrico Rizzarelli, Camillo Ricordi, Anna Casu, Gioacchin Iannolo & Pier Giulio Conaldi. (2018) Carnosine protects pancreatic beta cells and islets against oxidative stress damage. Molecular and Cellular Endocrinology 474, pages 105-118.
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Alan R. Hipkiss. (2018) Glycotoxins: Dietary and Metabolic Origins; Possible Amelioration of Neurotoxicity by Carnosine, with Special Reference to Parkinson’s Disease. Neurotoxicity Research 34:1, pages 164-172.
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Minghui Ding, Guihua Jiao, Haizhou Shi & Yanrong Chen. (2017) Investigations on in vitro anti-carcinogenic potential of l-carnosine in liver cancer cells. Cytotechnology 70:1, pages 163-167.
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Damian Strzemecki, Magdalena Guzowska & Paweł Grieb. (2017) Survival rates of homozygotic Tp53 knockout rats as a tool for preclinical assessment of cancer prevention and treatment. Cellular & Molecular Biology Letters 22:1.
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Sepideh Ketabi & Leila Rahmani. (2017) Carbon nanotube as a carrier in drug delivery system for carnosine dipeptide: A computer simulation study. Materials Science and Engineering: C 73, pages 173-181.
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Barbara Chiavarina, Marie-Julie Nokin, Justine Bellier, Florence Durieux, Noëlla Bletard, Félicie Sherer, Pierre Lovinfosse, Olivier Peulen, Laurine Verset, Romain Dehon, Pieter Demetter, Andrei Turtoi, Koji Uchida, Serge Goldman, Roland Hustinx, Philippe Delvenne, Vincent Castronovo & Akeila Bellahcène. (2017) Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer. International Journal of Molecular Sciences 18:1, pages 213.
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Alan R. Hipkiss. (2017) Depression, Diabetes and Dementia: Formaldehyde May Be a Common Causal Agent; Could Carnosine, a Pluripotent Peptide, Be Protective?. Aging and disease 8:2, pages 128.
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Alan R. Hipkiss. (2017) On the Relationship between Energy Metabolism, Proteostasis, Aging and Parkinson’s Disease: Possible Causative Role of Methylglyoxal and Alleviative Potential of Carnosine. Aging and disease 8:3, pages 334.
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Henry Oppermann, Lutz Schnabel, Jürgen Meixensberger & Frank Gaunitz. (2016) Pyruvate attenuates the anti-neoplastic effect of carnosine independently from oxidative phosphorylation. Oncotarget 7:52, pages 85848-85860.
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Henry Oppermann, Yonghong Ding, Jeevan Sharma, Mandy Berndt Paetz, Jürgen Meixensberger, Frank Gaunitz & Claudia Birkemeyer. (2016) Metabolic response of glioblastoma cells associated with glucose withdrawal and pyruvate substitution as revealed by GC-MS. Nutrition & Metabolism 13:1.
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Alan R. Hipkiss, Estifanos Baye & Barbora de Courten. (2016) Carnosine and the processes of ageing. Maturitas 93, pages 28-33.
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Muthuraman Pandurangan, Gansukh Enkhtaivan & Doo Hwan Kim. (2016) Therapeutic efficacy of natural dipeptide carnosine against human cervical carcinoma cells. Journal of Molecular Recognition 29:9, pages 426-435.
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Magdalena Kwolek-Mirek, Mateusz Molon, Pawel Kaszycki & Renata Zadrag-Tecza. (2016) l-carnosine enhanced reproductive potential of the Saccharomyces cerevisiae yeast growing on medium containing glucose as a source of carbon. Biogerontology 17:4, pages 737-747.
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Victoria I. Bunik, Garik Mkrtchyan, Aneta Grabarska, Henry Oppermann, Danilo Daloso, Wagner L. Araujo, Malgorzata Juszczak, Wojciech Rzeski, Lucien Bettendorff, Alisdair R. Fernie, Jürgen Meixensberger, Andrzej Stepulak & Frank Gaunitz. (2016) Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner. Oncotarget 7:18, pages 26400-26421.
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Estifanos Baye, Barbara Ukropcova, Jozef Ukropec, Alan Hipkiss, Giancarlo Aldini & Barbora de Courten. (2016) Physiological and therapeutic effects of carnosine on cardiometabolic risk and disease. Amino Acids 48:5, pages 1131-1149.
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Kian-Kai Cheng, Yuichi Akasaki, Emmanuelle Lecommandeur, Ross T. Lindsay, Steven Murfitt, Kenneth Walsh & Julian L. Griffin. (2014) Metabolomic Analysis of Akt1-Mediated Muscle Hypertrophy in Models of Diet-Induced Obesity and Age-Related Fat Accumulation. Journal of Proteome Research 14:1, pages 342-352.
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Thomas N. Seyfried, Roberto Flores, Angela M. Poff, Dominic P. D’Agostino & Purna Mukherjee. (2015) Metabolic therapy: A new paradigm for managing malignant brain cancer. Cancer Letters 356:2, pages 289-300.
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Zuzana Ditte, Peter Ditte, Martina Labudova, Veronika Simko, Filippo Iuliano, Miriam Zatovicova, Lucia Csaderova, Silvia Pastorekova & Jaromir Pastorek. (2014) Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts. BMC Cancer 14:1.
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Yao Shen, Jianbo Yang, Juan Li, Xiaojie Shi, Li Ouyang, Yueyang Tian & Jianxin Lu. (2014) Carnosine Inhibits the Proliferation of Human Gastric Cancer SGC-7901 Cells through Both of the Mitochondrial Respiration and Glycolysis Pathways. PLoS ONE 9:8, pages e104632.
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Yao Shen, Yueyang Tian, Jianbo Yang, Xiaojie Shi, Li Ouyang, Jieqiong Gao & Jianxin Lu. (2014) Dual effects of carnosine on energy metabolism of cultured cortical astrocytes under normal and ischemic conditions. Regulatory Peptides 192-193, pages 45-52.
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Alan R. Hipkiss. (2014) Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents. Neurobiology of Aging 35:6, pages 1469-1472.
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Ulrike Letzien, Henry Oppermann, Jürgen Meixensberger & Frank Gaunitz. (2014) The antineoplastic effect of carnosine is accompanied by induction of PDK4 and can be mimicked by l-histidine. Amino Acids 46:4, pages 1009-1019.
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Alan R. Hipkiss & Frank Gaunitz. (2013) Inhibition of tumour cell growth by carnosine: some possible mechanisms. Amino Acids 46:2, pages 327-337.
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Alan R Hipkiss, Stephanie P Cartwright, Clare Bromley, Stephane R Gross & Roslyn M Bill. (2013) Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?. Chemistry Central Journal 7:1.
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Geoffrey Burnstock & Francesco Di Virgilio. (2013) Purinergic signalling and cancer. Purinergic Signalling 9:4, pages 491-540.
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Craig Sale, Guilherme G. Artioli, Bruno Gualano, Bryan Saunders, Ruth M. Hobson & Roger C. Harris. (2013) Carnosine: from exercise performance to health. Amino Acids 44:6, pages 1477-1491.
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Geoffrey Burnstock. 2013. Glioma Signaling. Glioma Signaling 1 12 .
Yu. S. Rybakova & A. A. Boldyrev. (2012) Effect of Carnosine and Related Compounds on Proliferation of Cultured Rat Pheochromocytoma PC-12 Cells. Bulletin of Experimental Biology and Medicine 154:1, pages 136-140.
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Thomas N. Seyfried, Jeremy Marsh, Laura M. Shelton, Leanne C. Huysentruyt & Purna Mukherjee. (2012) Is the restricted ketogenic diet a viable alternative to the standard of care for managing malignant brain cancer?. Epilepsy Research 100:3, pages 310-326.
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Frank Gaunitz & Alan R. Hipkiss. (2012) Carnosine and cancer: a perspective. Amino Acids 43:1, pages 135-142.
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Thomas N. Seyfried. 2012. Cancer as a Metabolic Disease. Cancer as a Metabolic Disease 119 132 .
Barbara Iovine, Maria Luigia Iannella, Francesca Nocella, Maria Rosaria Pricolo & Maria Assunta Bevilacqua. (2012) Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS production. Cancer Letters 315:2, pages 122-128.
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Adriana S. Beltran, Angela Russo, Haydee Lara, Cheng Fan, Paul M. Lizardi & Pilar Blancafort. (2011) Suppression of Breast Tumor Growth and Metastasis by an Engineered Transcription Factor. PLoS ONE 6:9, pages e24595.
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Alan R. Hipkiss. (2011) Energy metabolism, proteotoxic stress and age-related dysfunction – Protection by carnosine. Molecular Aspects of Medicine 32:4-6, pages 267-278.
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Marios Kyriazis. (2010) Anti-ageing potential of carnosine: approaches toward successful ageing. Drug Discovery Today: Therapeutic Strategies 7:3-4, pages 45-49.
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