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Neurological Research
A Journal of Progress in Neurosurgery, Neurology and Neurosciences
Volume 32, 2010 - Issue 1: Neuromyology II
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Articles

Celastrol causes apoptosis and cell cycle arrest in rat glioma cells

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Pages 94-100 | Published online: 19 Jul 2013

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Minxue Lian, Xiaodong Zhang, Hui Wang, Hao Liu, Wei Chen & Shiwen Guo. (2014) Increased 8-hydroxydeoxyguanosine in high-grade gliomas is associated with activation of autophagy. International Journal of Neuroscience 124:12, pages 926-934.
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Ling Yuan, Congyan Liu, Yan Chen, Zhenhai Zhang, Lei Zhou & Ding Qu. (2013) Antitumor activity of tripterine via cell-penetrating peptide-coated nanostructured lipid carriers in a prostate cancer model. International Journal of Nanomedicine 8, pages 4339-4350.
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Articles from other publishers (48)

Linyu Xiao, Bingjie Zhou, Shi Luo, Lang Deng, Yuan Xue, Ling Zhang, Zhengwu Du, Peiwen Li, Li Wang, Bole Tian, Zhirong Zhang & Yingchun Zeng. (2022) Liposomal co-delivery system encapsulating celastrol and paclitaxel displays highly enhanced efficiency and low toxicity against pancreatic cancer. Journal of Drug Delivery Science and Technology 78, pages 103947.
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Zhong Chen, Zhong Zhuang, Chen Meng, Zhonghua Zhu, Yin Zhang & Zhao Zhang. (2022) Induction of the ER stress response in NRVMs is linked to cardiotoxicity caused by celastrol. Acta Biochimica et Biophysica Sinica 54:8, pages 1180-1192.
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Xing Zhang, Jing Zhou, Yongping Zhu, Yin Kwan Wong, Dandan Liu, Peng Gao, Qingsong Lin, Jianbin Zhang, Xiao Chen & Jigang Wang. (2022) Quantitative chemical proteomics reveals anti-cancer targets of Celastrol in HCT116 human colon cancer cells. Phytomedicine 101, pages 154096.
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J. Li, T. Zeng, S. Tang, M. Zhong, Q. Huang, X. Li & X. He. (2021) Medical ozone induces proliferation and migration inhibition through ROS accumulation and PI3K/AKT/NF-κB suppression in human liver cancer cells in vitro. Clinical and Translational Oncology 23:9, pages 1847-1856.
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Xue Bai, Rui-Jia Fu, Shuo Zhang, Shi-Jun Yue, Yan-Yan Chen, Ding-Qiao Xu & Yu-Ping Tang. (2021) Potential medicinal value of celastrol and its synthesized analogues for central nervous system diseases. Biomedicine & Pharmacotherapy 139, pages 111551.
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Kholod A. Elhasany, Sherine N. Khattab, Adnan A. Bekhit, Doaa M. Ragab, Mohammad A. Abdulkader, Amira Zaky, Maged W. Helmy, Hayam M.A. Ashour, Mohamed Teleb, Nesreen S. Haiba & Ahmed O. Elzoghby. (2020) Combination of magnetic targeting with synergistic inhibition of NF-κB and glutathione via micellar drug nanomedicine enhances its anti-tumor efficacy. European Journal of Pharmaceutics and Biopharmaceutics 155, pages 162-176.
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Solmaz Mohammadi, Reza Arefnezhad, Shahla Danaii & Mehdi Yousefi. (2020) New insights into the core Hippo signaling and biological macromolecules interactions in the biology of solid tumors. BioFactors 46:4, pages 514-530.
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Wei Hou, Bo Liu & Hongtao Xu. (2020) Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. European Journal of Medicinal Chemistry 189, pages 112081.
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Xihong Liu, Peiyuan Zhao, Xiujuan Wang, Lei Wang, Yingjun Zhu, Yadi Song & Wei Gao. (2019) Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. Journal of Experimental & Clinical Cancer Research 38:1.
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Gang Wang, Qi Xiao, Yao Wu, Ying‐jie Wei, Yue Jing, Xiang‐rong Cao & Zhu‐nan Gong. (2019) Design and synthesis of novel celastrol derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish. Journal of Cellular Physiology 234:9, pages 16431-16446.
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Lorena Avila-Carrasco, Pedro Majano, José Antonio Sánchez-Toméro, Rafael Selgas, Manuel López-Cabrera, Abelardo Aguilera & Guadalupe González Mateo. (2019) Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition. Frontiers in Pharmacology 10.
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Ming-Ju Hsieh, Che-Wei Wang, Jen-Tsun Lin, Yi-Ching Chuang, Yi-Ting Hsi, Yu-Sheng Lo, Chia-Chieh Lin & Mu-Kuan Chen. (2019) Celastrol, a plant-derived triterpene, induces cisplatin-resistance nasopharyngeal carcinoma cancer cell apoptosis though ERK1/2 and p38 MAPK signaling pathway. Phytomedicine 58, pages 152805.
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Kiran Rawat, Amit Shard, Manali Jadhav, Mayuri Gandhi, Prince Anand, Rituraj Purohit, Yogendra Padwad & Arun K. Sinha. (2019) Styryl-cinnamate hybrid inhibits glioma by alleviating translation, bioenergetics and other key cellular responses leading to apoptosis. Experimental Cell Research 375:1, pages 11-21.
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Shuren Wang, Kai Ma, Cuiqi Zhou, Yu Wang, Guanghui Hu, Lechuang Chen, Zhuo Li, Chenfei Hu, Qing Xu, Hongxia Zhu, Mei Liu & Ningzhi Xu. (2019) LKB1 and YAP phosphorylation play important roles in Celastrol-induced β-catenin degradation in colorectal cancer. Therapeutic Advances in Medical Oncology 11, pages 175883591984373.
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Elif Mertoğlu, Aslıhan Şengelen, Ezgi Kıyga & Evren Önay-Uçar. 2019. Heat Shock Proteins in Neuroscience. Heat Shock Proteins in Neuroscience 189 208 .
Huang Xiao-pei, Chen Ji-kuai, Wei Xue, Yi-Fan Dong, Lang Yan, Zhang Xiao-fang, Pan Ya-min, Chang Wen-jun & Zhu Jiang-bo. (2018) Systematic identification of Celastrol-binding proteins reveals that Shoc2 is inhibited by Celastrol. Bioscience Reports 38:6.
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Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Tapan Mukherjee & Anupam Bishayee. (2018) Molecular targets of celastrol in cancer: Recent trends and advancements. Critical Reviews in Oncology/Hematology 128, pages 70-81.
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Nur S. Amirruddin, Alan P. Kumar, Adrian K.K. Teo & Gautam Sethi. 2018. Role of Nutraceuticals in Chemoresistance to Cancer. Role of Nutraceuticals in Chemoresistance to Cancer 141 150 .
Manoj K. Pandey, Subash C. Gupta, Ali Nabavizadeh & Bharat B. Aggarwal. (2017) Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment. Seminars in Cancer Biology 46, pages 158-181.
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Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo & Seong Jin Lee. (2017) Cytotoxic effect of celastrol alone or in combination with paclitaxel on anaplastic thyroid carcinoma cells. Tumor Biology 39:5, pages 101042831769836.
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Thomas Divya, Vadivel Dineshbabu, Syamala Soumyakrishnan, Anandasadagopan Sureshkumar & Ganapasam Sudhandiran. (2016) Celastrol enhances Nrf2 mediated antioxidant enzymes and exhibits anti-fibrotic effect through regulation of collagen production against bleomycin-induced pulmonary fibrosis. Chemico-Biological Interactions 246, pages 52-62.
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Lianjie Lin, Yan Sun, Dongxu Wang, Shihang Zheng, Jing Zhang & Changqing Zheng. (2016) Celastrol Ameliorates Ulcerative Colitis-Related Colorectal Cancer in Mice via Suppressing Inflammatory Responses and Epithelial-Mesenchymal Transition. Frontiers in Pharmacology 6.
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Zongwei Wang, Charlotta Dabrosin, Xin Yin, Mark M. Fuster, Alexandra Arreola, W. Kimryn Rathmell, Daniele Generali, Ganji P. Nagaraju, Bassel El-Rayes, Domenico Ribatti, Yi Charlie Chen, Kanya Honoki, Hiromasa Fujii, Alexandros G. Georgakilas, Somaira Nowsheen, Amedeo Amedei, Elena Niccolai, Amr Amin, S. Salman Ashraf, Bill Helferich, Xujuan Yang, Gunjan Guha, Dipita Bhakta, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Dorota Halicka, Sulma I. Mohammed, Asfar S. Azmi, Alan Bilsland, W. Nicol Keith & Lasse D. Jensen. (2015) Broad targeting of angiogenesis for cancer prevention and therapy. Seminars in Cancer Biology 35, pages S224-S243.
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Erik Niemelä, Diti Desai, Yves Nkizinkiko, John E. Eriksson & Jessica M. Rosenholm. (2015) Sugar-decorated mesoporous silica nanoparticles as delivery vehicles for the poorly soluble drug celastrol enables targeted induction of apoptosis in cancer cells. European Journal of Pharmaceutics and Biopharmaceutics 96, pages 11-21.
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Marco Lo Iacono, Valentina Monica, Tiziana Vavalà, Mara Gisabella, Silvia Saviozzi, Enrico Bracco, Silvia Novello, Mauro Papotti & Giorgio Vittorio Scagliotti. (2015) ATF2 contributes to cisplatin resistance in non-small cell lung cancer and celastrol induces cisplatin resensitization through inhibition of JNK/ATF2 pathway. International Journal of Cancer 136:11, pages 2598-2609.
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Pei-Pei Li, Wei He, Ping-Fan Yuan, Sha-Sha Song, Jing-Tao Lu & Wei Wei. (2015) Celastrol Induces Mitochondria-Mediated Apoptosis in Hepatocellular Carcinoma Bel-7402 Cells. The American Journal of Chinese Medicine 43:01, pages 137-148.
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Kaiyong Tang, Jinwen Huang, Junfang Pan, Xuan Zhang & Wei Lu. (2015) Design, synthesis and biological evaluation of C(6)-indole celastrol derivatives as potential antitumor agents. RSC Advances 5:25, pages 19620-19623.
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Andrew M. Fribley, Justin R. Miller, Amy L. Brownell, Danielle M. Garshott, Qinghua Zeng, Tyler E. Reist, Neha Narula, Peter Cai, Yue Xi, Michael U. Callaghan, Vamsi Kodali & Randal J. Kaufman. (2015) Celastrol induces unfolded protein response-dependent cell death in head and neck cancer. Experimental Cell Research 330:2, pages 412-422.
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Bin Peng, Xue Zhang, Fanfan Cao, Ying Wang, Limin Xu, Lu Cao, Chunxin Yang, Maoquan Li, Georges Uzan & Denghai Zhang. (2014) Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells. BMC Cancer 14:1.
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Xiaoxi Han, Shengkun Sun, Ming Zhao, Xiang Cheng, Guozhu Chen, Song Lin, Yifu Guan & Xiaodan Yu. (2014) Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis. PLoS ONE 9:11, pages e112470.
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S Boridy, P U Le, K Petrecca & D Maysinger. (2014) Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells. Cell Death & Disease 5:5, pages e1216-e1216.
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Yuan Liu, Guifeng Zhang, Lihong Deng, Jiandu Lei, Lianyan Wang & Jing He. (2014) Synthesis, characterization and adsorption performance of molecularly imprinted nanoparticles for tripterine by precipitation polymerization. Anal. Methods 6:3, pages 684-689.
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Mirela Matokanovic, Karmela Barisic, Jelena Filipovic-Grcic & Dusica Maysinger. (2013) Hsp70 silencing with siRNA in nanocarriers enhances cancer cell death induced by the inhibitor of Hsp90. European Journal of Pharmaceutical Sciences 50:1, pages 149-158.
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Hyereen Kang, Minjae Lee & Sung-Wuk Jang. (2013) Celastrol inhibits TGF-β1-induced epithelial–mesenchymal transition by inhibiting Snail and regulating E-cadherin expression. Biochemical and Biophysical Research Communications 437:4, pages 550-556.
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Panagiotis J. Vlachostergios, Ioannis A. Voutsadakis & Christos N. Papandreou. (2013) Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma. Cell Biology and Toxicology 29:4, pages 199-211.
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L Feng, D Zhang, C Fan, C Ma, W Yang, Y Meng, W Wu, S Guan, B Jiang, M Yang, X Liu & D Guo. (2013) ER stress-mediated apoptosis induced by celastrol in cancer cells and important role of glycogen synthase kinase-3β in the signal network. Cell Death & Disease 4:7, pages e715-e715.
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Chuanjiang Huang, Yinan Luo, Jingwei Zhao, Fuwei Yang, Hongwei Zhao, Wenhai Fan & Pengfei Ge. (2013) Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1. PLoS ONE 8:6, pages e66326.
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Haifeng Wang, Shuyan Zhang, Jiateng Zhong, Jizhou Zhang, Yinan Luo & Pengfei Ge. (2013) The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: An in vitro and in vivo study . Journal of International Medical Research 41:1, pages 72-81.
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Zengtao Xu, Guosheng Wu, Xu Wei, Xiuping Chen, Yitao Wang & Lidian Chen. (2013) Celastrol Induced DNA Damage, Cell Cycle Arrest, and Apoptosis in Human Rheumatoid Fibroblast-Like Synovial Cells. The American Journal of Chinese Medicine 41:03, pages 615-628.
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Wenzong Lu, Guangfeng Jia, Xiangyan Meng, Chen Zhao, Liang Zhang, Yumiao Ren, Haixian Pan & Yuan Ni. (2012) Beta-catenin mediates the apoptosis induction effect of celastrol in HT29 cells. Life Sciences 91:7-8, pages 279-283.
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Panagiotis J Vlachostergios, Ioannis A Voutsadakis & Christos N Papandreou. (2012) The ubiquitin-proteasome system in glioma cell cycle control. Cell Division 7:1, pages 18.
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Guozhu Chen, Xuhui Zhang, Ming Zhao, Yan Wang, Xiang Cheng, Di Wang, Yuanji Xu, Zhiyan Du & Xiaodan Yu. (2011) Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells. BMC Cancer 11:1.
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Lin-Li Zhou, Zhi-Xiu Lin, Kwok-Pui Fung, Christopher H.K. Cheng, Chun-Tao Che, Ming Zhao, Shi-Hua Wu & Zhong Zuo. (2011) Celastrol-induced apoptosis in human HaCaT keratinocytes involves the inhibition of NF-κB activity. European Journal of Pharmacology 670:2-3, pages 399-408.
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Haibo Mou, Yi Zheng, Peng Zhao, Hanying Bao, Weijia Fang & Nong Xu. (2011) Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways. Toxicology in Vitro 25:5, pages 1027-1032.
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Zi Liu, Liang Ma & Guang-Biao Zhou. (2011) The Main Anticancer Bullets of the Chinese Medicinal Herb, Thunder God Vine. Molecules 16:6, pages 5283-5297.
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Jingyuan Li, Xuemei Wang, Hui Jiang, Xiaohua Lu, Yudan Zhu & Baoan Chen. (2011) New strategy of photodynamic treatment of TiO2 nanofibers combined with celastrol for HepG2 proliferation in vitro. Nanoscale 3:8, pages 3115.
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Denghai Zhang, Limin Xu, Fanfan Cao, Tingxuan Wei, Chunxin Yang, Georges Uzan & Bin Peng. (2010) Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way. Cell Stress and Chaperones 15:6, pages 939-946.
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Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad & Bharat B. Aggarwal. (2010) Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer and Metastasis Reviews 29:3, pages 405-434.
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