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Hematology Volume 14, 2009 - Issue 3
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Cell Signalling

Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal

Satoru HaraLaboratory for Cell SignalingRIKEN Research Center for Allergy and Immunology, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Department of Clinical Cell Biology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-city, Chiba260-8670, Japan
,
Chiaki NakasekoDepartment of Clinical Cell BiologyChiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-city, Chiba260-8670, Japan
,
Sho YamasakiLaboratory for Cell SignalingRIKEN Research Center for Allergy and Immunology, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa230-0045, Japan
,
Masakazu HattoriDepartment of Immunology and Cell BiologyGraduate School of Medicine, Kyoto University, Kyoto606-8501, Japan
,
Johannes L. BosDepartment of Physiological Chemistry and Centre of Biomedical Genetics, University Medical Center Utrecht Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
,
Yasushi SaitoDepartment of Clinical Cell BiologyChiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba-city, Chiba260-8670, Japan
,
Nagahiro MinatoDepartment of Immunology and Cell BiologyGraduate School of Medicine, Kyoto University, Kyoto606-8501, Japan
&
Takashi SaitoLaboratory for Cell SignalingRIKEN Research Center for Allergy and Immunology, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa230-0045, Japan
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Pages 150-158 | Published online: 18 Jul 2013

Citations (10)

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Matthew C. Banton, Kerry L. Inder, Elke Valk, Christopher E. Rudd & Helga Schneider. (2014) Rab8 Binding to Immune Cell-Specific Adaptor LAX Facilitates Formation of trans-Golgi Network-Proximal CTLA-4 Vesicles for Surface Expression. Molecular and Cellular Biology 34:8, pages 1486-1499.
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Yoel Kloog & Adam Mor. (2014) Cytotoxic-T-Lymphocyte Antigen 4 Receptor Signaling for Lymphocyte Adhesion Is Mediated by C3G and Rap1. Molecular and Cellular Biology 34:6, pages 978-988.
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Kevin Sek, Christina Mølck, Gregory Stewart, Lev Kats, Phillip Darcy & Paul Beavis. (2018) Targeting Adenosine Receptor Signaling in Cancer Immunotherapy. International Journal of Molecular Sciences 19:12, pages 3837.
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William G. RobichauxIIIIII & Xiaodong Cheng. (2018) Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development. Physiological Reviews 98:2, pages 919-1053.
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Joanna Brzostek, Nicholas R. J. Gascoigne & Vasily Rybakin. (2016) Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition. Frontiers in Immunology 7.
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Sabine Ring, Anna Pushkarevskaya, Hansjörg Schild, Hans Christian Probst, Verena Jendrossek, Florian Wirsdörfer, Catherine Ledent, Simon Christopher Robson, Alexander H. Enk & Karsten Mahnke. (2015) Regulatory T Cell–Derived Adenosine Induces Dendritic Cell Migration through the Epac-Rap1 Pathway. The Journal of Immunology 194:8, pages 3735-3744.
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Helga Schneider & Christopher E. Rudd. (2014) Diverse Mechanisms Regulate the Surface Expression of Immunotherapeutic Target CTLA-4. Frontiers in Immunology 5.
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Amanda G. VangWilliam HousleyHongli DongChaitali BasoleShlomo Z. Ben-SassonBarbara E. KreamPaul M. EpsteinRobert B. ClarkStefan Brocke. (2013) Regulatory T-cells and cAMP suppress effector T-cells independently of PKA–CREM/ICER: a potential role for Epac. Biochemical Journal 456:3, pages 463-473.
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Nagahiro Minato. (2013) Rap G protein signal in normal and disordered lymphohematopoiesis. Experimental Cell Research 319:15, pages 2323-2328.
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Yuning Lu, Helga Schneider & Christopher E. Rudd. (2012) Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal. Blood 120:23, pages 4560-4570.
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