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Hematology Volume 16, 2011 - Issue 2
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Original Article

Simultaneous targeting of P‐gp and XIAP with siRNAs increases sensitivity of P‐gp overexpressing CML cells to imatinib

Hugo SecaCancer Biology GroupInstitute of Molecular Pathology and Immunology of the University of Porto, Portugal
,
Raquel T LimaCancer Biology GroupInstitute of Molecular Pathology and Immunology of the University of Porto, Portugal;Biological Sciences DepartmentLaboratory of Microbiology, Faculty of Pharmacy of the University of Porto, Portugal
,
José E GuimarãesCancer Biology GroupInstitute of Molecular Pathology and Immunology of the University of Porto, Portugal;Faculty of Medicine of the University of Porto, Portugal;HospitalSão João, Porto, Portugal
&
M Helena VasconcelosCancer Biology GroupInstitute of Molecular Pathology and Immunology of the University of Porto, Portugal;Biological Sciences DepartmentLaboratory of Microbiology, Faculty of Pharmacy of the University of Porto, PortugalCorrespondence[email protected]
Pages 100-108 | Published online: 12 Nov 2013

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Hong-Lin Xiang, Yu Chen, Jia-Wei Wang, Hui-Jie Wang, Xiao-Feng Gao, Hui Li & Sheng-Jun Mao. (2019) Enhancing cytotoxicity of daunorubicin on drug-resistant leukaemia cells with microparticle-mediated drug delivery system. Journal of Microencapsulation 36:3, pages 291-304.
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Articles from other publishers (15)

Diana Sousa, Raquel T. Lima, Vanessa Lopes-Rodrigues, Esperanza Gonzalez, Félix Royo, Cristina P. R. Xavier, Juan M. Falcón-Pérez & M. Helena Vasconcelos. (2021) Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles. Cells 10:11, pages 2886.
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Jinhua He, Zeping Han, Ziyi An, Yumin Li, Xingyi Xie, Jiabin Zhou, Sihua He, Yubing Lv, Mengling He, Hong Qu, Gexiu Liu & Yuguang Li. (2021) The miR-203a Regulatory Network Affects the Proliferation of Chronic Myeloid Leukemia K562 Cells. Frontiers in Cell and Developmental Biology 9.
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Diana Sousa, Rune Matthiesen, Raquel T. Lima & M. Helena Vasconcelos. (2020) Deep Sequencing Analysis Reveals Distinctive Non-Coding RNAs When Comparing Tumor Multidrug-Resistant Cells and Extracellular Vesicles with Drug-Sensitive Counterparts. Cancers 12:1, pages 200.
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Prajwal Boddu, Bing Z. Carter, Srdan Verstovsek & Naveen Pemmaraju. (2019) SMAC mimetics as potential cancer therapeutics in myeloid malignancies . British Journal of Haematology 185:2, pages 219-231.
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Raquel Maia, Flavia Vasconcelos, Paloma Souza & Vivian Rumjanek. (2018) Towards Comprehension of the ABCB1/P-Glycoprotein Role in Chronic Myeloid Leukemia. Molecules 23:1, pages 119.
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Vanessa Lopes-Rodrigues, Alessio Di Luca, Justyna Mleczko, Paula Meleady, Michael Henry, Milica Pesic, Diana Cabrera, Sebastiaan van Liempd, Raquel T. Lima, Robert O’Connor, Juan M. Falcon-Perez & M. Helena Vasconcelos. (2017) Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles. Scientific Reports 7:1.
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Vanessa Lopes-Rodrigues, Ana Oliveira, Marta Correia-da-Silva, Madalena Pinto, Raquel T. Lima, Emília Sousa & M. Helena Vasconcelos. (2017) A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells. Bioorganic & Medicinal Chemistry 25:2, pages 581-596.
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Vanessa Lopes-Rodrigues, Alessio Di Luca, Diana Sousa, Hugo Seca, Paula Meleady, Michael Henry, Raquel T. Lima, Robert O’Connor & M. Helena Vasconcelos. (2016) Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells. Data in Brief 6, pages 1023-1027.
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Vanessa Lopes-Rodrigues, Alessio Di Luca, Diana Sousa, Hugo Seca, Paula Meleady, Michael Henry, Raquel T. Lima, Robert O'Connor & M. Helena Vasconcelos. (2016) Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:3, pages 618-627.
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Vanessa Lopes-Rodrigues, Hugo Seca, Diana Sousa, Emília Sousa, Raquel T. Lima & M. Helena Vasconcelos. (2014) The network of P-glycoprotein and microRNAs interactions. International Journal of Cancer 135:2, pages 253-263.
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S Fulda. (2014) Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities. Leukemia 28:7, pages 1414-1422.
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Christine Victoria Ichim. (2014) Kinase-Independent Mechanisms of Resistance of Leukemia Stem Cells to Tyrosine Kinase Inhibitors. Stem Cells Translational Medicine 3:4, pages 405-415.
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Karina Lani Silva, Paloma Silva de Souza, Gabriela Nestal de Moraes, Arthur Moellmann-Coelho, Flavia da Cunha Vasconcelos & Raquel Ciuvalschi Maia. (2013) XIAP and P-glycoprotein co-expression is related to imatinib resistance in chronic myeloid leukemia cells. Leukemia Research 37:10, pages 1350-1358.
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Paloma Silva de Souza, Flavia da Cunha Vasconcelos, Luis Felipe R. Silva & Raquel Ciuvalschi Maia. (2012) Cyclosporine A enables vincristine-induced apoptosis during reversal of multidrug resistance phenotype in chronic myeloid leukemia cells. Tumor Biology 33:4, pages 943-956.
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Gabriela Nestal de Moraes, Paloma Silva Souza, Fernanda Casal de Faria Costas, Flavia Cunha Vasconcelos, Flaviana Ruade Souza Reis & Raquel Ciuvalschi Maia. (2012) The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia. Leukemia Research and Treatment 2012, pages 1-19.
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