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OriginalArticle

A novel hemostasis assay for the simultaneous measurement of coagulation and fibrinolysis

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Pages 327-336 | Published online: 12 Nov 2013

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Crossref
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Crossref
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Pleun C. M. van Poppel, Pauline Breedveld, Evertine J. Abbink, Hennie Roelofs, Waander van Heerde, Paul Smits, Wenzhi Lin, Aaitje H. Tan, Frans G. Russel, Rogier Donders, Cees J. Tack & Gerard A. Rongen. (2015) Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial. PLOS ONE 10:7, pages e0128695.
Crossref
Meera Chitlur & Mindy L. Simpson. 2014. Pediatric Thrombotic Disorders. Pediatric Thrombotic Disorders 142 157 .
Armando Tripodi. (2014) A(nother) Test Meant to Fill the Gap between In Vivo and Ex Vivo Hemostasis. Clinical Chemistry 60:9, pages 1137-1140.
Crossref
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Crossref
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Crossref
Tomoko Matsumoto, Keiji Nogami & Midori Shima. (2017) Simultaneous measurement of thrombin and plasmin generation to assess the interplay between coagulation and fibrinolysis. Thrombosis and Haemostasis 110:10, pages 761-768.
Crossref
M. Van GEFFEN, M. MENEGATTI, A. LOOF, P. LAP, M. KARIMI, B. A. P. LAROS‐van GORKOM, P. BRONS & W. L. Van HEERDE. (2012) Retrospective evaluation of bleeding tendency and simultaneous thrombin and plasmin generation in patients with rare bleeding disorders. Haemophilia 18:4, pages 630-638.
Crossref
Mark van Geffen & Waander L. van Heerde. (2012) Global haemostasis assays, from bench to bedside. Thrombosis Research 129:6, pages 681-687.
Crossref
M van Geffen, M Cugno, P Lap, A Loof, M Cicardi & W van Heerde. (2012) Alterations of coagulation and fibrinolysis in patients with angioedema due to C1-inhibitor deficiency. Clinical and Experimental Immunology 167:3, pages 472-478.
Crossref

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