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Redox Report
Communications in Free Radical Research
Volume 5, 2000 - Issue 6
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The cardioprotective effect of the iron chelator dexrazoxane (ICRF-187) on anthracycline-mediated cardiotoxicity

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Pages 317-324 | Published online: 19 Jul 2013

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Elly Barry, Jorge A Alvarez, Rebecca E Scully, Tracie L Miller & Steven E Lipshultz. (2007) Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management. Expert Opinion on Pharmacotherapy 8:8, pages 1039-1058.
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Varsha Kaushal, G. P. Kaushal & Paulette Mehta. (2004) Differential Toxicity of Anthracyclines on Cultured Endothelial Cells. Endothelium 11:5-6, pages 253-258.
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Articles from other publishers (19)

Felix Sebastian Nettersheim, Johannes David Schlüter, Wiebke Kreuzberg, Dennis Mehrkens, Simon Grimm, Harshal Nemade, Simon Braumann, Alexander Hof, Henning Guthoff, Vera Peters, Friedrich Felix Hoyer, Yulia Kargapolova, Jan-Wilm Lackmann, Stefan Müller, Christian P. Pallasch, Michael Hallek, Agapios Sachinidis, Matti Adam, Holger Winkels, Stephan Baldus, Simon Geißen & Martin Mollenhauer. (2023) Myeloperoxidase is a critical mediator of anthracycline-induced cardiomyopathy. Basic Research in Cardiology 118:1.
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Paweł Uruski, Julia Matuszewska, Aleksandra Leśniewska, Daniel Rychlewski, Arkadiusz Niklas, Justyna Mikuła-Pietrasik, Andrzej Tykarski & Krzysztof Książek. (2023) An integrative review of nonobvious puzzles of cellular and molecular cardiooncology. Cellular & Molecular Biology Letters 28:1.
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Jie Feng & Yanqing Wu. (2023) Endothelial-to-Mesenchymal Transition: Potential Target of Doxorubicin-Induced Cardiotoxicity. American Journal of Cardiovascular Drugs 23:3, pages 231-246.
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Cho-Won Kim & Kyung-Chul Choi. (2021) Effects of anticancer drugs on the cardiac mitochondrial toxicity and their underlying mechanisms for novel cardiac protective strategies. Life Sciences 277, pages 119607.
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Shengjie Cui, Tushar H. Ganjawala, Gary W. Abrams & Zhuo-Hua Pan. (2020) Effect of Proteasome Inhibitors on the AAV-Mediated Transduction Efficiency in Retinal Bipolar Cells. Current Gene Therapy 19:6, pages 404-412.
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Alessandra Murabito, Emilio Hirsch & Alessandra Ghigo. (2020) Mechanisms of Anthracycline-Induced Cardiotoxicity: Is Mitochondrial Dysfunction the Answer?. Frontiers in Cardiovascular Medicine 7.
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Sakshi Jasra & Jesus Anampa. (2018) Anthracycline Use for Early Stage Breast Cancer in the Modern Era: a Review. Current Treatment Options in Oncology 19:6.
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Annie CalvéWilliam NoilesIgal A. SebagLorraine E. Chalifour. (2012) The impact of doxorubicin and dexrazoxane injection of prepubertal female rats on pregnancy outcome and cardiac function postpartum. Canadian Journal of Physiology and Pharmacology 90:11, pages 1527-1534.
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Annie Calvé, Rami Haddad, Sarah-Neiel Barama, Melissa Meilleur, Igal A. Sebag & Lorraine E. Chalifour. (2012) Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training. American Journal of Physiology-Heart and Circulatory Physiology 302:10, pages H2048-H2057.
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Damian G. Deavall, Elizabeth A. Martin, Judith M. Horner & Ruth Roberts. (2012) Drug-Induced Oxidative Stress and Toxicity. Journal of Toxicology 2012, pages 1-13.
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Yu Yu, Danuta S. Kalinowski, Zaklina Kovacevic, Aritee R. Siafakas, Patric J. Jansson, Christian Stefani, David B. Lovejoy, Philip C. Sharpe, Paul V. Bernhardt & Des R. Richardson. (2009) Thiosemicarbazones from the Old to New: Iron Chelators That Are More Than Just Ribonucleotide Reductase Inhibitors. Journal of Medicinal Chemistry 52:17, pages 5271-5294.
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O Popelová, M Štěrba, P Hašková, T Šimůnek, M Hroch, I Gunčová, P Nachtigal, M Adamcová, V Geršl & Y Mazurová. (2009) Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death. British Journal of Cancer 101:5, pages 792-802.
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Aarif Y Khakoo & Edward TH Yeh. (2008) Therapy Insight: management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy. Nature Clinical Practice Oncology 5:11, pages 655-667.
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F Mwale, G Marguier, J.A Ouellet, A Petit, L.M Epure, J Antoniou & L.E Chalifour. (2008) Effect of Dexrazoxane and Amifostine on the Vertebral Bone Quality of Doxorubicin Treated Male Rats. The Open Orthopaedics Journal 2:1, pages 115-120.
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Martin Štěrba, Olga Popelová, Tomáš Šimůnek, Yvona Mazurová, Anna Potáčová, Michaela Adamcová, Ivana Gunčová, Helena Kaiserová, Vladimír Palička, Přemysl Poňka & Vladimír Geršl. (2007) Iron chelation-afforded cardioprotection against chronic anthracycline cardiotoxicity: A study of salicylaldehyde isonicotinoyl hydrazone (SIH). Toxicology 235:3, pages 150-166.
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Tomáš Šimůnek, Martin Štěrba, Magdaléna Holečková, Jana Kaplanová, Ivona Klimtová, Michaela Adamcová, Vladimír Geršl & Radomír Hrdina. (2005) Myocardial content of selected elements in experimental anthracycline-induced cardiomyopathy in rabbits. BioMetals 18:2, pages 163-169.
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F. Mwale, J. Antoniou, S. Héon, N. Servant, C. Wang, G. M. Kirby, C. N. Demers & L. E. Chalifour. (2004) Gender-Dependent Reductions in Vertebrae Length, Bone Mineral Density and Content by Doxorubicin Are Not Reduced by Dexrazoxane in Young Rats: Effect on Growth Plate and Intervertebral Discs. Calcified Tissue International 76:3, pages 214-221.
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Michael J Mihm, Fushun Yu, David M Weinstein, Peter J Reiser & John Anthony Bauer. (2009) Intracellular distribution of peroxynitrite during doxorubicin cardiomyopathy: evidence for selective impairment of myofibrillar creatine kinase. British Journal of Pharmacology 135:3, pages 581-588.
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Paul Whittaker, Harold E. Seifried, Richard H.C. San, Jane J. Clarke & Virginia C. Dunkel. (2001) Genotoxicity of iron chelators in L5178Y mouse lymphoma cells. Environmental and Molecular Mutagenesis 38:4, pages 347-356.
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