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Redox Report
Communications in Free Radical Research
Volume 7, 2002 - Issue 1
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Hypothesis

3-Methylcholanthrene-inducible hepatic DNA adducts: a mechanistic hypothesis linking sequence-specific DNA adducts to sustained cytochrome P4501A1 induction by 3-methylcholanthrene

Bhagavatula MoorthyDepartment of Pediatrics Baylor College of Medicine, Houston , Texas, USA
Pages 9-13 | Published online: 19 Jul 2013

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Ziad Naufal, Guo-dong Zhou, Thomas McDonald, Zhiwen Li, Zhu Li & K. C. Donnelly. (2007) Genotoxicity of Organic Extracts of House Dust from Shanxi, China. Journal of Toxicology and Environmental Health, Part A 70:24, pages 2080-2088.
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Articles from other publishers (8)

Weiwu Jiang, Lihua Wang, Sudha R. Kondraganti, Inayat S. Fazili, Xanthi I. Couroucli, Edward A. Felix & Bhagavatula Moorthy. (2010) Disruption of the Gene for CYP1A2 , which Is Expressed Primarily in Liver, Leads to Differential Regulation of Hepatic and Pulmonary Mouse CYP1A1 Expression and Augmented Human CYP1A1 Transcriptional Activation in Response to 3-Methylcholanthrene In Vivo . Journal of Pharmacology and Experimental Therapeutics 335:2, pages 369-379.
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Inayat S. Fazili, Weiwu Jiang, Lihua Wang, Edward A. Felix, Tanvir Khatlani, Xavier Coumoul, Robert Barouki & Bhagavatula Moorthy. (2010) Persistent Induction of Cytochrome P4501A1 in Human Hepatoma Cells by 3-Methylcholanthrene: Evidence for Sustained Transcriptional Activation of the CYP1A1 Promoter. Journal of Pharmacology and Experimental Therapeutics 333:1, pages 99-109.
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Weiwu Jiang, Lihua Wang, Weisheng Zhang, Richard Coffee, Inayat S. Fazili & Bhagavatula Moorthy. (2009) Persistent induction of cytochrome P450 (CYP)1A enzymes by 3-methylcholanthrene in vivo in mice is mediated by sustained transcriptional activation of the corresponding promoters. Biochemical and Biophysical Research Communications 390:4, pages 1419-1424.
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Sudha R. Kondraganti, Weiwu Jiang, Anil K. Jaiswal & Bhagavatula Moorthy. (2008) Persistent Induction of Hepatic and Pulmonary Phase II Enzymes by 3-Methylcholanthrene in Rats. Toxicological Sciences 102:2, pages 337-344.
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Bhagavatula Moorthy, Kathirvel Muthiah, Inayat S. Fazili, Sudha R. Kondraganti, Lihua Wang, Xanthi I. Couroucli & Weiwu Jiang. (2007) 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochemical and Biophysical Research Communications 354:4, pages 1071-1077.
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Damian Brauze, Magdalena Widerak, Joanna Cwykiel, Krzysztof Szyfter & Wanda Baer-Dubowska. (2006) The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1α, CYP1A1 and NQO1 genes in rat liver. Toxicology Letters 167:3, pages 212-220.
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Sudha R. Kondraganti, Kathirvel Muthiah, Weiwu Jiang, Roberto Barrios & Bhagavatula Moorthy. (2005) Effects of 3-Methylcholanthrene on Gene Expression Profiling in the Rat Using cDNA Microarray Analyses. Chemical Research in Toxicology 18:11, pages 1634-1641.
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Sudha R. Kondraganti, Weiwu Jiang & Bhagavatula Moorthy. (2002) Differential Regulation of Expression of Hepatic and Pulmonary Cytochrome P4501A Enzymes by 3-Methylcholanthrene in Mice Lacking the CYP1A2 Gene . Journal of Pharmacology and Experimental Therapeutics 303:3, pages 945-951.
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