1,008
Views
153
CrossRef citations to date
0
Altmetric
Short refereed paper

Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice

, , , , &
Pages 290-293 | Published online: 19 Jul 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Dinesh Kumar Chellappan, Jestin Chellian, Nur Suraiza Nabila Rahmah, Wee Jin Gan, Priyanka Banerjee, Saptarshi Sanyal, Pradipta Banerjee, Nandini Ghosh, Tanner Guith, Amitava Das, Gaurav Gupta, Sachin Kumar Singh, Kamal Dua, Anil Philip Kunnath, Nur Azeyanti Norhashim, Kuan Hung Ong & Kishneth Palaniveloo. (2023) Hypoglycaemic Molecules for the Management of Diabetes Mellitus from Marine Sources. Diabetes, Metabolic Syndrome and Obesity 16, pages 2187-2223.
Read now
Osman N. Kanwugu, Tatiana V. Glukhareva, Irina G. Danilova & Elena G. Kovaleva. (2022) Natural antioxidants in diabetes treatment and management: prospects of astaxanthin. Critical Reviews in Food Science and Nutrition 62:18, pages 5005-5028.
Read now
Penislusshiyan Sakayanathan, Chitra Loganathan & Palvannan Thayumanavan. (2022) Protection of pancreatic beta cells against high glucose-induced toxicity by astaxanthin-s-allyl cysteine diester: alteration of oxidative stress and apoptotic-related protein expression. Archives of Physiology and Biochemistry 0:0, pages 1-9.
Read now
Dan Li, Tian Zhang, Jinjian Lu, Cheng Peng & Ligen Lin. (2021) Natural constituents from food sources as therapeutic agents for obesity and metabolic diseases targeting adipose tissue inflammation. Critical Reviews in Food Science and Nutrition 61:12, pages 1947-1965.
Read now
Xueliang Sun, Yanbin Ji, Ayesha Tahir & Jun Kang. (2020) Network Pharmacology Combined with Transcriptional Analysis to Unveil the Biological Basis of Astaxanthin in Reducing the Oxidative Stress Induced by Diabetes Mellitus. Diabetes, Metabolic Syndrome and Obesity 13, pages 4281-4295.
Read now
H.A.M. Elwan, S.S. Elnesr, Y. Abdallah, A. Hamdy & A.H. El-Bogdady. (2019) Red yeast (Phaffia rhodozyma) as a source of Astaxanthin and its impacts on productive performance and physiological responses of poultry. World's Poultry Science Journal 75:2, pages 273-284.
Read now
Hüseyin Fındık, Levent Tumkaya, Adnan Yılmaz, Mehmet Gökhan Aslan, Murat Okutucu, Kerimali Akyildiz & Tolga Mercantepe. (2019) The protective effects of astaxanthin against cisplatin-induced retinal toxicity. Cutaneous and Ocular Toxicology 38:1, pages 59-65.
Read now
Mohammad Nazmul Alam, Md. Murad Hossain, Md. Mizanur Rahman, Nusrat Subhan, Md. Abdullah Al Mamun, Anayt Ulla, Hasan Mahmud Reza & Md. Ashraful Alam. (2018) Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats. Journal of Dietary Supplements 15:1, pages 42-54.
Read now
Tomohiro Otsuka, Masamitsu Shimazawa, Yuki Inoue, Yusuke Nakano, Kazuki Ojino, Hiroshi Izawa, Kazuhiro Tsuruma, Takashi Ishibashi & Hideaki Hara. (2016) Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models. Current Eye Research 41:11, pages 1465-1472.
Read now
Hidekatsu Yanai, Kumie Ito, Hiroshi Yoshida & Norio Tada. (2008) Antihypertensive effects of astaxanthin. Integrated Blood Pressure Control 1, pages 1-3.
Read now

Articles from other publishers (143)

Beifang Li, Ji-Young Lee & Yangchao Luo. (2023) Health benefits of astaxanthin and its encapsulation for improving bioavailability: A review. Journal of Agriculture and Food Research 14, pages 100685.
Crossref
Kartthigeen Tamel Selvan, Jo Aan Goon, Suzana Makpol & Jen Kit Tan. (2023) Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus. Marine Drugs 21:9, pages 462.
Crossref
Iswari Davan, Sharida Fakurazi, Ekram Alias, Nurul ‘Izzah Ibrahim, Ng Min Hwei & Haniza Hassan. (2023) Astaxanthin as a Potent Antioxidant for Promoting Bone Health: An Up-to-Date Review. Antioxidants 12:7, pages 1480.
Crossref
Wan-Yi Liu, Yun-Shan Hsieh, Horng-Huey Ko & Yu-Tse Wu. (2023) Formulation Approaches to Crystalline Status Modification for Carotenoids: Impacts on Dissolution, Stability, Bioavailability, and Bioactivities. Pharmaceutics 15:2, pages 485.
Crossref
Samia Elbahnaswy & Gehad E. Elshopakey. (2023) Recent progress in practical applications of a potential carotenoid astaxanthin in aquaculture industry: a review. Fish Physiology and Biochemistry.
Crossref
Anshul Kaushik, Rimjhim Sangtani, Hamendra Singh Parmar & Kiran Bala. (2023) Algal metabolites: Paving the way towards new generation antidiabetic therapeutics. Algal Research 69, pages 102904.
Crossref
Xiang Cheng & Mahfuzur Shah. 2023. Handbook of Food and Feed from Microalgae. Handbook of Food and Feed from Microalgae 221 236 .
T. S. Kumar, A. Josephine & G. Dharani. 2023. Haematococcus. Haematococcus 181 210 .
Apurva D. Patil, Pramod J. Kasabe & Padma B. Dandge. (2022) Pharmaceutical and nutraceutical potential of natural bioactive pigment: astaxanthin. Natural Products and Bioprospecting 12:1.
Crossref
Hikari Hirakida, Shinsuke Nakamura, Satoshi Inagaki, Shohei Tsuji, Masahiro Hayashi, Masamitsu Shimazawa & Hideaki Hara. (2022) Anti-diabetic effects of astaxanthin-rich extract derived from Paracoccus carotinifaciens on pancreatic β cells. Journal of Functional Foods 97, pages 105252.
Crossref
Louise W. Lu, Yao Gao, Siew-Young Quek, Meika Foster, Charles T. Eason, Min Liu, Mingfu Wang, Jie-Hua Chen & Feng Chen. (2022) The landscape of potential health benefits of carotenoids as natural supportive therapeutics in protecting against Coronavirus infection. Biomedicine & Pharmacotherapy 154, pages 113625.
Crossref
Damilohun Samuel Metibemu & Ifedayo Victor Ogungbe. (2022) Carotenoids in Drug Discovery and Medicine: Pathways and Molecular Targets Implicated in Human Diseases. Molecules 27:18, pages 6005.
Crossref
Nur Rafiqah Abdol Wahab, Meor Mohd Redzuan Meor Mohd Affandi, Sharida Fakurazi, Ekram Alias & Haniza Hassan. (2022) Nanocarrier System: State-of-the-Art in Oral Delivery of Astaxanthin. Antioxidants 11:9, pages 1676.
Crossref
Chung-Hsiung Huang, Chih-Heng Lin, Hsiao-Han Huang & Guo-Jane Tsai. (2022) Development of Fermented Shrimp Shell Product with Hypoglycemic and Hypolipidemic Effects on Diabetic Rats. Metabolites 12:8, pages 695.
Crossref
Mohammed F. El Basuini, Emad H. El-Bilawy, Zulhisyam Abdul Kari, Sayed Haidar Abbas Raza, Wanaporn Tapingkae, Hien Van Doan & Mahmoud A.O. Dawood. (2022) Pharmacotherapeutic potential of astaxanthin: Human and animal targeting roles – A review. Annals of Animal Science 22:3, pages 829-838.
Crossref
Shuai Wang & Xin Qi. (2022) The Putative Role of Astaxanthin in Neuroinflammation Modulation: Mechanisms and Therapeutic Potential. Frontiers in Pharmacology 13.
Crossref
Ritsu Yasuda, Kazuhiro Kamada, Takaaki Murakami, Ryo Inoue, Katsura Mizushima, Ryohei Hirose, Ken Inoue, Osamu Dohi, Naohisa Yoshida, Kazuhiro Katada, Kazuhiko Uchiyama, Osamu Handa, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yuji Naito & Yoshito Itoh. (2022) Astaxanthin attenuated the stress-induced intestinal motility disorder via altering the gut microbiota. International Journal for Vitamin and Nutrition Research.
Crossref
Maryam Aref, Ariyo Movahedi, Motahar Heidari-Beni & Roya Kelishadi. (2022) Effects of shrimp oil on cardio-metabolic risk factors in children and adolescents. International Journal for Vitamin and Nutrition Research.
Crossref
Sergio Davinelli, Luciano Saso, Floriana D’Angeli, Vittorio Calabrese, Mariano Intrieri & Giovanni Scapagnini. (2022) Astaxanthin as a Modulator of Nrf2, NF-κB, and Their Crosstalk: Molecular Mechanisms and Possible Clinical Applications. Molecules 27:2, pages 502.
Crossref
Zohreh Jafari, Ashkan Bigham, Sahar Sadeghi, Sayed Mehdi Dehdashti, Navid Rabiee, Alireza Abedivash, Mojtaba Bagherzadeh, Behzad Nasseri, Hassan Karimi-Maleh, Esmaeel Sharifi, Rajender S. Varma & Pooyan Makvandi. (2021) Nanotechnology-Abetted Astaxanthin Formulations in Multimodel Therapeutic and Biomedical Applications. Journal of Medicinal Chemistry 65:1, pages 2-36.
Crossref
LIANHUAN MA, SHOUPENG LIU, XIAOWEN ZHEN, WEIWEI QIAO, LINA MA & XIAOMIN ZHANG. (2022) Astaxanthin delayed the pathogenesis of diabetic nephropathy in type 1 diabetic rats. BIOCELL 46:8, pages 1911-1916.
Crossref
Sweta Priyadarshini Pradhan, Santwana Padhi, Monalisa Dash, Heena, Bharti Mittu & Anindita Behera. 2022. Nutraceuticals and Health Care. Nutraceuticals and Health Care 135 157 .
Zubda Yaqoob, Muhammad Sajid Arshad, Muhammad Imran, Haroon Munir, Tahira Batool Qaisrani, Waseem Khalid, Zubia Asghar & Hafiz Ansar Rasul Suleria. (2021) Mechanistic role of astaxanthin derived from shrimp against certain metabolic disorders. Food Science & Nutrition 10:1, pages 12-20.
Crossref
Yasuhiro Nishida, Allah Nawaz, Karen Hecht & Kazuyuki Tobe. (2021) Astaxanthin as a Novel Mitochondrial Regulator: A New Aspect of Carotenoids, beyond Antioxidants. Nutrients 14:1, pages 107.
Crossref
A. N. M. Mamun-Or-Rashid, Tanzima Tarannum Lucy, Masayuki Yagi & Yoshikazu Yonei. (2021) Inhibitory Effects of Astaxanthin on CML-HSA-Induced Inflammatory and RANKL-Induced Osteoclastogenic Gene Expression in RAW 264.7 Cells. Biomedicines 10:1, pages 54.
Crossref
Mark F. McCarty & James J. DiNicolantonio. (2021) Maintaining Effective Beta Cell Function in the Face of Metabolic Syndrome-Associated Glucolipotoxicity—Nutraceutical Options. Healthcare 10:1, pages 3.
Crossref
Masaharu Urakaze, Chikaaki Kobashi, Yukihiro Satou, Kouichi Shigeta, Masahiro Toshima, Masatoshi Takagi, Jiro Takahashi & Hiroshi Nishida. (2021) The Beneficial Effects of Astaxanthin on Glucose Metabolism and Modified Low-Density Lipoprotein in Healthy Volunteers and Subjects with Prediabetes. Nutrients 13:12, pages 4381.
Crossref
Allah Nawaz, Yasuhiro Nishida, Akiko Takikawa, Shiho Fujisaka, Tomonobu Kado, Aminuddin Aminuddin, Muhammad Bilal, Ishtiaq Jeelani, Muhammad Rahil Aslam, Ayumi Nishimura, Takahide Kuwano, Yoshiyuki Watanabe, Yoshiko Igarashi, Keisuke Okabe, Saeed Ahmed, Azhar Manzoor, Isao Usui, Kunimasa Yagi, Takashi Nakagawa & Kazuyuki Tobe. (2021) Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions. Nutrients 13:12, pages 4374.
Crossref
Kaleigh E. Beane, Mersady C. Redding, Xiaofan Wang, Jeong Hoon Pan, Brandy Le, Cara Cicalo, Suwon Jeon, Young Jun Kim, Jin Hyup Lee, Eui-Cheol Shin, Ying Li, Jiangchao Zhao & Jae Kyeom Kim. (2021) Effects of dietary fibers, micronutrients, and phytonutrients on gut microbiome: a review. Applied Biological Chemistry 64:1.
Crossref
Vemana Gowd, Jianbo Xiao, Mingfu Wang, Feng Chen & Ka‐Wing Cheng. (2021) Multi‐Mechanistic Antidiabetic Potential of Astaxanthin: An Update on Preclinical and Clinical Evidence. Molecular Nutrition & Food Research 65:24.
Crossref
Fatemeh Ebrahimi, Sahar Rostami, Saeid Nekoonam, Zahra Rashidi, Aligholi Sobhani & Fardin Amidi. (2021) The Effect of Astaxanthin and Metformin on Oxidative Stress in Granulosa Cells of BALB C Mouse Model of Polycystic Ovary Syndrome. Reproductive Sciences 28:10, pages 2807-2815.
Crossref
Vanessa Sovrani, Larissa Daniele Bobermin, Izaviany Schmitz, Guilhian Leipnitz & André Quincozes-Santos. (2021) Potential Glioprotective Strategies Against Diabetes-Induced Brain Toxicity. Neurotoxicity Research 39:5, pages 1651-1664.
Crossref
Rosa Paola Radice, Antonina Rita Limongi, Emanuele Viviano, Maria Carmela Padula, Giuseppe Martelli & Giovanna Bermano. (2021) Effects of astaxanthin in animal models of obesity-associated diseases: A systematic review and meta-analysis. Free Radical Biology and Medicine 171, pages 156-168.
Crossref
Olga Krestinina, Yulia Baburina & Roman Krestinin. (2021) Mitochondrion as a Target of Astaxanthin Therapy in Heart Failure. International Journal of Molecular Sciences 22:15, pages 7964.
Crossref
V. Sivamurugan, D. Radhika, Abirami Ramu Ganesan & S. Murugesan†. 2021. Recent Advances in Micro and Macroalgal Processing. Recent Advances in Micro and Macroalgal Processing 335 369 .
Xueqi Zhang, Yachen Hou, Jingan Li & Jianfeng Wang. (2021) The Role of Astaxanthin on Chronic Diseases. Crystals 11:5, pages 505.
Crossref
Pei Han, Jingjing Li, Huiqi Zhong, Jiawen Xie, Peidong Zhang, Qian Lu, Jun Li, Peilun Xu, Paul Chen, Lijian Leng & Wenguang Zhou. (2021) Anti-oxidation properties and therapeutic potentials of spirulina. Algal Research 55, pages 102240.
Crossref
Assunta Saide, Kevin A. Martínez, Adrianna Ianora & Chiara Lauritano. (2021) Unlocking the Health Potential of Microalgae as Sustainable Sources of Bioactive Compounds. International Journal of Molecular Sciences 22:9, pages 4383.
Crossref
Sajad Fakhri, Akram Yarmohammadi, Mostafa Yarmohammadi, Mohammad Hosein Farzaei & Javier Echeverria. (2021) Marine Natural Products: Promising Candidates in the Modulation of Gut-Brain Axis towards Neuroprotection. Marine Drugs 19:3, pages 165.
Crossref
MikhailA Filippov, OlgaG Tatarnikova, NataliaV Pozdnyakova & VasilyV Vorobyov. (2021) Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases: a role of mitochondria targeted catalase and xanthophylls. Neural Regeneration Research 16:2, pages 223.
Crossref
Fen Zhuge, Yinhua Ni, Chunyan Wan, Fen Liu & Zhengwei Fu. (2021) Anti-diabetic effects of astaxanthin on an STZ-induced diabetic model in rats. Endocrine Journal 68:4, pages 451-459.
Crossref
Xiang Cheng & Mahfuzur Shah. 2021. Global Perspectives on Astaxanthin. Global Perspectives on Astaxanthin 313 339 .
P. Madan Kumar, J. Naveen, R. Janani & V. Baskaran. 2021. Global Perspectives on Astaxanthin. Global Perspectives on Astaxanthin 569 591 .
João Soeiro Teodoro, Ivo F. Machado, Ana Catarina Castela, Anabela Pinto Rolo & Carlos Marques Palmeira. 2021. Nutraceuticals. Nutraceuticals 463 483 .
Yuji Naito, Kazuhiko Uchiyama, Osamu Handa & Wataru Aoi. 2021. Carotenoids: Biosynthetic and Biofunctional Approaches. Carotenoids: Biosynthetic and Biofunctional Approaches 239 248 .
Renald Blundell, Jean Claude Grech & Muhammad Ajmal Shah. 2021. Nutraceuticals and Cancer Signaling. Nutraceuticals and Cancer Signaling 145 178 .
Ranabir Sahu & Saikat Dewanjee. 2021. Carotenoids: Structure and Function in the Human Body. Carotenoids: Structure and Function in the Human Body 513 532 .
Saikat Dewanjee, Niloy Bhattacharjee, Pratik Chakraborty & Simanta Bhattacharjee. 2021. Carotenoids: Structure and Function in the Human Body. Carotenoids: Structure and Function in the Human Body 447 473 .
Issa Mohammadpourfard, Ali Khanjari, Afshin Akhonzadeh Basti, Carlos Herrero‐Latorre, Nabi Shariatifar & Hedayat Hosseini. (2020) Evaluation of microbiological, chemical, and sensory properties of cooked probiotic sausages containing different concentrations of astaxanthin, thymol, and nitrite. Food Science & Nutrition 9:1, pages 345-356.
Crossref
Yangyang Chen, Jichun Tang, Yinghong Zhang, Juan Du, Yuanli Wang, Hui Yu & Yanling He. (2020) Astaxanthin alleviates gestational diabetes mellitus in mice through suppression of oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology 393:12, pages 2517-2527.
Crossref
Samuel Jannel, Yanis Caro, Marc Bermudes & Thomas Petit. (2020) Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient. Journal of Marine Science and Engineering 8:10, pages 789.
Crossref
Federico Perozeni, Stefano Cazzaniga, Thomas Baier, Francesca Zanoni, Gianni Zoccatelli, Kyle J. Lauersen, Lutz Wobbe & Matteo Ballottari. (2020) Turning a green alga red: engineering astaxanthin biosynthesis by intragenic pseudogene revival in Chlamydomonas reinhardtii . Plant Biotechnology Journal 18:10, pages 2053-2067.
Crossref
Chunmei Li, Bixia Ma, Junhong Chen, Yoonhwa Jeong & Xiulong Xu. (2020) Astaxanthin Inhibits p70 S6 Kinase 1 Activity to Sensitize Insulin Signaling. Marine Drugs 18:10, pages 495.
Crossref
Malwina Mularczyk, Izabela Michalak & Krzysztof Marycz. (2020) Astaxanthin and other Nutrients from Haematococcus pluvialis—Multifunctional Applications. Marine Drugs 18:9, pages 459.
Crossref
M. Barbosa, P. Valentão & P.B. Andrade. 2020. Encyclopedia of Marine Biotechnology. Encyclopedia of Marine Biotechnology 1391 1426 .
Tso-Ting Lai, Chung-May Yang & Chang-Hao Yang. (2020) Astaxanthin Protects Retinal Photoreceptor Cells against High Glucose-Induced Oxidative Stress by Induction of Antioxidant Enzymes via the PI3K/Akt/Nrf2 Pathway. Antioxidants 9:8, pages 729.
Crossref
Han-A Park, Mary Margaret Hayden, Sydni Bannerman, Joseph Jansen & Kristi M. Crowe-White. (2020) Anti-Apoptotic Effects of Carotenoids in Neurodegeneration. Molecules 25:15, pages 3453.
Crossref
Diederich Aguilar-Machado, Carlota Delso, Juan Manuel Martinez, Lourdes Morales-Oyervides, Julio Montañez & Javier Raso. (2020) Enzymatic Processes Triggered by PEF for Astaxanthin Extraction From Xanthophyllomyces dendrorhous. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Rebecca Landon, Virginie Gueguen, Hervé Petite, Didier Letourneur, Graciela Pavon-Djavid & Fani Anagnostou. (2020) Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications. Marine Drugs 18:7, pages 357.
Crossref
Mai Matsumoto, Hiroyuki Suganuma, Sunao Shimizu, Hiroki Hayashi, Kahori Sawada, Itoyo Tokuda, Kazushige Ihara & Shigeyuki Nakaji. (2020) Skin Carotenoid Level as an Alternative Marker of Serum Total Carotenoid Concentration and Vegetable Intake Correlates with Biomarkers of Circulatory Diseases and Metabolic Syndrome. Nutrients 12:6, pages 1825.
Crossref
Xin‐Ming Zhu, Mu‐Yang Li, Xin‐Yu Liu, Chang‐Ge Xia, Xiao‐Tian Niu, Gui‐Qin Wang & Dong‐Ming Zhang. (2020) Effects of dietary astaxanthin on growth, blood biochemistry, antioxidant, immune and inflammatory response in lipopolysaccharide‐challenged Channa argus . Aquaculture Research 51:5, pages 1980-1991.
Crossref
Immacolata Faraone, Chiara Sinisgalli, Angela Ostuni, Maria Francesca Armentano, Monica Carmosino, Luigi Milella, Daniela Russo, Fabiana Labanca & Haroon Khan. (2020) Astaxanthin anticancer effects are mediated through multiple molecular mechanisms: A systematic review. Pharmacological Research 155, pages 104689.
Crossref
Weihong Feng, Yanxia Wang, Na Guo, Pu Huang & Yang Mi. (2020) Effects of Astaxanthin on Inflammation and Insulin Resistance in a Mouse Model of Gestational Diabetes Mellitus. Dose-Response 18:2, pages 155932582092676.
Crossref
Yasuhiro Nishida, Allah Nawaz, Tomonobu Kado, Akiko Takikawa, Yoshiko Igarashi, Yasuhiro Onogi, Tsutomu Wada, Toshiyasu Sasaoka, Seiji Yamamoto, Masakiyo Sasahara, Johji Imura, Kumpei Tokuyama, Isao Usui, Takashi Nakagawa, Shiho Fujisaka, Yagi Kunimasa & Kazuyuki Tobe. (2020) Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway. Journal of Cachexia, Sarcopenia and Muscle 11:1, pages 241-258.
Crossref
Santosh Kumar, Balraj Singh Gill, Aruna Verma, Madan L. Verma & Rekha Kushwaha. 2020. Biotechnological Production of Bioactive Compounds. Biotechnological Production of Bioactive Compounds 191 220 .
Ahmed Olatunde, Habibu Tijjani, Ahmed Adebayo Ishola, Chukwuebuka Egbuna, Sadia Hassan & Muhammad Akram. 2020. Functional Foods and Nutraceuticals. Functional Foods and Nutraceuticals 415 444 .
Manon Le Goff, Eric Le Ferrec, Claire Mayer, Virginie Mimouni, Dominique Lagadic-Gossmann, Benoît Schoefs & Lionel Ulmann. (2019) Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention. Biochimie 167, pages 106-118.
Crossref
Maha Benlarbi‐Ben Khedher, Khouloud Hajri, Ahmed Dellaa, Basma Baccouche, Imane Hammoum, Nourhene Boudhrioua‐Mihoubi, Wissal Dhifi & Rafika Ben Chaouacha‐Chekir. (2019) Astaxanthin inhibits aldose reductase activity in Psammomys obesus , a model of type 2 diabetes and diabetic retinopathy . Food Science & Nutrition 7:12, pages 3979-3985.
Crossref
Mónika Sztretye, Beatrix Dienes, Mónika Gönczi, Tamás Czirják, László Csernoch, László Dux, Péter Szentesi & Anikó Keller-Pintér. (2019) Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging. Oxidative Medicine and Cellular Longevity 2019, pages 1-14.
Crossref
Keng Chin Lim, Fatimah Md. Yusoff, Mohamed Shariff, Mohd. Salleh Kamarudin & Norio Nagao. (2019) Dietary supplementation of astaxanthin enhances hemato-biochemistry and innate immunity of Asian seabass, Lates calcarifer (Bloch, 1790). Aquaculture 512, pages 734339.
Crossref
Tong Zhao, Xiaojia Yan, Lijun Sun, Tianxin Yang, Xin Hu, Zixin He, Fuguo Liu & Xuebo Liu. (2019) Research progress on extraction, biological activities and delivery systems of natural astaxanthin. Trends in Food Science & Technology 91, pages 354-361.
Crossref
Andreas Bauer & Mirjana Minceva. (2019) Direct extraction of astaxanthin from the microalgae Haematococcus pluvialis using liquid–liquid chromatography . RSC Advances 9:40, pages 22779-22789.
Crossref
Bee Ling Tan & Mohd Esa Norhaizan. (2019) Carotenoids: How Effective Are They to Prevent Age-Related Diseases?. Molecules 24:9, pages 1801.
Crossref
Hamid Yaghooti, Narges Mohammadtaghvaei & Khadijeh Mahboobnia. (2019) Effects of palmitate and astaxanthin on cell viability and proinflammatory characteristics of mesenchymal stem cells. International Immunopharmacology 68, pages 164-170.
Crossref
Sajad Fakhri, Fatemeh Abbaszadeh, Leila Dargahi & Masoumeh Jorjani. (2018) Astaxanthin: A mechanistic review on its biological activities and health benefits. Pharmacological Research 136, pages 1-20.
Crossref
Congqiang Zhang. 2018. Progress in Carotenoid Research. Progress in Carotenoid Research.
Yonghao Feng, Aiqun Chu, Qiong Luo, Men Wu, Xiaohong Shi & Yinghui Chen. (2018) The Protective Effect of Astaxanthin on Cognitive Function via Inhibition of Oxidative Stress and Inflammation in the Brains of Chronic T2DM Rats. Frontiers in Pharmacology 9.
Crossref
GS Lim, RK Kayanoth, BF Broekman & CY Chee. (2018) Perception of a single-session pre-in vitro fertilisation counselling service and attitudes towards support group: a survey of patients in Singapore. Singapore Medical Journal 59:6, pages 316-321.
Crossref
Congqiang Zhang, Vui Yin Seow, Xixian Chen & Heng-Phon Too. (2018) Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli. Nature Communications 9:1.
Crossref
Kornchanok Wayakanon, Kanjana Rueangyotchanthana, Praween Wayakanon & Chatrudee Suwannachart. (2018) The inhibition of Caco-2 proliferation by astaxanthin from Xanthophyllomyces dendrorhous. Journal of Medical Microbiology 67:4, pages 507-513.
Crossref
Yuqing Yang, Irene Yang, Mingnan Cao, Zheng-yuan Su, Renyi Wu, Yue Guo, Mingzhu Fang & Ah-Ng Kong. (2018) Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells. The AAPS Journal 20:2.
Crossref
Ramaraj Sathasivam & Jang-Seu Ki. (2018) A Review of the Biological Activities of Microalgal Carotenoids and Their Potential Use in Healthcare and Cosmetic Industries. Marine Drugs 16:1, pages 26.
Crossref
Miaad Sayahi & Saeed Shirali. (2017) The Antidiabetic and Antioxidant Effects of Carotenoids: A Review. Asian Journal of Pharmaceutical Research and Health Care 9:4, pages 186-191.
Crossref
Trung T. Nguyen, Andrew R. Barber, Kendall Corbin & Wei Zhang. (2017) Lobster processing by-products as valuable bioresource of marine functional ingredients, nutraceuticals, and pharmaceuticals. Bioresources and Bioprocessing 4:1.
Crossref
Kazuaki Hara, Chieko Hamada, Keiichi Wakabayashi, Reo Kanda, Kayo Kaneko, Satoshi Horikoshi, Yasuhiko Tomino & Yusuke Suzuki. (2017) Scavenging of reactive oxygen species by astaxanthin inhibits epithelial–mesenchymal transition in high glucose-stimulated mesothelial cells. PLOS ONE 12:9, pages e0184332.
Crossref
Yuki Inoue, Masamitsu Shimazawa, Ryota Nagano, Yoshiki Kuse, Kei Takahashi, Kazuhiro Tsuruma, Masahiro Hayashi, Takashi Ishibashi, Takashi Maoka & Hideaki Hara. (2017) Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration. Journal of Pharmacological Sciences 134:3, pages 147-157.
Crossref
Ali Roohbakhsh, Gholamreza Karimi & Mehrdad Iranshahi. (2017) Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review. Biomedicine & Pharmacotherapy 91, pages 31-42.
Crossref
Atsuko Kitahara, Kazuto Takahashi, Naru Morita, Toshitaka Murashima, Hirohisa Onuma, Yoshikazu Sumitani, Toshiaki Tanaka, Takuma Kondo, Toshio Hosaka & Hitoshi Ishida. (2017) The Novel Mechanisms Concerning the Inhibitions of Palmitate-Induced Proinflammatory Factor Releases and Endogenous Cellular Stress with Astaxanthin on MIN6 β-Cells. Marine Drugs 15:6, pages 185.
Crossref
Yuqing Yang, Francisco Fuentes, Limin Shu, Chao Wang, Doug Pung, Wenji Li, Chengyue Zhang, Yue Guo & Ah-Ng Kong. (2016) Epigenetic CpG Methylation of the Promoter and Reactivation of the Expression of GSTP1 by Astaxanthin in Human Prostate LNCaP Cells. The AAPS Journal 19:2, pages 421-430.
Crossref
Hachiro KAMADA, Satoshi AKAGI & Shinya WATANABE. (2017) Astaxanthin increases progesterone production in cultured bovine luteal cells. Journal of Veterinary Medical Science 79:6, pages 1103-1109.
Crossref
Francesco Visioli & Christian Artaria. (2017) Astaxanthin in cardiovascular health and disease: mechanisms of action, therapeutic merits, and knowledge gaps. Food & Function 8:1, pages 39-63.
Crossref
Mi-hyang Ohh, Seongjin Kim, Sok Cheon Pak & Kew-mahn Chee. (2016) Effects of Dietary Supplementation with Astaxanthin on Histamine Induced Lesions in the Gizzard and Proventriculus of Broiler Chicks. Asian-Australasian Journal of Animal Sciences 29:6, pages 872-878.
Crossref
Emmanuel B. D’Alessandro & Nelson R. Antoniosi Filho. (2016) Concepts and studies on lipid and pigments of microalgae: A review. Renewable and Sustainable Energy Reviews 58, pages 832-841.
Crossref
Yoshimi Kishimoto, Hiroshi Yoshida & Kazuo Kondo. (2016) Potential Anti-Atherosclerotic Properties of Astaxanthin. Marine Drugs 14:2, pages 35.
Crossref
Po-Ting Yeh, Hsin-Wei Huang, Chung-May Yang, Wei-Shiung Yang & Chang-Hao Yang. (2016) Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats. PLOS ONE 11:1, pages e0146438.
Crossref
Warisa Amornrit & Rachana Santiyanont. (2015) Effect of Amaranthus on Advanced Glycation End-Products Induced Cytotoxicity and Proinflammatory Cytokine Gene Expression in SH-SY5Y Cells. Molecules 20:9, pages 17288-17308.
Crossref
Chan Hum ParkFeng Hao XuSeong-Soo RohYeong Ok SongKazuo UebabaJeong Sook NohTakako Yokozawa. (2015) Astaxanthin and Corni Fructus Protect Against Diabetes-Induced Oxidative Stress, Inflammation, and Advanced Glycation End Product in Livers of Streptozotocin-Induced Diabetic Rats. Journal of Medicinal Food 18:3, pages 337-344.
Crossref
S. Kathiresan, Arun Chandrashekar, G.A. Ravishankar & R. Sarada. (2015) Regulation of astaxanthin and its intermediates through cloning and genetic transformation of β-carotene ketolase in Haematococcus pluvialis. Journal of Biotechnology 196-197, pages 33-41.
Crossref
Li-hua Zhang, Yong-jian Peng, Xin-de Xu, Sheng-nan Wang, Lei-ming Yu, Yi-min Hong & Jin-ping Ma. (2015) Determination of Other Related Carotenoids Substances in Astaxanthin Crystals Extracted from <i>Adonis am</i><i>urensis </i>. Journal of Oleo Science 64:7, pages 751-759.
Crossref
Yue Yang, Bohkyung Kim, Young-Ki Park, Sung I. Koo & Ji-Young Lee. (2015) Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochimica et Biophysica Acta (BBA) - General Subjects 1850:1, pages 178-185.
Crossref
Yue Yang, Tho X. Pham, Casey J. Wegner, Bohkyung Kim, Chai Siah Ku, Young-Ki Park & Ji-Young Lee. (2014) Astaxanthin lowers plasma TAG concentrations and increases hepatic antioxidant gene expression in diet-induced obesity mice. British Journal of Nutrition 112:11, pages 1797-1804.
Crossref
Saravanan Bhuvaneswari, Baskaran Yogalakshmi, S. Sreeja & Carani Venkatraman Anuradha. (2013) Astaxanthin reduces hepatic endoplasmic reticulum stress and nuclear factor-κB-mediated inflammation in high fructose and high fat diet-fed mice. Cell Stress and Chaperones 19:2, pages 183-191.
Crossref
Ranga Ambati, Siew-Moi Phang, Sarada Ravi & Ravishankar Aswathanarayana. (2014) Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review. Marine Drugs 12:1, pages 128-152.
Crossref
Constance Lay Lay Saw, Anne Yuqing Yang, Yue Guo & Ah-Ng Tony Kong. (2013) Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2–ARE pathway. Food and Chemical Toxicology 62, pages 869-875.
Crossref
Ling-Yan Dong, Jie Jin, Gao Lu & Xiao-Li Kang. (2013) Astaxanthin Attenuates the Apoptosis of Retinal Ganglion Cells in db/db Mice by Inhibition of Oxidative Stress. Marine Drugs 11:12, pages 960-974.
Crossref
Tomohiro Otsuka, Masamitsu Shimazawa, Tomohiro Nakanishi, Yuta Ohno, Yuki Inoue, Kazuhiro Tsuruma, Takashi Ishibashi & Hideaki Hara. (2013) The Protective Effects of a Dietary Carotenoid, Astaxanthin, Against Light-Induced Retinal Damage. Journal of Pharmacological Sciences 123:3, pages 209-218.
Crossref
Saravanan BhuvaneswariCarani Venkatraman Anuradha. (2012) Astaxanthin prevents loss of insulin signaling and improves glucose metabolism in liver of insulin resistant mice. Canadian Journal of Physiology and Pharmacology 90:11, pages 1544-1552.
Crossref
Makoto Inoue, Hiroki Tanabe, Akira Matsumoto, Michiyo Takagi, Keizo Umegaki, Sakae Amagaya & Jiro Takahashi. (2012) Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor ? modulator in adipocytes and macrophages. Biochemical Pharmacology 84:5, pages 692-700.
Crossref
Juan-juan Wang, Zhi-qiang Chen & Wen-qing Lu. (2011) Hypoglycemic effect of astaxanthin from shrimp waste in alloxan-induced diabetic mice. Medicinal Chemistry Research 21:9, pages 2363-2367.
Crossref
Yuichi Uchino, M. Uchino, M. Dogru, K. Fukagawa & K. Tsubota. (2012) Improvement of accommodation with anti-oxidant supplementation in visual display terminal users. The journal of nutrition, health & aging 16:5, pages 478-481.
Crossref
Najmeh Sheikhzadeh, Hossein Tayefi-Nasrabadi, Ali Khani Oushani & Mohammad Hamed Najafi Enferadi. (2011) Effects of Haematococcus pluvialis supplementation on antioxidant system and metabolism in rainbow trout (Oncorhynchus mykiss). Fish Physiology and Biochemistry 38:2, pages 413-419.
Crossref
Youn-Ri Lee, Koan-Sik Woo, In-Guk Hwang, Hyun-Young Kim, Sang-Hoon Lee, Yun-Bae Kim, Jun-Soo Lee & Heon-Sang Jeong. (2012) Anti-diabetic Activity of Germinated Ilpum Rough Rice Extract Supplement in Mice. Journal of the Korean Society of Food Science and Nutrition 41:3, pages 339-344.
Crossref
Robert G. Fassett & Jeff S. Coombes. (2012) Astaxanthin in Cardiovascular Health and Disease. Molecules 17:2, pages 2030-2048.
Crossref
Michiyuki Saito, Kazuhiko Yoshida, Wataru Saito, Akio Fujiya, Kazuhiro Ohgami, Nobuyoshi Kitaichi, Hiroki Tsukahara, Susumu Ishida & Shigeaki Ohno. (2011) Astaxanthin increases choroidal blood flow velocity. Graefe's Archive for Clinical and Experimental Ophthalmology 250:2, pages 239-245.
Crossref
Yasuhiro Nishida. (2012) Astaxanthin: commercial production and its potential health-promoting effects. Oleoscience 12:10, pages 525-531.
Crossref
Robert G. Fassett & Jeff S. Coombes. (2011) Astaxanthin: A Potential Therapeutic Agent in Cardiovascular Disease. Marine Drugs 9:3, pages 447-465.
Crossref
Jian-Ping Yuan, Juan Peng, Kai Yin & Jiang-Hai Wang. (2011) Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Molecular Nutrition & Food Research 55:1, pages 150-165.
Crossref
M. F. Leite, A. De Lima, M. M. Massuyama & R. Otton. (2010) In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan‐induced diabetic rats . International Endodontic Journal 43:11, pages 959-967.
Crossref
G. Goswami, S. Chaudhuri & D. Dutta. (2010) The present perspective of astaxanthin with reference to biosynthesis and pharmacological importance. World Journal of Microbiology and Biotechnology 26:11, pages 1925-1939.
Crossref
Takashi Maoka & Hideo Etoh. 2010. Functional Foods of the East. Functional Foods of the East 85 97 .
Saravanan Bhuvaneswari, Elumalai Arunkumar, Periyasamy Viswanathan & Carani Venkatraman Anuradha. (2010) Astaxanthin restricts weight gain, promotes insulin sensitivity and curtails fatty liver disease in mice fed a obesity-promoting diet. Process Biochemistry 45:8, pages 1406-1414.
Crossref
Mariana Ferreira Leite, Amanda Martins de Lima, Monica Miyuki Massuyama & Rosemari Otton. (2010) Astaxanthin restores the enzymatic antioxidant profile in salivary gland of alloxan-induced diabetic rats. Archives of Oral Biology 55:7, pages 479-485.
Crossref
Akira Satoh, Masaharu Ishikura, Nagisa Murakami, Kai Zhang & Daisuke Sasaki. 2010. Biotechnology in Functional Foods and Nutraceuticals. Biotechnology in Functional Foods and Nutraceuticals 313 330 .
Yoshimi Nakajima, Yuta Inokuchi, Masamitsu Shimazawa, Kazumasa Otsubo, Takashi Ishibashi & Hideaki Hara. (2008) Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo. Journal of Pharmacy and Pharmacology 60:10, pages 1365-1374.
Crossref
Ikuo Nishigaki, Peramaiyan Rajendran, Ramachandran Venugopal, Gnapathy Ekambaram, Dhanapal Sakthisekaran & Yutaka Nishigaki. (2009) Cytoprotective role of astaxanthin against glycated protein/iron chelate‐induced toxicity in human umbilical vein endothelial cells. Phytotherapy Research 24:1, pages 54-59.
Crossref
Robert G FassettJeff S Coombes. (2009) Astaxanthin, oxidative stress, inflammation and cardiovascular disease. Future Cardiology 5:4, pages 333-342.
Crossref
Yuji Naito, Satomi Akagiri & Toshikazu Yoshikawa. 2008. Dietary Modulation of Cell Signaling Pathways. Dietary Modulation of Cell Signaling Pathways.
Emiko Manabe, Osamu Handa, Yuji Naito, Katsura Mizushima, Satomi Akagiri, Satoko Adachi, Tomohisa Takagi, Satoshi Kokura, Takashi Maoka & Toshikazu Yoshikawa. (2007) Astaxanthin protects mesangial cells from hyperglycemia‐induced oxidative signaling. Journal of Cellular Biochemistry 103:6, pages 1925-1937.
Crossref
Hiromi Miyawaki, Jiro Takahashi, Hiroki Tsukahara & Isao Takehara. (2008) Effects of Astaxanthin on Human Blood Rheology. Journal of Clinical Biochemistry and Nutrition 43:2, pages 69-74.
Crossref
Hiroki TSUKAHARATakashi KOIKEDA, Takanari ARAI, Hirotaka HAYASHI, Satoshi OHNO & Nobutaka SUZUKI. (2008) Supplementation Effect of Astaxanthin on Blood Flow and Shoulder Stiffness -A Preliminary Pilot Study-アスタキサンチン含有ソフトカプセル食品の肩血流量及び肩凝りに対する影響  ‐パイロット試験‐. Japanese Journal of Complementary and Alternative Medicine 5:1, pages 49-56.
Crossref
P.R. Augusti, G.M.M. Conterato, S. Somacal, R. Sobieski, P.R. Spohr, J.V. Torres, M.F. Charão, A.M. Moro, M.P. Rocha, S.C. Garcia & T. Emanuelli. (2008) Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Food and Chemical Toxicology 46:1, pages 212-219.
Crossref
Muhammad A. Abdul-Ghani & Ralph A. DeFronzo. 2008. Oxidative Stress in Aging. Oxidative Stress in Aging 191 211 .
Chien-Sheng Chen, Shih-Hsiung Wu, Ying-Ying Wu, Jim-Min Fang & Tzu-Hua Wu. (2007) Properties of Astaxanthin/Ca 2+ Complex Formation in the Deceleration of Cis/Trans Isomerization . Organic Letters 9:16, pages 2985-2988.
Crossref
Ghazi Hussein, Takako Nakagawa, Hirozo Goto, Yutaka Shimada, Kinzo Matsumoto, Ushio Sankawa & Hiroshi Watanabe. (2007) Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp. Life Sciences 80:6, pages 522-529.
Crossref
. (2006) Effects of Silk Protein Hydrolysates on Blood Glucose in C57BL/KsJ db/db Mice. Journal of the Korean Society of Food Science and Nutrition 35:9, pages 1166-1171.
Crossref
Sumio TERADAKikuo ITOAkira YOSHIMURANaoto NOGUCHITakashi ISHIDA. (2006) The Constituents Relate to Anti-oxidative and α-Glucosidase Inhibitory Activities in Yacon Aerial Part Extractヤーコン地上部の抗酸化活性とα-グルコシダーゼ阻害活性に関する成分. YAKUGAKU ZASSHI 126:8, pages 665-669.
Crossref
M. Z. Khaldi, H. Elouil, Y. Guiot, J. C. Henquin & J. C. Jonas. (2006) Antioxidants N -acetyl- l -cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent β-cell dysfunction in rat islets cultured in high glucose for 1 wk . American Journal of Physiology-Endocrinology and Metabolism 291:1, pages E137-E146.
Crossref
Ghazi Hussein, Ushio Sankawa, Hirozo Goto, Kinzo Matsumoto & Hiroshi Watanabe. (2005) Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition. Journal of Natural Products 69:3, pages 443-449.
Crossref
. (2005) Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the safety of use of colouring agents in animal nutrition - PART I. General Principles and Astaxanthin. EFSA Journal 3:12, pages 291.
Crossref
Toshikazu Yoshikawa, Kazuhiko Uchiyama & Yuji Naito. 2005. Molecular Interventions in Lifestyle-Related Diseases. Molecular Interventions in Lifestyle-Related Diseases 235 242 .
Ghazi Hussein, Masami Nakamura, Qi Zhao, Tomomi Iguchi, Hirozo Goto, Ushio Sankawa & Hiroshi Watanabe. (2005) Antihypertensive and Neuroprotective Effects of Astaxanthin in Experimental Animals. Biological and Pharmaceutical Bulletin 28:1, pages 47-52.
Crossref
John Dore. 2004. Phytopharmaceuticals in Cancer Chemoprevention. Phytopharmaceuticals in Cancer Chemoprevention.
Un Ju Jung, Myung-Sook Choi, Mi-Kyung Lee & Kyu-Shik Jeong. (2004) The Hypoglycemic Effects of Hesperidin and Naringin Are Partly Mediated by Hepatic Glucose-Regulating Enzymes in C57BL/KsJ-db/db Mice. The Journal of Nutrition 134:10, pages 2499-2503.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.