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Redox Report
Communications in Free Radical Research
Volume 8, 2003 - Issue 2
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Research Articles

Inhibition of THP-1 cell-mediated low-density lipoprotein oxidation by the macrophage-synthesised pterin, 7,8-dihydroneopterin

Steven P. GiesegFree Radical Biochemistry Laboratory Department of Zoology, University of Canterbury , Christchurch, New Zealand
&
Sara CatoFree Radical Biochemistry Laboratory Department of Zoology, University of Canterbury , Christchurch, New Zealand
Pages 113-115 | Published online: 19 Jul 2013

Citations (16)

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Read on this site (3)

Nooshin Ghodsian, Anthony Yeandle, Barry D. Hock & Steven P. Gieseg. (2022) CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin through modulation of PPAR-γ activity. Free Radical Research 56:5-6, pages 366-377.
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Tejraj V. Janmale, Angus Lindsay & Steven P. Gieseg. (2020) Nucleoside transporters are critical to the uptake and antioxidant activity of 7,8-dihydroneopterin in monocytic cells. Free Radical Research 54:5, pages 341-350.
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Carole A. Firth & Steven P. Gieseg. (2007) Redistribution of metal ions to control low density lipoprotein oxidation in Ham's F10 medium. Free Radical Research 41:10, pages 1109-1115.
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Articles from other publishers (13)

Ondrej Heneberk, Eliska Wurfelova & Vladimira Radochova. (2023) Neopterin, the Cell-Mediated Immune Response Biomarker, in Inflammatory Periodontal Diseases: A Narrative Review of a More than Fifty Years Old Biomarker. Biomedicines 11:5, pages 1294.
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Nooshin Ghodsian, Anthony Yeandle & Steven P. Gieseg. (2021) Foam cell formation but not oxLDL cytotoxicity is inhibited by CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin. The International Journal of Biochemistry & Cell Biology 133, pages 105918.
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Angus Lindsay, Alexandra Schmiechen, Christopher M. Chamberlain, James M. Ervasti & Dawn A. Lowe. (2018) Neopterin/7,8-dihydroneopterin is elevated in Duchenne muscular dystrophy patients and protects mdx skeletal muscle function . Experimental Physiology 103:7, pages 995-1009.
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Steven Gieseg, Gregory Baxter-Parker & Angus Lindsay. (2018) Neopterin, Inflammation, and Oxidative Stress: What Could We Be Missing?. Antioxidants 7:7, pages 80.
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Anastasia A. Shchepetkina, Barry D. Hock, Allison Miller, Martin A. Kennedy & Steven P. Gieseg. (2017) Effect of 7,8-dihydroneopterin mediated CD36 down regulation and oxidant scavenging on oxidised low-density lipoprotein induced cell death in human macrophages. The International Journal of Biochemistry & Cell Biology 87, pages 27-33.
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Tejraj Janmale, Rebecca Genet, Elizabeth Crone, Elizabeth Flavall, Carol Firth, John Pirker, Justin A. Roake & Steven P. Gieseg. (2015) Neopterin and 7,8-dihydroneopterin are generated within atherosclerotic plaques. Pteridines 26:3, pages 93-103.
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Steven P. GiesegZunika AmitYa-Ting YangAnastasia ShchepetkinaHanadi Katouah. (2010) Oxidant Production, oxLDL Uptake, and CD36 Levels in Human Monocyte–Derived Macrophages Are Downregulated by the Macrophage-Generated Antioxidant 7,8-Dihydroneopterin. Antioxidants & Redox Signaling 13:10, pages 1525-1534.
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Steven P. Gieseg, Elizabeth Crone & Zunika Amit. 2009. Endogenous Toxins. Endogenous Toxins 619 645 .
Carole A. Firth, Andrew D. Laing, Sarah K. Baird, Joseph Pearson & Steven P. Gieseg. (2008) Inflammatory sites as a source of plasma neopterin: Measurement of high levels of neopterin and markers of oxidative stress in pus drained from human abscesses. Clinical Biochemistry 41:13, pages 1078-1083.
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Carole A. Firth, Elizabeth M. Crone, Elizabeth A. Flavall, Justin A. Roake & Steven P. Gieseg. (2008) Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:6, pages 1095-1101.
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S P Gieseg, E M Crone, E A Flavall & Z Amit. (2008) Potential to inhibit growth of atherosclerotic plaque development through modulation of macrophage neopterin/7,8-dihydroneopterin synthesis. British Journal of Pharmacology 153:4, pages 627-635.
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Sarah K. Baird, Linzi Reid, Mark B. Hampton & Steven P. Gieseg. (2005) OxLDL induced cell death is inhibited by the macrophage synthesised pterin, 7,8-dihydroneopterin, in U937 cells but not THP-1 cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1745:3, pages 361-369.
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Kevin J. McGraw. (2005) The antioxidant function of many animal pigments: are there consistent health benefits of sexually selected colourants?. Animal Behaviour 69:4, pages 757-764.
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