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Short Refereed Papers

Role of 4-hydroxynonenal and its metabolites in signaling

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Pages 4-10 | Published online: 02 Dec 2013

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Ulf Hammerling, Jonas Bergman Laurila, Roland Grafström & Nils-Gunnar Ilbäck. (2016) Consumption of Red/Processed Meat and Colorectal Carcinoma: Possible Mechanisms Underlying the Significant Association. Critical Reviews in Food Science and Nutrition 56:4, pages 614-634.
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V. R. Mali & S. S. Palaniyandi. (2014) Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease. Free Radical Research 48:3, pages 251-263.
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Giancarlo Aldini, Giulio Vistoli, Milan Stefek, N. Chondrogianni, Tilman Grune, Jolanta Sereikaite, Izabela Sadowska-Bartosz & Grzegorz Bartosz. (2013) Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products. Free Radical Research 47:sup1, pages 93-137.
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Kalavathi Dasuri, Philip Ebenezer, Sun Ok Fernandez-Kim, Le Zhang, Zhanguo Gao, Annadora J. Bruce-Keller, Linnea R. Freeman & Jeffrey N. Keller. (2013) Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome. Free Radical Research 47:1, pages 8-19.
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G. Cohen, Y. Riahi & S. Sasson. (2011) Lipid peroxidation of poly-unsaturated fatty acids in normal and obese adipose tissues. Archives of Physiology and Biochemistry 117:3, pages 131-139.
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Anne Negre-Salvayre, Nathalie Auge, Victoria Ayala, Huveyda Basaga, Jordi Boada, Rainer Brenke, Sarah Chapple, Guy Cohen, Janos Feher, Tilman Grune, Gabriella Lengyel, Giovanni E. Mann, Reinald Pamplona, Giuseppe Poli, Manuel Portero-Otin, Yael Riahi, Robert Salvayre, Shlomo Sasson, Jose Serrano, Ofer Shamni, Werner Siems, Richard C. M. Siow, Ingrid Wiswedel, Kamelija Zarkovic & Neven Zarkovic. (2010) Pathological aspects of lipid peroxidation. Free Radical Research 44:10, pages 1125-1171.
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Jon Zárate, Encarnación Goicoechea, Jesús Pascual, Enrique Echevarría & Mariá D. Guillén. (2009) A study of the toxic effect of oxidized sunflower oil containing 4-hydroperoxy-2-nonenal and 4-hydroxy-2-nonenal on cortical TrkA receptor expression in rats. Nutritional Neuroscience 12:6, pages 249-259.
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Yogesh C. Awasthi, Pankaj Chaudhary, Rit Vatsyayan, Abha Sharma, Sanjay Awasthi & Rajendra Sharma. (2009) Physiological and Pharmacological Significance of Glutathione-Conjugate Transport. Journal of Toxicology and Environmental Health, Part B 12:7, pages 540-551.
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Olha Yelisyeyeva, Andriy Cherkas, Kamelija Zarkovic, Khrystyna Semen, Danylo Kaminskyy, Georg Waeg & Neven Zarkovic. (2008) The distribution of 4-hydroxynonenal-modified proteins in gastric mucosa of duodenal peptic ulcer patients. Free Radical Research 42:3, pages 205-211.
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Peter Kaplan, Zuzana Tatarkova, Peter Racay, Jan Lehotsky, Martina Pavlikova & Dusan Dobrota. (2007) Oxidative modifications of cardiac mitochondria and inhibition of cytochrome c oxidase activity by 4-hydroxynonenal. Redox Report 12:5, pages 211-218.
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J Pajaud, C Ribault, I Ben Mosbah, C Rauch, C Henderson, P Bellaud, C Aninat, P Loyer, F Morel & A Corlu. (2015) Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration. Cell Death & Disease 6:1, pages e1598-e1598.
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Surajit Banerjee, Plamen P. Christov, Albena Kozekova, Carmelo J. Rizzo, Martin Egli & Michael P. Stone. (2012) Replication Bypass of the trans -4-Hydroxynonenal-Derived (6 S ,8 R ,11 S )-1, N 2 -Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IV . Chemical Research in Toxicology 25:2, pages 422-435.
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Guy Cohen, Yael Riahi & Shlomo Sasson. 2012. Encyclopedia of Radicals in Chemistry, Biology and Materials. Encyclopedia of Radicals in Chemistry, Biology and Materials.
Julie Pajaud, Sandeep Kumar, Claudine Rauch, Fabrice Morel & Caroline Aninat. (2012) Regulation of Signal Transduction by Glutathione Transferases. International Journal of Hepatology 2012, pages 1-11.
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S.O. Abarikwu, E.O. Farombi, M.P. Kashyap & A.B. Pant. (2011) Atrazine induces transcriptional changes in marker genes associated with steroidogenesis in primary cultures of rat Leydig cells. Toxicology in Vitro 25:8, pages 1588-1595.
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Hai Huang, Hao Wang, Albena Kozekova, Carmelo J. Rizzo & Michael P. Stone. (2011) Formation of a N 2 -dG: N 2 -dG Carbinolamine DNA Cross-link by the trans -4-Hydroxynonenal-Derived (6 S ,8 R ,11 S ) 1, N 2 -dG Adduct . Journal of the American Chemical Society 133:40, pages 16101-16110.
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Siegfried Hekimi, Jérôme Lapointe & Yang Wen. (2011) Taking a “good” look at free radicals in the aging process. Trends in Cell Biology 21:10, pages 569-576.
Crossref
Kaname Uno, Katsuaki Kato, Gen Kusaka, Naoki Asano, Katsunori Iijima & Tooru Shimosegawa. (2011) The balance between 4‐hydroxynonenal and intrinsic glutathione/glutathione S ‐transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas . Molecular Carcinogenesis 50:10, pages 781-790.
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Piotr Zimniak. (2011) Relationship of electrophilic stress to aging. Free Radical Biology and Medicine 51:6, pages 1087-1105.
Crossref
MA Siddiqui, MP Kashyap, AA Al-Khedhairy, J. Musarrat, VK Khanna, S. Yadav & AB Pant. (2010) Protective potential of 17β-estradiol against co-exposure of 4-hydroxynonenal and 6-hydroxydopamine in PC12 cells. Human & Experimental Toxicology 30:8, pages 860-869.
Crossref
Jyotsana Singhal, Sushma Yadav, Lokesh Dalasanur Nagaprashantha, Rit Vatsyayan, Sharad S. Singhal & Sanjay Awasthi. (2011) Targeting p53-Null Neuroblastomas through RLIP76. Cancer Prevention Research 4:6, pages 879-889.
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Wolfhardt Freinbichler, Maria A. Colivicchi, Chiara Stefanini, Loria Bianchi, Chiara Ballini, Bashkim Misini, Peter Weinberger, Wolfgang Linert, Damir Varešlija, Keith F. Tipton & Laura Della Corte. (2011) Highly reactive oxygen species: detection, formation, and possible functions. Cellular and Molecular Life Sciences 68:12, pages 2067-2079.
Crossref
Kota V. Ramana. (2011) Aldose reductase: new insights for an old enzyme. BioMolecular Concepts 2:1-2, pages 103-114.
Crossref
William H. Hoffman, Sandra L. Siedlak, Yang Wang, Rudy J. Castellani & Mark A. Smith. (2011) Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis. Brain Research 1369, pages 194-202.
Crossref
Yael Riahi, Guy Cohen, Ofer Shamni & Shlomo Sasson. (2010) Signaling and cytotoxic functions of 4-hydroxyalkenals. American Journal of Physiology-Endocrinology and Metabolism 299:6, pages E879-E886.
Crossref
J.R. Roede, B.J. Stewart & D.R. Petersen. 2010. Comprehensive Toxicology. Comprehensive Toxicology 581 594 .
Hai Huang, Ivan D. Kozekov, Albena Kozekova, Hao Wang, R. Stephen Lloyd, Carmelo J. Rizzo & Michael P. Stone. (2010) DNA cross-link induced by trans-4-hydroxynonenal. Environmental and Molecular Mutagenesis, pages n/a-n/a.
Crossref
Markus Griesser, William E. Boeglin, Takashi Suzuki & Claus Schneider. (2009) Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments. Journal of Lipid Research 50:12, pages 2455-2462.
Crossref
Klaus Dittmann, Claus Mayer, Rainer Kehlbach, Marie-Christine Rothmund & H. Peter Rodemann. (2009) Radiation-induced lipid peroxidation activates src kinase and triggers nuclear EGFR transport. Radiotherapy and Oncology 92:3, pages 379-382.
Crossref
Velio Bocci, Emma Borrelli, Valter Travagli,Iacopo Zanardi. (2009) The ozone paradox: Ozone is a strong oxidant as well as a medical drug. Medicinal Research Reviews 29:4, pages 646-682.
Crossref
Hai Huang, Hao Wang, R. Stephen Lloyd, Carmelo J. Rizzo & Michael P. Stone. (2008) Conformational Interconversion of the trans -4-Hydroxynonenal-Derived (6 S ,8 R ,11 S ) 1, N 2 -Deoxyguanosine Adduct When Mismatched with Deoxyadenosine in DNA . Chemical Research in Toxicology 22:1, pages 187-200.
Crossref
Shogo J. Miyagi, Isaac W. Brown, Jessica M-L. Chock & Abby C. Collier. (2009) Developmental Changes in Hepatic Antioxidant Capacity Are Age-and Sex-Dependent. Journal of Pharmacological Sciences 111:4, pages 440-445.
Crossref
Stefania Pizzimenti, Manuela Ferracin, Silvia Sabbioni, Cristina Toaldo, Piergiorgio Pettazzoni, Mario Umberto Dianzani, Massimo Negrini & Giuseppina Barrera. (2009) MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation. Free Radical Biology and Medicine 46:2, pages 282-288.
Crossref
George I. Henderson, Jennifer Stewart & Steven Schenker. 2009. Metabolic Encephalopathy. Metabolic Encephalopathy 261 279 .
Piotr Zimniak. (2008) Detoxification reactions: Relevance to aging. Ageing Research Reviews 7:4, pages 281-300.
Crossref
Hai Huang, Hao Wang, Nan Qi, R. Stephen Lloyd, Carmelo J. Rizzo & Michael P. Stone. (2008) The Stereochemistry of trans -4-Hydroxynonenal-Derived Exocyclic 1, N 2 -2′-Deoxyguanosine Adducts Modulates Formation of Interstrand Cross-Links in the 5′-CpG-3′ Sequence . Biochemistry 47:44, pages 11457-11472.
Crossref
M.A. Siddiqui, G. Singh, M.P. Kashyap, V.K. Khanna, S. Yadav, D. Chandra & A.B. Pant. (2008) Influence of cytotoxic doses of 4-hydroxynonenal on selected neurotransmitter receptors in PC-12 cells. Toxicology in Vitro 22:7, pages 1681-1688.
Crossref
Hai Huang, Hao Wang, Nan Qi, Albena Kozekova, Carmelo J. Rizzo & Michael P. Stone. (2008) Rearrangement of the (6 S ,8 R ,11 S ) and (6 R ,8 S ,11 R ) Exocyclic 1, N 2 -Deoxyguanosine Adducts of trans -4-Hydroxynonenal to N 2 -Deoxyguanosine Cyclic Hemiacetal Adducts When Placed Complementary to Cytosine in Duplex DNA . Journal of the American Chemical Society 130:33, pages 10898-10906.
Crossref
Yogesh C. Awasthi, Rajendra Sharma, Abha Sharma, Sushma Yadav, Sharad S. Singhal, Pankaj Chaudhary & Sanjay Awasthi. (2008) Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radical Biology and Medicine 45:2, pages 111-118.
Crossref
Claus Schneider, Ned A. Porter & Alan R. Brash. (2008) Routes to 4-Hydroxynonenal: Fundamental Issues in the Mechanisms of Lipid Peroxidation. Journal of Biological Chemistry 283:23, pages 15539-15543.
Crossref
Sharda P. Singh, Maciej Niemczyk, Deepti Saini, Yogesh C. Awasthi, Ludwika Zimniak & Piotr Zimniak. (2008) Role of the Electrophilic Lipid Peroxidation Product 4-Hydroxynonenal in the Development and Maintenance of Obesity in Mice. Biochemistry 47:12, pages 3900-3911.
Crossref
Lawrence M. Sayre, George Perry & Mark A. Smith. (2007) Oxidative Stress and Neurotoxicity. Chemical Research in Toxicology 21:1, pages 172-188.
Crossref
Jiřina Hofmanová, Karel Souček, Alena Vaculová & Alois Kozubík. 2008. Oxidants in Biology. Oxidants in Biology 129 153 .
Yuji Naito, Tomohisa Takagi & Toshikazu Yoshikawa. (2007) Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease. Journal of Gastroenterology 42:10, pages 787-798.
Crossref
Yuji Naito, Tomohisa Takagi & Toshikazu Yoshikawa. (2007) Neutrophil-Dependent Oxidative Stress in Ulcerative Colitis. Journal of Clinical Biochemistry and Nutrition 41:1, pages 18-26.
Crossref

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