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Annals of Tropical Medicine & Parasitology Volume 99, 2005 - Issue 8
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Original Articles

Itraconazole or allopurinol in the treatment of chronic American trypanosomiasis: the results of clinical and parasitological examinations 11 years post-treatment

W. AptLaboratorio de Parasitología Básico–Clínico, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 427, Santiago 3, Chile
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A. ArribadaDepartamento de Medicina, Hospital San Borja Arriarán, Universidad de Chile, P.O. Box 9183, Santiago 1, Chile; Servicio Cardiología, Clínica INDISA, P.O. Box 9183, Santiago 1, Chile
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I. ZulantayLaboratorio de Parasitología Básico–Clínico, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 427, Santiago 3, Chile
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A. SolariLaboratorio Biología Molecular de Parásitos, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 70086, Santiago 7, Chile
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G. SánchezLaboratorio Biología Molecular de Parásitos, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 70086, Santiago 7, Chile
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K. MundacaLaboratorio de Parasitología Básico–Clínico, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 427, Santiago 3, Chile
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X. CoronadoLaboratorio de Parasitología Básico–Clínico, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 427, Santiago 3, Chile; Laboratorio Biología Molecular de Parásitos, Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 70086, Santiago 7, Chile
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J. RodríguezEscuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Independencia 1027, P.O. Box 427, Santiago 3, Chile
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L. C. GilServicio de Gastroenterología, Hospital Clínico, Universidad de Chile, Santos Dumont, P.O. Box 5, Santiago 7, Chile
&
A. OsunaDepartamento de Parasitología, Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Campus de Fuentenueva, Avenida Severo Ochoa s/n, E-18071, Granada, Spain
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Pages 733-741 | Published online: 18 Jul 2013

Citations (38)

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Maria-Jesús Pinazo, M Carmen Thomas, Jacqueline Bua, Alina Perrone, Alejandro-Gabriel Schijman, Rodolfo-Jorge Viotti, Janine-M Ramsey, Isabela Ribeiro, Sergio Sosa-Estani, Manuel-Carlos López & Joaquim Gascon. (2014) Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review. Expert Review of Anti-infective Therapy 12:4, pages 479-496.
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Emmanuel Bottieau, Marc Vekemans & Alfons Van Gompel. (2011) Therapy of vector-borne protozoan infections in nonendemic settings. Expert Review of Anti-infective Therapy 9:5, pages 583-608.
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Werner Apt. (2010) Current and developing therapeutic agents in the treatment of Chagas disease. Drug Design, Development and Therapy 4, pages 243-253.
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Matilde Jimenez-Coello, Karla Y. Acosta-Viana, Eugenia Guzman-Marin, Cuahutemoc Perez Gonzalez & Maria Salud Perez Gutierrez. (2010) Anti-trypanosomal activity of (8-hydroxymethylen)-trieicosanyl acetate against infective forms of Trypanosoma cruzi. Pharmaceutical Biology 48:6, pages 666-671.
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Jason Bowling & Elizabeth A Walter. (2009) Recognizing and meeting the challenge of Chagas disease in the USA. Expert Review of Anti-infective Therapy 7:10, pages 1223-1234.
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Maria Nazaré C Soeiro & Solange L de Castro. (2009) Trypanosoma cruzi targets for new chemotherapeutic approaches. Expert Opinion on Therapeutic Targets 13:1, pages 105-121.
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Charles Mady, Barbara Maria Ianni & José Leão de Souza$suffix/text()$suffix/text(). (2008) Benznidazole and Chagas disease: can an old drug be the answer to an old problem?. Expert Opinion on Investigational Drugs 17:10, pages 1427-1433.
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I. Zulantay, W. Apt, L. C. Gil, C. Rocha, K. Mundaca, A. Solari, G. Sánchez, C. Rodriguez, G. Martínez, L. M. De Pablos, L. Sandoval, J. Rodríguez, S. Vilchez & A. Osuna. (2007) The PCR-based detection of Trypanosoma cruzi in the faeces of Triatoma infestans fed on patients with chronic American trypanosomiasis gives higher sensitivity and a quicker result than routine xenodiagnosis. Annals of Tropical Medicine & Parasitology 101:8, pages 673-679.
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L. M. A. Braz, R. Raiz, V. Amato Neto, R. S. Alárcon, E. Gakyia & T. S. Okay. (2007) The detection of Trypanosoma cruzi in Triatoma infestans: comparison of a PCR-based assay with microscopical examination. Annals of Tropical Medicine & Parasitology 101:5, pages 461-465.
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Gabriele SassRoy T. MadiganLydia-Marie JoubertAdriana BozziNazish SayedJoseph C. WuDavid A. Stevens. (2019) A Combination of Itraconazole and Amiodarone Is Highly Effective against Trypanosoma cruzi Infection of Human Stem Cell–Derived Cardiomyocytes. The American Journal of Tropical Medicine and Hygiene 101:2, pages 383-391.
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W. Apt. 2017. American Trypanosomiasis Chagas Disease. American Trypanosomiasis Chagas Disease 751 771 .
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Joseph D. Planer, Matthew A. Hulverson, Jennifer A. Arif, Ranae M. Ranade, Robert Don & Frederick S. Buckner. (2014) Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi. PLoS Neglected Tropical Diseases 8:7, pages e2977.
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Juan Carlos Villar, Juan Guillermo Perez, Olga Lucia Cortes, Adelina Riarte, Micah Pepper, Jose Antonio Marin-Neto & Gordon H Guyatt. (2014) Trypanocidal drugs for chronic asymptomatic Trypanosoma cruzi infection . Cochrane Database of Systematic Reviews.
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W. Apt, A. Arribada, I. Zulantay, J. Rodriguez, M. Saavedra & A. Munoz. (2013) Treatment of Chagas' disease with itraconazole: electrocardiographic and parasitological conditions after 20 years of follow-up. Journal of Antimicrobial Chemotherapy 68:9, pages 2164-2169.
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Inés Zulantay, Werner Apt, Daniel Ramos, Lorena Godoy, Claudio Valencia, Matías Molina, Eduardo Sepúlveda, Patricio Thieme, Gabriela Martínez & Gabriela Corral. (2013) The Epidemiological Relevance of Family Study in Chagas Disease. PLoS Neglected Tropical Diseases 7:2, pages e1959.
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Anis RassiJr.Jr., Anis Rassi & Joffre Marcondes de Rezende. (2012) American Trypanosomiasis (Chagas Disease). Infectious Disease Clinics of North America 26:2, pages 275-291.
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Simon L. Croft. 2011. Neglected Diseases and Drug Discovery. Neglected Diseases and Drug Discovery 134 158 .
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Eva Rawlings Parker & Aisha Sethi. (2011) Chagas Disease: Coming to a Place Near You. Dermatologic Clinics 29:1, pages 53-62.
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Noelia L. Grosso, Jacqueline Bua, Alina E. Perrone, Mariela N. Gonzalez, Patricia L. Bustos, Miriam Postan & Laura E. Fichera. (2010) Trypanosoma cruzi: Biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs. Experimental Parasitology 126:2, pages 239-244.
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Julio A. Urbina. (2010) Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches. Acta Tropica 115:1-2, pages 55-68.
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Werner Apt. 2010. American Trypanosomiasis. American Trypanosomiasis 809 825 .
Maria de Nazaré C Soeiro, Andréia P Dantas, Anissa Daliry, Cristiane F da Silva, Denise GJ Batista, Elen M de Souza, Gabriel M Oliveira, Kelly Salomão, Marcos Meuser Batista, Michelle GO Pacheco, Patrícia Bernardino da Silva, Ricardo M Santa-Rita, Rubem FS Menna Barreto, David W Boykin & Solange Lisboa de Castro. (2009) Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies. Memórias do Instituto Oswaldo Cruz 104:suppl 1, pages 301-310.
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Sergio Sosa-Estani, Rodolfo Viotti & Elsa Leonor Segura. (2009) Therapy, diagnosis and prognosis of chronic Chagas disease: insight gained in Argentina. Memórias do Instituto Oswaldo Cruz 104:suppl 1, pages 167-180.
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Constança Carvalho Britto. (2009) Usefulness of PCR-based assays to assess drug efficacy in Chagas disease chemotherapy: value and limitations. Memórias do Instituto Oswaldo Cruz 104:suppl 1, pages 122-135.
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Frederick S. Buckner. 2008. Drug Targets in Kinetoplastid Parasites. Drug Targets in Kinetoplastid Parasites 61 80 .
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Juan M. Bustamante, María S. Lo Presti, Héctor W. Rivarola, Alicia R. Fernández, Julio E. Enders, Ricardo E. Fretes & Patricia Paglini-Oliva. (2007) Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy. International Journal of Antimicrobial Agents 29:6, pages 733-737.
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