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Keynote Articles

Conservation of Hearing and Protection of Auditory Hair Cells against Trauma-Induced Losses by Local Dexamethasone Therapy: Molecular and Genetic Mechanisms

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Pages 42-55 | Published online: 18 Jul 2013

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Read on this site (7)

Dong-Hyun Kim, Thu Nhan Nguyen, Young-Min Han, Phuong Tran, Jinhyung Rho, Jae-Young Lee, Hwa-Young Son & Jeong-Sook Park. (2021) Local drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment. Drug Delivery 28:1, pages 2268-2277.
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Scott Chambers, Carrie Newbold, Dimitra Stathopoulos, Karina Needham, Chris Miller, Frank Risi, Ya Lang Enke, Godofredo Timbol & Robert Cowan. (2019) Protecting against electrode insertion trauma using dexamethasone. Cochlear Implants International 20:1, pages 1-11.
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Changling Sun, Xueling Wang, Zhaozhu Zheng, Dongye Chen, Xiaoqin Wang, Fuxin Shi, Dehong Yu & Hao Wu. (2015) A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration. International Journal of Nanomedicine 10, pages 3567-3579.
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Min Young Lee, Jun Ho Lee, Ho Sun Lee, Jun-Jae Choi, Jongmoon Jang, Hongsoo Choi, Seung-Ha Oh & Jeong Hun Jang. (2015) Continuous topical drug delivery using osmotic pump in animal cochlear implant model: Continuous steroid delivery is effective for hearing preservation. Acta Oto-Laryngologica 135:8, pages 791-798.
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Friedrich Ihler, Sabrina Pelz, Melanie Coors, Christoph Matthias & Martin Canis. (2014) Application of a TNF-alpha-inhibitor into the scala tympany after cochlear electrode insertion trauma in guinea pigs: Preliminary audiologic results. International Journal of Audiology 53:11, pages 810-816.
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Chul Ho Jang, Si Young Jo & Yong Beom Cho. (2013) Matrix removal of labyrinthine fistulae by non-suction technique with intraoperative dexamethasone injection. Acta Oto-Laryngologica 133:9, pages 910-915.
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Elsa Erixon, Susanne Köbler & Helge Rask-Andersen. (2012) Cochlear implantation and hearing preservation: Results in 21 consecutively operated patients using the round window approach. Acta Oto-Laryngologica 132:9, pages 923-931.
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Articles from other publishers (26)

Muhammad Taifur Rahman, Brian J. Mostaert, Bryce Hunger, Utsow Saha, Alexander D. Claussen, Ibrahim Razu, Farjana Nasrin, Nashwaan Ali Khan, Peter Eckard, Sarah Coleman, Jacob Oleson, Jonathon R. Kirk, Keiko Hirose & Marlan R. Hansen. (2023) Contribution of macrophages to neural survival and intracochlear tissue remodeling responses following cochlear implantation. Journal of Neuroinflammation 20:1.
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Rachele Sangaletti, Ilmar Tamames, Stephanie Lynn Yahn, James Seungyeon Choi, Jae K. Lee, Curtis King & Suhrud M. Rajguru. (2022) Mild therapeutic hypothermia protects against inflammatory and proapoptotic processes in the rat model of cochlear implant trauma. Hearing Research, pages 108680.
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Amit Amar, Eli Lewis, Daniel Kaplan & Sabri El-Saied. (2022) Preservation of Inner Ear Functions: Extending Glucocorticoid Therapy by Tissue-Protective α1-Antitrypsin. Applied Sciences 12:18, pages 9359.
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Xue Bai, Miao Wang, Xun Niu, Hong Yu, Jian‐Xin Yue & Yu Sun. (2022) Effect of N‐acetyl‐cysteine treatment on sensorineural hearing loss: a meta‐analysis. World Journal of Otorhinolaryngology - Head and Neck Surgery 8:3, pages 205-212.
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Muhammad T. Rahman, Divya A. Chari, Gail Ishiyama, Ivan Lopez, Alicia M. Quesnel, Akira Ishiyama, Joseph B. Nadol & Marlan R. Hansen. (2022) Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation. Hearing Research 422, pages 108536.
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Devon C. Pawley, Stefania Goncalves, Esperanza Bas, Emre Dikici, Sapna K. Deo, Sylvia Daunert & Fred Telischi. (2021) Dexamethasone (DXM)‐Coated Poly(lactic‐ co ‐glycolic acid) (PLGA) Microneedles as an Improved Drug Delivery System for Intracochlear Biodegradable Devices . Advanced Therapeutics 4:11.
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Stephen J. O'Leary, June Choi, Karina Brady, Sheila Matthews, Katie Boncza Ozdowska, Matthew Payne, Tim McLean, Alex Rousset, Jonathon Lo, Nathan Creber, Sylvia Tari, Richard Dowell & Robert Briggs. (2021) Systemic methylprednisolone for hearing preservation during cochlear implant surgery: A double blinded placebo-controlled trial. Hearing Research 404, pages 108224.
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Thomas J. Muelleman, Kaley Pippin, Matthew Shew, Mark Villwock, James Lin, Alicia M. QuesnelLuke Ledbetter & Hinrich Staecker. (2020) The Size of Internal Auditory Canal Diverticula Is Unrelated to Degree of Hearing Loss. The Laryngoscope 130:4, pages 1011-1015.
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Navid Ahmadi, Julia Clara Gausterer, Clemens Honeder, Marlene Mötz, Hanna Schöpper, Chengjing Zhu, Nodir Saidov, Franz Gabor & Christoph Arnoldner. (2019) Long-term effects and potential limits of intratympanic dexamethasone-loaded hydrogels combined with dexamethasone-eluting cochlear electrodes in a low-insertion trauma Guinea pig model. Hearing Research 384, pages 107825.
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Eric C. Bielefeld, Ryan T. Harrison & J. Riley DeBacker. (2019) Pharmaceutical otoprotection strategies to prevent impulse noise-induced hearing loss. The Journal of the Acoustical Society of America 146:5, pages 3790-3799.
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Enrique Perez, Andrea Viziano, Zaid Al-Zaghal, Fred F. Telischi, Rachele Sangaletti, Weitao Jiang, William Dalton Dietrich, Curtis King, Michael E. Hoffer & Suhrud M. Rajguru. (2019) Anatomical Correlates and Surgical Considerations for Localized Therapeutic Hypothermia Application in Cochlear Implantation Surgery. Otology & Neurotology 40:9, pages 1167-1177.
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Renato Torres, Huan Jia, Mylène Drouillard, Jean‐Loup Bensimon, Olivier Sterkers, Evelyne Ferrary & Yann Nguyen. (2018) An Optimized Robot‐Based Technique for Cochlear Implantation to Reduce Array Insertion Trauma. Otolaryngology–Head and Neck Surgery 159:5, pages 900-907.
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Çağrı Çelik, Mehmet Emrah Ceylan, Aynur Aliyeva, Ufuk Düzenli & Abdullah Dalgıç. (2018) The Effect Of Perioperative I.V. Corticosteroids On Hearing Outcome Following Stapedotomy. ENT Updates, pages 82-87.
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Mun Young Chang, Yoon Chan Rah, Jun Jae Choi, Shin Wook Woo, Yu-Jung Hwang, Hayden Eastwood, Stephen J. O’Leary & Jun Ho Lee. (2017) The Effect of Systemic Steroid on Hearing Preservation After Cochlear Implantation via Round Window Approach: A Guinea Pig Model. Otology & Neurotology 38:7, pages 962-969.
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Ilmar Tamames, Curtis King, Esperanza Bas, W. Dalton Dietrich, Fred Telischi & Suhrud M. Rajguru. (2016) A cool approach to reducing electrode-induced trauma: Localized therapeutic hypothermia conserves residual hearing in cochlear implantation. Hearing Research 339, pages 32-39.
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Esperanza Bas, Jorge Bohorquez, Stefania Goncalves, Enrique Perez, Christine T. Dinh, Carolyn Garnham, Roland Hessler, Adrien A. Eshraghi & Thomas R. Van De Water. (2016) Electrode array-eluted dexamethasone protects against electrode insertion trauma induced hearing and hair cell losses, damage to neural elements, increases in impedance and fibrosis: A dose response study. Hearing Research 337, pages 12-24.
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George B. Wanna, Jack H. Noble, Rene H. Gifford, Mary S. Dietrich, Alex D. Sweeney, Dongqing Zhang, Benoit M. Dawant, Alejandro Rivas & Robert F. Labadie. (2015) Impact of Intrascalar Electrode Location, Electrode Type, and Angular Insertion Depth on Residual Hearing in Cochlear Implant Patients. Otology & Neurotology 36:8, pages 1343-1348.
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Jafri Kuthubutheen, Harvey Coates, Corwyn Rowsell, Julian Nedzelski, Joseph M. Chen & Vincent Lin. (2015) The role of extended preoperative steroids in hearing preservation cochlear implantation. Hearing Research 327, pages 257-264.
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Ingeborg Hochmair, Erwin Hochmair, Peter Nopp, Melissa Waller & Claude Jolly. (2015) Deep electrode insertion and sound coding in cochlear implants. Hearing Research 322, pages 14-23.
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Yann Nguyen, Daniele Bernardeschi, Guillaume Kazmitcheff, Mathieu Miroir, Thomas Vauchel, Evelyne Ferrary & Olivier Sterkers. (2015) Effect of Embedded Dexamethasone in Cochlear Implant Array on Insertion Forces in an Artificial Model of Scala Tympani. Otology & Neurotology 36:2, pages 354-358.
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Vinay T Fernandes & Vincent YW Lin. (2014) Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection. Journal of Otolaryngology - Head & Neck Surgery 43:1.
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G Malkoc, A Dalgic, M Koc, T Kandogan, S Korkmaz, M E Ceylan, S Inan & L Olgun. (2014) Histopathological and audiological effects of mechanical trauma associated with the placement of an intracochlear electrode, and the benefit of corticosteroid infusion: prospective animal study. The Journal of Laryngology & Otology 128:8, pages 702-708.
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Naoki Oishi, Jun Chen, Hong-Wei Zheng, Kayla Hill, Jochen Schacht & Su-Hua Sha. (2013) Tumor Necrosis Factor-alpha-mutant Mice Exhibit High Frequency Hearing Loss. Journal of the Association for Research in Otolaryngology 14:6, pages 801-811.
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Kenneth H. Brookler. (2013) Re. Otology & Neurotology 34:8, pages 1545-1546.
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Huan Jia, Jing Wang, Florence François, Alain Uziel, Jean-Luc Puel & Frédéric Venail. (2013) Molecular and Cellular Mechanisms of Loss of Residual Hearing after Cochlear Implantation. Annals of Otology, Rhinology & Laryngology 122:1, pages 33-39.
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Esperanza Bas Infante, Guyan A. Channer, Fred F. Telischi, Chhavi Gupta, John T. Dinh, Ly Vu, Adrien A. A. Eshraghi & Thomas R. Van De Water. (2012) Mannitol Protects Hair Cells Against Tumor Necrosis Factor α–Induced Loss. Otology & Neurotology 33:9, pages 1656-1663.
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